{"id":"https://openalex.org/W2754411658","doi":"https://doi.org/10.1126/scitranslmed.aad4000","title":"Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin\u2019s glucose-lowering effects","display_name":"Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin\u2019s glucose-lowering effects","publication_year":2017,"publication_date":"2017-09-13","ids":{"openalex":"https://openalex.org/W2754411658","doi":"https://doi.org/10.1126/scitranslmed.aad4000","mag":"2754411658","pmid":"https://pubmed.ncbi.nlm.nih.gov/28904225","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703224"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.aad4000","doi":"https://doi.org/10.1126/scitranslmed.aad4000","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aad4000","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022861947","display_name":"Cheol Hwangbo","orcid":"https://orcid.org/0000-0001-6505-3080","observed_orcids":["https://orcid.org/0000-0001-6505-3080"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheol Hwangbo","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0001-6505-3080","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000300986","display_name":"Jingxia Wu","orcid":"https://orcid.org/0000-0002-7573-4741","observed_orcids":["https://orcid.org/0000-0002-7573-4741"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jingxia Wu","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-7573-4741","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038808513","display_name":"Irinna Papangeli","orcid":"https://orcid.org/0000-0002-3151-4237","observed_orcids":["https://orcid.org/0000-0002-3151-4237"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irinna Papangeli","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-3151-4237","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021599044","display_name":"Takaomi Adachi","orcid":"https://orcid.org/0000-0003-3160-1872","observed_orcids":["https://orcid.org/0000-0003-3160-1872"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takaomi Adachi","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0003-3160-1872","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033993779","display_name":"Bikram Sharma","orcid":"https://orcid.org/0000-0003-0479-0823","observed_orcids":["https://orcid.org/0000-0003-0479-0823"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bikram Sharma","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039117774","display_name":"Saejeong Park","orcid":"https://orcid.org/0000-0002-0926-8076","observed_orcids":["https://orcid.org/0000-0002-0926-8076"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saejeong Park","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609521","display_name":"Lina Zhao","orcid":"https://orcid.org/0000-0002-2983-8590","observed_orcids":["https://orcid.org/0000-0002-2983-8590"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Zhao","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026659591","display_name":"Hyekyung Ju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyekyung Ju","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057567620","display_name":"Gwang\u2010woong Go","orcid":"https://orcid.org/0000-0002-3848-8705","observed_orcids":["https://orcid.org/0000-0002-3848-8705"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwang-woong Go","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-3848-8705","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037980406","display_name":"Guoliang Cui","orcid":"https://orcid.org/0000-0001-5559-7957","observed_orcids":["https://orcid.org/0000-0001-5559-7957"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoliang Cui","raw_affiliation_strings":["Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0001-5559-7957","affiliations":[{"raw_affiliation_string":"Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060637064","display_name":"Mohammed Inayathullah","orcid":"https://orcid.org/0000-0001-7646-1709","observed_orcids":["https://orcid.org/0000-0001-7646-1709"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Inayathullah","raw_affiliation_strings":["Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":"https://orcid.org/0000-0001-7646-1709","affiliations":[{"raw_affiliation_string":"Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003665444","display_name":"Judith K. Job","orcid":"https://orcid.org/0000-0002-2393-5613","observed_orcids":["https://orcid.org/0000-0002-2393-5613"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith K. Job","raw_affiliation_strings":["Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":"https://orcid.org/0000-0002-2393-5613","affiliations":[{"raw_affiliation_string":"Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054272206","display_name":"Jayakumar Rajadas","orcid":"https://orcid.org/0000-0001-6520-3923","observed_orcids":["https://orcid.org/0000-0001-6520-3923"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayakumar Rajadas","raw_affiliation_strings":["Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063082872","display_name":"Stephanie L. Kwei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. Kwei","raw_affiliation_strings":["Section of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043641375","display_name":"Ming O. Li","orcid":"https://orcid.org/0000-0002-1383-0535","observed_orcids":["https://orcid.org/0000-0002-1383-0535"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming O. Li","raw_affiliation_strings":["Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-1383-0535","affiliations":[{"raw_affiliation_string":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018421980","display_name":"Alan