{"id":"https://openalex.org/W2755812911","doi":"https://doi.org/10.1080/10428194.2017.1376746","title":"Risk adjusted therapy in chronic lymphocytic leukemia: a phase II cancer trials Ireland (CTRIAL-IE [ICORG 07-01]) study of fludarabine, cyclophosphamide, and rituximab therapy evaluating response adapted, abbreviated frontline therapy with FCR in non-del(17p) CLL","display_name":"Risk adjusted therapy in chronic lymphocytic leukemia: a phase II cancer trials Ireland (CTRIAL-IE [ICORG 07-01]) study of fludarabine, cyclophosphamide, and rituximab therapy evaluating response adapted, abbreviated frontline therapy with FCR in non-del(17p) CLL","publication_year":2017,"publication_date":"2017-09-19","ids":{"openalex":"https://openalex.org/W2755812911","doi":"https://doi.org/10.1080/10428194.2017.1376746","mag":"2755812911","pmid":"https://pubmed.ncbi.nlm.nih.gov/28925785"},"language":"en","primary_location":{"id":"doi:10.1080/10428194.2017.1376746","doi":"https://doi.org/10.1080/10428194.2017.1376746","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10428194.2017.1376746","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068775777","display_name":"Niamh Appleby","orcid":"https://orcid.org/0000-0001-5063-9652","observed_orcids":["https://orcid.org/0000-0001-5063-9652"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Niamh Appleby","raw_affiliation_strings":["Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071370413","display_name":"David O\u2019Brien","orcid":"https://orcid.org/0000-0002-0588-7427","observed_orcids":["https://orcid.org/0000-0002-0588-7427"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"David O\u2019Brien","raw_affiliation_strings":["Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014047039","display_name":"Fiona Quinn","orcid":"https://orcid.org/0000-0001-5467-9109","observed_orcids":["https://orcid.org/0000-0001-5467-9109"]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Fiona M. Quinn","raw_affiliation_strings":["Department of Cancer Molecular Diagnostics, St. James\u2019s Hospital, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Molecular Diagnostics, St. James\u2019s Hospital, Dublin, Ireland;","institution_ids":["https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082349971","display_name":"Liam Smyth","orcid":"https://orcid.org/0000-0002-2219-5780","observed_orcids":["https://orcid.org/0000-0002-2219-5780"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Liam Smyth","raw_affiliation_strings":["Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110489383","display_name":"Johanna Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Johanna Kelly","raw_affiliation_strings":["Department of Medical Genetics, Our Lady's Hospital for Children, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Our Lady's Hospital for Children, Dublin, Ireland;","institution_ids":["https://openalex.org/I3017411684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021113834","display_name":"Imelda Parker","orcid":"https://orcid.org/0000-0001-7084-9075","observed_orcids":["https://orcid.org/0000-0001-7084-9075"]},"institutions":[{"id":"https://openalex.org/I4210103332","display_name":"Cancer Trials Ireland","ror":"https://ror.org/01dpkyq75","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210103332"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Imelda Parker","raw_affiliation_strings":["Cancer Trials Ireland, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Trials Ireland, Dublin, Ireland;","institution_ids":["https://openalex.org/I4210103332"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kathleen Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103332","display_name":"Cancer Trials Ireland","ror":"https://ror.org/01dpkyq75","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210103332"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kathleen Scott","raw_affiliation_strings":["Cancer Trials Ireland, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Trials Ireland, Dublin, Ireland;","institution_ids":["https://openalex.org/I4210103332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038292671","display_name":"Mary R. Cahill","orcid":"https://orcid.org/0000-0002-1655-3078","observed_orcids":["https://orcid.org/0000-0002-1655-3078"]},"institutions":[{"id":"https://openalex.org/I2802396013","display_name":"Cork University Hospital","ror":"https://ror.org/04q107642","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2802396013"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mary R. Cahill","raw_affiliation_strings":["Department of Haematology, Cork University Hospital, Cork, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Cork University Hospital, Cork, Ireland;","institution_ids":["https://openalex.org/I2802396013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045279459","display_name":"Gerard M. Crotty","orcid":"https://orcid.org/0000-0003-4105-9589","observed_orcids":["https://orcid.org/0000-0003-4105-9589"]},"institutions":[{"id":"https://openalex.org/I2801819740","display_name":"Midland Regional Hospital at Tullamore","ror":"https://ror.org/03df3zw56","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2801819740","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Gerard Crotty","raw_affiliation_strings":["Department of Haematology, Midlands Regional Hospital, Tullamore, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Midlands Regional Hospital, Tullamore, Ireland;","institution_ids":["https://openalex.org/I2801819740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035544782","display_name":"Helen Enright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803035300","display_name":"Tallaght University