{"id":"https://openalex.org/W2751827192","doi":"https://doi.org/10.18632/oncotarget.20649","title":"Synthesis of methylprednisolone loaded ibuprofen modified dextran based nanoparticles and their application for drug delivery in acute spinal cord injury","display_name":"Synthesis of methylprednisolone loaded ibuprofen modified dextran based nanoparticles and their application for drug delivery in acute spinal cord injury","publication_year":2017,"publication_date":"2017-09-05","ids":{"openalex":"https://openalex.org/W2751827192","doi":"https://doi.org/10.18632/oncotarget.20649","mag":"2751827192","pmid":"https://pubmed.ncbi.nlm.nih.gov/29245932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5725123"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.20649","doi":"https://doi.org/10.18632/oncotarget.20649","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20649","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20649&path%5B%5D=65813","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20649&path%5B%5D=65813","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Qi","raw_affiliation_strings":["Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087920969","display_name":"Haiyan Jiang","orcid":"https://orcid.org/0000-0003-2756-4335","observed_orcids":["https://orcid.org/0000-0003-2756-4335"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyan Jiang","raw_affiliation_strings":["Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102117033","display_name":"Xiaohui Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Cui","raw_affiliation_strings":["Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084221789","display_name":"Guiwen Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiwen Liang","raw_affiliation_strings":["Department of Geriatric Medicine, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Gao","raw_affiliation_strings":["Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103135544","display_name":"Zhongwei Huang","orcid":"https://orcid.org/0000-0001-7451-6497","observed_orcids":["https://orcid.org/0000-0001-7451-6497","https://orcid.org/0000-0003-2904-0519"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongwei Huang","raw_affiliation_strings":["Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103150269","display_name":"Qinghua Xi","orcid":"https://orcid.org/0000-0001-5625-6118","observed_orcids":["https://orcid.org/0000-0001-5625-6118","https://orcid.org/0000-0002-2689-5506"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghua Xi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087920969"],"corresponding_institution_ids":["https://openalex.org/I4210086801"],"apc_list":null,"apc_paid":null,"fwci":0.9929,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.68180654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"59","first_page":"99666","last_page":"99680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.09130000323057175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.6010000109672546},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8450000286102295},{"id":"https://openalex.org/keywords/acute-spinal-cord-injury","display_name":"acute spinal cord injury","score":0.9559999704360962},{"id":"https://openalex.org/keywords/esterification","display_name":"esterification","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drug-nanocarriers","display_name":"drug nanocarriers","score":0.6869999766349792},{"id":"https://openalex.org/keywords/neurological-deficit-recovery","display_name":"neurological deficit recovery","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.8113831281661987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7341606616973877},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.7307687401771545},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5077865719795227},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.49959731101989746},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4116200804710388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3795854449272156},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31131792068481445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1782662272453308},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1205393373966217},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.10378983616828918},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.08318373560905457}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.20649","doi":"https://doi.org/10.18632/oncotarget.20649","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20649","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20649&path%5B%5D=65813","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5725123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5725123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29245932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29245932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.20649","doi":"https://doi.org/10.18632/oncotarget.20649","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20649","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20649&path%5B%5D=65813","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2751827192.pdf","grobid_xml":"https://content.openalex.org/works/W2751827192.