{"id":"https://openalex.org/W2755714531","doi":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","title":"OP0103 The effect of sirukumab plus methotrexate on circulating biomarkers of joint destruction in moderate to severe rheumatoid arthritis patients from the sirround-d phase 3 study","display_name":"OP0103 The effect of sirukumab plus methotrexate on circulating biomarkers of joint destruction in moderate to severe rheumatoid arthritis patients from the sirround-d phase 3 study","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2755714531","doi":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","mag":"2755714531"},"language":"en","primary_location":{"id":"doi:10.1136/annrheumdis-2017-eular.3588","doi":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","pdf_url":"https://ard.bmj.com/content/annrheumdis/76/Suppl_2/94.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ard.bmj.com/content/annrheumdis/76/Suppl_2/94.2.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045508043","display_name":"Bidisha Dasgupta","orcid":"https://orcid.org/0009-0001-2721-0652","observed_orcids":["https://orcid.org/0009-0001-2721-0652"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Dasgupta","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103091434","display_name":"Kim Campbell","orcid":"https://orcid.org/0000-0003-3789-416X","observed_orcids":["https://orcid.org/0000-0003-3789-416X"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Campbell","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A-C Bay-Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A-C Bay-Jensen","raw_affiliation_strings":["Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063475809","display_name":"M.A. Karsdal","orcid":"https://orcid.org/0000-0001-5026-8740","observed_orcids":["https://orcid.org/0000-0001-5026-8740"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"M Karsdal","raw_affiliation_strings":["Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114073147","display_name":"Kristen Sweet","orcid":"https://orcid.org/0000-0001-9825-003X","observed_orcids":["https://orcid.org/0000-0001-9825-003X"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Sweet","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016111792","display_name":"M Sims","orcid":"https://orcid.org/0009-0007-4492-8600","observed_orcids":["https://orcid.org/0009-0007-4492-8600"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Sims","raw_affiliation_strings":["GlaxoSmithKline, Stevenage, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Stevenage, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083419581","display_name":"M. J. Loza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MJ Loza","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":null,"first_page":"94","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.878000020980835},{"id":"https://openalex.org/keywords/sirukumab","display_name":"sirukumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/il-6-inhibition","display_name":"IL-6 inhibition","score":0.9359999895095825},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8859999775886536},{"id":"https://openalex.org/keywords/c-terminal-telopeptide-of-type-i-collagen","display_name":"C-terminal telopeptide of type I collagen","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.746999979019165},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6729999780654907},{"id":"https://openalex.org/keywords/structural-damage-progression","display_name":"structural damage progression","score":0.722000002861023},{"id":"https://openalex.org/keywords/radiographic-progression","display_name":"radiographic progression","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9086746573448181},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7831147313117981},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.552094042301178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5403658747673035},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5072528719902039},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4504261910915375},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.44565534591674805},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3210775852203369},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.258294016122818},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/annrheumdis-2017-eular.3588","doi":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","pdf_url":"https://ard.bmj.com/content/annrheumdis/76/Suppl_2/94.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1136/annrheumdis-2017-eular.3588","doi":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2017-eular.3588","pdf_url":"https://ard.bmj.com/content/annrheumdis/76/Suppl_2/94.2.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320318316","display_name":"Celltrion","ror":"https://ror.org/05k84m754"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2755714531.pdf","grobid_xml":"https://content.openalex.org/works/W2755714531.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2527818415","https://openalex.org/W2317109651","https://openalex.org/W2751269869","https://openalex.org/W3092469568","https://openalex.org/W2900542692","https://openalex.org/W3022885547","https://openalex.org/W2908644959","https://openalex.org/W2041555342","https://openalex.org/W2790022206","https://openalex.org/W2526047368"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-09-25T00:00:00"}
