{"id":"https://openalex.org/W2754178554","doi":null,"title":"Development and sexual differentiation of the circadian system of Octodon degus .","display_name":"Development and sexual differentiation of the circadian system of Octodon degus .","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2754178554","mag":"2754178554"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126057","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/126057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076671943","display_name":"Daniel L. Hummer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel L. Hummer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076671943"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octodon-degus","display_name":"Octodon degus","score":0.8709999918937683},{"id":"https://openalex.org/keywords/circadian-pacemaker","display_name":"circadian pacemaker","score":0.8320000171661377},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.675000011920929},{"id":"https://openalex.org/keywords/sexual-differentiation","display_name":"sexual differentiation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/gonadal-hormones","display_name":"gonadal hormones","score":0.7210000157356262},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.8379999995231628},{"id":"https://openalex.org/keywords/free-running-period","display_name":"free-running period","score":0.7480000257492065},{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.8849999904632568},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/gonadectomy","display_name":"gonadectomy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/circadian-phase-delay","display_name":"circadian phase delay","score":0.6359999775886536},{"id":"https://openalex.org/keywords/sleep-onset-delay","display_name":"sleep onset delay","score":0.5920000076293945},{"id":"https://openalex.org/keywords/adolescent-sleep","display_name":"adolescent sleep","score":0.367000013589859},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6104090213775635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5808188319206238},{"id":"https://openalex.org/C63405245","wikidata":"https://www.wikidata.org/wiki/Q9076644","display_name":"Sexual differentiation","level":3,"score":0.5020341873168945},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.387734055519104},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31922999024391174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14714011549949646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126057","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/126057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2754178554","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/126057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095358893","https://openalex.org/W2010585634","https://openalex.org/W2738290469","https://openalex.org/W2580871478","https://openalex.org/W7096411342","https://openalex.org/W2749386003","https://openalex.org/W2013920612","https://openalex.org/W5998780","https://openalex.org/W1972124647","https://openalex.org/W2153014242"],"abstract_inverted_index":{"Human":[0],"adolescents":[1],"exhibit":[2,165],"delays":[3],"in":[4,31,41,92,105,133,146,149,153,169,190,195,215,251,271,297],"their":[5],"circadian":[6,34,77,116,234,268,292],"rhythms":[7],"during":[8,72,98,118,184,206,280],"puberty":[9,119,139,162],"(e.g.,":[10],"spontaneous":[11,45],"waking,":[12,46],"alertness,":[13],"sleep":[14,42],"onset).":[15],"The":[16,58],"combination":[17],"of":[18,55,68,79,96,221,231,265,290,310,314],"later":[19],"bedtimes":[20],"and":[21,44,65,158],"earlier":[22],"school":[23],"days":[24],"contributes":[25],"to":[26,38,179,204],"daytime":[27],"sleepiness.":[28],"Pubertal":[29],"changes":[30],"the":[32,39,48,53,63,75,93,100,124,219,225,229,232,240,249,266,291,306,315],"underlying":[33,125,267],"pacemaker":[35,78],"may":[36,321],"lead":[37],"delay":[40,91],"onset":[43,95],"because":[47,127],"pacemaker's":[49],"endogenous":[50],"period":[51,142,154,170,188,194,209,214,244],"influences":[52],"phase":[54,117],"entrained":[56],"rhythms.":[57],"data":[59,260,320],"presented":[60],"here":[61],"clarify":[62],"immediate":[64],"long-term":[66],"impact":[67],"gonadal":[69],"hormone":[70],"exposure":[71,178],"adolescence":[73],"on":[74,123],"central":[76,233,316],"a":[80,90,150,166,175,185,191,274,281,323],"slowly-maturing,":[81],"long-lived":[82],"rodent,":[83],"Octodon":[84],"degus":[85,88,106,272],"(degus).":[86],"Gonadally-intact":[87],"exhibited":[89],"daily":[94],"activity":[97],"puberty;":[99],"phase-delay":[101],"did":[102,163,210],"not":[103,164,182,211,256],"occur":[104],"gonadectomized":[107,160],"before":[108,161,201],"puberty.":[109,202,333],"It":[110],"is":[111,273,295,305],"unlikely":[112],"that":[113,197,242,262,278,330],"hormones":[114],"mediate":[115],"by":[120],"acting":[121],"directly":[122],"pacemaker,":[126],"there":[128],"was":[129,255],"no":[130],"corresponding":[131],"change":[132],"free-running":[134,141,193,213,243],"period.":[135,284],"Several":[136],"months":[137],"after":[138,237,332],"however,":[140],"became":[143],"significantly":[144],"shorter":[145],"males,":[147],"resulting":[148],"sex":[151,167,328],"difference":[152,168],"at":[155,171],"12-months.":[156],"Males":[157],"females":[159],"any":[172],"age.":[173],"In":[174],"subsequent":[176],"experiment,":[177],"estradiol":[180,205],"(but":[181],"dihydrotestosterone)":[183],"post-pubertal":[186,282,311],"sensitive":[187,208,283],"resulted":[189],"shortened":[192],"males":[196],"had":[198],"been":[199],"castrated":[200],"Exposure":[203],"this":[207,304],"affect":[212],"female":[216],"degus.":[217],"Finally,":[218],"expression":[220,254],"estrogen":[222,252],"receptors":[223],"within":[224],"suprachiasmatic":[226],"nucleus":[227],"(i.e.,":[228],"site":[230],"pacemaker)":[235],"increased":[236],"puberty,":[238],"around":[239],"age":[241],"becomes":[245],"sexually":[246],"dimorphic.":[247],"However,":[248],"increase":[250],"receptor":[253],"sex-specific.":[257],"Together,":[258],"these":[259],"indicate":[261],"sexual":[263,312],"differentiation":[264,313],"timekeeping":[269],"mechanism":[270,294],"sex-specific,":[275],"estrogen-mediated":[276],"effect":[277],"occurs":[279],"Questions":[285],"remain":[286],"about":[287],"how":[288],"masculinization":[289],"clock":[293],"avoided":[296],"females.":[298],"So":[299],"far":[300],"as":[301],"we":[302],"know,":[303],"only":[307],"animal":[308],"model":[309],"nervous":[317],"system.":[318],"These":[319],"provide":[322],"framework":[324],"for":[325],"understanding":[326],"behavioral":[327],"differences":[329],"emerge":[331]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-09-25T00:00:00"}