{"id":"https://openalex.org/W2752820122","doi":"https://doi.org/10.1182/bloodadvances.2017005710","title":"RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells","display_name":"RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells","publication_year":2017,"publication_date":"2017-09-06","ids":{"openalex":"https://openalex.org/W2752820122","doi":"https://doi.org/10.1182/bloodadvances.2017005710","mag":"2752820122","pmid":"https://pubmed.ncbi.nlm.nih.gov/29296817","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728331"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2017005710","doi":"https://doi.org/10.1182/bloodadvances.2017005710","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2017005710","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1182/bloodadvances.2017005710","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053599485","display_name":"Takahiro Suzuki","orcid":"https://orcid.org/0000-0002-0972-6911","observed_orcids":["https://orcid.org/0000-0002-0972-6911"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Suzuki","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","Graduate School of Medical Life Science, Yokohama City University, Yokohama City, Japan; and","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":"https://orcid.org/0000-0002-0972-6911","affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Graduate School of Medical Life Science, Yokohama City University, Yokohama City, Japan; and","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019263333","display_name":"Yuri Shimizu","orcid":"https://orcid.org/0000-0001-8761-8847","observed_orcids":["https://orcid.org/0000-0001-8761-8847"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuri Shimizu","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035264446","display_name":"Erina Furuhata","orcid":"https://orcid.org/0009-0008-3811-1263","observed_orcids":["https://orcid.org/0009-0008-3811-1263"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Erina Furuhata","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112639126","display_name":"Shiori Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shiori Maeda","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073539209","display_name":"Mami Kishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mami Kishima","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108422238","display_name":"Hajime Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Nishimura","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083433872","display_name":"Saaya Enomoto","orcid":"https://orcid.org/0000-0002-4388-7938","observed_orcids":["https://orcid.org/0000-0002-4388-7938"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saaya Enomoto","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","Graduate School of Medical Life Science, Yokohama City University, Yokohama City, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Graduate School of Medical Life Science, Yokohama City University, Yokohama City, Japan; and","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032097008","display_name":"Yoshihide Hayashizaki","orcid":"https://orcid.org/0000-0002-0561-2802","observed_orcids":["https://orcid.org/0000-0002-0561-2802"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide Hayashizaki","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","RIKEN Preventive Medical and Diagnosis Innovation Program, Wako City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Preventive Medical and Diagnosis Innovation Program, Wako City, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018063097","display_name":"Harukazu Suzuki","orcid":"https://orcid.org/0000-0002-8087-0836","observed_orcids":["https://orcid.org/0000-0002-8087-0836"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harukazu Suzuki","raw_affiliation_strings":["Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama City, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019263333","https://openalex.org/A5035264446","https://openalex.org/A5112639126"],"corresponding_institution_ids":["https://openalex.org/I4210110652"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":2.8251,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.92054507,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"1","issue":"20","first_page":"1699","last_page":"1711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":1.0},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/site-specificity","display_name":"site specificity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tet3","display_name":"TET3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tdg","display_name":"TDG","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gadd45","display_name":"GADD45","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hematopoietic-development","display_name":"hematopoietic development","score":0.8759999871253967},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dna-methylome","display_name":"methylome","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C16824249","wikidata":"https://www.wikidata.org/wiki/Q5205753","display_name":"DNA demethylation","level":5,"score":0.849141001701355},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.7958605289459229},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6290907859802246},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.628020703792572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5159690976142883},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4434933364391327},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37107032537460327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3574199080467224},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3414630591869354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3390619158744812},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1850595772266388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09312665462493896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.042018741369247437}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1182/bloodadvances.2017005710","doi":"https://doi.org/10.1182/bloodadvances.2017005710","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2017005710","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4662840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5728331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmid:29296817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29296817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:481eea583066470397a43716550728a8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/481eea583066470397a43716550728a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Advances, Vol 