Morrison","orcid":"https://orcid.org/0000-0002-2412-7669","observed_orcids":["https://orcid.org/0000-0002-2412-7669"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Morrison","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-2412-7669","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051232840","display_name":"Thomas Quertermous","orcid":"https://orcid.org/0000-0002-7645-9067","observed_orcids":["https://orcid.org/0000-0002-7645-9067"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Quertermous","raw_affiliation_strings":["Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":"https://orcid.org/0000-0002-7645-9067","affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041279122","display_name":"Arya Mani","orcid":"https://orcid.org/0000-0001-6699-259X","observed_orcids":["https://orcid.org/0000-0001-6699-259X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arya Mani","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0001-6699-259X","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069632263","display_name":"Kristy Red\u2010Horse","orcid":"https://orcid.org/0000-0003-1541-601X","observed_orcids":["https://orcid.org/0000-0003-1541-601X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy Red-Horse","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA 94304, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009143841","display_name":"Hyung J. Chun","orcid":"https://orcid.org/0000-0003-3508-2678","observed_orcids":["https://orcid.org/0000-0003-3508-2678"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hyung J. Chun","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0003-3508-2678","affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000300986","https://openalex.org/A5009143841","https://openalex.org/A5022861947"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":5.5469,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.96836793,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"407","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apelin","display_name":"apelin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/apelin-receptor","display_name":"apelin receptor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.9779999852180481},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.5690000057220459},{"id":"https://openalex.org/keywords/fabp4","display_name":"FABP4","score":0.8040000200271606},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glucose-lowering-effect","display_name":"glucose-lowering effect","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2779546753","wikidata":"https://www.wikidata.org/wiki/Q2386988","display_name":"Apelin","level":3,"score":0.9107105731964111},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5020995140075684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.460932195186615},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45498624444007874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40585044026374817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38937240839004517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3642966151237488},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28389090299606323},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16018632054328918}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000073861","descriptor_name":"Apelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000075244","descriptor_name":"Apelin Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/scitranslmed.aad4000","doi":"https://doi.org/10.1126/scitranslmed.aad4000","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aad4000","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:28904225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28904225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5082282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703224","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5703224","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703224","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"},{"id":"pmh:oai:repository.hanyang.ac.kr:20.500.11754/115560","doi":null,"is_oa":false,"landing_page_url":"http://repository.hanyang.ac.kr/handle/20.500.11754/115560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401328","display_name":"The Royal Society of Chemistry\u2019s Journals, Books and Databases (The Royal Society of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2751430930","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/I2751430930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5082282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703224","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119895177","display_name":null,"funder_award_id":"1-14-BS-035","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G208265151","display_name":"CardioPulmonary Vascular Biology COBRE","funder_award_id":"P20GM103652","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2739435298","display_name":null,"funder_award_id":"award333193","funder_id":"https://openalex.org/F4320338282","funder_display_name":"Actelion Pharmaceuticals"},{"id":"https://openalex.org/G2750908624","display_name":"Genetic and physiological causes of inherited Vascular and Metabolic Diseases","funder_award_id":"R01HL094784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2766351402","display_name":null,"funder_award_id":"award299649","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2777112485","display_name":null,"funder_award_id":"award299654","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2940777275","display_name":null,"funder_award_id":"DK59637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3099743713","display_name":"Vanderbilt