{"id":"https://openalex.org/W2746545692","doi":"https://doi.org/10.3389/fped.2017.00178","title":"Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development","display_name":"Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development","publication_year":2017,"publication_date":"2017-08-22","ids":{"openalex":"https://openalex.org/W2746545692","doi":"https://doi.org/10.3389/fped.2017.00178","mag":"2746545692","pmid":"https://pubmed.ncbi.nlm.nih.gov/28879172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5572264"},"language":"en","primary_location":{"id":"doi:10.3389/fped.2017.00178","doi":"https://doi.org/10.3389/fped.2017.00178","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2017.00178","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2017.00178/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fped.2017.00178/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016235947","display_name":"Flavia Indrio","orcid":"https://orcid.org/0000-0002-0606-1360","observed_orcids":["https://orcid.org/0000-0002-0606-1360"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Indrio","raw_affiliation_strings":["Department of Pediatrics, Aldo Moro University, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Aldo Moro University, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036349374","display_name":"Silvia Martini","orcid":"https://orcid.org/0000-0003-2078-7114","observed_orcids":["https://orcid.org/0000-0003-2078-7114"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvia Martini","raw_affiliation_strings":["Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065943107","display_name":"Ruggiero Francavilla","orcid":"https://orcid.org/0000-0002-4603-974X","observed_orcids":["https://orcid.org/0000-0002-4603-974X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ruggiero Francavilla","raw_affiliation_strings":["Department of Pediatrics, Aldo Moro University, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Aldo Moro University, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033915212","display_name":"Luigi Corvaglia","orcid":"https://orcid.org/0000-0002-8119-7743","observed_orcids":["https://orcid.org/0000-0002-8119-7743","https://orcid.org/0000-0003-4541-2458"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Corvaglia","raw_affiliation_strings":["Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069412370","display_name":"Fernanda Cristofori","orcid":"https://orcid.org/0000-0001-5849-8110","observed_orcids":["https://orcid.org/0000-0001-5849-8110"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fernanda Cristofori","raw_affiliation_strings":["Department of Pediatrics, Aldo Moro University, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Aldo Moro University, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031825864","display_name":"Salvatore Andrea Mastrolia","orcid":"https://orcid.org/0000-0002-1522-8732","observed_orcids":["https://orcid.org/0000-0002-1522-8732"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Andrea Mastrolia","raw_affiliation_strings":["Department of Biomedical Science and Human Oncology, Section of Obstetrics and Gynecology, Aldo Moro University, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Human Oncology, Section of Obstetrics and Gynecology, Aldo Moro University, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067723376","display_name":"Josef Neu","orcid":"https://orcid.org/0000-0002-6973-0592","observed_orcids":["https://orcid.org/0000-0002-6973-0592"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josef Neu","raw_affiliation_strings":["Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015904288","display_name":"Samuli Rautava","orcid":"https://orcid.org/0000-0003-0935-3593","observed_orcids":["https://orcid.org/0000-0003-0935-3593"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Samuli Rautava","raw_affiliation_strings":["Department of Pediatrics, University of Turku, Turku University Hospital, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Turku, Turku University Hospital, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081564073","display_name":"Giovanna Russo Spena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Russo Spena","raw_affiliation_strings":["Division of Neonatology, Department of Translational Medical Sciences, University \"Federico II\" di Napoli, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Translational Medical Sciences, University \"Federico II\" di Napoli, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076181708","display_name":"Francesco Raimondi","orcid":"https://orcid.org/0000-0003-3250-1582","observed_orcids":["https://orcid.org/0000-0003-3250-1582"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Raimondi","raw_affiliation_strings":["Division