{"id":"https://openalex.org/W2752071018","doi":"https://doi.org/10.1038/s41467-017-00525-4","title":"Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster","display_name":"Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster","publication_year":2017,"publication_date":"2017-08-31","ids":{"openalex":"https://openalex.org/W2752071018","doi":"https://doi.org/10.1038/s41467-017-00525-4","mag":"2752071018","pmid":"https://pubmed.ncbi.nlm.nih.gov/28878259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5587646"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-017-00525-4","doi":"https://doi.org/10.1038/s41467-017-00525-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-017-00525-4","pdf_url":"https://www.nature.com/articles/s41467-017-00525-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-017-00525-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anil Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Rana","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041468323","display_name":"Matheus Oliveira","orcid":"https://orcid.org/0000-0002-2124-8799","observed_orcids":["https://orcid.org/0000-0002-2124-8799"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Matheus P. Oliveira","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","Instituto de Bioquimica Medica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, 21941-590, Brazil","Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Instituto de Bioquimica Medica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, 21941-590, Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055294558","display_name":"Andy V. Khamoui","orcid":"https://orcid.org/0000-0003-4449-536X","observed_orcids":["https://orcid.org/0000-0003-4449-536X"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]},{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy V. Khamoui","raw_affiliation_strings":["Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA","Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA","LA BioMed - Los Angeles Biomedical Research Institute (1124 West Carson Street Torrance, CA 90502. - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA","institution_ids":["https://openalex.org/I63772739"]},{"raw_affiliation_string":"Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"LA BioMed - Los Angeles Biomedical Research Institute (1124 West Carson Street Torrance, CA 90502. - United States)","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003233715","display_name":"Ricardo Apar\u00edcio","orcid":"https://orcid.org/0000-0003-3670-0466","observed_orcids":["https://orcid.org/0000-0003-3670-0466"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Aparicio","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107462803","display_name":"Micha\u00ebl Rera","orcid":"https://orcid.org/0000-0002-6574-6511","observed_orcids":["https://orcid.org/0000-0002-6574-6511"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4403386693","display_name":"Physiologie De L'Axe Gonadotrope","ror":"https://ror.org/04gh2v067","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386693"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Michael Rera","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","Laboratory of Degenerative Processes, Stress and Aging, Universit\u00e9 Paris Diderot, Paris, 75013, France","BFA (UMR_8251 / U1133) - Unit\u00e9 de Biologie Fonctionnelle et Adaptative (Universit\u00e9 Paris Diderot, B\u00e2t. Buffon, 4 rue Marie-Andr\u00e9e Lagroua Weill-Hall\u00e9, case postale 7081 , 75205 Paris cedex 13 - France)","Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)"],"raw_orcid":"https://orcid.org/0000-0002-6574-6511","affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Laboratory of Degenerative Processes, Stress and Aging, Universit\u00e9 Paris Diderot, Paris, 75013, France","institution_ids":["https://openalex.org/I4387154366"]},{"raw_affiliation_string":"BFA (UMR_8251 / U1133) - Unit\u00e9 de Biologie Fonctionnelle et Adaptative (Universit\u00e9 Paris Diderot, B\u00e2t. Buffon, 4 rue Marie-Andr\u00e9e Lagroua Weill-Hall\u00e9, case postale 7081 , 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4210137329","https://openalex.org/I4387154366","https://openalex.org/I4403386693"]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024289844","display_name":"Harry B. Rossiter","orcid":"https://orcid.org/0000-0002-7884-0726","observed_orcids":["https://orcid.org/0000-0002-7884-0726"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Harry B. Rossiter","raw_affiliation_strings":["Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA","Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","LA BioMed - Los Angeles Biomedical Research Institute (1124 West Carson Street Torrance, CA 90502. - United States)","University of Leeds (Woodhouse Lane, Leeds  LS2 9JT - United Kingdom)"],"raw_orcid":"https://orcid.org/0000-0002-7884-0726","affiliations":[{"raw_affiliation_string":"Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"LA BioMed - Los Angeles Biomedical Research Institute (1124 West Carson Street Torrance, CA 90502. - United States)","institution_ids":["https://openalex.org/I177607063"]},{"raw_affiliation_string":"University