{"id":"https://openalex.org/W2751925138","doi":null,"title":"ABCA1 expression and function under physiological and pathological conditions","display_name":"ABCA1 expression and function under physiological and pathological conditions","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2751925138","mag":"2751925138"},"language":"en","primary_location":{"id":"mag:2751925138","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/603724","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112621510","display_name":"Albrecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albrecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044180629","display_name":"Christiane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christiane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25483944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8920000195503235},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hdl-deficiency","display_name":"HDL deficiency","score":0.7670000195503235},{"id":"https://openalex.org/keywords/scott-syndrome","display_name":"Scott syndrome","score":0.8550000190734863},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.777999997138977},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/complicated-pregnancy","display_name":"complicated pregnancy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.9510953426361084},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5742809772491455},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5531376004219055},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.4955042600631714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4794422686100006},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.45682409405708313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.448598712682724},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.436148464679718},{"id":"https://openalex.org/C2779982054","wikidata":"https://www.wikidata.org/wiki/Q1442621","display_name":"Tangier disease","level":5,"score":0.4295896887779236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42705458402633667},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4247113764286041},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41990208625793457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37127530574798584},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3672483563423157},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3396282494068146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.284389853477478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2739308476448059},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.23229369521141052},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.13607341051101685},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1251126527786255},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1049080491065979}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2751925138","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/603724","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3028846301","https://openalex.org/W2300262116","https://openalex.org/W1901285641","https://openalex.org/W7096592155","https://openalex.org/W3126186575","https://openalex.org/W2108295599","https://openalex.org/W1970329005","https://openalex.org/W2059256286","https://openalex.org/W2324964117","https://openalex.org/W6989406719"],"abstract_inverted_index":{"ABCA1,":[0],"a":[1,15,35,52,119,161],"member":[2],"of":[3,18,73,125,132,144,157],"the":[4,68,123,126,130,142],"ATP-binding":[5],"cassette":[6],"transporter":[7],"family,":[8],"has":[9],"been":[10],"shown":[11],"as":[12,174],"to":[13,180],"be":[14,95,105,178],"key":[16],"regulator":[17],"lipid":[19],"homeostasis.":[20],"Our":[21],"studies":[22,139,167],"revealed":[23],"that":[24,46,62,91,102],"this":[25,158],"gene":[26,159],"is":[27,48,64,118],"not":[28],"only":[29],"implicated":[30,106],"in":[31,51,67,85,107,122,134,149,160],"familial":[32],"HDL":[33,41],"deficiency,":[34],"hereditary":[36],"disease":[37,162],"characterised":[38],"by":[39,97],"low":[40],"and":[42,71,81,116,147,152,184],"apolipoprotein":[43],"concentrations,":[44],"but":[45],"it":[47],"also":[49,60],"involved":[50,66],"rare":[53],"bleeding":[54],"disorder":[55],"called":[56,163],"Scott":[57],"syndrome.":[58,165],"We":[59],"demonstrated":[61,89],"ABCA1":[63,80,103,133,145],"potentially":[65],"initiation,":[69],"progression":[70],"pathogenesis":[72],"atherosclerotic":[74],"vascular":[75],"disease.":[76],"An":[77],"association":[78],"between":[79],"fasting":[82],"glucose":[83,98],"levels":[84,99,156],"healthy":[86],"probands":[87],"was":[88],"proposing":[90],"its":[92],"expression":[93],"may":[94],"regulated":[96],"or":[100],"even":[101],"could":[104,177],"diseases":[108,183],"like":[109],"type":[110],"2":[111],"diabetes.":[112],"As":[113],"cholesterol":[114],"homeostasis":[115],"transfer":[117],"critical":[120],"step":[121],"development":[124],"embryo,":[127],"we":[128,140],"tested":[129],"role":[131],"complicated":[135],"pregnancies.":[136],"In":[137],"these":[138,182],"identified":[141],"localisation":[143],"mRNA":[146],"protein":[148],"human":[150],"placenta":[151],"detected":[153],"substanitially":[154],"reduced":[155],"antiphospholipd":[164],"These":[166],"open":[168],"new":[169],"options":[170],"for":[171],"therapeutical":[172],"intervention":[173],"therapeutic":[175],"strategies":[176],"devised":[179],"prevent":[181],"their":[185],"complications.":[186]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2017-09-15T00:00:00"}