{"id":"https://openalex.org/W2758192012","doi":"https://doi.org/10.18596/jotcsa.329108","title":"Synthesis, Characterization, and Cytotoxic Activities of a Schiff Base Ligand and Its Binuclear Copper(II) and Manganese(III) Complexes","display_name":"Synthesis, Characterization, and Cytotoxic Activities of a Schiff Base Ligand and Its Binuclear Copper(II) and Manganese(III) Complexes","publication_year":2017,"publication_date":"2017-09-21","ids":{"openalex":"https://openalex.org/W2758192012","doi":"https://doi.org/10.18596/jotcsa.329108","mag":"2758192012"},"language":"en","primary_location":{"id":"doi:10.18596/jotcsa.329108","doi":"https://doi.org/10.18596/jotcsa.329108","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.329108","pdf_url":"https://dergipark.org.tr/en/download/article-file/343165","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society, Section A: Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/343165","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085527752","display_name":"Zafer Uyar","orcid":"https://orcid.org/0000-0002-6310-8823","observed_orcids":["https://orcid.org/0000-0002-6310-8823"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zafer Uyar","raw_affiliation_strings":["HARRAN \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HARRAN \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060721106","display_name":"Di\u011fdem Erdener","orcid":"https://orcid.org/0000-0002-4226-0455","observed_orcids":["https://orcid.org/0000-0002-4226-0455"]},"institutions":[{"id":"https://openalex.org/I115953327","display_name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","ror":"https://ror.org/05rsv8p09","country_code":"TR","type":"education","lineage":["https://openalex.org/I115953327"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Di\u011fdem Erdener","raw_affiliation_strings":["\u00c7anakkale Onsekiz Mart University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7anakkale Onsekiz Mart University","institution_ids":["https://openalex.org/I115953327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085388960","display_name":"\u0130smail Koyuncu","orcid":"https://orcid.org/0000-0002-9469-4757","observed_orcids":["https://orcid.org/0000-0002-9469-4757"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130smail Koyuncu","raw_affiliation_strings":["HARRAN \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HARRAN \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025590866","display_name":"\u00dclk\u00fc Arslan","orcid":"https://orcid.org/0000-0001-5409-9067","observed_orcids":["https://orcid.org/0000-0001-5409-9067"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00dclk\u00fc Arslan","raw_affiliation_strings":["HARRAN \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HARRAN \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3926,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61948959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"963","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schiff-base-ligands","display_name":"Schiff base ligands","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mn-iii-complexes","display_name":"manganese(III) complexes","score":1.0},{"id":"https://openalex.org/keywords/dinuclear-complexes","display_name":"dinuclear complexes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/metal-chelation","display_name":"metal chelation","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dld-1-cells","display_name":"DLD-1 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2776428424","wikidata":"https://www.wikidata.org/wiki/Q2602701","display_name":"Schiff base","level":2,"score":0.6679680347442627},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6510197520256042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.643231213092804},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6134697198867798},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.5599046349525452},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4817357361316681},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.4725213646888733},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.4625721573829651},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4491618573665619},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4201383590698242},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3435612916946411},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.304915189743042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22274142503738403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17821720242500305},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1219034194946289},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10627225041389465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09416118264198303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09374892711639404},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0642150342464447},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06101354956626892},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.18596/jotcsa.329108","doi":"https://doi.org/10.18596/jotcsa.329108","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.329108","pdf_url":"https://dergipark.org.tr/en/download/article-file/343165","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society, Section