{"id":"https://openalex.org/W2748370720","doi":null,"title":"Habituation of hypothalamic -pituitary -adrenal responses to repeated stress: Role of the posterior paraventricular thalamus and medial prefrontal cortex.","display_name":"Habituation of hypothalamic -pituitary -adrenal responses to repeated stress: Role of the posterior paraventricular thalamus and medial prefrontal cortex.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2748370720","mag":"2748370720"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126176","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/126176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010639458","display_name":"Azra Jaferi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Azra Jaferi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010639458"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repeated-stress","display_name":"repeated stress","score":0.9129999876022339},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8090000152587891},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.8270000219345093},{"id":"https://openalex.org/keywords/crh-receptors","display_name":"CRH receptors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.7519999742507935},{"id":"https://openalex.org/keywords/stress-experience","display_name":"stress experience","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.7834413051605225},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7231767773628235},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.7043843269348145},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6402695178985596},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45247331261634827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32732218503952026},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126176","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/126176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2748370720","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/126176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165949694","https://openalex.org/W1521382255","https://openalex.org/W2000081665","https://openalex.org/W2621207595","https://openalex.org/W2171165949","https://openalex.org/W7043132622","https://openalex.org/W1789822793","https://openalex.org/W4212951341","https://openalex.org/W3201154797","https://openalex.org/W2053794165"],"abstract_inverted_index":{"Previous":[0],"research":[1],"suggested":[2],"that":[3,28,116,233,258,282],"the":[4,26,29,43,50,58,78,93,103,107,117,134,137,150,157,173,178,189,199,204,211,220,224,256,259,283,309,314,326,329,336],"posterior":[5],"paraventricular":[6],"thalamus":[7],"(pPVTh)":[8],"regulates":[9,261],"habituation":[10,185,192,209,262],"of":[11,47,53,60,68,81,85,100,124,136,153,160,181,206,236,253,263,297,311],"hypothalamic-pituitary-adrenal":[12],"(HPA)":[13],"responses":[14,70,162],"to":[15,63,71,106,149,163,210,223,245,273,322,325,348],"repeated":[16,145,164,212],"stress":[17,21,113,146,165,182,207,299,323,350],"without":[18],"affecting":[19],"acute":[20,98,143],"responses.":[22],"This":[23],"thesis":[24],"tested":[25,255],"hypothesis":[27,257],"pPVTh":[30,55,94,104,118,138,174,200,221,330],"inhibits":[31],"HPA":[32,69,161,237,264,291],"activity":[33,238,265,292],"in":[34,92,102,127,139,172,198,219,269,277,313],"habituated":[35],"animals":[36,271],"by":[37,242],"serving":[38],"as":[39,335],"a":[40,122,274],"site":[41,123,337],"for":[42],"negative":[44,66,125,140],"feedback":[45,67,126,141],"effects":[46],"corticosterone.":[48],"In":[49,77,215],"first":[51],"set":[52,80,252],"studies,":[54,82],"lesions":[56],"attenuated":[57],"ability":[59],"peripherally-administered":[61],"dexamethasone":[62],"induce":[64],"maximal":[65],"repeated,":[72],"but":[73,328],"not":[74,167],"acute,":[75],"stress.":[76],"second":[79],"week-long":[83],"manipulations":[84],"glucocorticoid":[86],"(GRs)":[87],"and":[88,227,266,272,293,301,341],"mineralocorticoid":[89],"receptors":[90,171,197],"(MRs)":[91],"altered":[95,168,194],"habituation.":[96],"However,":[97],"blockade":[99],"GRs+MRs":[101],"prior":[105,298,349],"1":[108],"st":[109],"or":[110],"8":[111],"th":[112],"exposure":[114],"revealed":[115],"can":[119],"also":[120],"be":[121,332],"acutely":[128],"stressed":[129],"animals.":[130,279],"The":[131,250],"difference":[132],"between":[133],"role":[135],"under":[142],"versus":[144],"conditions":[147],"relates":[148],"time":[151],"course":[152],"corticosterone's":[154],"actions":[155,310],"at":[156],"pPVTh.":[158],"Habituation":[159],"is":[166,186,193,239,344],"when":[169,195,208],"corticosteroid":[170,196],"are":[175,201],"manipulated":[176,202],"on":[177,183,289],"final":[179],"day":[180],"which":[184],"expressed.":[187],"On":[188],"other":[190],"hand,":[191],"throughout":[203],"week":[205],"stressor":[213],"develops.":[214],"addition,":[216],"GR-containing":[217],"cells":[218],"project":[222],"basolateral":[225],"amygdala":[226],"medial":[228],"prefrontal":[229],"cortex":[230],"(mPFC),":[231],"suggesting":[232],"pPVTh-induced":[234],"inhibition":[235],"potentially":[240],"mediated":[241],"its":[243],"projections":[244],"these":[246],"select":[247],"limbic":[248],"structures.":[249],"last":[251],"studies":[254],"mPFC":[260,284,315],"anxiety":[267,294],"behavior":[268,295],"acutely-stressed":[270],"greater":[275],"extent":[276],"repeatedly-stressed":[278],"We":[280],"found":[281],"exerts":[285],"an":[286],"excitatory":[287],"influence":[288],"stress-induced":[290],"regardless":[296],"experience":[300,324],"does":[302],"so":[303],"via":[304],"CRH":[305,312],"receptor":[306],"activation.":[307],"Therefore,":[308],"might":[316],"contribute":[317],"important":[318,334],"cognitive":[319,340],"information":[320,343],"related":[321],"pPVTh,":[327],"may":[331],"more":[333],"where":[338],"sensory,":[339],"emotional":[342],"integrated":[345],"with":[346],"respect":[347],"experience.":[351]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-08-31T00:00:00"}
