{"id":"https://openalex.org/W2754580693","doi":"https://doi.org/10.3389/fphys.2017.00698","title":"Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels","display_name":"Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels","publication_year":2017,"publication_date":"2017-09-13","ids":{"openalex":"https://openalex.org/W2754580693","doi":"https://doi.org/10.3389/fphys.2017.00698","mag":"2754580693","pmid":"https://pubmed.ncbi.nlm.nih.gov/28955251","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5601423"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2017.00698","doi":"https://doi.org/10.3389/fphys.2017.00698","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2017.00698","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2017.00698/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2017.00698/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018197410","display_name":"Zhen\u2010Ye Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158071","display_name":"Wuxi People's Hospital","ror":"https://ror.org/05pb5hm55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158071"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Ye Zhang","raw_affiliation_strings":["Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China","institution_ids":["https://openalex.org/I4210158071","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081199666","display_name":"Lingling Qian","orcid":"https://orcid.org/0000-0001-9282-301X","observed_orcids":["https://orcid.org/0000-0001-9282-301X"]},"institutions":[{"id":"https://openalex.org/I4210158071","display_name":"Wuxi People's Hospital","ror":"https://ror.org/05pb5hm55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158071"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Ling Qian","raw_affiliation_strings":["Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China","institution_ids":["https://openalex.org/I4210158071","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053928481","display_name":"Ruxing Wang","orcid":"https://orcid.org/0000-0001-7355-5048","observed_orcids":["https://orcid.org/0000-0001-7355-5048","https://orcid.org/0000-0002-3490-0280"]},"institutions":[{"id":"https://openalex.org/I4210158071","display_name":"Wuxi People's Hospital","ror":"https://ror.org/05pb5hm55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158071"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ru-Xing Wang","raw_affiliation_strings":["Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China","institution_ids":["https://openalex.org/I4210158071","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053928481"],"corresponding_institution_ids":["https://openalex.org/I4210158071","https://openalex.org/I83519826"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.2048,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.29703191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":null,"first_page":"698","last_page":"698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.8629999756813049},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8119999766349792},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.7960000038146973},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8270000219345093},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/electrolyte-homeostasis","display_name":"electrolyte balance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.7752783298492432},{"id":"https://openalex.org/C61144316","wikidata":"https://www.wikidata.org/wiki/Q4835827","display_name":"BK channel","level":3,"score":0.5596708059310913},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5466206669807434},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.47123321890830994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40119031071662903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36930155754089355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3690856695175171},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2234569787979126},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.1800244152545929},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10004368424415588}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2017.00698","doi":"https://doi.org/10.3389/fphys.2017.00698","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2017.00698","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2017.00698/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4536730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5601423","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5601423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5601423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:28955251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28955251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4274022c5d9348b9b42a921d93afd9ea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4274022c5d9348b9b42a921d93afd9ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 8 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2017.00698","doi":"https://doi.org/10.3389/fphys.2017.00698","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2017.00698","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2017.00698/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1655885531","display_name":null,"funder_award_id":"BK20151110","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G6131675735","display_name":"n-3\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\u5bf9\u7cd6\u5c3f\u75c5\u51a0\u72b6\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80deBK\u901a\u9053\u7684\u6fc0\u6d3b\u4f5c\u7528\u53ca\u5176\u673a\u5236\u7814\u7a76","funder_award_id":"81370303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6980178360","display_name":null,"funder_award_id":"81500249","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2754580693.pdf","grobid_xml":"https://content.openalex.org/works/W2754580693.