{"id":"https://openalex.org/W2747428866","doi":null,"title":"Molecular neuroanatomy: mouse-human homologies and the landscape of genes implicated in language disorders","display_name":"Molecular neuroanatomy: mouse-human homologies and the landscape of genes implicated in language disorders","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2747428866","mag":"2747428866"},"language":"en","primary_location":{"id":"pmh:oai:null:2144/23390","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/23390","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis/Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2144/23390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033216809","display_name":"Emma M. Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emma Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033216809"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10730","display_name":"Language Development and Disorders","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-transcriptome","display_name":"brain transcriptome","score":0.7490000128746033},{"id":"https://openalex.org/keywords/allen-human-brain-atlas","display_name":"Allen Human Brain Atlas","score":0.8320000171661377},{"id":"https://openalex.org/keywords/allen-mouse-brain-atlas","display_name":"Allen Mouse Brain Atlas","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.35600000619888306},{"id":"https://openalex.org/keywords/coexpression-network","display_name":"co-expression network","score":0.6330000162124634},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.6119999885559082},{"id":"https://openalex.org/keywords/speech-and-language-disorders","display_name":"speech and language disorders","score":0.8370000123977661},{"id":"https://openalex.org/keywords/developmental-stuttering","display_name":"developmental stuttering","score":0.9259999990463257},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/astrocyte-markers","display_name":"astrocyte markers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C103378370","wikidata":"https://www.wikidata.org/wiki/Q948647","display_name":"Neuroanatomy","level":2,"score":0.6014859080314636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5375139117240906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5095789432525635},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4542246162891388},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4138583540916443},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3294545114040375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3002302050590515}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:null:2144/23390","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/23390","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis/Dissertation"},{"id":"pmh:oai:open.bu.edu:2144/23390","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/23390","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis/Dissertation"},{"id":"mag:2747428866","doi":null,"is_oa":false,"landing_page_url":"https://open.bu.edu/handle/2144/23390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:null:2144/23390","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/23390","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis/Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7133002289","https://openalex.org/W4308370378","https://openalex.org/W2528291562","https://openalex.org/W3009746164","https://openalex.org/W2055655674","https://openalex.org/W2162127197","https://openalex.org/W7098022205","https://openalex.org/W2617890026","https://openalex.org/W6921321550","https://openalex.org/W74870055"],"abstract_inverted_index":{"The":[0,111,178,271],"distinctiveness":[1],"of":[2,15,78,96,113,161,171,181,235,261,274,280,316,340],"brain":[3,23,130,143,196,293,303],"structures":[4,304],"and":[5,21,40,70,73,87,108,117,134,241,259,288,291,311],"circuits":[6],"depends":[7],"on":[8],"interacting":[9],"gene":[10,29,79,214],"products,":[11],"yet":[12],"the":[13,34,76,106,128,141,169,335],"organization":[14,64,103,175],"these":[16,320],"molecules":[17],"(the":[18],"\"transcriptome\")":[19],"within":[20,69,194],"across":[22,71,138,176,211],"areas":[24],"remains":[25],"unclear.":[26],"High-throughput,":[27],"neuroanatomically-specific":[28],"expression":[30,80,192,233],"datasets":[31],"such":[32],"as":[33,82],"Allen":[35,41],"Human":[36],"Brain":[37,43],"Atlas":[38,44],"(AHBA)":[39],"Mouse":[42],"(AMBA)":[45],"have":[46,283],"recently":[47],"become":[48],"available,":[49],"providing":[50],"unprecedented":[51],"opportunities":[52],"to":[53,60,66,74,168,199,308],"quantify":[54],"molecular":[55,173,227],"neuroanatomy.":[56],"This":[57],"dissertation":[58,183,276],"seeks":[59],"clarify":[61],"how":[62],"transcriptomic":[63,102],"relates":[65],"conventional":[67],"neuroanatomy":[68],"species,":[72],"introduce":[75],"use":[77,112,160],"data":[81],"a":[83,150,278,338],"bridge":[84],"between":[85,124],"genotype":[86],"phenotype":[88],"in":[89,105,140,149,164,286,334,343],"complex":[90],"behavioral":[91],"disorders.":[92,321],"\\n\\tThe":[93,158,257],"first":[94],"part":[95,180,273],"this":[97,182,275,344],"work":[98],"examines":[99],"large-scale,":[100],"regional":[101],"separately":[104],"mouse":[107,162],"human":[109,142,152],"brain.":[110],"dimensionality":[114],"reduction":[115],"methods":[116],"cross-sample":[118],"correlations":[119],"both":[120],"revealed":[121],"greater":[122],"similarity":[123,202],"samples":[125],"drawn":[126],"from":[127,205],"same":[129],"region.":[131],"Sample":[132],"profiles":[133,193],"differentially":[135],"expressed":[136,299],"genes":[137,237,262,281,317,324],"regions":[139,197,294],"also":[144],"showed":[145,314,330],"consistent":[146],"anatomical":[147],"specificity":[148],"second":[151,179],"dataset":[153],"with":[154,208,305,319,326],"distinct":[155],"sampling":[156],"properties.":[157],"frequent":[159],"models":[163],"clinical":[165],"research":[166],"points":[167],"importance":[170,342],"comparing":[172],"neuroanatomical":[174],"species.":[177],"describes":[184,277],"three":[185],"comparative":[186],"approaches.":[187],"First,":[188],"at":[189],"genome":[190],"scale,":[191],"homologous":[195],"tended":[198],"show":[200],"higher":[201],"than":[203,247],"those":[204],"non-homologous":[206],"regions,":[207],"substantial":[209],"variability":[210],"regions.":[212],"Second,":[213],"subsets":[215],"(defined":[216],"using":[217],"co-expression":[218,260,315,333],"relationships":[219,265],"or":[220,300],"shared":[221],"annotations),":[222],"which":[223],"provide":[224],"region-specific,":[225],"cross-species":[226],"signatures":[228],"were":[229,238,244,254],"identified.":[230],"Finally,":[231],"brain-wide":[232],"patterns":[234],"orthologous":[236],"compared.":[239],"Neuron":[240],"oligodendrocyte":[242],"markers":[243,253],"more":[245],"correlated":[246],"expected":[248],"by":[249],"chance,":[250],"while":[251],"astrocyte":[252],"less":[255],"so.":[256],"localization":[258],"reflect":[263],"functional":[264],"that":[266,282],"may":[267],"underlie":[268],"high-level":[269],"functions.":[270],"final":[272],"database":[279],"been":[284],"implicated":[285],"speech":[287,310],"language":[289,312],"disorders,":[290],"identifies":[292],"where":[295],"they":[296],"are":[297],"preferentially":[298],"co-expressed.":[301],"Several":[302],"functions":[306],"relevant":[307],"four":[309],"disorders":[313],"associated":[318,325],"In":[322],"particular,":[323],"persistent":[327],"developmental":[328],"stuttering":[329],"stronger":[331],"preferential":[332],"basal":[336],"ganglia,":[337],"structure":[339],"known":[341],"disorder.":[345]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-08-31T00:00:00"}
