{"id":"https://openalex.org/W2755942467","doi":"https://doi.org/10.5061/dryad.st5rk","title":"Data from: Factors associated with pulmonary impairment in HIV-infected South African adults","display_name":"Data from: Factors associated with pulmonary impairment in HIV-infected South African adults","publication_year":2017,"publication_date":"2017-08-31","ids":{"openalex":"https://openalex.org/W2755942467","doi":"https://doi.org/10.5061/dryad.st5rk","mag":"2755942467"},"language":"en","primary_location":{"id":"pmh:oai:easy.dans.knaw.nl:easy-dataset:98827","doi":null,"is_oa":false,"landing_page_url":"https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:98827","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/4999540","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041913334","display_name":"Akshay Gupte","orcid":"https://orcid.org/0000-0002-5179-773X","observed_orcids":["https://orcid.org/0000-0002-5179-773X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gupte, Akshay N.","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053699535","display_name":"Michelle Wong","orcid":"https://orcid.org/0000-0001-7178-7953","observed_orcids":["https://orcid.org/0000-0001-7178-7953"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Wong, Michelle L.","raw_affiliation_strings":["University of the Witwatersrand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033315217","display_name":"Reginah Masandiwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masandiwa, Reginah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059911706","display_name":"Grace Link Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barnes, Grace L.","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112618656","display_name":"Jonathan Golub","orcid":"https://orcid.org/0000-0003-2398-3145","observed_orcids":["https://orcid.org/0000-0003-2398-3145"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Golub, Jonathan","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071106707","display_name":"Richard E. Chaisson","orcid":"https://orcid.org/0000-0003-4710-925X","observed_orcids":["https://orcid.org/0000-0003-4710-925X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaisson, Richard E.","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052108604","display_name":"Christopher J. Hoffmann","orcid":"https://orcid.org/0000-0002-9422-0519","observed_orcids":["https://orcid.org/0000-0002-9422-0519"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoffmann, Christopher J.","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080719777","display_name":"Neil Alexander Martinson","orcid":"https://orcid.org/0000-0002-0184-5705","observed_orcids":["https://orcid.org/0000-0002-0184-5705"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Martinson, Neil A.","raw_affiliation_strings":["University of the Witwatersrand","Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":null,"display_name":"Msandiwa, Reginah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Msandiwa, Reginah","raw_affiliation_strings":["University of the Witwatersrand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21768788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.6029999852180481},{"id":"https://openalex.org/keywords/obstructive-pulmonary-disease","display_name":"obstructive lung disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pulmonary-impairment","display_name":"pulmonary impairment","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.8640000224113464},{"id":"https://openalex.org/keywords/spirometry","display_name":"spirometry","score":0.7919999957084656},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5699999928474426},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.7279999852180481},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.8510000109672546},{"id":"https://openalex.org/keywords/black-people","display_name":"Black people","score":0.5379999876022339},{"id":"https://openalex.org/keywords/fev1-fvc-ratio","display_name":"FEV1/FVC ratio","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cvd-risk-factors","display_name":"CVD risk