{"id":"https://openalex.org/W2755393274","doi":"https://doi.org/10.1371/journal.ppat.1006569","title":"Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells","display_name":"Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells","publication_year":2017,"publication_date":"2017-09-14","ids":{"openalex":"https://openalex.org/W2755393274","doi":"https://doi.org/10.1371/journal.ppat.1006569","mag":"2755393274","pmid":"https://pubmed.ncbi.nlm.nih.gov/28910403"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1006569","doi":"https://doi.org/10.1371/journal.ppat.1006569","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006569","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006569&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006569&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063802827","display_name":"Derek B. Danahy","orcid":"https://orcid.org/0000-0002-3481-8797","observed_orcids":["https://orcid.org/0000-0002-3481-8797"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek B. Danahy","raw_affiliation_strings":["Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3481-8797","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007120433","display_name":"Scott M. Anthony","orcid":"https://orcid.org/0000-0002-1590-7401","observed_orcids":["https://orcid.org/0000-0002-1590-7401"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Anthony","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1590-7401","affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061261855","display_name":"Isaac J. Jensen","orcid":"https://orcid.org/0000-0002-3107-3961","observed_orcids":["https://orcid.org/0000-0002-3107-3961"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac J. Jensen","raw_affiliation_strings":["Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3107-3961","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028539861","display_name":"Stacey M. Hartwig","orcid":"https://orcid.org/0000-0002-4220-113X","observed_orcids":["https://orcid.org/0000-0002-4220-113X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey M. Hartwig","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4220-113X","affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044206698","display_name":"Qiang Shan","orcid":"https://orcid.org/0000-0002-7089-0278","observed_orcids":["https://orcid.org/0000-0002-7089-0278"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Shan","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008319091","display_name":"Hai\u2010Hui Xue","orcid":"https://orcid.org/0000-0002-9163-7669","observed_orcids":["https://orcid.org/0000-0002-9163-7669"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai-Hui Xue","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056006599","display_name":"John T. Harty","orcid":"https://orcid.org/0000-0001-7266-2802","observed_orcids":["https://orcid.org/0000-0001-7266-2802"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Harty","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076681768","display_name":"Thomas S. Griffith","orcid":"https://orcid.org/0000-0002-7205-9859","observed_orcids":["https://orcid.org/0000-0002-7205-9859"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210117246","display_name":"Minneapolis VA Health Care System","ror":"https://ror.org/02ry60714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Griffith","raw_affiliation_strings":["Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America","Department of Urology, University of Minnesota, Minneapolis, Minnesota, United States of America","Microbiology, Immunology and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, Minnesota, United States of America","Minneapolis VA Health Care System, Minneapolis, Minnesota, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7205-9859","affiliations":[{"raw_affiliation_string":"Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Urology, University of Minnesota, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Microbiology, Immunology and Cancer Biology Ph.D. Program, University of Minnesota, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Minneapolis VA Health Care System, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I4210117246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090796277","display_name":"Vladimir P. Badovinac","orcid":"https://orcid.org/0000-0003-3180-2439","observed_orcids":["https://orcid.org/0000-0003-3180-2439"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir P. Badovinac","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3180-2439","affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090796277"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.5124,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.89815267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"e1006569","last_page":"e1006569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tissue-resident-memory-t-cells","display_name":"tissue-resident memory T cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/memory-cd8-t-cells","display_name":"memory CD8+ T cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.75},{"id":"https://openalex.org/keywords/ifn-gamma-receptor-1","display_name":"IFN-gamma receptor 1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.800000011920929},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7749999761581421},{"id":"https://openalex.org/keywords/secondary-infection-susceptibility","display_name":"secondary infection