Hospital","ror":"https://ror.org/01fvmtt37","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803035300"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Helen Enright","raw_affiliation_strings":["Department of Haematology, Adelaide, Meath and National Children\u2019s Hospital, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Adelaide, Meath and National Children\u2019s Hospital, Dublin, Ireland;","institution_ids":["https://openalex.org/I2803035300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004102701","display_name":"Bryan T. Hennessy","orcid":"https://orcid.org/0000-0002-7871-6477","observed_orcids":["https://orcid.org/0000-0002-7871-6477"]},"institutions":[{"id":"https://openalex.org/I2799853345","display_name":"University Hospital Waterford","ror":"https://ror.org/007pvy114","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799853345","https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brian Hennessy","raw_affiliation_strings":["Department of Haematology, University Hospital Waterford, Waterford, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University Hospital Waterford, Waterford, Ireland;","institution_ids":["https://openalex.org/I2799853345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005892752","display_name":"Andrew J. Hodgson","orcid":"https://orcid.org/0009-0005-0591-2935","observed_orcids":["https://orcid.org/0009-0005-0591-2935"]},"institutions":[{"id":"https://openalex.org/I2799680125","display_name":"Sligo University Hospital","ror":"https://ror.org/03ke5zk82","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799680125","https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Andrew Hodgson","raw_affiliation_strings":["Department of Haematology, Sligo Regional Hospital, Sligo, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Sligo Regional Hospital, Sligo, Ireland;","institution_ids":["https://openalex.org/I2799680125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103732425","display_name":"Maeve Leahy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802992464","display_name":"University Hospital Limerick","ror":"https://ror.org/04y3ze847","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802992464","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maeve Leahy","raw_affiliation_strings":["Department of Haematology, University Hospital Limerick, Limerick, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University Hospital Limerick, Limerick, Ireland;","institution_ids":["https://openalex.org/I2802992464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084969109","display_name":"Hilary M O'Leary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802992464","display_name":"University Hospital Limerick","ror":"https://ror.org/04y3ze847","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802992464","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hilary O\u2019Leary","raw_affiliation_strings":["Department of Haematology, University Hospital Limerick, Limerick, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University Hospital Limerick, Limerick, Ireland;","institution_ids":["https://openalex.org/I2802992464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009840054","display_name":"Michael E O'Dwyer","orcid":"https://orcid.org/0000-0002-6173-7140","observed_orcids":["https://orcid.org/0000-0002-6173-7140"]},"institutions":[{"id":"https://openalex.org/I2802635630","display_name":"University Hospital Galway","ror":"https://ror.org/04scgfz75","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802635630","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael O\u2019Dwyer","raw_affiliation_strings":["Department of Haematology, University Hospital Galway, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University Hospital Galway, Galway, Ireland","institution_ids":["https://openalex.org/I2802635630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112248992","display_name":"Amjad Hayat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802635630","display_name":"University Hospital Galway","ror":"https://ror.org/04scgfz75","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802635630","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Amjad Hayat","raw_affiliation_strings":["Department of Haematology, University Hospital Galway, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University Hospital Galway, Galway, Ireland","institution_ids":["https://openalex.org/I2802635630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079949206","display_name":"Elisabeth Vandenberghe","orcid":"https://orcid.org/0000-0002-7731-9437","observed_orcids":["https://orcid.org/0000-0002-7731-9437"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Elisabeth A. Vandenberghe","raw_affiliation_strings":["Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, St. James\u2019s Hospital and Trinity College Dublin, Dublin, Ireland;","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5068775777"],"corresponding_institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"],"apc_list":null,"apc_paid":null,"fwci":0.8257,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72725259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"59","issue":"6","first_page":"1338","last_page":"1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fludarabine-cyclophosphamide-and-rituximab","display_name":"fludarabine-cyclophosphamide-rituximab","score":0.921999990940094},{"id":"https://openalex.org/keywords/fcr","display_name":"FCR","score":0.5879999995231628},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/time-to-treatment-failure","display_name":"time to treatment failure","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ighv-mutation-status","display_name":"IGHV mutation