factors","score":0.47200000286102295},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6019999980926514},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6218934655189514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5831419229507446},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32870447635650635},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31727027893066406}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:easy.dans.knaw.nl:easy-dataset:98827","doi":null,"is_oa":false,"landing_page_url":"https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:98827","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:zenodo.org:4999540","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4999540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},{"id":"doi:10.5061/dryad.st5rk","doi":"https://doi.org/10.5061/dryad.st5rk","is_oa":true,"landing_page_url":"https://doi.org/10.5061/dryad.st5rk","pdf_url":null,"source":{"id":"https://openalex.org/S7407051161","display_name":"DRYAD","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"mag:2755942467","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/collections/Data_from_Factors_associated_with_pulmonary_impairment_in_HIV-infected_South_African_adults/3881269","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:zenodo.org:4999540","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4999540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2755245816","https://openalex.org/W3196201981","https://openalex.org/W7099428431","https://openalex.org/W2105413647","https://openalex.org/W2888201519","https://openalex.org/W2079887820","https://openalex.org/W3031066450","https://openalex.org/W4212780622","https://openalex.org/W2901244199","https://openalex.org/W3214442462"],"abstract_inverted_index":{"Background:":[0],"HIV-infected":[1,56,295,314],"individuals":[2],"have":[3],"increased":[4],"risk":[5],"of":[6,51,101,131,161,168,228,249,269,301,305],"developing":[7],"obstructive":[8],"lung":[9,52,311],"disease":[10],"(OLD).":[11],"Studies":[12],"from":[13],"developed":[14],"countries":[15],"report":[16],"high":[17],"viral":[18,140,218],"load,":[19],"low":[20],"CD4":[21,137,210,290],"counts,":[22],"and":[23,67,94,104,123,139,148,193,226,259,271,284,292,308],"anti-retroviral":[24],"therapy":[25],"(ART)":[26],"to":[27,39,78],"be":[28,37],"associated":[29,81,203,278],"with":[30,82,126,204,246,279],"OLD;":[31],"but":[32,288],"these":[33],"findings":[34],"may":[35],"not":[36,289],"generalizable":[38],"populations":[40,315],"in":[41,54,92,174,294,313],"resource-limited":[42],"settings.":[43],"Methods:":[44],"We":[45],"conducted":[46],"a":[47,127,247,253],"prospective":[48],"cohort":[49],"study":[50],"function":[53,312],"730":[55],"black":[57],"South":[58,296],"African":[59,297],"adults.":[60,298],"Pre-bronchodilator":[61],"spirometry":[62],"was":[63,116,172,241,277],"performed":[64],"at":[65,87,114,142,158,164,177,206],"enrollment":[66,115,143],"repeated":[68],"annually":[69],"for":[70],"three":[71],"years.":[72],"Logistic":[73],"regression":[74],"models":[75],"were":[76,96,121,144,155,201,234],"used":[77],"identify":[79],"factors":[80],"OLD,":[83],"defined":[84],"as":[85,98],"FEV1/FVC<0.70,":[86],"enrollment.":[88,178],"Excess":[89],"annual":[90],"declines":[91],"FEV1":[93,270],"FVC":[95,272],"modelled":[97],"the":[99,302],"product-term":[100],"follow-up":[102,239],"time":[103,240],"exposures":[105],"using":[106],"random":[107],"effects":[108,304],"regression.":[109],"Results:":[110],"Median":[111,135],"(IQR)":[112,129,136,238],"age":[113,180],"36":[117],"(32-41)":[118],"years,":[119],"85%":[120],"female":[122],"30%":[124],"ever-smoked":[125],"median":[128,237],"exposure":[130],"3":[132],"(1-6)":[133],"pack-years.":[134],"count":[138,211],"load":[141,219],"372":[145],"(261-518)":[146],"cells/mm3":[147,214],"2655":[149],"(91-13,548)":[150],"copies/mL":[151],"respectively.":[152,273],"Overall,":[153],"25%":[154],"receiving":[156],"ART":[157,169,229],"enrollment,":[159],"16%":[160],"whom":[162],"reported":[163],"least":[165],"6":[166],"months":[167],"receipt.":[170],"OLD":[171,205,276],"found":[173],"35":[175,254],"(5%)":[176],"Increasing":[179],"(aOR=2.08":[181],"per":[182,196,221,265],"10-years":[183],"[95%CI":[184,190,198,215,223,231],"1.22-3.57],":[185],"p=0.007),":[186],"current":[187,282],"smoking":[188,283,307],"(aOR=3.55":[189],"1.20-10.53],":[191],"p=0.02),":[192],"CRP":[194,286],"(aOR=1.01":[195],"unit-increase":[197],"1.00-1.03],":[199],"p=0.04)":[200],"significantly":[202],"enrollment;":[207],"while":[208],"increasing":[209],"(aOR=1.02":[212],"per-100":[213],"0.85-1.22],":[216],"p=0.82),":[217],"(aOR=0.67":[220],"log-increase":[222],"0.43-1.10],":[224],"p=0.12)":[225],"receipt":[227],"(aOR=0.57":[230],"0.18-1.75],":[232],"p=0.32)":[233],"not.":[235],"The":[236],"18":[242],"(12-24)":[243],"months.":[244],"Participants":[245],"history":[248],"tuberculosis":[250],"(TB)":[251],"had":[252],"mL":[255,261],"(95%CI":[256,262],"2-68,":[257],"p=0.03)":[258],"57":[260],"19-96,":[263],"p=0.003)":[264],"year":[266],"excess":[267],"loss":[268],"Conclusion:":[274],"Prevalent":[275],"older":[280],"age,":[281],"higher":[285],"levels,":[287],"counts":[291],"ART,":[293],"Better":[299],"understanding":[300],"long-term":[303],"TB,":[306],"inflammation":[309],"on":[310],"is":[316],"urgently":[317],"needed.":[318]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-09-25T00:00:00"}