susceptibility","score":0.5640000104904175},{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.6349999904632568},{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.8897736072540283},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7013682126998901},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.562602698802948},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.529864490032196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5078921914100647},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4971981346607208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3947303891181946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3412402868270874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2564161419868469},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24353507161140442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10852009057998657},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.ppat.1006569","doi":"https://doi.org/10.1371/journal.ppat.1006569","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006569","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006569&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmid:28910403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28910403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5599054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5599054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:ppat00:1006569","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006569","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0dc611150e4242fab88bf6698417c9cc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0dc611150e4242fab88bf6698417c9cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 13, Iss 9, p e1006569 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5410291","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Polymicrobial_sepsis_impairs_bystander_recruitment_of_effector_cells_to_infected_skin_despite_optimal_sensing_and_alarming_function_of_skin_resident_memory_CD8_T_cells/5410291","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1006569","doi":"https://doi.org/10.1371/journal.ppat.1006569","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006569","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006569&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1296717744","display_name":null,"funder_award_id":"AI114543","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1419578588","display_name":null,"funder_award_id":"GM 113961","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1973313420","display_name":null,"funder_award_id":"GM115462","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1980925608","display_name":null,"funder_award_id":"5T32AI007485","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2325236711","display_name":null,"funder_award_id":"AI119160","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2678572296","display_name":null,"funder_award_id":"T32 AI007485","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G417569116","display_name":null,"funder_award_id":"T32 AI007511","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4217087388","display_name":"Molecular mechanisms controlling differentiation of memory CD8 T cells","funder_award_id":"R21AI119160","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5559844677","display_name":null,"funder_award_id":"R01 AI114543","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G630064964","display_name":null,"funder_award_id":"P30CA086862]","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6861986753","display_name":null,"funder_award_id":"5T32HL007-30","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G701660491","display_name":null,"funder_award_id":"I01 BX001324","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8008545360","display_name":null,"funder_award_id":"R01 GM113961","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8159052870","display_name":"Alterations in CD4 T cells during sepsis","funder_award_id":"R01GM115462","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000037765","display_name":null,"funder_award_id":"T32 AI007485","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000106642","display_name":null,"funder_award_id":"AI114543","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000148696","display_name":null,"funder_award_id":"GM115462","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000213985","display_name":null,"funder_award_id":"GM113961","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000300037","display_name":null,"funder_award_id":"AI119160","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2755393274.pdf","grobid_xml":"https://content.openalex.org/works/W2755393274.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W114205036","https://openalex.org/W184708334","https://openalex.org/W1421625302","https://openalex.org/W1492950536","https://openalex.org/W1502260800","https://openalex.org/W1549568102","https://openalex.org/W1573380982","https://openalex.org/W1608509077","https://openalex.org/W1632859538","https://openalex.org/W1652390872","https://openalex.org/W1668274701","https://openalex.org/W1795093163","https://openalex.org/W1858915087","https://openalex.org/W1867300250","https://openalex.org/W1926790978","https://openalex.org/W1986448564","https://openalex.org/W1988511365","https://openalex.org/W2006760510","https://openalex.org/W2007816613","https://openalex.org/W2009253992","https://openalex.org/W2012497305","https://openalex.org/W2014748042","https://openalex.org/W2017669223","https://openalex.org/W2023945291","https://openalex.org/W2029128803","https://openalex