of Leeds (Woodhouse Lane, Leeds  LS2 9JT - United Kingdom)","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020966831","display_name":"David W. Walker","orcid":"https://orcid.org/0000-0002-9422-2178","observed_orcids":["https://orcid.org/0000-0002-9422-2178"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. Walker","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA. davidwalker@ucla.edu","Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA. davidwalker@ucla.edu","Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA. davidwalker@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA. davidwalker@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology (University of California, Los Angeles (UCLA), Los Angeles, CA 900095-7246 - United States)","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5020966831"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":9.5028,"has_fulltext":true,"cited_by_count":304,"citation_normalized_percentile":{"value":0.98773585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"448","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.19210000336170197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.8500000238418579},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5490000247955322},{"id":"https://openalex.org/keywords/flight-muscle","display_name":"flight muscle","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-function","display_name":"mitochondrial respiratory function","score":0.7599999904632568},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.9291783571243286},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.9176192879676819},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.8864016532897949},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6155266761779785},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5828214883804321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.55877685546875},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.48781803250312805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4844822585582733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2844622731208801},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13523656129837036},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10376676917076111}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1038/s41467-017-00525-4","doi":"https://doi.org/10.1038/s41467-017-00525-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-017-00525-4","pdf_url":"https://www.nature.com/articles/s41467-017-00525-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:28878259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28878259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5587646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5587646/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:121036","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/121036/13/s41467-017-00525-4.pdf","pdf_url":"https://eprints.whiterose.ac.uk/121036/13/s41467-017-00525-4.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:HAL:hal-02347415v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02347415","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 2017, 8, pp.448. ⟨10.1038/s41467-017-00525-4⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00525-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-017-00525-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:56b69cd7b02648e89c37e7fc3efa2845","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/56b69cd7b02648e89c37e7fc3efa2845","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:768f7067be3441c38fc2efdc019f9dce","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/768f7067be3441c38fc2efdc019f9dce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6pv0c2ws","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6pv0c2ws","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications, vol 8, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6pv0c2ws","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6pv0c2ws","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 8, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-017-00525-4","doi":"https://doi.org/10.1038/s41467-017-00525-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-017-00525-4","pdf_url":"https://www.nature.com/articles/s41467-017-00525-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3972112027","display_name":"Metabolic regulation of stem cell behavior and longevity","funder_award_id":"R01AG040288","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000095838","display_name":null,"funder_award_id":"NIH-P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000859977","display_name":"Role of Intestinal Homeostasis in Organismal Aging","funder_award_id":"R01AG049157","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000904008","display_name":"Role of Mitochondrial Homeostasis in Animal Aging","funder_award_id":"R01AG037514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2752071018.pdf","grobid_xml":"https://content.openalex.org/works/W2752071018.