{"id":"https://openalex.org/W2751101774","doi":null,"title":"Mechanisms of Memory Deficits in Mouse Models of Alzheimer's Disease","display_name":"Mechanisms of Memory Deficits in Mouse Models of Alzheimer's Disease","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2751101774","mag":"2751101774"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/65495","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/65495","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b76e714-9475-4308-964a-f88342848ee3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/3b76e714-9475-4308-964a-f88342848ee3/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080089008","display_name":"Adelaide P. Yiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adelaide P. Yiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080089008"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.9160000085830688},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7239999771118164},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.7760000228881836},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6740000247955322},{"id":"https://openalex.org/keywords/ampa-receptor-endocytosis","display_name":"AMPA receptor endocytosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dendritic-spine-plasticity","display_name":"dendritic spine plasticity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tgcrnd8-mice","display_name":"TgCRND8 mice","score":0.9259999990463257},{"id":"https://openalex.org/keywords/viral-gene-expression","display_name":"viral gene expression","score":0.6710000038146973},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6081330180168152},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5113458037376404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41638290882110596},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.36263126134872437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3501129746437073},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13974463939666748}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/65495","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/65495","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b76e714-9475-4308-964a-f88342848ee3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/65495","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/65495","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2751101774","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/65495?mode=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/65495","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/65495","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b76e714-9475-4308-964a-f88342848ee3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119968089","display_name":null,"funder_award_id":"MOP74650","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2751101774.pdf","grobid_xml":"https://content.openalex.org/works/W2751101774.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W86686525","https://openalex.org/W1513394904","https://openalex.org/W1652624724","https://openalex.org/W1792321114","https://openalex.org/W1886575365","https://openalex.org/W1893543180","https://openalex.org/W1907864144","https://openalex.org/W1929828037","https://openalex.org/W1948557773","https://openalex.org/W1964826832","https://openalex.org/W1965572030","https://openalex.org/W1968946845","https://openalex.org/W1973166472","https://openalex.org/W1973276273","https://openalex.org/W1975211057","https://openalex.org/W1977077283","https://openalex.org/W1979170530","https://openalex.org/W1980796284","https://openalex.org/W1982373527","https://openalex.org/W1982543679","https://openalex.org/W1982913203","https://openalex.org/W1984260356","https://openalex.org/W1987499801","https://openalex.org/W1988316651","https://openalex.org/W1991607389","https://openalex.org/W1993327536","https://openalex.org/W1994061936","https://openalex.org/W1994067502","https://openalex.org/W1997277329","https://openalex.org/W1999234381","https://openalex.org/W2000075190","https://openalex.org/W2002280328","https://openalex.org/W2004266498","https://openalex.org/W2006410115","https://openalex.org/W2009174342","https://openalex.org/W2010592788","https://openalex.org/W2011046807","https://openalex.org/W2011306899","https://openalex.org/W2011335492","https://openalex.org/W2012365932","https://openalex.org/W2014719301","https://openalex.org/W2017539411","https://openalex.org/W2017550829","https://openalex.org/W2017756285","https://openalex.org/W2020951538","https://openalex.org/W2021608362","https://openalex.org/W2021668537","https://openalex.org/W2022025213","https://openalex.org/W2027397361","https://openalex.org/W2028072033","https://openalex.org/W2035763500","https://openalex.org/W2037392168","https://openalex.org/W2037520178","https://openalex.org/W2038120217","https://openalex.org/W2038915296","https://openalex.org/W2040420412","https://openalex.org/W2042354286","https://openalex.org/W2043838674","https://openalex.org/W2046952010","https://openalex.org/W2048685634","https://openalex.org/W2051005796","https://openalex.org/W2051437484","https://openalex.org/W2052430755","https://openalex.org/W2053116497","https://openalex.org/W2053544091","https://openalex.org/W2054388625","https://openalex.org/W2056007987","https://openalex.org/W2056439017","https://openalex.org/W2060929383","https://openalex.org/W2061029688","https://openalex.org/W2062214806","https://openalex.org/W2066110504","https