.org/W2030133200","https://openalex.org/W2030378290","https://openalex.org/W2037123168","https://openalex.org/W2041658172","https://openalex.org/W2046700010","https://openalex.org/W2052275203","https://openalex.org/W2061402985","https://openalex.org/W2070743921","https://openalex.org/W2074503728","https://openalex.org/W2076753860","https://openalex.org/W2083513831","https://openalex.org/W2094650342","https://openalex.org/W2095799131","https://openalex.org/W2099206158","https://openalex.org/W2100609582","https://openalex.org/W2113628320","https://openalex.org/W2122022314","https://openalex.org/W2122340134","https://openalex.org/W2122647885","https://openalex.org/W2125944425","https://openalex.org/W2127349884","https://openalex.org/W2127381016","https://openalex.org/W2140368190","https://openalex.org/W2144589352","https://openalex.org/W2144716650","https://openalex.org/W2144919892","https://openalex.org/W2146800979","https://openalex.org/W2149987444","https://openalex.org/W2150992850","https://openalex.org/W2151322257","https://openalex.org/W2170651277","https://openalex.org/W2171414837","https://openalex.org/W2273021913","https://openalex.org/W2274798460","https://openalex.org/W2320077053","https://openalex.org/W2337400960","https://openalex.org/W2405078719","https://openalex.org/W2419572133","https://openalex.org/W2462013578","https://openalex.org/W2466002355","https://openalex.org/W2481045488","https://openalex.org/W2531471715","https://openalex.org/W2533830780","https://openalex.org/W2545336209","https://openalex.org/W2550811433","https://openalex.org/W2569985415","https://openalex.org/W2587714628","https://openalex.org/W4242141803"],"related_works":["https://openalex.org/W2053004761","https://openalex.org/W2060232277","https://openalex.org/W2372296322","https://openalex.org/W2370719635","https://openalex.org/W2359636035","https://openalex.org/W2620667791","https://openalex.org/W2083162155","https://openalex.org/W1971732845","https://openalex.org/W2015652414","https://openalex.org/W1979091441"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"a":[2,65,204],"systemic":[3,46],"infection":[4,73,91,135],"that":[5,23,99,187,290],"enhances":[6],"host":[7,80],"vulnerability":[8],"to":[9,39,45,86,92,101,130,160,162,167,180,196,222,228,237,253,275,292],"secondary":[10,171],"infections":[11],"normally":[12],"controlled":[13],"by":[14,81,243],"T":[15],"cells.":[16],"Using":[17],"CLP":[18,140],"sepsis":[19,24,104,271,299],"model,":[20],"we":[21,97,185],"observed":[22,182],"induces":[25],"apoptosis":[26],"of":[27,52,67,89,111,127,133,152,170,208,231,249,259,266],"circulating":[28],"memory":[29,57,153],"CD8":[30,41,58,154],"T-cells":[31,59,155],"(TCIRCM)":[32],"and":[33,77,147,165,214,234],"diminishes":[34],"their":[35,117,145],"effector":[36,118,232,260],"functions,":[37],"leading":[38,227],"impaired":[40],"T-cell":[42],"mediated":[43],"protection":[44,63],"pathogen":[47,94,238],"re-infection.":[48],"In":[49],"the":[50,79,87,90,131,157,168,181,263,273,295],"context":[51],"localized":[53,134,264],"re-infections,":[54],"tissue":[55],"resident":[56],"(TRM)":[60],"provide":[61],"robust":[62],"in":[64,74,139,156,220,257,298],"variety":[66],"infectious":[68],"models.":[69],"TRM":[70,143,267,278,284],"rapidly":[71,190],"'sense'":[72],"non-lymphoid":[75],"tissues":[76],"'alarm'":[78],"enhancing":[82],"immune":[83,128],"cell":[84],"recruitment":[85,126,258],"site":[88,132,169,265],"accelerate":[93],"clearance.":[95],"Here,":[96],"show":[98],"compared":[100],"pathogen-specific":[102],"TCIRCM,":[103],"does":[105],"not":[106],"invoke":[107],"significant":[108],"numerical":[109],"decline":[110],"Vaccinia":[112],"virus":[113],"induced":[114],"skin-TRM":[115],"keeping":[116],"functions":[119],"(e.g.,":[120],"Ag-dependent":[121],"IFN-\u03b3":[122,188,224],"production)":[123],"intact.":[124],"IFN-\u03b3-mediated":[125],"cells":[129,219,233,261],"was,":[136],"however,":[137],"reduced":[138,197],"hosts":[141],"despite":[142],"maintaining":[144],"'sensing":[146],"alarming'":[148],"functions.":[149],"The":[150],"capacity":[151,274],"septic":[158],"environment":[159],"respond":[161],"inflammatory":[163],"cues":[164],"arrive":[166],"infection/antigen":[172],"exposure":[173],"remained":[174],"normal":[175],"suggesting":[176],"T-cell-extrinsic":[177],"factors":[178],"contributed":[179],"lesion.":[183],"Mechanistically,":[184],"showed":[186],"produced":[189],"during":[191],"sepsis-induced":[192,255],"cytokine":[193],"storm":[194],"leads":[195],"IFN-\u03b3R1":[198],"expression":[199,207],"on":[200,216],"vascular":[201],"endothelium.":[202],"As":[203],"consequence,":[205],"decreased":[206],"adhesion":[209],"molecules":[210],"and/or":[211,286],"chemokines":[212],"(VCAM1":[213],"CXCL9)":[215],"skin":[217,277],"endothelial":[218],"response":[221],"TRM-derived":[223],"was":[225,251],"observed,":[226],"sub-optimal":[229],"bystander-recruitment":[230],"increased":[235],"susceptibility":[236],"re-encounter.":[239],"Importantly,":[240],"as":[241],"visualized":[242],"intravital":[244],"2-photon":[245],"microscopy,":[246],"exogenous":[247],"administration":[248],"CXCL9/10":[250],"sufficient":[252],"correct":[254],"impairments":[256],"at":[262],"antigen":[268],"recognition.":[269],"Thus,":[270],"has":[272],"alter":[276],"anamnestic":[279],"responses":[280],"without":[281],"directly":[282],"impacting":[283],"number":[285],"function,":[287],"an":[288],"observation":[289],"helps":[291],"further":[293],"define":[294],"immunoparalysis":[296],"phase":[297],"survivors.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}