A: Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.gov.tr:article/329108","doi":null,"is_oa":true,"landing_page_url":"http://dergipark.gov.tr/jotcsa/issue/30155/329108","pdf_url":null,"source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\\n Volume: 4, Issue: 3\\n 963-980\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/329108","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jotcsa/issue/30155/329108","pdf_url":null,"source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:4836741d-bb44-4a55-ab39-e9b141d10baf","doi":null,"is_oa":false,"landing_page_url":"https://avesis.comu.edu.tr/publication/details/4836741d-bb44-4a55-ab39-e9b141d10baf/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055198","display_name":"\u00c7anakkale Onsekiz Mart University AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:30f3573f1a974e1d9475a0b85cdc9436","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/30f3573f1a974e1d9475a0b85cdc9436","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 4, Iss 3, Pp 963-980 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18596/jotcsa.329108","doi":"https://doi.org/10.18596/jotcsa.329108","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.329108","pdf_url":"https://dergipark.org.tr/en/download/article-file/343165","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society, Section A: Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2758192012.pdf","grobid_xml":"https://content.openalex.org/works/W2758192012.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W405567791","https://openalex.org/W1561156962","https://openalex.org/W1969784763","https://openalex.org/W1969844217","https://openalex.org/W1987954645","https://openalex.org/W1996421437","https://openalex.org/W1996588803","https://openalex.org/W2000153603","https://openalex.org/W2008507180","https://openalex.org/W2008680953","https://openalex.org/W2020034453","https://openalex.org/W2024974231","https://openalex.org/W2036622746","https://openalex.org/W2036825911","https://openalex.org/W2037092540","https://openalex.org/W2040928199","https://openalex.org/W2042838586","https://openalex.org/W2047903898","https://openalex.org/W2050026721","https://openalex.org/W2051430112","https://openalex.org/W2057573750","https://openalex.org/W2058659065","https://openalex.org/W2059035986","https://openalex.org/W2060448279","https://openalex.org/W2060767531","https://openalex.org/W2069185832","https://openalex.org/W2070911712","https://openalex.org/W2102322990","https://openalex.org/W2106030535","https://openalex.org/W2120853161","https://openalex.org/W2139539412","https://openalex.org/W2145824104","https://openalex.org/W2156416336","https://openalex.org/W2165175723","https://openalex.org/W2267090133","https://openalex.org/W2284894100","https://openalex.org/W2465940863","https://openalex.org/W4210469667"],"related_works":["https://openalex.org/W2978570402","https://openalex.org/W4282039998","https://openalex.org/W2967387861","https://openalex.org/W3089144728","https://openalex.org/W7112500436","https://openalex.org/W4295290089","https://openalex.org/W6968468646","https://openalex.org/W7171386822","https://openalex.org/W2054253634","https://openalex.org/W2016849951"],"abstract_inverted_index":{"A":[0],"novel":[1],"symmetrical":[2],"N2O2":[3],"type":[4],"Schiff":[5],"base":[6],"(1)":[7],"and":[8,13,20,25,30,37,43,46,70,109,144],"its":[9,71],"copper":[10,36],"(II)":[11],"(2)":[12],"manganese":[14,38,161],"(III)":[15],"(3)":[16],"complexes":[17,48,73],"were":[18,113],"synthesized":[19],"characterized":[21],"by":[22,115,150],"spectroscopic,":[23],"analytical,":[24],"magnetic":[26,31],"susceptibility":[27,32],"studies.":[28],"Spectroscopic":[29],"studies":[33],"suggested":[34],"that":[35,133],"ions":[39],"are":[40],"in":[41,56,158],"2+":[42],"3+":[44],"states":[45],"their":[47,117],"have":[49],"a":[50,168],"binuclear":[51],"double":[52],"stranded":[53],"helical":[54],"structure":[55],"the":[57,68,121,136,172,179,186,189],"form":[58],"of":[59,67,135,191],"2:2":[60],"(metal":[61],"to":[62,188],"ligand)":[63],"stoichiometry.":[64],"Cytotoxic":[65],"effects":[66],"ligand":[69,137],"metal":[72,151],"against":[74],"MCF-7":[75],"(human":[76,82,88,94,99,105],"breast":[77,100],"cancer":[78,84,90,96,101,107,142],"cell":[79,85,91,102,174],"line),":[80,86,92,97,103],"DLD-1":[81],"colorectal":[83],"ECC-1":[87],"endometrium":[89],"DU-145":[93],"prostate":[95,106],"MDA-MB231":[98],"PC-3":[104],"line)":[108],"HEK293":[110,148],"(normal":[111],"cells)":[112],"evaluated":[114],"determining":[116],"cellular":[118],"viability":[119],"using":[120],"colorimetric":[122],"3-(4,5-":[123],"dimethylthiazole-2-yl)-2,5-biphenyl":[124],"tetrazolium":[125],"bromide":[126],"(MTT)":[127],"assay.":[128],"It":[129],"has":[130],"been":[131],"found":[132],"cytotoxicity":[134],"was":[138],"significantly":[139],"enhanced":[140],"towards":[141,146],"cells":[143,149],"declined":[145],"normal":[147,180],"chelation.":[152],"Copper":[153],"complex":[154,166],"yielded":[155],"better":[156],"results":[157],"comparison":[159],"with":[160],"complex.":[162],"Particularly,":[163],"c":[164],"opper":[165],"showed":[167],"selective":[169],"cytotoxicity,":[170],"harming":[171],"cancerous":[173],"lines":[175],"while":[176],"not":[177],"impairing":[178],"cells,":[181],"which":[182],"is":[183],"considered":[184],"as":[185],"key":[187],"future":[190],"cytotoxic":[192],"therapy.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2017-10-06T00:00:00"}
