{"id":"https://openalex.org/W2756564530","doi":"https://doi.org/10.5530/pj.2017.6.150","title":"Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats","display_name":"Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2756564530","doi":"https://doi.org/10.5530/pj.2017.6.150","mag":"2756564530"},"language":"en","primary_location":{"id":"doi:10.5530/pj.2017.6.150","doi":"https://doi.org/10.5530/pj.2017.6.150","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6.150","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9-957_0.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://phcogj.com/sites/default/files/PharmacognJ-9-957_0.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012361276","display_name":"Gomathi Swaminathan","orcid":"https://orcid.org/0000-0003-4458-5445","observed_orcids":["https://orcid.org/0000-0003-4458-5445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swaminathan Gomathi","raw_affiliation_strings":["Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy , Komarapalayam , Namakkal , Tamil Nadu - 638183 , INDIA","Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy , Komarapalayam , Namakkal , Tamil Nadu - 638183 , INDIA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045759616","display_name":"Rajagopal Shanmuga Sundaram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rajagopal Shanmuga Sundaram","raw_affiliation_strings":["Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060544352","display_name":"Vellaichamy Muthupandi Annapandian","orcid":"https://orcid.org/0000-0001-6232-0091","observed_orcids":["https://orcid.org/0000-0001-6232-0091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vellaichamy Muthupandi Annapandian","raw_affiliation_strings":["Department of Pharmacology ,","Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA","Department of Pharmacology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology ,","institution_ids":[]},{"raw_affiliation_string":"Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050752838","display_name":"M. Vijayabaskaran","orcid":"https://orcid.org/0000-0002-7638-4149","observed_orcids":["https://orcid.org/0000-0002-7638-4149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manickam Vijayabaskaran","raw_affiliation_strings":["Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy , Komarapalayam , Namakkal , Tamil Nadu - 638183 , INDIA","Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy , Komarapalayam , Namakkal , Tamil Nadu - 638183 , INDIA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu -638183, INDIA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045759616"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.19955412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"6","first_page":"957","last_page":"962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pedalium-murex","display_name":"Pedalium murex","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6309999823570251},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6800000071525574},{"id":"https://openalex.org/keywords/behavioural-disorders","display_name":"behavioural disorders","score":0.5929999947547913},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.7839999794960022},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8433867692947388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5947558283805847},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5912524461746216},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.586432158946991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5603200793266296},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.48946964740753174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23677963018417358}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5530/pj.2017.6.150","doi":"https://doi.org/10.5530/pj.2017.6.150","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6.150","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9-957_0.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5530/pj.2017.6.150","doi":"https://doi.org/10.5530/pj.2017.6.150","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6.150","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9-957_0.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2756564530.pdf","grobid_xml":"https://content.openalex.org/works/W2756564530.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W12682092","https://openalex.org/W228150772","https://openalex.org/W1525713084","https://openalex.org/W1634993844","https://openalex.org/W1969433430","https://openalex.org/W1979574875","https://openalex.org/W1983310681","https://openalex.org/W1983991279","https://openalex.org/W1985188769","https://openalex.org/W1989259597","https://openalex.org/W1990547035","https://openalex.org/W1996011091","https://openalex.org/W2019926315","https://openalex.org/W2020639149","https://openalex.org/W2024484257","https://openalex.org/W2069606452","https://openalex.org/W2074162608","https://openalex.org/W2091843298","https://openalex.org/W2166248226","https://openalex.org/W2169473035","https://openalex.org/W2317639561"],"related_works":["https://openalex.org/W2077655479","https://openalex.org/W2095198015","https://openalex.org/W2995727304","https://openalex.org/W1517805603","https://openalex.org/W1593223226","https://openalex.org/W2034773528","https://openalex.org/W1988725105","https://openalex.org/W4295886409","https://openalex.org/W123747276","https://openalex.org/W2481738341"],"abstract_inverted_index":{"Introduction:":[0],"Effective":[1],"treatment":[2],"is":[3,31,212],"necessary":[4],"to":[5,23,26,48,133,144,194],"minimize":[6],"the":[7,50,103,106,136,160],"neuronal":[8],"damage":[9,224],"and":[10,98,116,156,220],"oxidative":[11],"stress.Traditional":[12],"medicines":[13],"offer":[14],"potent":[15],"pharmacological":[16],"activity":[17],"with":[18,70,83,169],"minimal":[19],"side":[20],"effects":[21],"compared":[22,132,168,193],"synthetic":[24],"drugs":[25],"treat":[27],"such":[28],"chronic":[29],"disorders.There":[30],"no":[32],"renowned":[33],"remedy":[34],"for":[35,216],"arrest":[36],"or":[37,40],"rescuing":[38],"infection":[39,219],"inflammation-induced":[41],"brain":[42,111,223],"damage.The":[43],"present":[44],"study":[45],"was":[46,66,114,126,142,187,199],"aimed":[47],"evaluate":[49],"neuroprotective":[51],"effect":[52],"of":[53,56,75,85,105,151,162,218],"ethanol":[54],"extract":[55],"Pedalium":[57],"murex":[58],"Linn.(EEPM)":[59],"leaves":[60],"against":[61],"lipopolysaccharide":[62],"(LPS)-induced":[63],"endotoxemia.Methods:":[64],"Neurodegeneration":[65],"induced":[67,79,222],"in":[68,128,147,164,180,189],"rats":[69,108,130,191],"a":[71,213],"single":[72],"intraperitoneal":[73],"injection":[74],"LPS":[76],"(1":[77],"mg/kg).The":[78],"endotoxemia":[80],"constantly":[81],"linked":[82],"battery":[84],"behavioural":[86],"tests":[87],"viz.,":[88],"choice":[89],"reaction":[90],"time":[91],"task":[92],"(CRT),":[93],"8-arm":[94],"radial":[95],"maze":[96,100],"(RAM)":[97],"water":[99],"test":[101],"(WMT).At":[102],"end":[104],"study,":[107],"were":[109,119],"sacrificed,":[110],"hippocampal":[112],"region":[113],"removed":[115],"biochemical":[117],"parameters":[118],"measured.Results:":[120],"In":[121],"WMT":[122],"swimming":[123,137],"length":[124,138],"(cm)":[125],"increased":[127,183],"LPS-treated":[129,190],"when":[131,167,192],"control":[134,170,195],"animals,":[135],"(EEPM;":[139],"400":[140,157,175,204],"mg/kg)":[141],"found":[143],"be":[145],"significant;":[146],"RAM,":[148],"different":[149],"doses":[150],"EEPM":[152,202,211],"at":[153,174,203],"100,":[154],"200":[155],"mg/kg":[158,176,205],"decreased":[159],"number":[161],"errors":[163],"entry":[165],"4.00\u00b10.36,4.16\u00b10.16and3.33\u00b12.79respectively":[166],"animals":[171],"(2.66\u00b1":[172],"0.21).EEPM":[173],"showed":[177,209],"significant":[178],"activity,":[179],"CRT":[181],"apparatus":[182],"incorrect":[184],"lever":[185,197],"pressing":[186,198],"observed":[188],"animals.Incorrect":[196],"minimized":[200],"by":[201,225],"(43.5\u00b12.40).Conclusions:":[206],"Our":[207],"results":[208],"that":[210],"hopeful":[214],"aspirant":[215],"hindrance":[217],"inflammation":[221],"LPS.":[226]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
