{"id":"https://openalex.org/W2748536775","doi":"https://doi.org/10.2147/ijn.s139687","title":"Nanomedicinal products: a survey on specific toxicity and side effects","display_name":"Nanomedicinal products: a survey on specific toxicity and side effects","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2748536775","doi":"https://doi.org/10.2147/ijn.s139687","mag":"2748536775","pmid":"https://pubmed.ncbi.nlm.nih.gov/28883724","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5574663"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s139687","doi":"https://doi.org/10.2147/ijn.s139687","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s139687","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38064","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=38064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086079715","display_name":"Walter Brand","orcid":"https://orcid.org/0000-0001-9573-8507","observed_orcids":["https://orcid.org/0000-0001-9573-8507"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Walter Brand","raw_affiliation_strings":["Centre for Safety of Substances and Products","centre for health Protection, National Institute for Public health and the environment (rIVM), Bilthoven,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Safety of Substances and Products","institution_ids":[]},{"raw_affiliation_string":"centre for health Protection, National Institute for Public health and the environment (rIVM), Bilthoven,","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cornelle W Noorlander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelle W Noorlander","raw_affiliation_strings":["Centre for Safety of Substances and Products"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Safety of Substances and Products","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025890845","display_name":"Christina Giannakou","orcid":"https://orcid.org/0000-0001-5204-795X","observed_orcids":["https://orcid.org/0000-0001-5204-795X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christina Giannakou","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","Department of Toxicogenomics, Maastricht University, Maastricht"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","institution_ids":["https://openalex.org/I4210104433"]},{"raw_affiliation_string":"Department of Toxicogenomics, Maastricht University, Maastricht","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110429395","display_name":"Wim de Jong","orcid":"https://orcid.org/0009-0006-2134-5181","observed_orcids":["https://orcid.org/0009-0006-2134-5181"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wim De Jong","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020753309","display_name":"Myrna Kooi","orcid":"https://orcid.org/0000-0002-5765-6786","observed_orcids":["https://orcid.org/0000-0002-5765-6786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myrna Kooi","raw_affiliation_strings":["Centre for Safety of Substances and Products"],"raw_orcid":"https://orcid.org/0000-0002-5765-6786","affiliations":[{"raw_affiliation_string":"Centre for Safety of Substances and Products","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090114803","display_name":"Margriet V.D.Z. Park","orcid":"https://orcid.org/0000-0002-6158-8026","observed_orcids":["https://orcid.org/0000-0002-6158-8026"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Margriet Park","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055672042","display_name":"Rob J. Vandebriel","orcid":"https://orcid.org/0000-0001-9140-952X","observed_orcids":["https://orcid.org/0000-0001-9140-952X"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob Vandebriel","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven"],"raw_orcid":"https://orcid.org/0000-0001-9140-952X","affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037587428","display_name":"Irene E. M. Bosselaers","orcid":"https://orcid.org/0000-0001-7598-0208","observed_orcids":["https://orcid.org/0000-0001-7598-0208"]},"institutions":[{"id":"https://openalex.org/I4210150351","display_name":"Medicines Evaluation Board","ror":"https://ror.org/05mv4rb84","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210150351"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Irene Bosselaers","raw_affiliation_strings":["Section Pharmacology, Toxicology and Pharmacokinetics, Medicines Evaluation Board (CBG-MEB), Utrecht","Medicines evaluation Board (cBg-MeB), Utrecht,","section Pharmacology, Toxicology and Pharmacokinetics,"],"raw_orcid":"https://orcid.org/0000-0001-7598-0208","affiliations":[{"raw_affiliation_string":"Section Pharmacology, Toxicology and Pharmacokinetics, Medicines Evaluation Board (CBG-MEB), Utrecht","institution_ids":["https://openalex.org/I4210150351"]},{"raw_affiliation_string":"Medicines evaluation Board (cBg-MeB), Utrecht,","institution_ids":["https://openalex.org/I4210150351"]},{"raw_affiliation_string":"section Pharmacology, Toxicology and Pharmacokinetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022033197","display_name":"Joep H. G. Scholl","orcid":"https://orcid.org/0000-0002-9222-5965","observed_orcids":["https://orcid.org/0000-0002-9222-5965"]},"institutions":[{"id":"https://openalex.org/I4210139651","display_name":"Netherlands Pharmacovigilance