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1553646233","https://openalex.org/W1916235480","https://openalex.org/W1934317139","https://openalex.org/W1953989222","https://openalex.org/W1966987996","https://openalex.org/W1977659817","https://openalex.org/W1980359098","https://openalex.org/W1988472050","https://openalex.org/W1989490275","https://openalex.org/W1991193137","https://openalex.org/W1994668150","https://openalex.org/W1996051526","https://openalex.org/W1998675589","https://openalex.org/W2003716397","https://openalex.org/W2006324925","https://openalex.org/W2006353836","https://openalex.org/W2006985572","https://openalex.org/W2007372862","https://openalex.org/W2013178091","https://openalex.org/W2020268794","https://openalex.org/W2020317483","https://openalex.org/W2025937578","https://openalex.org/W2026089352","https://openalex.org/W2029652412","https://openalex.org/W2031211185","https://openalex.org/W2032435718","https://openalex.org/W2036664649","https://openalex.org/W2038514787","https://openalex.org/W2048644561","https://openalex.org/W2050420714","https://openalex.org/W2050767894","https://openalex.org/W2061378848","https://openalex.org/W2063044361","https://openalex.org/W2064205875","https://openalex.org/W2065931051","https://openalex.org/W2067541658","https://openalex.org/W2069111106","https://openalex.org/W2070502135","https://openalex.org/W2077561912","https://openalex.org/W2084130233","https://openalex.org/W2084903350","https://openalex.org/W2091685020","https://openalex.org/W2093090047","https://openalex.org/W2095490308","https://openalex.org/W2097249865","https://openalex.org/W2098577403","https://openalex.org/W2103148871","https://openalex.org/W2104313154","https://openalex.org/W2108906398","https://openalex.org/W2113930277","https://openalex.org/W2115239727","https://openalex.org/W2115676911","https://openalex.org/W2118967804","https://openalex.org/W2121621776","https://openalex.org/W2122995536","https://openalex.org/W2126046035","https://openalex.org/W2127156790","https://openalex.org/W2132813757","https://openalex.org/W2134899427","https://openalex.org/W2140150081","https://openalex.org/W2142766228","https://openalex.org/W2145710039","https://openalex.org/W2147206026","https://openalex.org/W2149390328","https://openalex.org/W2149568071","https://openalex.org/W2156835140","https://openalex.org/W2157906583","https://openalex.org/W2162591155","https://openalex.org/W2163618830","https://openalex.org/W2166507618","https://openalex.org/W2167350525","https://openalex.org/W2168237435","https://openalex.org/W2170345337","https://openalex.org/W2171864508","https://openalex.org/W2172264769","https://openalex.org/W2182749815","https://openalex.org/W2183451240","https://openalex.org/W2231434046","https://openalex.org/W2239050330","https://openalex.org/W2284479604","https://openalex.org/W2291763506","https://openalex.org/W2314457777","https://openalex.org/W2345480984","https://openalex.org/W2349645132","https://openalex.org/W2383909651","https://openalex.org/W2419384423","https://openalex.org/W2516237911","https://openalex.org/W2589597444","https://openalex.org/W2610112373","https://openalex.org/W2735829239","https://openalex.org/W4234980549","https://openalex.org/W4240941479","https://openalex.org/W6704648703"],"related_works":["https://openalex.org/W2088113513","https://openalex.org/W2072492847","https://openalex.org/W2990081668","https://openalex.org/W2028982762","https://openalex.org/W2129170513","https://openalex.org/W2418685664","https://openalex.org/W2034655787","https://openalex.org/W2135944883","https://openalex.org/W4415469794","https://openalex.org/W2063277354"],"abstract_inverted_index":{"-sensitive":[0],"voltage-dependent":[1],"potassium":[2],"channels":[3,80],"and":[4,30,40,43,61,86],"play":[5],"a":[6,32,90],"vital":[7,24],"role":[8,34],"in":[9,13,25,35],"various":[10],"physiological":[11],"activities":[12],"the":[14,26,36,52,59,72,76,83],"human":[15],"body.":[16],"The":[17],"renin-angiotensin-aldosterone":[18,53,84],"system":[19,29,54,85],"is":[20,48],"acknowledged":[21],"as":[22,89],"being":[23],"body's":[27],"hormone":[28],"plays":[31],"fundamental":[33],"maintenance":[37],"of":[38,63,78],"water":[39],"electrolyte":[41],"balance":[42],"blood":[44],"pressure":[45],"regulation.":[46],"There":[47],"growing":[49],"evidence":[50],"that":[51],"has":[55],"profound":[56],"influences":[57],"on":[58,71],"expression":[60],"bioactivity":[62],"BK":[64,79],"channels.":[65],"In":[66],"this":[67],"review,":[68],"we":[69],"focus":[70],"molecular":[73],"mechanisms":[74],"underlying":[75],"regulation":[77],"mediated":[81],"by":[82],"its":[87],"potential":[88],"target":[91],"for":[92],"clinical":[93],"drugs.":[94]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-09-25T00:00:00"}