{"id":"https://openalex.org/W2754584751","doi":"https://doi.org/10.1007/978-3-319-44981-4_1","title":"Global Nonlinear Fitness Function for Protein Structures","display_name":"Global Nonlinear Fitness Function for Protein Structures","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2754584751","doi":"https://doi.org/10.1007/978-3-319-44981-4_1","mag":"2754584751"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-44981-4_1","doi":"https://doi.org/10.1007/978-3-319-44981-4_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-44981-4_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210173559","display_name":"Health information science","issn_l":"2366-0988","issn":["2366-0988","2366-0996"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2754197982","display_name":"Health Informatics Data Analysis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yun Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Xu","raw_affiliation_strings":["Department of Bioengineering, University of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079708996","display_name":"Changyu Hu","orcid":"https://orcid.org/0000-0002-7636-0235","observed_orcids":["https://orcid.org/0000-0002-7636-0235","https://orcid.org/0009-0003-7173-8328"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changyu Hu","raw_affiliation_strings":["Department of Bioengineering, University of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025440962","display_name":"Yang David Dai","orcid":"https://orcid.org/0000-0002-7638-849X","observed_orcids":["https://orcid.org/0000-0002-7638-849X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Dai","raw_affiliation_strings":["Department of Bioengineering, University of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091558783","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0002-2773-6427","observed_orcids":["https://orcid.org/0000-0002-2773-6427"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Liang","raw_affiliation_strings":["Department of Bioengineering, University of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091558783"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15708394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-fitness-landscapes","display_name":"protein fitness landscapes","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-sequence-design","display_name":"protein sequence design","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.4440000057220459},{"id":"https://openalex.org/keywords/newton-s-method","display_name":"Newton's method","score":0.5580000281333923},{"id":"https://openalex.org/keywords/basis-set-selection","display_name":"basis set selection","score":0.5379999876022339},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.3610000014305115},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5558675527572632},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.452411413192749},{"id":"https://openalex.org/C176066374","wikidata":"https://www.wikidata.org/wiki/Q629118","display_name":"Fitness function","level":3,"score":0.4348561763763428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3540995121002197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25743240118026733},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.17423582077026367},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14093303680419922},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0585656464099884},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-44981-4_1","doi":"https://doi.org/10.1007/978-3-319-44981-4_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-44981-4_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210173559","display_name":"Health information science","issn_l":"2366-0988","issn":["2366-0988","2366-0996"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W38916856","https://openalex.org/W60615445","https://openalex.org/W1480928214","https://openalex.org/W1490016045","https://openalex.org/W1509269256","https://openalex.org/W1560724230","https://openalex.org/W1576520375","https://openalex.org/W1621799579","https://openalex.org/W1852517750","https://openalex.org/W1965245026","https://openalex.org/W1969644422","https://openalex.org/W1970812247","https://openalex.org/W1973460506","https://openalex.org/W1974885083","https://openalex.org/W1975017420","https://openalex.org/W1977212042","https://openalex.org/W1980120676","https://openalex.org/W1980471666","https://openalex.org/W1982792504","https://openalex.org/W1983002366","https://openalex.org/W1985907120","https://openalex.org/W1987696643","https://openalex.org/W1995824897","https://openalex.org/W1998072661","https://openalex.org/W2008505479","https://openalex.org/W2010249440","https://openalex.org/W2018249267","https://openalex.org/W2019475286","https://openalex.org/W2020564163","https://openalex.org/W2023235722","https://openalex.org/W2027071679","https://openalex.org/W2028841335","https://openalex.org/W2031490363","https://openalex.org/W2032630890","https://openalex.org/W2033496784","https://openalex.org/W2035376403","https://openalex.org/W2035999724","https://openalex.org/W2037928576","https://openalex.org/W2047477476","https://openalex.org/W2051085340","https://openalex.org/W2052564542","https://openalex.org/W2059681116","https://openalex.org/W2060100112","https://openalex.org/W2060778016","https://openalex.org/W2065367476","https://openalex.org/W2066381187","https://openalex.org/W2072843928","https://openalex.org/W2074970710","https://openalex.org/W2082260955","https://openalex.org/W2082296224","https://openalex.org/W2085497102","https://openalex.org/W2085764610","https://openalex.org/W2087928415","https://openalex.org/W2090265120","https://openalex.org/W2090847673","https://openalex.org/W2091778154","https://openalex.org/W2093404847","https://openalex.org/W2101220662","https://openalex.org/W2104460080","https://openalex.org/W2107538253","https://openalex.org/W2109610280","https://openalex.org/W2113712276","https://openalex.org/W2117452829","https://openalex.org/W2124730634","https://openalex.org/W2127828823","https://openalex.org/W2128114611","https://openalex.org/W2133155722","https://openalex.org/W2135815512","https://openalex.org/W2137736208","https://openalex.org/W2139212933","https://openalex.org/W2143562636","https://openalex.org/W2146760785","https://openalex.org/W2153153865","https://openalex.org/W2156909104","https://openalex.org/W2160529747","https://openalex.org/W2160879227","https://openalex.org/W2161776897","https://openalex.org/W2164308539","https://openalex.org/W2165011009","https://openalex.org/W2167254721","https://openalex.org/W2171546617","https://openalex.org/W2611147814","https://openalex.org/W2611330204","https://openalex.org/W3144619878","https://openalex.org/W4211047273","https://openalex.org/W4293775970","https://openalex.org/W4299702438","https://openalex.org/W4300640952","https://openalex.org/W6606674134"],"related_works":["https://openalex.org/W1974429394","https://openalex.org/W2066735716","https://openalex.org/W2769358864","https://openalex.org/W7099392800","https://openalex.org/W2542718473","https://openalex.org/W2128114611","https://openalex.org/W1822356811","https://openalex.org/W3024890260","https://openalex.org/W2099064665","https://openalex.org/W3044593510"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-09-25T00:00:00"}