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1493882194","https://openalex.org/W1500436940","https://openalex.org/W1512819323","https://openalex.org/W1514640681","https://openalex.org/W1969752287","https://openalex.org/W1972597570","https://openalex.org/W1973352176","https://openalex.org/W1975473156","https://openalex.org/W1976391651","https://openalex.org/W1976645698","https://openalex.org/W1979645469","https://openalex.org/W1985119207","https://openalex.org/W1989026904","https://openalex.org/W1994166158","https://openalex.org/W1997842854","https://openalex.org/W1999477136","https://openalex.org/W2006070103","https://openalex.org/W2011124366","https://openalex.org/W2012178564","https://openalex.org/W2019637022","https://openalex.org/W2021343145","https://openalex.org/W2022161896","https://openalex.org/W2023402149","https://openalex.org/W2024782183","https://openalex.org/W2032022203","https://openalex.org/W2034087770","https://openalex.org/W2035453462","https://openalex.org/W2037064466","https://openalex.org/W2038028875","https://openalex.org/W2038976751","https://openalex.org/W2045459244","https://openalex.org/W2049016912","https://openalex.org/W2051704317","https://openalex.org/W2054556550","https://openalex.org/W2055486023","https://openalex.org/W2058653820","https://openalex.org/W2066027084","https://openalex.org/W2074111563","https://openalex.org/W2080270879","https://openalex.org/W2082425146","https://openalex.org/W2082970812","https://openalex.org/W2087945271","https://openalex.org/W2089145020","https://openalex.org/W2099934453","https://openalex.org/W2099981888","https://openalex.org/W2104412320","https://openalex.org/W2108326484","https://openalex.org/W2110072051","https://openalex.org/W2113431427","https://openalex.org/W2126525177","https://openalex.org/W2130979925","https://openalex.org/W2139636031","https://openalex.org/W2149090315","https://openalex.org/W2155643523","https://openalex.org/W2156754173","https://openalex.org/W2157334943","https://openalex.org/W2157443158","https://openalex.org/W2157765869","https://openalex.org/W2158363851","https://openalex.org/W2170660730","https://openalex.org/W2200046622","https://openalex.org/W2262829592","https://openalex.org/W2289876562","https://openalex.org/W2293782839","https://openalex.org/W2321856601","https://openalex.org/W2400420771","https://openalex.org/W2419425946","https://openalex.org/W2429359053","https://openalex.org/W2470574011","https://openalex.org/W2472002677","https://openalex.org/W2527422074","https://openalex.org/W2607434574","https://openalex.org/W2752326209","https://openalex.org/W2968590403","https://openalex.org/W4231604814","https://openalex.org/W7211999992"],"related_works":["https://openalex.org/W7030409930","https://openalex.org/W3214311135","https://openalex.org/W4400803517","https://openalex.org/W2008332742","https://openalex.org/W2963984502","https://openalex.org/W3182470400","https://openalex.org/W4381892093","https://openalex.org/W2050229842","https://openalex.org/W3043370561","https://openalex.org/W2022161896"],"abstract_inverted_index":{"The":[0],"accumulation":[1,75],"of":[2,14,46,76,113,131,168,183],"dysfunctional":[3,77],"mitochondria":[4,78],"has":[5],"been":[6],"implicated":[7],"in":[8,48,79,87,99,135,139,171,175],"aging,":[9],"but":[10,173],"a":[11,61,65],"deeper":[12],"understanding":[13],"mitochondrial":[15,33,68,85,94,116,125,149,169],"dynamics":[16],"and":[17,39,56,59,91,97,133,142,164,181],"mitophagy":[18,90],"during":[19],"aging":[20],"is":[21,50,71,107],"missing.":[22],"Here,":[23,151],"we":[24,103],"show":[25,104,165],"that":[26,31,43,105,121,123,155,166],"upregulating":[27],"Drp1-a":[28],"Dynamin-related":[29],"protein":[30],"promotes":[32],"fission-in":[34],"midlife,":[35,49,88,172],"prolongs":[36],"Drosophila":[37],"lifespan":[38],"healthspan.":[40],"We":[41],"find":[42],"short-term":[44],"induction":[45,167],"Drp1,":[47],"sufficient":[51],"to":[52,73,147],"improve":[53],"organismal":[54],"health":[55,180],"prolong":[57],"lifespan,":[58],"observe":[60],"midlife":[62,114],"shift":[63],"toward":[64],"more":[66,159],"elongated":[67],"morphology,":[69],"which":[70],"linked":[72],"the":[74,110,129,152,179],"aged":[80,100],"flight":[81],"muscle.":[82],"Promoting":[83],"Drp1-mediated":[84,115],"fission,":[86],"facilitates":[89],"improves":[92],"both":[93],"respiratory":[95],"function":[96],"proteostasis":[98],"flies.":[101,184],"Finally,":[102],"autophagy":[106],"required":[108],"for":[109],"anti-aging":[111],"effects":[112],"fission.":[117],"Our":[118],"findings":[119],"indicate":[120],"interventions":[122],"promote":[124],"fission":[126,141,170],"could":[127],"delay":[128],"onset":[130],"pathology":[132],"mortality":[134],"mammals":[136],"when":[137],"applied":[138],"midlife.Mitochondrial":[140],"fusion":[143],"are":[144],"important":[145],"mechanisms":[146],"maintain":[148],"function.":[150],"authors":[153],"report":[154],"middle-aged":[156],"flies":[157],"have":[158],"elongated,":[160],"or":[161],"'hyper-fused'":[162],"mitochondria,":[163],"not":[174],"early":[176],"life,":[177],"extends":[178],"life":[182]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":40},{"year":2022,"cited_by_count":44},{"year":2021,"cited_by_count":44},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-09-15T00:00:00"}