{"id":"https://openalex.org/W2748728358","doi":null,"title":"Bidirectional cargo transport by microtubule-based molecular motors","display_name":"Bidirectional cargo transport by microtubule-based molecular motors","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2748728358","mag":"2748728358"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/29460","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/29460","pdf_url":"http://hdl.handle.net/2142/29460","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/29460","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006267783","display_name":"Melinda Tonks Hoffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melinda Tonks Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006267783"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynein","display_name":"dynein","score":0.9800000190734863},{"id":"https://openalex.org/keywords/kinesin","display_name":"kinesin","score":1.0},{"id":"https://openalex.org/keywords/tug-of-war","display_name":"tug-of-war","score":0.7120000123977661},{"id":"https://openalex.org/keywords/backward-steps","display_name":"backward steps","score":0.6290000081062317},{"id":"https://openalex.org/keywords/intracellular-transport","display_name":"intracellular transport","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7227194905281067},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.7114039063453674},{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.5380333065986633},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.35416823625564575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33579355478286743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2191060483455658}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/29460","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/29460","pdf_url":"http://hdl.handle.net/2142/29460","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.455.745","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.455.745","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://people.physics.illinois.edu/Selvin/PRS/students/ThesisMindyHoffman.pdf","raw_type":"text"},{"id":"mag:2748728358","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/29460","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/29460","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/29460","pdf_url":"http://hdl.handle.net/2142/29460","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2748728358.pdf","grobid_xml":"https://content.openalex.org/works/W2748728358.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1487659884","https://openalex.org/W1545569420","https://openalex.org/W1572832088","https://openalex.org/W1618955965","https://openalex.org/W1619209825","https://openalex.org/W1875835053","https://openalex.org/W1965539063","https://openalex.org/W1965584832","https://openalex.org/W1966790730","https://openalex.org/W1968395339","https://openalex.org/W1972398314","https://openalex.org/W1972898402","https://openalex.org/W1974276027","https://openalex.org/W1974345291","https://openalex.org/W1980819945","https://openalex.org/W1981662243","https://openalex.org/W1982003147","https://openalex.org/W1984108094","https://openalex.org/W1984376417","https://openalex.org/W1984939118","https://openalex.org/W1989370009","https://openalex.org/W1989567397","https://openalex.org/W2000479770","https://openalex.org/W2001060611","https://openalex.org/W2006666141","https://openalex.org/W2008666091","https://openalex.org/W2014898742","https://openalex.org/W2015404233","https://openalex.org/W2018709028","https://openalex.org/W2022214576","https://openalex.org/W2023150579","https://openalex.org/W2031194197","https://openalex.org/W2033859483","https://openalex.org/W2036035032","https://openalex.org/W2038819923","https://openalex.org/W2044730950","https://openalex.org/W2045465799","https://openalex.org/W2049462154","https://openalex.org/W2051958637","https://openalex.org/W2053376533","https://openalex.org/W2056217914","https://openalex.org/W2057959735","https://openalex.org/W2058101090","https://openalex.org/W2061900255","https://openalex.org/W2066898519","https://openalex.org/W2072278366","https://openalex.org/W2072596507","https://openalex.org/W2073764400","https://openalex.org/W2076532008","https://openalex.org/W2078056153","https://openalex.org/W2080025371","https://openalex.org/W2084729729","https://openalex.org/W2085796374","https://openalex.org/W2086991716","https://openalex.org/W2096526911","https://openalex.org/W2099573762","https://openalex.org/W2102345134","https://openalex.org/W2102582606","https://openalex.org/W2110641277","https://openalex.org/W2118642774","https://openalex.org/W2125551383","https://openalex.org/W2130612942","https://openalex.org/W2131112743","https://openalex.org/W2132550454","https://openalex.org/W2135012523","https://openalex.org/W2144151547","https://openalex.org/W2145684136","https://openalex.org/W2145992318","https://openalex.org/W2147353977","https://openalex.org/W2152516404","https://openalex.org/W2160226734","https://openalex.org/W2162897213","https://openalex.org/W2167387669","https://openalex.org/W2170640142","https://openalex.org/W2170991710","https://openalex.org/W2171539493"],"related_works":["https://openalex.org/W4211178366","https://openalex.org/W2020250367","https://openalex.org/W4388830396","https://openalex.org/W2790229970","https://openalex.org/W7045575975","https://openalex.org/W2269648136","https://openalex.org/W2006666141","https://openalex.org/W7002160523","https://openalex.org/W4408819282","https://openalex.org/W2021688560"],"abstract_inverted_index":{"We":[0,91],"have":[1],"reconstituted":[2],"a":[3,17,35,41,66],"simple":[4],"in":[5,27,34,86,89],"vitro":[6],"system":[7],"using":[8],"only":[9],"mammalian":[10,13,95,113],"dynein":[11,60,83,110],"and":[12,69],"kinesin":[14,81,114],"attached":[15],"to":[16,73],"single":[18],"cargo.":[19],"These":[20],"cargoes":[21],"undergo":[22],"saltatory":[23],"motion":[24,85],"typically":[25],"seen":[26],"vivo,":[28],"indicating":[29],"that":[30,94],"the":[31,38,43,59,63,75],"motors":[32],"engage":[33],"tug-of-war.":[36],"When":[37],"complex":[39],"hits":[40],"barrier,":[42],"cargo":[44,64],"often":[45,100],"reverses":[46],"direction.":[47],"In":[48],"some":[49],"cases,":[50],"it":[51],"tries":[52],"several":[53],"up-and-back":[54],"motions,":[55],"during":[56],"which":[57],"time":[58],"likely":[61],"pulls":[62],"onto":[65],"different":[67],"protofilament,":[68],"is":[70],"sometimes":[71],"able":[72],"bypass":[74],"blockage.":[76],"This":[77],"explains":[78],"why":[79],"eliminating":[80],"or":[82],"stops":[84],"both":[87],"directions":[88],"vivo.":[90],"also":[92],"find":[93],"dynein,":[96],"but":[97],"not":[98,116],"kinesin,":[99],"takes":[101],"backwards":[102],"steps":[103],"when":[104],"under":[105],"backward":[106],"force.":[107],"However,":[108],"yeast":[109],"coupled":[111],"with":[112],"does":[115],"display":[117],"these":[118],"attributes,":[119],"as":[120],"expected.":[121]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2017-08-31T00:00:00"}