{"id":"https://openalex.org/W2755427641","doi":null,"title":"Inhibition of allergen-mediated mast cell activation by TAK1 inhibitor 5Z-7-oxozeaenol","display_name":"Inhibition of allergen-mediated mast cell activation by TAK1 inhibitor 5Z-7-oxozeaenol","publication_year":2017,"publication_date":"2017-09-14","ids":{"openalex":"https://openalex.org/W2755427641","mag":"2755427641"},"language":"en","primary_location":{"id":"pmh:oai:dr.library.brocku.ca:10464/12992","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10464/12992","pdf_url":"http://hdl.handle.net/10464/12992","source":{"id":"https://openalex.org/S4306401333","display_name":"Brock University Digital Repository (Brock University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186803428","host_organization_name":"Brock University","host_organization_lineage":["https://openalex.org/I186803428"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10464/12992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074046800","display_name":"Colton J. F. Watson","orcid":"https://orcid.org/0000-0002-4257-3742","observed_orcids":["https://orcid.org/0000-0002-4257-3742"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Colton J. F. Watson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4257-3742","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074046800"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tak1","display_name":"TAK1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/5z-7-oxozeaenol","display_name":"5Z-7-oxozeaenol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mast-cell-activation","display_name":"mast cell activation","score":0.949999988079071},{"id":"https://openalex.org/keywords/allergic-inflammation","display_name":"allergic inflammation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9700000286102295},{"id":"https://openalex.org/keywords/allergen-sensitization","display_name":"allergen sensitization","score":0.6050000190734863},{"id":"https://openalex.org/keywords/bone-marrow-derived-mast-cells","display_name":"bone marrow-derived mast cells","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6373786926269531},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6179362535476685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4200862944126129},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4121885895729065},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3493086099624634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34573233127593994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2686302959918976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24536266922950745}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dr.library.brocku.ca:10464/12992","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10464/12992","pdf_url":"http://hdl.handle.net/10464/12992","source":{"id":"https://openalex.org/S4306401333","display_name":"Brock University Digital Repository (Brock University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186803428","host_organization_name":"Brock University","host_organization_lineage":["https://openalex.org/I186803428"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:brocku.scholaris.ca:10464/12992","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10464/12992","pdf_url":null,"source":{"id":"https://openalex.org/S4306401333","display_name":"Brock University Digital Repository (Brock University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186803428","host_organization_name":"Brock University","host_organization_lineage":["https://openalex.org/I186803428"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2755427641","doi":null,"is_oa":false,"landing_page_url":"https://dr.library.brocku.ca/handle/10464/12992","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dr.library.brocku.ca:10464/12992","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10464/12992","pdf_url":"http://hdl.handle.net/10464/12992","source":{"id":"https://openalex.org/S4306401333","display_name":"Brock University Digital Repository (Brock University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186803428","host_organization_name":"Brock University","host_organization_lineage":["https://openalex.org/I186803428"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2755427641.pdf","grobid_xml":"https://content.openalex.org/works/W2755427641.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W41880031","https://openalex.org/W85194748","https://openalex.org/W124143665","https://openalex.org/W1501778305","https://openalex.org/W1503586314","https://openalex.org/W1505084152","https://openalex.org/W1517648667","https://openalex.org/W1521510973","https://openalex.org/W1552802415","https://openalex.org/W1558367558","https://openalex.org/W1574785846","https://openalex.org/W1599249369","https://openalex.org/W1600472471","https://openalex.org/W1634158134","https://openalex.org/W1817073110","https://openalex.org/W1876623932","https://openalex.org/W1902360293","https://openalex.org/W1914434417","https://openalex.org/W1936847024","https://openalex.org/W1964002710","https://openalex.org/W1965503707","https://openalex.org/W1967866252","https://openalex.org/W1968585354","https://openalex.org/W1970152214","https://openalex.org/W1971393286","https://openalex.org/W1973470648","https://openalex.org/W1973755752","https://openalex.org/W1974935166","https://openalex.org/W1975071004","https://openalex.org/W1975523550","https://openalex.org/W1981047637","https://openalex.org/W1982386486","https://openalex.org/W1984756562","https://openalex.org/W1987354452","https://openalex.org/W1989216370","https://openalex.org/W1991790975","https://openalex.org/W1993305093","https://openalex.org/W1994017311","https://openalex.org/W1997685431","https://openalex.org/W2007534521","https