of Neonatology, Department of Translational Medical Sciences, University \"Federico II\" di Napoli, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Translational Medical Sciences, University \"Federico II\" di Napoli, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042288276","display_name":"Giuseppe Loverro","orcid":"https://orcid.org/0000-0002-8192-9959","observed_orcids":["https://orcid.org/0000-0002-8192-9959"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Loverro","raw_affiliation_strings":["Department of Biomedical Science and Human Oncology, Section of Obstetrics and Gynecology, Aldo Moro University, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Human Oncology, Section of Obstetrics and Gynecology, Aldo Moro University, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5036349374"],"corresponding_institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.7807,"has_fulltext":true,"cited_by_count":253,"citation_normalized_percentile":{"value":0.93642612,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"5","issue":null,"first_page":"178","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-programming","display_name":"epigenetic programming","score":0.8090000152587891},{"id":"https://openalex.org/keywords/early-life-nutrition","display_name":"early life nutrition","score":0.7609999775886536},{"id":"https://openalex.org/keywords/maternal-nutrition","display_name":"maternal nutrition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neonatal-nutrition","display_name":"neonatal nutrition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.906000018119812},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.5},{"id":"https://openalex.org/keywords/gastrointestinal-colonization","display_name":"intestinal colonization","score":0.5659999847412109},{"id":"https://openalex.org/keywords/mode-of-delivery","display_name":"mode of delivery","score":0.7350000143051147},{"id":"https://openalex.org/keywords/skin-to-skin-contact","display_name":"skin-to-skin contact","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pollutant-exposure","display_name":"contaminant exposure","score":0.7739999890327454},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gut-mucosal-barrier","display_name":"gut mucosal barrier","score":0.8539999723434448},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.5630000233650208},{"id":"https://openalex.org/keywords/long-term-health-effects","display_name":"long-term health effects","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.905724287033081},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6760060787200928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49621492624282837},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4960056245326996},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4608874022960663},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4597499668598175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43812400102615356},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4193664789199829},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41867557168006897},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.41464120149612427},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3645612597465515},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34132644534111023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25144246220588684},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17249014973640442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11549976468086243},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08519941568374634}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3389/fped.2017.00178","doi":"https://doi.org/10.3389/fped.2017.00178","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2017.00178","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2017.00178/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},{"id":"pmid:28879172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28879172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5572264","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5572264/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pediatr","raw_type":"Text"},{"id":"pmh:oai:ricerca.uniba.it:11586/210771","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11586/210771","pdf_url":"http://hdl.handle.net/11586/210771","source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:utupub.fi:11111/29550","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/29550","pdf_url":"https://www.utupub.fi/bitstreams/74f71675-bc68-4fec-a033-8dfed4f796fc/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/155027","raw_type":null},{"id":"pmh:oai:www.utupub.fi:10024/155027","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/10024/155027","pdf_url":"https://www.utupub.fi/bitstream/10024/155027/1/fped-05-00178epic.pdf","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/621548","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/621548","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:eb3ee9be46244a128dbdcb5b5be9f372","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/eb3ee9be46244a128dbdcb5b5be9f372","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, Vol 