Centre Lareb","ror":"https://ror.org/04fp8ns78","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210139651"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joep Scholl","raw_affiliation_strings":["Research & Analysis Department, Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Analysis Department, Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands","institution_ids":["https://openalex.org/I4210139651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002326137","display_name":"Robert E. Geertsma","orcid":"https://orcid.org/0000-0003-0979-9077","observed_orcids":["https://orcid.org/0000-0003-0979-9077"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Geertsma","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven","institution_ids":["https://openalex.org/I4210104433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086079715"],"corresponding_institution_ids":["https://openalex.org/I4210104433"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.5415,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.44987775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"Volume 12","issue":null,"first_page":"6107","last_page":"6129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.718999981880188},{"id":"https://openalex.org/keywords/nanoformulations","display_name":"nanoformulations","score":0.7900000214576721},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5669999718666077},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/liposomal-daunorubicin","display_name":"liposomal daunorubicin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anaphylactoid-reactions","display_name":"anaphylactoid reactions","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/iron-nanoparticles","display_name":"iron nanoparticles","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cytostatic-drugs","display_name":"cytostatic agents","score":0.6669999957084656},{"id":"https://openalex.org/keywords/safety-assessment","display_name":"safety assessment","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.718509316444397},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.5993550419807434},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5334665179252625},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.5060283541679382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47519147396087646},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.473150372505188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30923330783843994},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2619921863079071},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.09727919101715088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.2147/ijn.s139687","doi":"https://doi.org/10.2147/ijn.s139687","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s139687","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38064","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5574663","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5574663","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:28883724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28883724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/e52907c3-c26f-4cfc-aafd-f712b0479601","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/e52907c3-c26f-4cfc-aafd-f712b0479601","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brand, W, Noorlander, C W, Giannakou, C, De Jong, W H, Kooi, M W, Park, M V D Z, Vandebriel, R J, Bosselaers, I E M, Scholl, J H G & Geertsma, R E 2017, 'Nanomedicinal products : a survey on specific toxicity and side effects', International Journal of Nanomedicine, vol. 12, pp. 6107-6129. https://doi.org/10.2147/IJN.S139687","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:574bf00bea8143c08df144926a48c06c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/574bf00bea8143c08df144926a48c06c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 12, Pp 6107-6129 (2017)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/34376","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/nanomedicinal-products-a-survey-on-specific-toxicity-and-side-effects-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:rivm.openrepository.com:10029/621104","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/621104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:rivm.openrepository.com:10029/650443","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/650443","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:rivm:oai:rivm.openrepository.com:10029/621104","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/621104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/e52907c3-c26f-4cfc-aafd-f712b0479601","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/e52907c3-c26f-4cfc-aafd-f712b0479601","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, 12, 6107 - 6129. Dove Medical Press Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s139687","doi":"https://doi.org/10.2147/ijn.s139687","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s139687","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38064","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321644","display_name":"College ter Beoordeling van Geneesmiddelen","ror":"https://ror.org/041evnj42"},{"id":"https://openalex.org/F4320335216","display_name":"Rijksinstituut voor Volksgezondheid en Milieu","ror":"https://ror.org/01cesdt21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2748536775.pdf","grobid_xml":"https://content.openalex.org/works/W2748536775.