{"id":"https://openalex.org/W275166406","doi":null,"title":"Amino acid and catecholamine markers of metabolic abnormalities in human focal epilepsy.","display_name":"Amino acid and catecholamine markers of metabolic abnormalities in human focal epilepsy.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W275166406","mag":"275166406","pmid":"https://pubmed.ncbi.nlm.nih.gov/2871718"},"language":"en","primary_location":{"id":"pmid:2871718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in neurology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043499047","display_name":"Allan L. Sherwin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Sherwin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034435337","display_name":"N. M. van Gelder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N M van Gelder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6576,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.88097307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"44","issue":null,"first_page":"1011","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.8679999709129333},{"id":"https://openalex.org/keywords/catecholamine-metabolism","display_name":"catecholamine metabolism","score":0.9789999723434448},{"id":"https://openalex.org/keywords/epileptic-foci","display_name":"epileptic foci","score":0.5759999752044678},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.7990000247955322},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":1.0},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.925000011920929},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.49799999594688416},{"id":"https://openalex.org/keywords/animal-models-of-epilepsy","display_name":"animal models of epilepsy","score":0.5400000214576721},{"id":"https://openalex.org/keywords/interictal-period","display_name":"interictal period","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.7994565963745117},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.761096715927124},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6126371622085571},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5946997404098511},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.5536473989486694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.523409903049469},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.5056469440460205},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49153241515159607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4828682243824005},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.4721522331237793},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.46892884373664856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4000126123428345},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3960008919239044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35304519534111023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.319031685590744},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2831830382347107}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004056","descriptor_name":"Differential Threshold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2871718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in neurology","raw_type":"Journal Article"},{"id":"mag:275166406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2094708946","https://openalex.org/W2119537965","https://openalex.org/W2007479287","https://openalex.org/W2094796895","https://openalex.org/W2144500905","https://openalex.org/W1561135223","https://openalex.org/W2038238721","https://openalex.org/W2357847465","https://openalex.org/W2006773723","https://openalex.org/W1986794921"],"abstract_inverted_index":{"Studies":[0],"of":[1,4,18,26,38,41,44,85,91,143,167,176,182,206,220,267,279,292,299,307,337,356,372,399,402],"various":[2],"parameters":[3],"amino":[5,104,146,404],"acid":[6,105,138,208,222,232,242,246,346,358],"and":[7,87,132,154,174,247,386],"catecholamine":[8,275,284],"metabolism":[9,285,309],"in":[10,46,71,96,124,130,150,171,186,203,217,230,253,264,283,296,310,322,344,364,384,388,396],"human":[11,325],"cerebral":[12,98,326],"cortex":[13],"have":[14,32,100],"provided":[15],"a":[16,39,101,127,133,179,200,228,261,280,293,341,382,400],"number":[17,40,298,401],"biochemical":[19],"markers":[20],"that":[21,212],"appear":[22,149],"to":[23,55,81,109,156,319,353,368],"delineate":[24],"areas":[25],"focal":[27,281],"epileptic":[28,94,187],"activity.":[29],"These":[30],"observations":[31],"been":[33,236,317],"consolidated":[34],"further":[35],"by":[36,288,334],"investigations":[37],"experimental":[42,330],"models":[43],"epilepsy":[45],"animals.":[47],"In":[48,225,376],"appraising":[49],"this":[50,238],"data,":[51],"it":[52],"is":[53,76,121,199,248,260,286,366,379],"important":[54,78,215,250,305],"take":[56],"into":[57],"consideration":[58],"whether":[59],"the":[60,83,97,141,144,152,160,172,204,218,254,265,270,289,297,360,369,373,397],"tissue":[61,347],"samples":[62],"were":[63],"obtained":[64,112],"during":[65],"an":[66,72,122,210,214,354,394],"actual":[67],"seizure":[68],"state":[69],"or":[70],"interictal":[73],"period.":[74],"It":[75],"also":[77,235,316,381],"when":[79,107],"possible":[80],"assess":[82],"extent":[84],"astrogliosis":[86],"neuronal":[88],"loss.":[89],"Sites":[90],"spontaneously":[92],"active":[93],"spiking":[95,324],"neocortex":[99],"somewhat":[102],"different":[103],"profile":[106],"compared":[108],"gray":[110],"matter":[111],"from":[113,223,244,329,359],"surrounding":[114],"nonspiking":[115],"gyri":[116],"several":[117],"centimeters":[118],"away.":[119],"There":[120,198],"elevation":[123],"glycine":[125],"content,":[126],"relative":[128,294],"diminution":[129],"taurine,":[131],"trend":[134],"towards":[135],"lowered":[136],"glutamic":[137,207,221,231,245,345,357],"levels.":[139],"However,":[140],"concentrations":[142],"eight":[145],"acids":[147],"measured":[148],"both":[151],"foci":[153,332],"surround":[155],"still":[157],"be":[158,320,351],"within":[159],"general":[161],"range":[162],"for":[163,251,274],"normal":[164],"tissue.":[165],"Measurements":[166],"key":[168],"enzymes":[169],"involved":[170],"synthesis":[173,219],"regulation":[175],"neurotransmitters":[177],"provide":[178],"complementary":[180],"method":[181],"evaluating":[183],"functional":[184],"changes":[185],"brain":[188],"as":[189,391,393],"they":[190],"are":[191],"generally":[192],"less":[193],"labile":[194],"than":[195],"their":[196],"substrates.":[197],"moderate":[201],"increase":[202,263,395],"activity":[205,266,371],"dehydrogenase,":[209],"enzyme":[211,239,272],"plays":[213],"role":[216],"glucose.":[224],"some":[226],"patients":[227],"decrease":[229,295,383],"decarboxylase":[233],"has":[234,315],"reported:":[237],"forms":[240],"gamma-aminobutyric":[241],"(GABA)":[243],"thus":[249],"inhibition":[252],"central":[255],"nervous":[256],"system.":[257],"Moreover,":[258],"there":[259,378],"striking":[262],"tyrosine":[268],"hydroxylase,":[269],"rate-limiting":[271],"responsible":[273],"synthesis.":[276],"The":[277],"possibility":[278],"abnormality":[282],"reinforced":[287],"simultaneous":[290],"finding":[291],"alpha-1":[300],"postsynaptic":[301],"receptor":[302],"sites.":[303],"An":[304],"marker":[306],"energy":[308],"neural":[311],"tissue,":[312],"Na+,K+-ATPase":[313],"activity,":[314],"found":[318],"decreased":[321],"actively":[323],"cortex.":[327],"Data":[328],"animal":[331],"produced":[333],"topical":[335],"application":[336],"convulsant":[338],"agents":[339],"show":[340],"consistent":[342],"drop":[343],"content.":[348],"This":[349],"can":[350],"matched":[352],"efflux":[355],"cortical":[361],"surface,":[362],"which":[363],"turn":[365],"proportional":[367],"electrographic":[370],"spike":[374],"focus.":[375],"addition,":[377],"often":[380],"taurine":[385],"GABA":[387],"such":[389],"foci,":[390],"well":[392],"levels":[398],"neutral":[403],"acids.(ABSTRACT":[405],"TRUNCATED":[406],"AT":[407],"400":[408],"WORDS)":[409]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}