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W161399351","https://openalex.org/W1582088281","https://openalex.org/W1841023972","https://openalex.org/W1952251625","https://openalex.org/W1990696170","https://openalex.org/W2048466476","https://openalex.org/W2056831033","https://openalex.org/W2060928497","https://openalex.org/W2085335311","https://openalex.org/W2085977293","https://openalex.org/W2128271902","https://openalex.org/W2130945911","https://openalex.org/W2146719839","https://openalex.org/W2170141023","https://openalex.org/W2174706468","https://openalex.org/W2203450785","https://openalex.org/W2205256123","https://openalex.org/W2209299476","https://openalex.org/W2234954424","https://openalex.org/W2289946257","https://openalex.org/W2291156263","https://openalex.org/W2334720382","https://openalex.org/W2337694833","https://openalex.org/W2340928440","https://openalex.org/W2345229643","https://openalex.org/W2380010782","https://openalex.org/W2384658817","https://openalex.org/W2396039754","https://openalex.org/W2411163370","https://openalex.org/W2417880986","https://openalex.org/W2428238739","https://openalex.org/W2461734239","https://openalex.org/W2501640039","https://openalex.org/W3173807017"],"related_works":["https://openalex.org/W2056831033","https://openalex.org/W18532993","https://openalex.org/W2285464231","https://openalex.org/W2912536289","https://openalex.org/W2062487182","https://openalex.org/W129387716","https://openalex.org/W2808887988","https://openalex.org/W4226285423","https://openalex.org/W2593211473","https://openalex.org/W3154792555"],"abstract_inverted_index":{"//":[0],"Lei":[1,96],"Qi":[2],"1,":[3,8],"*":[4,9,77],",":[5,10,14,18,22],"Haiyan":[6,100],"Jiang":[7],"Xiaohui":[11],"Cui":[12],"1":[13,25,30],"Guiwen":[15],"Liang":[16],"2":[17,42],"Ming":[19],"Gao":[20],"3":[21,54],"Zhongwei":[23,88],"Huang":[24],"and":[26,68,168,189,238,280],"Qinghua":[27,92],"Xi":[28],"4":[29,64],"Department":[31,43,65],"of":[32,37,44,49,58,66,72,133,165,172,178,197,226,231,235,259,291,294],"Emergency":[33],"Medicine,":[34,46],"Affiliated":[35,47,70],"Hospital":[36,48,71],"Nantong":[38,50,60,73],"University,":[39,51,61,74],"Jiangsu,":[40,52,75],"China":[41,53,63,76],"Geriatric":[45],"Jiangsu":[55],"Key":[56],"Laboratory":[57],"Neuroregeneration,":[59],"Nantong,":[62],"Obstetrics":[67],"Gynecology,":[69],"These":[78],"authors":[79],"have":[80],"contributed":[81],"equally":[82],"to":[83],"this":[84],"work":[85],"Correspondence":[86],"to:":[87],"Huang,":[89],"email:":[90,94,98,102],"hzw889@163.com":[91],"Xi,":[93],"ntdxfsyyxqh@163.com":[95],"Qi,":[97],"ntdxfsyyql@163.com":[99],"Jiang,":[101],"lansyne@163.com":[103],"Keywords:":[104],"methylprednisolone,":[105],"nanoparticle,":[106],"drug":[107,109,167,283],"delivery,":[108],"nanocarrier,":[110],"acute":[111,203],"spinal":[112,134,277],"cord":[113,135,278],"injury":[114,136,279],"Received:":[115],"April":[116],"11,":[117],"2017":[118,122,126],"Accepted:":[119],"July":[120],"25,":[121],"Published:":[123],"September":[124],"05,":[125],"ABSTRACT":[127],"To":[128],"improve":[129],"the":[130,138,146,162,169,173,198,202,224,240,250,254,272],"therapeutic":[131,195],"efficacy":[132,196],"(SCI),":[137],"methylprednisolone":[139,179,213,260],"was":[140,154,182,207],"incorporated":[141],"into":[142],"nanoparticles":[143,181,200,219,266,281],"based":[144,218,265,282],"on":[145,201],"ibuprofen":[147,151,215,262],"modified":[148,152,216,263],"dextran.":[149],"The":[150,176,194],"dextran":[153,217,264],"synthesized":[155],"using":[156],"a":[157,268,288],"direct":[158],"esterification":[159],"linkage":[160],"between":[161],"carboxylic":[163],"acids":[164],"hydrophobic":[166],"hydroxyl":[170],"groups":[171],"polymer":[174],"backbone.":[175],"morphology":[177],"loaded":[180,214,261],"evaluated":[183],"by":[184],"transmission":[185],"electron":[186],"microscopy":[187],"(TEM)":[188],"dynamic":[190],"light":[191],"scattering":[192],"(DLS).":[193],"prepared":[199],"SCI":[204,251],"model":[205],"rats":[206],"assessed.":[208],"It":[209],"is":[210],"demonstrated":[211],"that":[212,257],"(MP-loaded":[220],"NPs)":[221],"could":[222],"promote":[223],"recovery":[225],"neurological":[227],"deficits,":[228],"enhance":[229],"growth":[230],"neurons,":[232],"decrease":[233],"degeneration":[234],"injuried":[236],"neurons":[237],"reduce":[239],"tissue":[241],"tumor":[242],"necrosis":[243],"factor":[244],"alpha":[245],"(TNF-\u03b1)":[246],"levels":[247],"significantly":[248],"in":[249,271],"rats.":[252],"Subsequently,":[253],"study":[255],"indicates":[256],"synthesis":[258],"has":[267],"great":[269],"potential":[270],"synergetic":[273],"effect":[274],"treatment":[275],"for":[276],"delivery":[284],"system":[285],"will":[286],"become":[287],"powerful":[289],"weapon":[290],"human":[292],"conquest":[293],"disease.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-09-15T00:00:00"}