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W154088998","https://openalex.org/W266054894","https://openalex.org/W1576849454","https://openalex.org/W1863422868","https://openalex.org/W1935541780","https://openalex.org/W1966120037","https://openalex.org/W1968376422","https://openalex.org/W1979704127","https://openalex.org/W1996486246","https://openalex.org/W2003968695","https://openalex.org/W2009230632","https://openalex.org/W2012405585","https://openalex.org/W2018180334","https://openalex.org/W2023164220","https://openalex.org/W2034665844","https://openalex.org/W2046963479","https://openalex.org/W2048456734","https://openalex.org/W2048801712","https://openalex.org/W2055212149","https://openalex.org/W2055691090","https://openalex.org/W2056609366","https://openalex.org/W2058865733","https://openalex.org/W2066936530","https://openalex.org/W2078191070","https://openalex.org/W2078761335","https://openalex.org/W2089539307","https://openalex.org/W2091796668","https://openalex.org/W2092856965","https://openalex.org/W2106810178","https://openalex.org/W2118183380","https://openalex.org/W2119692843","https://openalex.org/W2128090828","https://openalex.org/W2142504874","https://openalex.org/W2143320924","https://openalex.org/W2149144667","https://openalex.org/W2153017356","https://openalex.org/W2153771870","https://openalex.org/W2166173762","https://openalex.org/W2194502287","https://openalex.org/W2207973369","https://openalex.org/W2211617619","https://openalex.org/W2216883766","https://openalex.org/W2333982222","https://openalex.org/W2335904071","https://openalex.org/W2472550594","https://openalex.org/W2766250687","https://openalex.org/W4255762755","https://openalex.org/W6745730503"],"related_works":["https://openalex.org/W2472550594","https://openalex.org/W2792414775","https://openalex.org/W4389848990","https://openalex.org/W3112723447","https://openalex.org/W3015094396","https://openalex.org/W2613428154","https://openalex.org/W2973492129","https://openalex.org/W2921680014","https://openalex.org/W2889667764","https://openalex.org/W2528473550"],"abstract_inverted_index":{"Due":[0],"to":[1,18,31,78,93,101,126,144,158,185,193,228,233],"their":[2],"specific":[3,37,83,96,221],"properties":[4],"and":[5,14,107,236,243,260],"pharmacokinetics,":[6],"nanomedicinal":[7],"products":[8,61],"(NMPs)":[9],"may":[10],"present":[11],"different":[12],"toxicity":[13,45,97,133,139],"side":[15,81,118,202,230],"effects":[16,36,82,119,191,203,231,253],"compared":[17,125],"non-nanoformulated,":[19],"conventional":[20,71,128],"medicines.":[21],"To":[22],"facilitate":[23],"the":[24,43,51,63,85,115,121,166,172,180,199,214,224,229,249],"safety":[25],"assessment":[26],"of":[27,60,88,105,111,117,120,132,147,149,160,171,201,204,207,216,254],"NMPs,":[28,150],"we":[29,76,261],"aimed":[30,77],"gain":[32],"insight":[33],"into":[34],"toxic":[35],"for":[38,84,169],"NMPs":[39,49,106,222,256],"by":[40,56],"systematically":[41],"analyzing":[42],"available":[44,250],"data":[46,134,168],"on":[47,248],"approved":[48],"in":[50,69,123,156,179,223,226],"European":[52],"Union.":[53],"In":[54],"addition,":[55],"comparing":[57],"five":[58,205],"sets":[59,206],"with":[62,183,220,240],"same":[64],"active":[65],"pharmaceutical":[66],"ingredient":[67],"(API)":[68],"a":[70,74,109,127],"formulation":[72],"versus":[73],"nanoformulation,":[75],"identify":[79],"any":[80],"nano":[86],"aspect":[87],"NMPs.":[89],"The":[90,130],"objective":[91],"was":[92],"investigate":[94],"whether":[95,108],"could":[98,141],"be":[99,142,194,258],"related":[100,143],"certain":[102,145,255],"structural":[103],"types":[104,146],"nanoformulation":[110],"an":[112],"API":[113],"altered":[114],"nature":[116],"product":[122,173],"humans":[124],"formulation.":[129],"survey":[131],"did":[135],"not":[136],"reveal":[137],"nanospecific":[138],"that":[140,263],"structures":[148],"other":[151],"than":[152],"those":[153],"reported":[154],"previously":[155],"relation":[157],"accumulation":[159],"iron":[161],"nanoparticles":[162],"(NPs).":[163],"However,":[164],"given":[165],"limited":[167],"some":[170],"groups":[174],"or":[175],"toxicological":[176],"end":[177,265],"points":[178],"analysis,":[181],"conclusions":[182],"regard":[184],"(a":[186],"lack":[187],"of)":[188],"potential":[189],"nanomedicine-specific":[190],"need":[192],"considered":[195],"carefully.":[196],"Results":[197],"from":[198],"comparison":[200],"drugs":[208],"(mainly":[209],"liposomes":[210],"and/or":[211],"cytostatics)":[212],"confirmed":[213],"induction":[215],"pseudo-allergic":[217],"responses":[218],"associated":[219],"literature,":[225],"addition":[227],"common":[232],"both":[234],"nanoformulations":[235],"regular":[237],"formulations,":[238],"eg,":[239],"liposomal":[241,245],"doxorubicin,":[242],"possibly":[244],"daunorubicin.":[246],"Based":[247],"data,":[251],"immunotoxicological":[252],"cannot":[257],"excluded,":[259],"conclude":[262],"this":[264],"point":[266],"requires":[267],"further":[268],"attention.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2017-08-31T00:00:00"}
