{"id":"https://openalex.org/W2748201142","doi":"https://doi.org/10.2147/jpr.s141981","title":"Pharmacological mechanisms involved in the analgesia induced by ethanol extract of Hybanthus enneaspermus leaves","display_name":"Pharmacological mechanisms involved in the analgesia induced by ethanol extract of Hybanthus enneaspermus leaves","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2748201142","doi":"https://doi.org/10.2147/jpr.s141981","mag":"2748201142","pmid":"https://pubmed.ncbi.nlm.nih.gov/28860854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5573038"},"language":"en","primary_location":{"id":"doi:10.2147/jpr.s141981","doi":"https://doi.org/10.2147/jpr.s141981","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s141981","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38053","source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=38053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052711760","display_name":"Oladele Ayobami Afolabi","orcid":"https://orcid.org/0000-0003-2461-8035","observed_orcids":["https://orcid.org/0000-0003-2461-8035"]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oladele Afolabi","raw_affiliation_strings":["Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067607087","display_name":"Abdullateef Isiaka Alagbonsi","orcid":"https://orcid.org/0000-0002-5462-9950","observed_orcids":["https://orcid.org/0000-0002-5462-9950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdullateef Alagbonsi","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine and Health Sciences, University of Gitwe, Gitwe, Republic of Rwanda"],"raw_orcid":"https://orcid.org/0000-0002-5462-9950","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine and Health Sciences, University of Gitwe, Gitwe, Republic of Rwanda","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097518114","display_name":"Jubril Aliyu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Jubril Aliyu","raw_affiliation_strings":["Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria","institution_ids":["https://openalex.org/I45230691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.5214,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68753259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"Volume 10","issue":null,"first_page":"1997","last_page":"2002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.27469998598098755,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hybanthus-enneaspermus","display_name":"Hybanthus enneaspermus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.800000011920929},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8930000066757202},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/adrenergic-receptors","display_name":"adrenergic receptors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tail-immersion-test","display_name":"tail immersion test","score":0.699999988079071},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pain-mechanisms","display_name":"pain mechanisms","score":0.4790000021457672},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.4000000059604645},{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.6010000109672546},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9390000104904175},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7824785709381104},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6495708227157593},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.6453046202659607},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6142051219940186},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.46244364976882935},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.44272756576538086},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34125959873199463}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/jpr.s141981","doi":"https://doi.org/10.2147/jpr.s141981","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s141981","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38053","source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5573038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5573038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pain Res","raw_type":"Text"},{"id":"pmid:28860854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28860854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pain research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f453c4a1e88c4e1886c7cf8b0b0f02ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f453c4a1e88c4e1886c7cf8b0b0f02ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pain Research, Vol Volume 10, Pp 1997-2002 (2017)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/34365","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/pharmacological-mechanisms-involved-in-the-analgesia-induced-by-ethano-peer-reviewed-article-JPR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/jpr.s141981","doi":"https://doi.org/10.2147/jpr.s141981","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s141981","pdf_url":"https://www.dovepress.com/getfile.php?fileID=38053","source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2748201142.pdf","grobid_xml":"https://content.openalex.org/works/W2748201142.