{"id":"https://openalex.org/W2747950677","doi":"https://doi.org/10.7554/elife.29145","title":"A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development","display_name":"A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development","publication_year":2017,"publication_date":"2017-08-23","ids":{"openalex":"https://openalex.org/W2747950677","doi":"https://doi.org/10.7554/elife.29145","mag":"2747950677","pmid":"https://pubmed.ncbi.nlm.nih.gov/28832322","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5599238"},"language":"en","primary_location":{"id":"doi:10.7554/elife.29145","doi":"https://doi.org/10.7554/elife.29145","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.29145","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.29145","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004064642","display_name":"Christie Ciarlo","orcid":"https://orcid.org/0000-0002-2876-2432","observed_orcids":["https://orcid.org/0000-0002-2876-2432"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie Ciarlo","raw_affiliation_strings":["Harvard Medical School, Boston, United States","Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":"https://orcid.org/0000-0002-2876-2432","affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011623358","display_name":"Charles K. Kaufman","orcid":"https://orcid.org/0000-0003-3122-1677","observed_orcids":["https://orcid.org/0000-0003-3122-1677"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles K Kaufman","raw_affiliation_strings":["Department of Developmental Biology, Washington University School of Medicine, St. Louis, United States","Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084601947","display_name":"Beste K\u0131n\u0131ko\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beste Kinikoglu","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States","Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075890891","display_name":"Michael Jonathan","orcid":"https://orcid.org/0000-0001-9640-1420","observed_orcids":["https://orcid.org/0000-0001-9640-1420"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Michael","raw_affiliation_strings":["Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006676791","display_name":"Song P. Yang","orcid":"https://orcid.org/0000-0002-3064-3141","observed_orcids":["https://orcid.org/0000-0002-3064-3141"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Yang","raw_affiliation_strings":["Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048461403","display_name":"Christopher R. D'Amato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D\u2032Amato","raw_affiliation_strings":["Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039081478","display_name":"Sasja Blokzijl-Franke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322597698","display_name":"Royal Netherlands Academy of Arts and Sciences","ror":"https://ror.org/043c0p156","country_code":"NL","type":"government","lineage":["https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sasja Blokzijl-Franke","raw_affiliation_strings":["Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Utrecht, Netherlands","Hubrecht Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I1322597698","https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Hubrecht Institute,","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037786135","display_name":"Jeroen den Hertog","orcid":"https://orcid.org/0000-0002-8642-8088","observed_orcids":["https://orcid.org/0000-0002-8642-8088"]},"institutions":[{"id":"https://openalex.org/I1322597698","display_name":"Royal Netherlands Academy of Arts and Sciences","ror":"https://ror.org/043c0p156","country_code":"NL","type":"government","lineage":["https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen den Hertog","raw_affiliation_strings":["Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Utrecht, Netherlands","Hubrecht Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I1322597698","https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Hubrecht Institute,","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059923659","display_name":"Thorsten M. Schlaeger","orcid":"https://orcid.org/0000-0002-1599-9908","observed_orcids":["https://orcid.org/0000-0002-1599-9908"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thorsten M Schlaeger","raw_affiliation_strings":["Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101881010","display_name":"Yi Zhou","orcid":"https://orcid.org/0000-0003-0935-1635","observed_orcids":["https://orcid.org/0000-0003-0935-1635"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":["Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076166634","display_name":"Eric Chien-Wei Liao","orcid":"https://orcid.org/0000-0001-6385-7448","observed_orcids":["https://orcid.org/0000-0001-6385-7448","https://orcid.org/0000-0003-3989-5115"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Liao","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States","Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, United States","Harvard Medical School, Boston, United States","Harvard Stem Cell Institute, Cambridge, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, United States","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086372369","display_name":"Leonard Ira Zon","orcid":"https://orcid.org/0000-0003-0860-926X","observed_orcids":["https://orcid.org/0000-0003-0860-926X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonard