{"id":"https://openalex.org/W2751663657","doi":null,"title":"Study on G-protein-coupled receptor polymorphisms reveals close relationship with asthma in a population of China","display_name":"Study on G-protein-coupled receptor polymorphisms reveals close relationship with asthma in a population of China","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2751663657","mag":"2751663657"},"language":"en","primary_location":{"id":"mag:2751663657","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/study-on-gproteincoupled-receptor-polymorphisms-reveals-close-relationship-with-asthma-in-a-population-of-china.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003383584","display_name":"Zhengang Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengang Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063917024","display_name":"Zhaozhong Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaozhong Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15","first_page":"6626","last_page":"6630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpra","display_name":"GPRA","score":0.8009999990463257},{"id":"https://openalex.org/keywords/asthma-susceptibility","display_name":"asthma susceptibility","score":0.8569999933242798},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9879999756813049},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.8100000023841858},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.853024423122406},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8089497089385986},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7477332353591919},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.66319340467453},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6613523960113525},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5510679483413696},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5217046141624451},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5133504271507263},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.43595758080482483},{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.43191012740135193},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42814770340919495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4104140102863312},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37241604924201965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35982272028923035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3030654788017273},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10772526264190674}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2751663657","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/study-on-gproteincoupled-receptor-polymorphisms-reveals-close-relationship-with-asthma-in-a-population-of-china.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1584306966","https://openalex.org/W1808276465","https://openalex.org/W1967270778","https://openalex.org/W1968922952","https://openalex.org/W1971480919","https://openalex.org/W1995932778","https://openalex.org/W2022822773","https://openalex.org/W2049352641","https://openalex.org/W2053559093","https://openalex.org/W2061298798","https://openalex.org/W2062855264","https://openalex.org/W2087225411","https://openalex.org/W2098065100","https://openalex.org/W2113612251","https://openalex.org/W2116260634","https://openalex.org/W2139762530","https://openalex.org/W2142590472","https://openalex.org/W2146876068","https://openalex.org/W2152664025","https://openalex.org/W2159567282","https://openalex.org/W2162530578","https://openalex.org/W2162647412"],"related_works":["https://openalex.org/W2053559093","https://openalex.org/W2159567282","https://openalex.org/W2024500758","https://openalex.org/W2062855264","https://openalex.org/W2385956087","https://openalex.org/W2472027643","https://openalex.org/W2374682798","https://openalex.org/W2061298798","https://openalex.org/W2116260634","https://openalex.org/W3032761614"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,15,41,84,90,110],"relationship":[3],"of":[4,43,79],"G":[5],"protein-coupled":[6],"receptor":[7],"for":[8,92,102,148],"asthma":[9,13,66,93,103,115,140,149],"susceptibility":[10,141],"(GPRA)":[11],"with":[12,77],"and":[14,37,46,59,114,142],"total":[16,125],"IgE":[17,62,126],"levels":[18],"in":[19,53,139],"a":[20,137],"Chinese":[21],"population.":[22],"Six":[23],"Single":[24],"Nucleotide":[25],"Polymorphisms":[26],"(SNPs)":[27],"from":[28,150],"GPRA":[29,134],"were":[30],"determined":[31],"by":[32,39],"Taqman":[33],"SNP":[34,112],"genotyping":[35],"assay":[36],"genotyped":[38],"studying":[40],"subjects":[42],"143":[44],"cases":[45],"171":[47],"controls.":[48],"We":[49],"assessed":[50],"Hardy-Weinberg":[51],"equilibrium":[52],"control":[54],"group.":[55],"Association":[56],"between":[57,109],"SNPs":[58],"corresponding":[60],"haplotypes,":[61],"as":[63,65],"well":[64],"was":[67,100,116,122],"studied.":[68],"Regarding":[69],"allelic":[70],"distribution,":[71],"current":[72],"study":[73,131],"showed":[74],"similar":[75],"pattern":[76],"that":[78,133],"other":[80],"populations.":[81],"For":[82],"rs324981,":[83],"minor":[85],"allele":[86],"homozygotes":[87],"AA":[88],"lowered":[89],"risk":[91],"(case-control":[94],"OR:":[95],"0.34,":[96],"P=0.002).":[97],"rs324396":[98],"(TT)":[99],"protective":[101,146],"(OR:":[104,127],"0.42,":[105],"P=0.003).":[106],"Although":[107],"association":[108],"six":[111],"haplotypes":[113],"not":[117],"observed,":[118],"haplotype":[119],"H3":[120],"CTACGA":[121],"related":[123],"to":[124],"1.53,":[128],"P=0.004).":[129],"Our":[130],"supports":[132],"gene":[135],"plays":[136],"role":[138],"also":[143],"suggests":[144],"two":[145],"factors":[147],"this":[151],"gene.":[152]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-09-15T00:00:00"}