status","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sf3b1-mutation","display_name":"SF3B1 mutation","score":0.925000011920929},{"id":"https://openalex.org/keywords/notch1-mutation","display_name":"NOTCH1 mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8570844531059265},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.84610915184021},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.8246634602546692},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7563092112541199},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6024483442306519},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5559219121932983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5211841464042664},{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.45510566234588623},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.4129101634025574},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3417699933052063},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22951075434684753},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.16687020659446716}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10428194.2017.1376746","doi":"https://doi.org/10.1080/10428194.2017.1376746","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10428194.2017.1376746","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},{"id":"pmid:28925785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28925785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & lymphoma","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000370754","display_name":null,"funder_award_id":"ICORG-2016-1","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W60865865","https://openalex.org/W1016810471","https://openalex.org/W1429374962","https://openalex.org/W1971289548","https://openalex.org/W1973388908","https://openalex.org/W1974465533","https://openalex.org/W1980260104","https://openalex.org/W1996452057","https://openalex.org/W2001850157","https://openalex.org/W2001934131","https://openalex.org/W2010779916","https://openalex.org/W2016042196","https://openalex.org/W2020094108","https://openalex.org/W2050401106","https://openalex.org/W2057432590","https://openalex.org/W2072921368","https://openalex.org/W2079976394","https://openalex.org/W2080959192","https://openalex.org/W2084952484","https://openalex.org/W2088388800","https://openalex.org/W2095674530","https://openalex.org/W2106135268","https://openalex.org/W2111403010","https://openalex.org/W2121721101","https://openalex.org/W2122284868","https://openalex.org/W2125134816","https://openalex.org/W2131078883","https://openalex.org/W2136272158","https://openalex.org/W2138681120","https://openalex.org/W2140606816","https://openalex.org/W2142099365","https://openalex.org/W2150487985","https://openalex.org/W2156693813","https://openalex.org/W2156824251","https://openalex.org/W2162125647","https://openalex.org/W2169269721","https://openalex.org/W2170340332","https://openalex.org/W2234243759","https://openalex.org/W2295348655","https://openalex.org/W2318933236","https://openalex.org/W2337485820","https://openalex.org/W2344922936","https://openalex.org/W2396328865","https://openalex.org/W2463911777","https://openalex.org/W2513443919","https://openalex.org/W2533368262","https://openalex.org/W2550016312","https://openalex.org/W2561188085","https://openalex.org/W2590684902","https://openalex.org/W2602893476","https://openalex.org/W2603874101","https://openalex.org/W2608696803","https://openalex.org/W4244099216"],"related_works":["https://openalex.org/W2980253975","https://openalex.org/W2979314674","https://openalex.org/W2993990382","https://openalex.org/W2468504514","https://openalex.org/W2738464324","https://openalex.org/W2057432590","https://openalex.org/W4234074256","https://openalex.org/W2513443919","https://openalex.org/W2337485820","https://openalex.org/W2924450507"],"abstract_inverted_index":{"Minimal":[0],"residual":[1],"disease":[2],"negative":[3],"complete":[4],"response":[5],"(MRD-negative":[6],"CR)":[7],"provides":[8],"an":[9],"early":[10,91,137],"marker":[11],"for":[12,134],"time":[13],"to":[14],"treatment":[15,64],"failure":[16],"(TTF)":[17],"in":[18,114,144],"CLL":[19],"treated":[20],"with":[21,75,90,104],"fludarabine,":[22],"cyclophosphamide,":[23],"and":[24,55,100,147],"rituximab":[25],"(FCR).":[26],"MRD":[27,141],"was":[28,68,110],"assessed":[29],"after":[30,53,117],"four":[31,118],"FCR":[32,130],"cycles":[33,121],"(FCR4);":[34],"MRD-negative":[35,51,59,92,115,138],"CR":[36,52,60,116],"patients":[37,41,49,113,135],"discontinued":[38],"treatment.":[39],"Fifty-two":[40],"(35M;":[42],"17F)":[43],"were":[44,58,88,102],"enrolled.":[45],"Eighteen":[46],"(18/52;":[47],"34.6%)":[48],"reached":[50],"FCR4":[54],"29/52":[56],"(55.8%)":[57],"at":[61],"end":[62],"of":[63],"(EOT).":[65],"Median":[66],"TTF":[67,108],"71.1":[69],"months":[70],"(95%":[71],"CI":[72],"61.3-84.1":[73],"months),":[74],"median":[76],"overall":[77],"survival":[78],"not":[79],"reached.":[80],"Mutated":[81],"immunoglobulin":[82],"heavy":[83],"chain":[84],"gene":[85],"rearrangements":[86],"(IGHV)":[87],"associated":[89,103],"remissions,":[93],"translating":[94],"into":[95],"prolonged":[96],"TTF.":[97,106],"Unmutated-IGHV,":[98],"mutated-SF3B1":[99],"mutated-NOTCH1":[101],"shortened":[105],"No":[107],"difference":[109],"observed":[111],"between":[112],"versus":[119,123],"six":[120],"(82.2":[122],"85.3":[124],"months,":[125],"p":[126],"=":[127],".6306).":[128],"Abbreviated":[129],"therapy":[131,146],"is":[132],"effective":[133],"achieving":[136],"remissions.":[139],"Interim":[140],"assessment":[142],"assists":[143],"personalizing":[145],"reducing":[148],"chemotherapy-associated":[149],"toxicity.":[150]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-09-25T00:00:00"}