I Zon","raw_affiliation_strings":["Harvard Medical School, Boston, United States","Harvard Stem Cell Institute, Cambridge, United States","Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","Howard Hughes Medical Institute, Boston, United States;"],"raw_orcid":"https://orcid.org/0000-0003-0860-926X","affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Boston, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, United States;","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5086372369"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":1.8984,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.8605431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-crest-development","display_name":"neural crest development","score":0.9940000176429749},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sox10","display_name":"SOX10","score":0.8230000138282776},{"id":"https://openalex.org/keywords/melanocyte-differentiation","display_name":"melanocyte differentiation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chemical-screen","display_name":"chemical screen","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7680000066757202},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9383817911148071},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.8831052780151367},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.5982769131660461},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5929861068725586},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5916267037391663},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5485974550247192},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5389182567596436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4882965087890625},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45370620489120483},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.4464699625968933},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.23951712250709534},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2148618996143341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15475860238075256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06484827399253845}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":12,"locations":[{"id":"doi:10.7554/elife.29145","doi":"https://doi.org/10.7554/elife.29145","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.29145","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5599238","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5599238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:28832322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28832322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pure.knaw.nl:openaire/fc884fed-a9d7-4206-afd4-26134d74fa21","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/fc884fed-a9d7-4206-afd4-26134d74fa21","pdf_url":null,"source":{"id":"https://openalex.org/S4306400439","display_name":"KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ciarlo, C, Kaufman, C K, Kinikoglu, B, Michael, J, Yang, S, D Amato, C, Blokzijl-Franke, S, den Hertog, J, Schlaeger, T M, Zhou, Y, Liao, E & Zon, L I 2017, 'A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development', eLife, vol. 6. https://doi.org/10.7554/eLife.29145","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-7339","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/6333","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/6333","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/34492086","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492086","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:knaw:oai:pure.knaw.nl:publications/fc884fed-a9d7-4206-afd4-26134d74fa21","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/fc884fed-a9d7-4206-afd4-26134d74fa21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 6. eLife Sciences Publications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4e867ca3e3604b41ae20053ecbe3739f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4e867ca3e3604b41ae20053ecbe3739f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 6 (2017)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/356432","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/356432","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pure.knaw.nl:openaire_cris_publications/fc884fed-a9d7-4206-afd4-26134d74fa21","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11755/fc884fed-a9d7-4206-afd4-26134d74fa21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401286","display_name":"KNAW research portal (Royal Academy of Art and Sciences (KNAW))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ciarlo, C, Kaufman, C K, Kinikoglu, B, Michael, J, Yang, S, D Amato, C, Blokzijl-Franke, S, den Hertog, J, Schlaeger, T M, Zhou, Y, Liao, E & Zon, L I 2017, 'A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development', eLife, vol. 6. https://doi.org/10.7554/eLife.29145","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/356432","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/356432","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 2017(6). eLife Sciences Publications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/356432","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/356432","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 