1, Iss 20, Pp 1699-1711 (2017)","raw_type":"article"},{"id":"mag:2768295694","doi":null,"is_oa":false,"landing_page_url":"https://confit.atlas.jp/guide/event/conbio2017/subject/3P-0562/classlist","pdf_url":null,"source":{"id":"https://openalex.org/S4306532260","display_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","raw_type":null}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2017005710","doi":"https://doi.org/10.1182/bloodadvances.2017005710","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2017005710","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W125903238","https://openalex.org/W376254103","https://openalex.org/W1494954858","https://openalex.org/W1620920429","https://openalex.org/W1753172918","https://openalex.org/W1948381206","https://openalex.org/W1965241494","https://openalex.org/W1966052560","https://openalex.org/W1973020652","https://openalex.org/W1977772936","https://openalex.org/W1981463058","https://openalex.org/W1985260876","https://openalex.org/W1986175684","https://openalex.org/W1986223165","https://openalex.org/W1987189614","https://openalex.org/W1987677365","https://openalex.org/W1987897013","https://openalex.org/W1992391979","https://openalex.org/W1993627126","https://openalex.org/W1997453048","https://openalex.org/W2004729058","https://openalex.org/W2012499563","https://openalex.org/W2012701284","https://openalex.org/W2013480319","https://openalex.org/W2024090882","https://openalex.org/W2025545218","https://openalex.org/W2026344296","https://openalex.org/W2035617473","https://openalex.org/W2036636377","https://openalex.org/W2046812959","https://openalex.org/W2048786084","https://openalex.org/W2056040742","https://openalex.org/W2062211740","https://openalex.org/W2071329887","https://openalex.org/W2072852987","https://openalex.org/W2076154138","https://openalex.org/W2083782960","https://openalex.org/W2084051071","https://openalex.org/W2084620487","https://openalex.org/W2085293170","https://openalex.org/W2088973409","https://openalex.org/W2089266451","https://openalex.org/W2093149606","https://openalex.org/W2107279676","https://openalex.org/W2108664872","https://openalex.org/W2121417064","https://openalex.org/W2123115454","https://openalex.org/W2124049725","https://openalex.org/W2129270269","https://openalex.org/W2131052524","https://openalex.org/W2140261058","https://openalex.org/W2147357092","https://openalex.org/W2148033929","https://openalex.org/W2152807349","https://openalex.org/W2154371397","https://openalex.org/W2156626022","https://openalex.org/W2161224111","https://openalex.org/W2161326542","https://openalex.org/W2162806047","https://openalex.org/W2168606329","https://openalex.org/W2168967248","https://openalex.org/W2171808845","https://openalex.org/W2219596071","https://openalex.org/W2418737438","https://openalex.org/W6653855832"],"related_works":["https://openalex.org/W2605351877","https://openalex.org/W2113380956","https://openalex.org/W4250017839","https://openalex.org/W4416842537","https://openalex.org/W2008412081","https://openalex.org/W4220664061","https://openalex.org/W2608352448","https://openalex.org/W2561872587","https://openalex.org/W2590376524","https://openalex.org/W2113933754"],"abstract_inverted_index":{"RUNX1":[0,23,32,39,55,88,106,144],"is":[1],"an":[2,74],"essential":[3],"master":[4],"transcription":[5],"factor":[6],"in":[7,14,43,48,69,81,109,163],"hematopoietic":[8,50,82,135,164],"development":[9],"and":[10,89,97,107,155],"plays":[11],"important":[12],"roles":[13],"immune":[15],"functions.":[16],"Although":[17],"the":[18,28,57,110,138],"gene":[19],"regulatory":[20],"mechanism":[21],"of":[22,31,54,76,105,116,128,148,153],"has":[24],"been":[25],"characterized":[26],"extensively,":[27],"epigenetic":[29],"role":[30],"remains":[33],"unclear.":[34],"Here,":[35],"we":[36],"demonstrate":[37],"that":[38,143],"contributes":[40,145],"DNA":[41,60,64,70,90,117,149],"demethylation":[42,65,78,91,118,150],"a":[44],"binding":[45,161],"site-directed":[46,59],"manner":[47],"human":[49],"cells.":[51,165],"Overexpression":[52],"analysis":[53,124],"showed":[56,84],"RUNX1-binding":[58,129],"demethylation.":[61],"The":[62],"RUNX1-mediated":[63],"was":[66],"also":[67],"observed":[68],"replication-arrested":[71],"cells,":[72],"suggesting":[73],"involvement":[75],"active":[77],"mechanism.":[79],"Coimmunoprecipitation":[80],"cells":[83],"physical":[85],"interactions":[86],"between":[87],"machinery":[92,119],"enzymes":[93,158],"TET2,":[94],"TET3,":[95],"TDG,":[96],"GADD45.":[98],"Further":[99],"chromatin":[100],"immunoprecipitation":[101],"sequencing":[102],"revealed":[103,125],"colocalization":[104],"TET2":[108],"same":[111],"genomic":[112],"regions,":[113],"indicating":[114],"recruitment":[115,152],"by":[120,151],"RUNX1.":[121],"Finally,":[122],"methylome":[123],"significant":[126],"overrepresentation":[127],"sites":[130,162],"at":[131],"demethylated":[132],"regions":[133],"during":[134],"development.":[136],"Collectively,":[137],"present":[139],"data":[140],"provide":[141],"evidence":[142],"site":[146],"specificity":[147],"TET":[154],"other":[156],"demethylation-related":[157],"to":[159],"its":[160]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-09-15T00:00:00"}