Mouse Metabolic Phenotyping Center","funder_award_id":"U2CDK059637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3787827884","display_name":"Role of MicroRNAs 424 and 503 in Pulmonary Arterial Hypertension","funder_award_id":"R01HL113005","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G395665603","display_name":"Yale Cardiovascular Center faculty recruitment","funder_award_id":"P30HL101284","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4099681973","display_name":"Vanderbilt Mouse Metabolic Phenotyping Center","funder_award_id":"U24DK059637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4305165846","display_name":"The Identification and characterization of genetic variants underlying cardiovascular diseases","funder_award_id":"R35HL135767","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4365929287","display_name":"Nutrient Sensing and mTORC1 Signaling in the Control of Regulatory T Cell Generation and Function","funder_award_id":"R01AI102888","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6191685371","display_name":null,"funder_award_id":"award299653","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G6495404200","display_name":null,"funder_award_id":"award299650","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G6991607900","display_name":null,"funder_award_id":"award332907","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7189789683","display_name":"Mechanotransduction and transcriptional regulation during artery development","funder_award_id":"R01HL128503","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7713687303","display_name":"Role of Apelin in the Systemic and Pulmonary Vasculature","funder_award_id":"K08HL095654","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7882011945","display_name":null,"funder_award_id":"award299645","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G792016239","display_name":null,"funder_award_id":"IK2BX002527","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8413681444","display_name":null,"funder_award_id":"award299646","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338282","display_name":"Actelion Pharmaceuticals","ror":"https://ror.org/001yedb91"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W172609984","https://openalex.org/W1485518802","https://openalex.org/W1522801511","https://openalex.org/W1526927233","https://openalex.org/W1532082124","https://openalex.org/W1576950583","https://openalex.org/W1609108565","https://openalex.org/W1965947775","https://openalex.org/W1966508121","https://openalex.org/W1972559234","https://openalex.org/W1973622869","https://openalex.org/W1977654090","https://openalex.org/W1978657976","https://openalex.org/W1988826263","https://openalex.org/W2004523281","https://openalex.org/W2008589619","https://openalex.org/W2022419155","https://openalex.org/W2034458870","https://openalex.org/W2036496650","https://openalex.org/W2040358658","https://openalex.org/W2043803772","https://openalex.org/W2050098287","https://openalex.org/W2059842910","https://openalex.org/W2064130493","https://openalex.org/W2067187286","https://openalex.org/W2076103389","https://openalex.org/W2081361720","https://openalex.org/W2083350649","https://openalex.org/W2083554435","https://openalex.org/W2089394474","https://openalex.org/W2093842837","https://openalex.org/W2096979174","https://openalex.org/W2100393234","https://openalex.org/W2101890597","https://openalex.org/W2104010513","https://openalex.org/W2106632025","https://openalex.org/W2107402601","https://openalex.org/W2111645882","https://openalex.org/W2114250030","https://openalex.org/W2114552998","https://openalex.org/W2114927063","https://openalex.org/W2116563158","https://openalex.org/W2120593855","https://openalex.org/W2124847962","https://openalex.org/W2124909544","https://openalex.org/W2127854619","https://openalex.org/W2137035181","https://openalex.org/W2139804418","https://openalex.org/W2140368468","https://openalex.org/W2147393987","https://openalex.org/W2148562280","https://openalex.org/W2152060936","https://openalex.org/W2152509794","https://openalex.org/W2152877944","https://openalex.org/W2155126563","https://openalex.org/W2157122261","https://openalex.org/W2158962006","https://openalex.org/W2164015929","https://openalex.org/W2164212234","https://openalex.org/W2164256953","https://openalex.org/W2166525118","https://openalex.org/W2168526937","https://openalex.org/W2170793571","https://openalex.org/W2294856235","https://openalex.org/W2912349604","https://openalex.org/W4254261652","https://openalex.org/W4388338332"],"related_works":["https://openalex.org/W2154455571","https://openalex.org/W7099152698","https://openalex.org/W2537993246","https://openalex.org/W2040358658","https://openalex.org/W2368755361","https://openalex.org/W2053120221","https://openalex.org/W2252936036","https://openalex.org/W2120670293","https://openalex.org/W2116563158","https://openalex.org/W2758242575"],"abstract_inverted_index":{"mice":[0,14],"was":[1],"associated":[2],"with":[3,15],"excess":[4],"FA":[5],"accumulation":[6],"in":[7],"the":[8,32],"skeletal":[9],"muscle.":[10],"Treatment":[11],"of":[12],"these":[13,20],"an":[16],"FABP4":[17],"inhibitor":[18],"abrogated":[19],"metabolic":[21,41],"phenotypes.":[22],"These":[23],"findings":[24],"provide":[25],"mechanistic":[26],"insights":[27],"that":[28],"could":[29],"greatly":[30],"expand":[31],"therapeutic":[33],"repertoire":[34],"for":[35],"type":[36],"2":[37],"diabetes":[38],"and":[39],"related":[40],"disorders.":[42]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-09-25T00:00:00"}