://openalex.org/W2066418720","https://openalex.org/W2067317040","https://openalex.org/W2071736940","https://openalex.org/W2081150698","https://openalex.org/W2082615027","https://openalex.org/W2087931726","https://openalex.org/W2089553401","https://openalex.org/W2095456987","https://openalex.org/W2095704733","https://openalex.org/W2098977708","https://openalex.org/W2099370040","https://openalex.org/W2100126489","https://openalex.org/W2100226513","https://openalex.org/W2100407725","https://openalex.org/W2102508963","https://openalex.org/W2103092643","https://openalex.org/W2104757313","https://openalex.org/W2106927158","https://openalex.org/W2106931873","https://openalex.org/W2108773796","https://openalex.org/W2110517474","https://openalex.org/W2120145202","https://openalex.org/W2124638528","https://openalex.org/W2125993125","https://openalex.org/W2126800086","https://openalex.org/W2129412868","https://openalex.org/W2130144581","https://openalex.org/W2133029179","https://openalex.org/W2136579519","https://openalex.org/W2138938985","https://openalex.org/W2139279518","https://openalex.org/W2141680511","https://openalex.org/W2143731392","https://openalex.org/W2145976523","https://openalex.org/W2147532876","https://openalex.org/W2153747061","https://openalex.org/W2156275187","https://openalex.org/W2157232890","https://openalex.org/W2158714604","https://openalex.org/W2168068084","https://openalex.org/W2168758637","https://openalex.org/W2169779038","https://openalex.org/W2185500845","https://openalex.org/W4214891130","https://openalex.org/W4231147928","https://openalex.org/W4297846234","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W2038120217","https://openalex.org/W1964558863","https://openalex.org/W2201801060","https://openalex.org/W7132887427","https://openalex.org/W1948557773","https://openalex.org/W2563237493","https://openalex.org/W2003237579","https://openalex.org/W2093419961","https://openalex.org/W2898292065","https://openalex.org/W2071736940"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,33],"disease":[1,34],"(AD),":[2],"a":[3,175],"neurodegenerative":[4],"disorder":[5],"initially":[6],"characterized":[7],"by":[8,161],"mild":[9],"memory":[10,157,203,217],"impairments,":[11],"progresses":[12],"to":[13,49,106,137,141,146,199,268],"global":[14],"cognitive":[15],"deficits":[16,87,159,231],"and":[17,25,28,41,58,60,123,167,185,204,247,254],"eventually":[18],"death.":[19],"AD":[20,77,188],"pathological":[21],"hallmarks":[22],"are":[23,104],"plaques":[24],"tangles.":[26],"Acute":[27,81,110],"chronic":[29,186],"effects":[30],"of":[31,64,83,94,112,152,236,263,275],"familial":[32],"(FAD)":[35],"genes":[36,53,85,114,154],"were":[37],"examined":[38,99],"in":[39,69,79,88,129,163,183,225,232,259,271,296],"WT":[40],"transgenic":[42],"mice":[43,265],"respectively.":[44],"We":[45,97,228],"used":[46],"viral":[47],"vectors":[48],"acutely":[50,255],"express":[51],"FAD":[52,84,113,153],"encoding":[54],"the":[55,70,89,118,201,209,233,260],"Swedish,":[56],"Indiana,":[57],"Swedish":[59],"Indiana":[61],"double":[62,192],"mutation,":[63],"amyloid":[65],"precursor":[66],"protein":[67],"(APP)":[68],"hippocampal":[71],"CA1":[72,131,150,261],"region":[73,262],"(which":[74],"exhibits":[75],"early":[76],"pathology)":[78],"mice.":[80,227],"expression":[82,111,151],"produced":[86,155],"formation":[90,158,218],"but":[91,125],"not":[92,116],"retreival":[93],"spatial":[95,156,202],"memory.":[96],"next":[98],"spine":[100,127,165,205],"density":[101,128,206],"as":[102],"changes":[103],"thought":[105],"affect":[107,117],"synaptic":[108],"plasticity.":[109],"did":[115],"structure":[119],"(dendritic":[120],"length,":[121],"intersections":[122],"nodes),":[124],"decreased":[126],"infected":[130],"neurons.":[132],"Amyloid":[133],"beta":[134],"(A\u03b2)":[135],"binds":[136],"excitatory":[138],"synapses,":[139],"particularly":[140],"GluA2-AMPA":[142],"receptors":[143],"(AMPAR)":[144],"leading":[145],"endocytosis.":[147,171],"Therefore,,":[148],"acute":[149,184],"mediated":[160],"impairments":[162],"dendritic":[164],"plasticity":[166],"transmission":[168],"via":[169],"AMPAR":[170,181],"Additionally,":[172],"infusing":[173],"GluA2-3Y,":[174],"peptide":[176],"that":[177,286],"prevents":[178],"A\u03b2":[179,280],"induced":[180],"endocytosis":[182],"(TgCRND8)":[187],"mouse":[189],"models":[190],"expressing":[191],"mutated":[193],"APP":[194],"genes,":[195],"was":[196,266],"similarly":[197],"able":[198],"rescue":[200],"deficits.":[207],"Since":[208],"transcription":[210],"factor":[211],"CREB":[212,257,290],"is":[213],"critical":[214],"for":[215],"normal":[216],"across":[219],"species,":[220],"we":[221],"investigated":[222],"its":[223],"role":[224],"TgCRND8":[226,237,264],"observed":[229],"additional":[230],"dorsal":[234],"hippocampus":[235],"mice,":[238],"including":[239],"1)":[240],"biochemistry":[241],"(CREB":[242],"activation),":[243],"2)":[244],"neuronal":[245,249],"structure,":[246],"3)":[248],"network":[250],"activity.":[251],"Moreover,":[252],"locally":[253],"increasing":[256],"function":[258,270],"sufficient":[267],"restore":[269],"each":[272],"domain":[273],"independent":[274],"plaque":[276],"load":[277],"or":[278,289],"aggregated":[279],"levels.":[281],"Together,":[282],"these":[283],"studies":[284],"indicate":[285],"targeting":[287],"GluA2":[288],"may":[291],"be":[292],"useful":[293],"therapeutic":[294],"strategies":[295],"treating":[297],"AD.":[298]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-09-15T00:00:00"}
