{"id":"https://openalex.org/W2746944156","doi":"https://doi.org/10.1084/jem.20170335","title":"Dendritic cell and antigen dispersal landscapes regulate T cell immunity","display_name":"Dendritic cell and antigen dispersal landscapes regulate T cell immunity","publication_year":2017,"publication_date":"2017-08-28","ids":{"openalex":"https://openalex.org/W2746944156","doi":"https://doi.org/10.1084/jem.20170335","mag":"2746944156","pmid":"https://pubmed.ncbi.nlm.nih.gov/28847868","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5626399"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20170335","doi":"https://doi.org/10.1084/jem.20170335","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20170335","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1084/jem.20170335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085564578","display_name":"Michael Y. Gerner","orcid":"https://orcid.org/0000-0001-5406-8308","observed_orcids":["https://orcid.org/0000-0001-5406-8308"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Y. Gerner","raw_affiliation_strings":["Department of Immunology, University of Washington, Seattle, WA 1"],"raw_orcid":"https://orcid.org/0000-0001-5406-8308","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA 1","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051881041","display_name":"Kerry Anne Casey","orcid":"https://orcid.org/0000-0001-7194-8585","observed_orcids":["https://orcid.org/0000-0001-7194-8585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerry A. Casey","raw_affiliation_strings":["Department of Respiratory, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD 2"],"raw_orcid":"https://orcid.org/0000-0001-7194-8585","affiliations":[{"raw_affiliation_string":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD 2","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037220835","display_name":"Wolfgang Kastenm\u00fcller","orcid":"https://orcid.org/0000-0002-3835-1485","observed_orcids":["https://orcid.org/0000-0002-3835-1485"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Kastenmuller","raw_affiliation_strings":["Institute of Experimental Immunology, University of Bonn, Bonn, Germany 3"],"raw_orcid":"https://orcid.org/0000-0002-3835-1485","affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, University of Bonn, Bonn, Germany 3","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088777789","display_name":"Ronald N. Germain","orcid":"https://orcid.org/0000-0003-1495-9143","observed_orcids":["https://orcid.org/0000-0003-1495-9143"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald N. Germain","raw_affiliation_strings":["Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 4","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085564578"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":9.2236,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.98860264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"214","issue":"10","first_page":"3105","last_page":"3122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.4690000116825104},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mhc-class-ii-presentation","display_name":"MHC class II presentation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphatic-sinuses","display_name":"lymphatic sinuses","score":0.8169999718666077},{"id":"https://openalex.org/keywords/paracortex","display_name":"paracortex","score":0.8999999761581421},{"id":"https://openalex.org/keywords/clonal-diversity","display_name":"clonal diversity","score":0.722000002861023},{"id":"https://openalex.org/keywords/protein-immunization","display_name":"protein immunization","score":0.7570000290870667},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C2778973524","wikidata":"https://www.wikidata.org/wiki/Q3910755","display_name":"Cross-presentation","level":5,"score":0.6843736171722412},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6310835480690002},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6129910945892334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5983930826187134},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5918561220169067},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5869196653366089},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5849161744117737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5574004650115967},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.5412932634353638},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.48222243785858154},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.47940418124198914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43334439396858215},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41488727927207947},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.34876126050949097},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32722076773643494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06605422496795654},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.20170335","doi":"https://doi.org/10.1084/jem.20170335","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20170335","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5626399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5626399","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:28847868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28847868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.20170335","doi":"https://doi.org/10.1084/jem.20170335","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20170335","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7963477992","display_name":"Micro-anatomical