{"id":"https://openalex.org/W2755642157","doi":null,"title":"Mutations in CHEK2 and risk of gastric cancer: a case-control study","display_name":"Mutations in CHEK2 and risk of gastric cancer: a case-control study","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2755642157","mag":"2755642157"},"language":"en","primary_location":{"id":"mag:2755642157","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/mutations-in-chek2-and-risk-of-gastric-cancer-a-casecontrol-study.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022626401","display_name":"Zhong-chuan Lv","orcid":"https://orcid.org/0000-0002-0071-1756","observed_orcids":["https://orcid.org/0000-0002-0071-1756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong-chuan Lv","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0071-1756","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101528744","display_name":"Ruihua Liu","orcid":"https://orcid.org/0000-0003-4426-9696","observed_orcids":["https://orcid.org/0000-0003-4426-9696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruihua Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4426-9696","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041315671","display_name":"Linsong Mu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linsong Mu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100308555","display_name":"Jinping Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinping Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101502425","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0002-4732-9327","observed_orcids":["https://orcid.org/0000-0002-4732-9327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4732-9327","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"17","first_page":"7373","last_page":"7377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.17100000381469727,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.15929999947547913,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chek2","display_name":"CHEK2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chek2-1100delc","display_name":"CHEK2 1100delC","score":0.8059999942779541},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8809999823570251},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2776071976","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"CHEK2","level":5,"score":0.9461647272109985},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5721086263656616},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.5662063956260681},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5537595748901367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5241387486457825},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5053089261054993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48889365792274475},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4845815896987915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45427119731903076},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.44611504673957825},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4060608744621277},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36433547735214233},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3571314811706543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3170895576477051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31214720010757446},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.21213889122009277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17909467220306396}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2755642157","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/mutations-in-chek2-and-risk-of-gastric-cancer-a-casecontrol-study.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1979543776","https://openalex.org/W2000302807","https://openalex.org/W2004505249","https://openalex.org/W2027808340","https://openalex.org/W2035701062","https://openalex.org/W2053730749","https://openalex.org/W2055512874","https://openalex.org/W2072881647","https://openalex.org/W2074026594","https://openalex.org/W2094634275","https://openalex.org/W2149805321","https://openalex.org/W2166548889","https://openalex.org/W2169402189","https://openalex.org/W2302568027","https://openalex.org/W2400927555","https://openalex.org/W2484735274","https://openalex.org/W2554638282"],"related_works":["https://openalex.org/W2042575240","https://openalex.org/W2736965279","https://openalex.org/W2091001195","https://openalex.org/W2034735724","https://openalex.org/W3135352953","https://openalex.org/W2099396868","https://openalex.org/W4230410924","https://openalex.org/W4409114956","https://openalex.org/W7204159148","https://openalex.org/W3124834201"],"abstract_inverted_index":{"CHEK2":[0,21,36,73,98,135,150,165,182,197],"mutations":[1,22],"have":[2],"been":[3],"reported":[4],"to":[5,153,155,186],"be":[6],"associated":[7,127],"with":[8,128,138,176],"different":[9],"human":[10],"cancers.":[11],"However,":[12],"the":[13,18,129,133,192],"genetic":[14,94],"defects":[15],"distribution":[16],"and":[17,43,54,70,85,91,103,114,171,173,194],"roles":[19],"of":[20,132,196,201],"in":[23,48,60,72,78,97,107,149],"gastric":[24,51,82,111,122,177],"cancer":[25,52,83,112,123,202],"carcinogenesis":[26],"remain":[27],"poorly":[28],"understood.":[29],"In":[30,179],"this":[31,61],"study,":[32],"we":[33],"detected":[34],"two":[35],"alleles:":[37],"a":[38,44,92],"protein":[39],"truncating":[40],"(1100delC,":[41],"IVS2+1G>A)":[42],"missense":[45],"variant":[46,95,130,147,181],"(I157T)":[47],"63":[49],"unselected":[50],"cases":[53,84,113],"96":[55],"healthy":[56],"controls.":[57,86,115],"The":[58],"results":[59],"study":[62],"demonstrated":[63,104,161],"that":[64,121,146],"four":[65,134],"SNPs":[66,166,193],"(rs201688553,":[67,167],"rs376099090,":[68,168],"rs777046932":[69],"rs372452522)":[71],"1100delC":[74],"achieved":[75],"significant":[76,105,162],"difference":[77,106],"their":[79,108,139],"distributions":[80,109],"between":[81,110,164],"Moreover,":[87,142],"one":[88],"polymorphism":[89],"(rs7289973)":[90],"novel":[93],"(IVS2-372T>C)":[96],"IVS2+1G>A":[99],"regions":[100],"were":[101,125],"identified":[102],"Multiple":[116],"logistic":[117],"regression":[118],"analyses":[119],"revealed":[120],"risk":[124],"significantly":[126],"genotypes":[131],"polymorphisms":[136],"comparing":[137],"wild-type":[140],"genotypes.":[141],"it":[143],"was":[144],"found":[145],"rs372452522":[148,170,183],"might":[151,184],"contribute":[152,185],"susceptibility":[154],"lymph":[156,187],"node":[157,188],"metastasis.":[158],"Our":[159],"data":[160],"associations":[163],"rs777046932,":[169],"rs7289973)":[172],"mutation":[174,195],"IVS2-372T>C":[175],"cancer.":[178],"advance,":[180],"metastasis":[189],"susceptibility,":[190],"implying":[191],"as":[198],"potential":[199],"predictors":[200],"susceptibility.":[203]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-09-25T00:00:00"}