://openalex.org/W2007589345","https://openalex.org/W2011211995","https://openalex.org/W2012717711","https://openalex.org/W2013090515","https://openalex.org/W2014103699","https://openalex.org/W2014623953","https://openalex.org/W2016934076","https://openalex.org/W2019604999","https://openalex.org/W2021678927","https://openalex.org/W2032134195","https://openalex.org/W2034203371","https://openalex.org/W2036224418","https://openalex.org/W2036431526","https://openalex.org/W2038331455","https://openalex.org/W2039057009","https://openalex.org/W2039952205","https://openalex.org/W2048325240","https://openalex.org/W2054542309","https://openalex.org/W2059421466","https://openalex.org/W2059534402","https://openalex.org/W2059969460","https://openalex.org/W2060922997","https://openalex.org/W2062636299","https://openalex.org/W2064439294","https://openalex.org/W2066963386","https://openalex.org/W2067049479","https://openalex.org/W2070782085","https://openalex.org/W2072505432","https://openalex.org/W2073253686","https://openalex.org/W2075663643","https://openalex.org/W2077575210","https://openalex.org/W2084001707","https://openalex.org/W2094982088","https://openalex.org/W2097662200","https://openalex.org/W2100516030","https://openalex.org/W2104186296","https://openalex.org/W2105863578","https://openalex.org/W2107378603","https://openalex.org/W2110463517","https://openalex.org/W2115683859","https://openalex.org/W2117969431","https://openalex.org/W2119621206","https://openalex.org/W2129242841","https://openalex.org/W2130433101","https://openalex.org/W2135525156","https://openalex.org/W2135959535","https://openalex.org/W2140557346","https://openalex.org/W2140958822","https://openalex.org/W2142564954","https://openalex.org/W2150009399","https://openalex.org/W2158093352","https://openalex.org/W2162017876","https://openalex.org/W2163132209","https://openalex.org/W2163303312","https://openalex.org/W2170720109","https://openalex.org/W2172089201","https://openalex.org/W2203590148","https://openalex.org/W2255585558","https://openalex.org/W2331616367","https://openalex.org/W2336588424","https://openalex.org/W2399303500","https://openalex.org/W2419408332","https://openalex.org/W2421395535","https://openalex.org/W2462468251","https://openalex.org/W2520601585","https://openalex.org/W2563021883","https://openalex.org/W2791343520","https://openalex.org/W4248939300","https://openalex.org/W7097347689"],"related_works":["https://openalex.org/W3016676707","https://openalex.org/W3008351465","https://openalex.org/W4313368904","https://openalex.org/W7046227149","https://openalex.org/W1985936346","https://openalex.org/W7043016510","https://openalex.org/W2039559621","https://openalex.org/W2530608876","https://openalex.org/W4313379457","https://openalex.org/W6889730172"],"abstract_inverted_index":{"Introduction":[0],"&":[1],"Aim:":[2],"Allergic":[3],"inflammatory":[4],"disorders":[5],"are":[6],"at":[7],"epidemic":[8],"levels":[9],"worldwide.":[10],"Mast":[11,117],"cells":[12,95,243],"drive":[13],"this":[14],"inappropriate":[15],"immune":[16],"response":[17,27],"via":[18],"release":[19,132,141],"of":[20,23,67,84,115,152,169,190,211],"a":[21,54,184,208,232],"variety":[22],"pro-inflammatory":[24,130,170,191],"mediators":[25],"in":[26,57,69,86,110,146,149,187,201,218,241,251],"to":[28,80,245],"environmental":[29],"cues":[30],"detected":[31],"by":[32,122,128,133,139],"the":[33,42,65,82,104,111,150,188,219,236],"IgE-Fc\u03b5RI":[34,70],"complex,":[35],"but":[36],"we":[37],"do":[38],"not":[39],"fully":[40],"understand":[41],"contributing":[43],"molecular":[44],"mechanisms.":[45],"Transforming":[46],"growth":[47],"factor":[48],"\u03b2-activated":[49],"kinase":[50,164],"1":[51],"(TAK1)":[52],"is":[53],"known":[55],"participant":[56],"related":[58],"signaling":[59,71,119,233],"through":[60],"MAPK":[61,237],"and":[62,72,101,135,157,175,179,194,196,199,223,238,247],"NF-\u03baB;":[63],"however":[64],"role":[66,83],"TAK1":[68,85,229],"resultant":[73],"allergic":[74],"inflammation":[75],"remains":[76],"unknown.":[77],"We":[78],"aim":[79],"assess":[81],"IgE-mediated":[87],"mast":[88,94,136,212,242],"cell":[89,118,137,203,213],"activation.":[90],"Methods:":[91],"Bone":[92],"marrow-derived":[93],"were":[96,181],"sensitized":[97],"with":[98,103],"allergen-specific":[99],"IgE":[100],"treated":[102],"corresponding":[105],"allergen":[106,246],"for":[107],"various":[108,153],"times":[109],"presence":[112],"or":[113],"absence":[114],"5Z-7-oxozeaenol.":[116],"was":[120,205,215],"measured":[121],"western":[123],"blotting,":[124],"induced":[125],"gene":[126,167],"expression":[127,168],"qPCR,":[129],"mediator":[131],"ELISA":[134],"degranulation":[138,214],"\u03b2-hexosaminidase":[140],"assay.":[142],"Results:":[143],"TAK1-inhibition":[144],"resulted":[145],"significant":[147,209],"impairment":[148],"phosphorylation":[151],"MAPKs":[154],"(p38,":[155],"ERK":[156],"JNK)":[158],"as":[159,161,231],"well":[160],"NF-\u03baB":[162,239],"pathway":[163],"I\u03baB\u03b1.":[165],"Impaired":[166],"cytokines":[171],"IL-4,":[172],"IL-6,":[173],"IL-13,":[174],"chemokines":[176,197],"CCL1,":[177],"-2,":[178],"-3":[180],"detected.":[182,206],"Furthermore,":[183],"drastic":[185],"decrease":[186],"concentration":[189],"cytokines,":[192],"IL-6":[193],"TNF,":[195],"CCL1":[198],"CCL2,":[200],"stimulated":[202],"supernatants":[204],"Finally,":[207],"inhibition":[210],"also":[216],"observed":[217],"TAK1-inhibited":[220],"cells.":[221],"Conclusion":[222],"Significance:":[224],"These":[225],"results":[226],"suggest":[227],"that":[228],"acts":[230],"node":[234],"linking":[235],"pathways":[240],"responding":[244],"may":[248],"warrant":[249],"consideration":[250],"future":[252],"therapeutic":[253],"development.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-09-25T00:00:00"}