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W249063887","https://openalex.org/W1563143030","https://openalex.org/W1969272687","https://openalex.org/W1971841034","https://openalex.org/W1972856190","https://openalex.org/W1975763112","https://openalex.org/W1982412276","https://openalex.org/W1997936479","https://openalex.org/W1998080960","https://openalex.org/W2003696602","https://openalex.org/W2008248024","https://openalex.org/W2009113222","https://openalex.org/W2011900910","https://openalex.org/W2013786129","https://openalex.org/W2021908531","https://openalex.org/W2029738259","https://openalex.org/W2036433746","https://openalex.org/W2036732725","https://openalex.org/W2046526172","https://openalex.org/W2057250059","https://openalex.org/W2064175661","https://openalex.org/W2069498450","https://openalex.org/W2073541816","https://openalex.org/W2075657946","https://openalex.org/W2084230118","https://openalex.org/W2084693379","https://openalex.org/W2087254433","https://openalex.org/W2092363158","https://openalex.org/W2092762440","https://openalex.org/W2114730119","https://openalex.org/W2117916905","https://openalex.org/W2123220826","https://openalex.org/W2127872798","https://openalex.org/W2136814937","https://openalex.org/W2149615443","https://openalex.org/W2157073178","https://openalex.org/W2172803682","https://openalex.org/W2206043426","https://openalex.org/W2410935930","https://openalex.org/W2473589150","https://openalex.org/W2585294008","https://openalex.org/W4232327310"],"related_works":["https://openalex.org/W2922344333","https://openalex.org/W249063887","https://openalex.org/W2081244848","https://openalex.org/W1988427718","https://openalex.org/W4307921928","https://openalex.org/W2774530548","https://openalex.org/W2588301775","https://openalex.org/W6977728555","https://openalex.org/W4407296179","https://openalex.org/W2016870429"],"abstract_inverted_index":{"Background:":[0],"Hybanthus":[1,211],"enneaspermus":[2,38,212],"(HE)":[3],"leaves":[4,39],"are":[5],"being":[6],"used":[7],"traditionally":[8],"to":[9,23,200],"relieve":[10],"pain,":[11,214],"and":[12,42,62,76,86,109,136,170,193],"scientific":[13],"studies":[14],"have":[15],"demonstrated":[16],"their":[17],"analgesic":[18,31,180],"potential.":[19],"This":[20],"study":[21],"attempted":[22],"elucidate":[24],"the":[25,30,147,151,179,195,204],"pharmacological":[26],"mechanism(s)":[27],"involved":[28],"in":[29,56,127,146,154,184],"action":[32],"of":[33,36,134,143,163,182],"ethanol":[34],"extract":[35],"H.":[37],"(EEHE).":[40],"Materials":[41],"methods:":[43],"Forty-two":[44],"male":[45],"Wistar":[46],"rats":[47,55],"were":[48,94],"separately":[49],"randomized":[50],"into":[51],"seven":[52],"groups":[53,74],"(n=6":[54],"each":[57],"group)":[58],"for":[59],"tail":[60,215],"immersion":[61,216],"formalin":[63,209],"tests.":[64],"Group":[65],"I":[66],"(control)":[67],"received":[68,78],"distilled":[69],"water":[70],"(10":[71],"mL/kg)":[72],"while":[73],"II":[75],"III":[77],"acetaminophen":[79],"(the":[80],"reference":[81],"drug,":[82],"100":[83],"mg/kg":[84,89,99,103,107,112,120],"ip)":[85],"EEHE":[87,118,183],"(1000":[88,119],"po),":[90],"respectively.":[91],"Groups":[92],"IV\u2013VII":[93],"pretreated":[95],"with":[96],"cimetidine":[97],"(50":[98],"ip),":[100,104,108,113],"naloxone":[101],"(5":[102],"propranolol":[105],"(0.15":[106,111],"prazosin":[110],"respectively,":[114],"1":[115],"hour":[116],"before":[117],"po)":[121],"treatment.":[122],"Results:":[123],"The":[124],"EEHE-induced":[125,152,201],"increase":[126],"tail-flick":[128,148],"latency":[129],"was":[130,158],"reduced":[131],"by":[132,141,161,168],"blockade":[133,142,162],"histamine":[135,169],"adrenergic":[137,171],"receptors":[138,172],"but":[139,166],"prevented":[140,159],"opiate":[144,164],"receptor":[145,165],"test.":[149],"However,":[150],"decrease":[153],"paw":[155],"licking":[156],"time":[157],"only":[160],"unaffected":[167],"blockers.":[173],"Conclusion:":[174],"These":[175],"findings":[176],"suggest":[177],"that":[178,194],"effect":[181],"different":[185,190],"pain":[186],"types":[187],"may":[188],"involve":[189],"neural":[191],"mechanisms":[192],"opioidergic":[196],"pathway":[197],"contributes":[198],"more":[199],"analgesia":[202],"than":[203],"other":[205],"pathways.":[206],"Keywords:":[207],"analgesia,":[208],"test,":[210],",":[213],"test":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-31T00:00:00"}