5 (2017)","raw_type":"article"},{"id":"pmh:oai:iris.unisalento.it:11587/502131","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11587/502131","pdf_url":null,"source":{"id":"https://openalex.org/S7407055257","display_name":"AIRUS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fped.2017.00178","doi":"https://doi.org/10.3389/fped.2017.00178","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2017.00178","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2017.00178/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2746545692.pdf","grobid_xml":"https://content.openalex.org/works/W2746545692.grobid-xml"},"referenced_works_count":161,"referenced_works":["https://openalex.org/W97106314","https://openalex.org/W340610577","https://openalex.org/W1176937736","https://openalex.org/W1489671371","https://openalex.org/W1490861410","https://openalex.org/W1524217669","https://openalex.org/W1527957830","https://openalex.org/W1765879118","https://openalex.org/W1778662842","https://openalex.org/W1832427420","https://openalex.org/W1852459075","https://openalex.org/W1860290282","https://openalex.org/W1928709709","https://openalex.org/W1945327512","https://openalex.org/W1963466636","https://openalex.org/W1964227923","https://openalex.org/W1964394970","https://openalex.org/W1966509583","https://openalex.org/W1969235931","https://openalex.org/W1969615942","https://openalex.org/W1969905245","https://openalex.org/W1971670713","https://openalex.org/W1973047339","https://openalex.org/W1973922750","https://openalex.org/W1974509836","https://openalex.org/W1978695620","https://openalex.org/W1981379568","https://openalex.org/W1985400712","https://openalex.org/W1989665582","https://openalex.org/W1991449209","https://openalex.org/W1993399595","https://openalex.org/W1993623582","https://openalex.org/W1997895988","https://openalex.org/W2000452395","https://openalex.org/W2001897420","https://openalex.org/W2002121686","https://openalex.org/W2004539856","https://openalex.org/W2004757700","https://openalex.org/W2011684607","https://openalex.org/W2015778107","https://openalex.org/W2021061885","https://openalex.org/W2021414400","https://openalex.org/W2021992685","https://openalex.org/W2023506796","https://openalex.org/W2023773362","https://openalex.org/W2028342249","https://openalex.org/W2030328205","https://openalex.org/W2030500910","https://openalex.org/W2030842783","https://openalex.org/W2031801942","https://openalex.org/W2031881109","https://openalex.org/W2032028601","https://openalex.org/W2032249126","https://openalex.org/W2032408145","https://openalex.org/W2035467636","https://openalex.org/W2035781048","https://openalex.org/W2037318849","https://openalex.org/W2038081036","https://openalex.org/W2038165419","https://openalex.org/W2042457590","https://openalex.org/W2043873211","https://openalex.org/W2045297515","https://openalex.org/W2046498828","https://openalex.org/W2046979924","https://openalex.org/W2047014433","https://openalex.org/W2047798386","https://openalex.org/W2048550695","https://openalex.org/W2052061412","https://openalex.org/W2053022788","https://openalex.org/W2053039168","https://openalex.org/W2054277786","https://openalex.org/W2059131885","https://openalex.org/W2060689946","https://openalex.org/W2062256663","https://openalex.org/W2065498897","https://openalex.org/W2067414455","https://openalex.org/W2073171519","https://openalex.org/W2080957046","https://openalex.org/W2081000399","https://openalex.org/W2085696605","https://openalex.org/W2085870514","https://openalex.org/W2086050354","https://openalex.org/W2090869834","https://openalex.org/W2093378583","https://openalex.org/W2096036780","https://openalex.org/W2096205027","https://openalex.org/W2096283645","https://openalex.org/W2099471877","https://openalex.org/W2103761010","https://openalex.org/W2106695657","https://openalex.org/W2113582196","https://openalex.org/W2113686145","https://openalex.org/W2116534551","https://openalex.org/W2122398832","https://openalex.org/W2122540809","https://openalex.org/W2123117007","https://openalex.org/W2126694989","https://openalex.org/W2129129511","https://openalex.org/W2130981374","https://openalex.org/W2132815713","https