{"id":"https://openalex.org/W2750325185","doi":null,"title":"Advancing Translational Space Research Through Biospecimen Sharing: Amplifying the Impact of Ground-Based Studies","display_name":"Advancing Translational Space Research Through Biospecimen Sharing: Amplifying the Impact of Ground-Based Studies","publication_year":2017,"publication_date":"2017-01-23","ids":{"openalex":"https://openalex.org/W2750325185","mag":"2750325185"},"language":"en","primary_location":{"id":"mag:2750325185","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20170000834.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031466291","display_name":"April E. Ronca","orcid":"https://orcid.org/0000-0001-8821-1299","observed_orcids":["https://orcid.org/0000-0001-8821-1299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"April E. Ronca","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8821-1299","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112606444","display_name":"L. Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067485448","display_name":"B. Staten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Staten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112301530","display_name":"E. L. Moyer","orcid":"https://orcid.org/0000-0002-1463-1677","observed_orcids":["https://orcid.org/0000-0002-1463-1677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. L. Moyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009176504","display_name":"\u0412\u0430\u0434\u0438\u043c \u0410\u043d\u0430\u0442\u043e\u043b\u0456\u0439\u043e\u0432\u0438\u0447 \u0412\u0456\u0437\u0456\u0440","orcid":"https://orcid.org/0000-0002-5486-2963","observed_orcids":["https://orcid.org/0000-0002-5486-2963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0412\u0430\u0434\u0438\u043c \u0410\u043d\u0430\u0442\u043e\u043b\u0456\u0439\u043e\u0432\u0438\u0447 \u0412\u0456\u0437\u0456\u0440","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5486-2963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077023121","display_name":"Heinrich S. Gompf","orcid":"https://orcid.org/0000-0002-8749-5776","observed_orcids":["https://orcid.org/0000-0002-8749-5776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinrich S. Gompf","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8749-5776","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041258138","display_name":"Tana M. Hoban\u2010Higgins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tana M. Hoban\u2010Higgins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008986234","display_name":"Charles A. Fuller","orcid":"https://orcid.org/0000-0002-9831-7473","observed_orcids":["https://orcid.org/0000-0002-9831-7473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles A. Fuller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15749443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12717","display_name":"Space exploration and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3320","display_name":"Political Science and International Relations"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biospecimen-sharing","display_name":"biospecimen sharing","score":0.9520000219345093},{"id":"https://openalex.org/keywords/spaceflight-research","display_name":"spaceflight research","score":0.5320000052452087},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.722000002861023},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.5210000276565552},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.5669999718666077},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.5680000185966492},{"id":"https://openalex.org/keywords/head-down-tilt","display_name":"head-down tilt","score":0.7020000219345093},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9539999961853027},{"id":"https://openalex.org/keywords/retinal-changes","display_name":"retinal changes","score":0.859000027179718},{"id":"https://openalex.org/keywords/tissue-preservation","display_name":"tissue preservation","score":0.44699999690055847},{"id":"https://openalex.org/keywords/sample-tracking","display_name":"sample tracking","score":0.7160000205039978},{"id":"https://openalex.org/keywords/long-duration-spaceflight","display_name":"long-duration spaceflight","score":0.6119999885559082},{"id":"https://openalex.org/keywords/countermeasures","display_name":"countermeasures","score":0.6299999952316284},{"id":"https://openalex.org/keywords/artificial-gravity","display_name":"artificial gravity","score":0.5429999828338623},{"id":"https://openalex.org/keywords/nasa-human-research-program","display_name":"NASA Human Research Program","score":0.7089999914169312},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.803884744644165},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.5305132269859314},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.4859405755996704},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.4416424334049225},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.43706923723220825},{"id":"https://openalex.org/C178802073","wikidata":"https://www.wikidata.org/wiki/Q8421","display_name":"Aeronautics","level":1,"score":0.33991920948028564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3343901038169861},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3259788751602173},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.303676575422287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24780356884002686},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.20117121934890747},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.188953697681427},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2750325185","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20170000834.