organization of innate and adaptive immune responses","funder_award_id":"K22AI108628","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1039201796","https://openalex.org/W1524841546","https://openalex.org/W1557759563","https://openalex.org/W1564678055","https://openalex.org/W1894685526","https://openalex.org/W1943771969","https://openalex.org/W1959677146","https://openalex.org/W1962442499","https://openalex.org/W1964077677","https://openalex.org/W1977274736","https://openalex.org/W1977980568","https://openalex.org/W1987838854","https://openalex.org/W1994001162","https://openalex.org/W1994500716","https://openalex.org/W1996384179","https://openalex.org/W1997337311","https://openalex.org/W1998270050","https://openalex.org/W2007761469","https://openalex.org/W2008471218","https://openalex.org/W2010008322","https://openalex.org/W2015776459","https://openalex.org/W2016055373","https://openalex.org/W2021943943","https://openalex.org/W2023841575","https://openalex.org/W2030436099","https://openalex.org/W2031537098","https://openalex.org/W2036564362","https://openalex.org/W2041061869","https://openalex.org/W2049332097","https://openalex.org/W2049398130","https://openalex.org/W2053483416","https://openalex.org/W2056927031","https://openalex.org/W2059528812","https://openalex.org/W2062690397","https://openalex.org/W2068838772","https://openalex.org/W2068903660","https://openalex.org/W2071969437","https://openalex.org/W2074545819","https://openalex.org/W2076397065","https://openalex.org/W2078013078","https://openalex.org/W2081287274","https://openalex.org/W2086221877","https://openalex.org/W2089543767","https://openalex.org/W2091991410","https://openalex.org/W2096084302","https://openalex.org/W2108449579","https://openalex.org/W2112891300","https://openalex.org/W2114256385","https://openalex.org/W2124152040","https://openalex.org/W2128055407","https://openalex.org/W2131905612","https://openalex.org/W2132757833","https://openalex.org/W2133447888","https://openalex.org/W2134254929","https://openalex.org/W2137670912","https://openalex.org/W2138853264","https://openalex.org/W2144733364","https://openalex.org/W2147155368","https://openalex.org/W2149019783","https://openalex.org/W2150903174","https://openalex.org/W2154756633","https://openalex.org/W2158670001","https://openalex.org/W2161195685","https://openalex.org/W2167028666","https://openalex.org/W2168028214","https://openalex.org/W2168628444","https://openalex.org/W2170319274","https://openalex.org/W2170912872","https://openalex.org/W2177188076","https://openalex.org/W2230720026","https://openalex.org/W2238741732","https://openalex.org/W2258848421","https://openalex.org/W2264544376","https://openalex.org/W2289160872","https://openalex.org/W2295202170","https://openalex.org/W2302910861","https://openalex.org/W2408728605","https://openalex.org/W2469744638"],"related_works":["https://openalex.org/W2885766682","https://openalex.org/W4313349623","https://openalex.org/W2509033762","https://openalex.org/W4313350126","https://openalex.org/W2751461922","https://openalex.org/W2113127251","https://openalex.org/W2901221545","https://openalex.org/W2068903660","https://openalex.org/W1977980568","https://openalex.org/W4400599031"],"abstract_inverted_index":{"Dendritic":[0],"cell":[1,12,48,133,156],"(DC)":[2],"subsets":[3],"with":[4,66,112,130,158],"biased":[5],"capacity":[6],"for":[7,79,161],"CD4+":[8,97,131],"and":[9,46,58,86,96,136,146,152],"CD8+":[10,95,128],"T":[11,47,98,132,155],"activation":[13,49,93],"are":[14,108],"asymmetrically":[15],"distributed":[16],"in":[17,69,91,110,118,127],"lymph":[18],"nodes":[19],"(LNs),":[20],"but":[21],"how":[22],"this":[23],"affects":[24],"adaptive":[25],"responses":[26],"has":[27],"not":[28],"been":[29],"extensively":[30],"studied.":[31],"Here":[32],"we":[33],"used":[34],"quantitative":[35],"imaging":[36],"to":[37,122],"examine":[38],"the":[39,63,70,140,150],"relationships":[40],"among":[41],"antigen":[42,114,119,144],"dispersal,":[43],"DC":[44,147],"positioning,":[45],"after":[50],"protein":[51],"immunization.":[52],"Antigens":[53],"rapidly":[54],"drained":[55],"into":[56],"LNs":[57],"formed":[59],"gradients":[60],"extending":[61],"from":[62],"lymphatic":[64],"sinuses,":[65],"reduced":[67],"abundance":[68],"deep":[71],"LN":[72,102],"paracortex.":[73],"Differential":[74],"localization":[75],"of":[76,94,143,154],"DCs":[77,107],"specialized":[78],"major":[80],"histocompatibility":[81],"complex":[82],"I":[83],"(MHC":[84],"I)":[85],"MHC":[87,105],"II":[88],"presentation":[89],"resulted":[90],"preferential":[92],"cells":[99],"within":[100],"distinct":[101],"regions.":[103],"Because":[104],"I\u2013specialized":[106],"positioned":[109],"regions":[111],"limited":[113],"delivery,":[115],"modest":[116],"reductions":[117],"dose":[120],"led":[121],"a":[123],"substantially":[124],"greater":[125],"decline":[126],"compared":[129],"activation,":[134],"expansion,":[135],"clonal":[137],"diversity.":[138],"Thus,":[139],"collective":[141],"action":[142],"dispersal":[145],"positioning":[148],"regulates":[149],"extent":[151],"quality":[153],"immunity,":[157],"important":[159],"implications":[160],"vaccine":[162],"design.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-31T00:00:00"}