://openalex.org/W2132929849","https://openalex.org/W2133570884","https://openalex.org/W2133699833","https://openalex.org/W2136848239","https://openalex.org/W2138089671","https://openalex.org/W2139247373","https://openalex.org/W2140734898","https://openalex.org/W2141227362","https://openalex.org/W2146872402","https://openalex.org/W2147725723","https://openalex.org/W2148195572","https://openalex.org/W2148422863","https://openalex.org/W2150065866","https://openalex.org/W2150866117","https://openalex.org/W2150968312","https://openalex.org/W2151312927","https://openalex.org/W2151836397","https://openalex.org/W2155581161","https://openalex.org/W2159633664","https://openalex.org/W2159809460","https://openalex.org/W2159812564","https://openalex.org/W2160403269","https://openalex.org/W2163759450","https://openalex.org/W2164015729","https://openalex.org/W2166122517","https://openalex.org/W2168108700","https://openalex.org/W2168373620","https://openalex.org/W2169929899","https://openalex.org/W2171217592","https://openalex.org/W2203528802","https://openalex.org/W2271134226","https://openalex.org/W2289142974","https://openalex.org/W2293544761","https://openalex.org/W2312627937","https://openalex.org/W2319290978","https://openalex.org/W2321945161","https://openalex.org/W2322471302","https://openalex.org/W2337121958","https://openalex.org/W2370282838","https://openalex.org/W2400971304","https://openalex.org/W2413222197","https://openalex.org/W2414733892","https://openalex.org/W2437841363","https://openalex.org/W2506490546","https://openalex.org/W2507252508","https://openalex.org/W2508774651","https://openalex.org/W2512235203","https://openalex.org/W2514744092","https://openalex.org/W2516846297","https://openalex.org/W2524542341","https://openalex.org/W2559057166","https://openalex.org/W2564771691","https://openalex.org/W2576385788","https://openalex.org/W2591600218","https://openalex.org/W2593288917","https://openalex.org/W2604644728","https://openalex.org/W2609340709","https://openalex.org/W2609646274","https://openalex.org/W2612110965","https://openalex.org/W2613213903","https://openalex.org/W4235311234"],"related_works":["https://openalex.org/W3126832964","https://openalex.org/W6931128111","https://openalex.org/W4414571560","https://openalex.org/W4210990310","https://openalex.org/W2289142974","https://openalex.org/W2978794664","https://openalex.org/W7117310106","https://openalex.org/W2888916586","https://openalex.org/W7160450691","https://openalex.org/W2597065316"],"abstract_inverted_index":{"Epigenetic":[0],"modifications":[1],"are":[2],"among":[3],"the":[4,26,31,51,57,67,71,89,118,135,149,165],"most":[5],"important":[6],"mechanisms":[7,151],"by":[8,83,98],"which":[9],"environmental":[10,176],"factors":[11,177],"can":[12,63,116],"influence":[13,77],"early":[14,104],"cellular":[15],"differentiation":[16],"and":[17,24,39,45,50,81,88,107,124,154,160,169,174,182,185],"create":[18],"new":[19],"phenotypic":[20],"traits":[21],"during":[22],"pregnancy":[23],"within":[25,157],"neonatal":[27,46,108,170],"period":[28],"without":[29],"altering":[30],"deoxyribonucleic":[32],"acid":[33],"sequence.":[34],"A":[35],"number":[36],"of":[37,53,59,102,121,137,143,152,167],"antenatal":[38],"postnatal":[40],"factors,":[41],"such":[42],"as":[43],"maternal":[44,99,168],"nutrition,":[47,171],"pollutant":[48],"exposure,":[49],"composition":[52],"microbiota,":[54],"contribute":[55],"to":[56,70,111,134,147,161],"establishment":[58],"epigenetic":[60,113,150,180],"changes":[61,181],"that":[62,115],"not":[64],"only":[65],"modulate":[66],"individual":[68],"adaptation":[69],"environment":[72],"but":[73],"also":[74],"have":[75],"an":[76],"on":[78],"lifelong":[79],"health":[80],"disease":[82],"modifying":[84],"inflammatory":[85,139],"molecular":[86],"pathways":[87],"immune":[90],"response.":[91],"Postnatal":[92],"intestinal":[93],"colonization,":[94],"in":[95,163,178],"turn":[96],"determined":[97],"flora,":[100],"mode":[101],"delivery,":[103],"skin-to-skin":[105],"contact":[106],"diet,":[109],"leads":[110],"specific":[112],"signatures":[114],"affect":[117],"barrier":[119],"properties":[120],"gut":[122],"mucosa":[123],"their":[125,183],"protective":[126],"role":[127,166],"against":[128],"later":[129],"insults,":[130],"thus":[131],"potentially":[132],"predisposing":[133],"development":[136,155],"late-onset":[138],"diseases.":[140],"The":[141],"aim":[142],"this":[144],"review":[145],"is":[146],"outline":[148],"programming":[153],"acting":[156],"early-life":[158],"stages":[159],"examine":[162],"detail":[164],"microbiota":[172],"composition,":[173],"other":[175],"determining":[179],"short-":[184],"long-term":[186],"effects.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-08-31T00:00:00"}