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6979766761","https://openalex.org/W2588832089","https://openalex.org/W6989004940","https://openalex.org/W3174126142","https://openalex.org/W7203831415","https://openalex.org/W2583539739","https://openalex.org/W4414260580","https://openalex.org/W2401839618","https://openalex.org/W6993045224","https://openalex.org/W4407271403"],"abstract_inverted_index":{"Biospecimen":[0],"Sharing":[1],"Programs":[2],"(BSPs)":[3],"have":[4,179],"been":[5,180],"organized":[6],"by":[7,70,226,348],"NASA":[8,72,360],"Ames":[9,54],"Research":[10,74,351],"Center":[11],"since":[12],"the":[13,16,61,71,108,161,295,349],"1960s":[14],"with":[15,113,184,242],"goal":[17],"of":[18,64,110,223,235,297,320],"maximizing":[19],"utilization":[20],"and":[21,27,122,146,149,154,194,197,268,289,299,312,331,359],"scientific":[22,62],"return":[23],"from":[24,38,136],"rare,":[25],"complex":[26],"costly":[28],"spaceflight":[29,343],"experiments.":[30,47],"BSPs":[31],"involve":[32],"acquiring":[33],"otherwise":[34,178],"unused":[35],"biological":[36],"specimens":[37],"primary":[39],"space":[40,93,121],"research":[41,65,111],"experiments":[42],"for":[43,102,116,144,168,188,208],"distribution":[44],"to":[45,59,87,160,206,220,306,323,337,341],"secondary":[46],"Here":[48],"we":[49,128],"describe":[50],"a":[51,142,280],"collaboration":[52],"leveraging":[53],"expertise":[55],"in":[56,120],"biospecimen":[57,85],"sharing":[58,86],"magnify":[60],"impact":[63],"informing":[66],"astronaut":[67],"health":[68,119],"funded":[69],"Human":[73,77,350,354],"Program":[75,352],"(HRP)":[76,353],"Health":[78,355],"Countermeasures":[79,356],"(HHC)":[80,357],"Element.":[81],"The":[82,157,314],"concept":[83],"expands":[84],"one-off":[88],"ground-based":[89],"studies":[90],"utilizing":[91],"analogue":[92],"platforms":[94],"(e.g.,":[95],"Hind":[96],"limb":[97],"Unloading":[98],"(HLU),":[99],"Artificial":[100],"Gravity)":[101],"rodent":[103],"experiments,":[104],"thereby":[105],"significantly":[106],"broadening":[107],"range":[109],"opportunities":[112],"translational":[114],"relevance":[115],"protecting":[117],"human":[118],"on":[123,131,328,345],"Earth.":[124],"In":[125],"this":[126],"presentation,":[127],"will":[129],"report":[130],"biospecimens":[132],"currently":[133],"being":[134,204],"acquired":[135],"HHC":[137],"Award":[138],"Head-Down":[139],"Tilt":[140],"as":[141,182],"Model":[143],"Intracranial":[145],"Intraocular":[147],"Pressures,":[148],"Retinal":[150],"Changes":[151],"during":[152],"Spaceflight,":[153],"their":[155],"availability.":[156],"BSP":[158],"add-on":[159],"project":[162],"described":[163],"herein":[164],"has":[165],"already":[166],"yielded":[167],"HHC-funded":[169],"investigators":[170],"more":[171],"than":[172],"4,700":[173],"additional":[174,185],"tissues":[175,186,246],"that":[176],"would":[177],"discarded":[181],"waste,":[183],"available":[187],"analysis.":[189],"Young":[190],"(3-mo":[191],"old)":[192,200],"male":[193,201],"female":[195],"rats":[196,202],"Older":[198],"(9-mo":[199],"are":[203,218,240,271],"exposed":[205,219],"HLU":[207],"either":[209,227],"7,":[210,228],"14,":[211,229],"28,":[212],"or":[213,232,325],"90":[214,221,233],"days.":[215],"Additional":[216],"groups":[217],"days":[222,231,234],"unloading":[224,308,326,339],"followed":[225],"28":[230],"recovery":[236],"(normal":[237],"loading).":[238],"Comparisons":[239],"made":[241],"non-suspended":[243],"controls.":[244],"Unused":[245],"are:":[247],"Skin,":[248],"Lungs,":[249],"Thymus,":[250],"Adrenals,":[251],"Kidneys,":[252],"Spleen,":[253],"Hindlimb":[254],"Muscles":[255],"(Soleus,":[256],"Extensor":[257],"Digitorum":[258],"Longus,":[259],"Tibialis":[260],"Anterior,":[261],"Plantaris":[262],"Gastrocnemius),":[263],"Fat":[264],"Pads,":[265],"Reproductive":[266],"Organs,":[267],"Intestines.":[269],"Tissues":[270],"harvested,":[272],"weighed,":[273],"preserved":[274],"then":[275],"archived":[276],"(with":[277],"metadata)":[278],"using":[279],"sample":[281],"tracking":[282],"system":[283],"(CryoTrack).":[284],"Preservation":[285],"techniques":[286],"include":[287],"snap-freezing":[288],"RNALatersnap-freezing.":[290],"Specimens":[291],"were":[292],"weighed":[293],"at":[294],"time":[296],"dissection,":[298],"organ":[300],"mass:":[301],"body":[302],"mass":[303],"ratios":[304],"analyzed":[305],"determine":[307],"effects":[309,319],"across":[310],"conditions":[311],"durations.":[313],"results":[315],"corroborate":[316],"previously":[317],"reported":[318],"short-term":[321],"exposure":[322,327],"microgravity":[324],"various":[329],"organs,":[330],"provide":[332],"new":[333],"insights":[334],"into":[335],"adaptation":[336],"long-duration":[338],"relevant":[340],"sustained":[342],"exposures":[344],"ISS.":[346],"Supported":[347],"Element":[358],"Grant":[361],"NNX13AD94G":[362],"(CAF).":[363]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-31T00:00:00"}