2017(6)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7554/elife.29145","doi":"https://doi.org/10.7554/elife.29145","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.29145","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2466092408","display_name":"Cancer Biology in the Zebrafish","funder_award_id":"R01CA103846","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2963218958","display_name":"Regulators of Melanocyte and Melanoma Cell Identity","funder_award_id":"K08AR061071","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4054915342","display_name":"Chemical suppressors of the neural crest lineage for the treatment of melanoma","funder_award_id":"F31CA180313","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4337204068","display_name":"A CENTER OF MOLECULAR HEMATOLOGY","funder_award_id":"U54DK110805","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4966761656","display_name":"Functional Analysis of wntless (wls) in Palate Development","funder_award_id":"R03DE024490","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7344814241","display_name":"Embryonic Hematopoiesis","funder_award_id":"R01HL048801","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320311069","display_name":"Lawrence Ellison Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1541209562","https://openalex.org/W1559850800","https://openalex.org/W1965857163","https://openalex.org/W1969000984","https://openalex.org/W1969600648","https://openalex.org/W1971417705","https://openalex.org/W1979224825","https://openalex.org/W1981998503","https://openalex.org/W1982532675","https://openalex.org/W1985368135","https://openalex.org/W1985721503","https://openalex.org/W1988476050","https://openalex.org/W1992109292","https://openalex.org/W1993176607","https://openalex.org/W1995714143","https://openalex.org/W1997889534","https://openalex.org/W2011936682","https://openalex.org/W2014677321","https://openalex.org/W2015009944","https://openalex.org/W2018207073","https://openalex.org/W2019096287","https://openalex.org/W2019751519","https://openalex.org/W2025805962","https://openalex.org/W2026321840","https://openalex.org/W2032909215","https://openalex.org/W2036615528","https://openalex.org/W2040034548","https://openalex.org/W2053188090","https://openalex.org/W2054116393","https://openalex.org/W2055202626","https://openalex.org/W2070732456","https://openalex.org/W2070826332","https://openalex.org/W2070942270","https://openalex.org/W2071284347","https://openalex.org/W2072486463","https://openalex.org/W2076103389","https://openalex.org/W2078293551","https://openalex.org/W2104593771","https://openalex.org/W2105437003","https://openalex.org/W2109831900","https://openalex.org/W2117757143","https://openalex.org/W2122952423","https://openalex.org/W2122972967","https://openalex.org/W2125349610","https://openalex.org/W2128844924","https://openalex.org/W2147026669","https://openalex.org/W2149783560","https://openalex.org/W2162585555","https://openalex.org/W2164927488","https://openalex.org/W2165389148","https://openalex.org/W2166884973","https://openalex.org/W2172096465","https://openalex.org/W2226626398","https://openalex.org/W2256617982","https://openalex.org/W2268569236","https://openalex.org/W2345663842","https://openalex.org/W2402845798","https://openalex.org/W2480478051"],"related_works":["https://openalex.org/W2985780790","https://openalex.org/W2066055930","https://openalex.org/W2805609856","https://openalex.org/W2051791753","https://openalex.org/W2057781452","https://openalex.org/W7084152086","https://openalex.org/W2783114553","https://openalex.org/W1999913971","https://openalex.org/W1990125829","https://openalex.org/W3006093560"],"abstract_inverted_index":{"The":[0,19],"neural":[1,15,29,41,61,82,100,139],"crest":[2,42,62,83,101,140],"is":[3],"a":[4,50,133],"dynamic":[5],"progenitor":[6],"cell":[7],"population":[8],"that":[9,59,72],"arises":[10],"at":[11,27],"the":[12,28,36,73],"border":[13,31],"of":[14,22,113],"and":[16,25,87,99,124],"non-neural":[17],"ectoderm.":[18],"inductive":[20],"roles":[21],"FGF,":[23],"Wnt,":[24],"BMP":[26],"plate":[30],"are":[32,106],"well":[33],"established,":[34],"but":[35],"signals":[37],"required":[38,137],"for":[39,57,138],"subsequent":[40],"development":[43],"remain":[44],"poorly":[45],"characterized.":[46],"Here,":[47],"we":[48],"conducted":[49],"screen":[51],"in":[52,103],"primary":[53],"zebrafish":[54],"embryo":[55],"cultures":[56],"chemicals":[58],"disrupt":[60],"development,":[63],"as":[64,132],"read":[65],"out":[66],"by":[67,90,108,116],"crestin:EGFP":[68],"expression.":[69],"We":[70],"found":[71],"natural":[74],"product":[75],"caffeic":[76],"acid":[77],"phenethyl":[78],"ester":[79],"(CAPE)":[80],"disrupts":[81],"gene":[84],"expression,":[85],"migration,":[86],"melanocytic":[88],"differentiation":[89],"reducing":[91],"Sox10":[92,125],"activity.":[93,126],"CAPE":[94],"inhibits":[95],"FGF-stimulated":[96],"PI3K/Akt":[97],"signaling,":[98],"defects":[102],"CAPE-treated":[104],"embryos":[105],"suppressed":[107],"constitutively":[109,117],"active":[110,118],"Akt1.":[111],"Inhibition":[112],"Akt":[114,131],"activity":[115],"PTEN":[119],"similarly":[120],"decreases":[121],"crestin":[122],"expression":[123],"Our":[127],"study":[128],"has":[129],"identified":[130],"novel":[134],"intracellular":[135],"pathway":[136],"differentiation.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-31T00:00:00"}