{"id":"https://openalex.org/W27464282","doi":null,"title":"Microarray Gene Expression Profiling of Bisphosphonate-Treated Normal Human Oral Keratinocytes","display_name":"Microarray Gene Expression Profiling of Bisphosphonate-Treated Normal Human Oral Keratinocytes","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W27464282","mag":"27464282"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3zf300k5","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3zf300k5","pdf_url":"https://escholarship.org/uc/item/3zf300k5","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/3zf300k5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004423470","display_name":"Rachel Suhhee Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel Suhhee Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004423470"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.8709999918937683},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oral-keratinocytes","display_name":"oral keratinocytes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7860000133514404},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cyclin-a2","display_name":"cyclin A2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.5929999947547913},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.6980000138282776},{"id":"https://openalex.org/keywords/chromosome-replication","display_name":"chromosome replication","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6627973318099976},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.609390914440155},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5328232645988464},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.5222821235656738},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.49975085258483887},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4944727420806885},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4874291718006134},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.4860427975654602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4828377366065979},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.47184017300605774},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.4366689622402191},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.4281764328479767},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.42799943685531616},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41716644167900085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4083332121372223},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35980600118637085},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.27123284339904785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20376598834991455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06956979632377625}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt3zf300k5","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3zf300k5","pdf_url":"https://escholarship.org/uc/item/3zf300k5","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:27464282","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt3zf300k5/qt3zf300k5.pdf?t=ndy19g","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3zf300k5","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3zf300k5","pdf_url":"https://escholarship.org/uc/item/3zf300k5","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W27464282.pdf","grobid_xml":"https://content.openalex.org/works/W27464282.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1840946893","https://openalex.org/W1972681033","https://openalex.org/W1974986519","https://openalex.org/W1976711506","https://openalex.org/W1979440035","https://openalex.org/W1991272056","https://openalex.org/W1994414479","https://openalex.org/W2001897537","https://openalex.org/W2011505056","https://openalex.org/W2025733870","https://openalex.org/W2032806645","https://openalex.org/W2037935981","https://openalex.org/W2044388407","https://openalex.org/W2045369683","https://openalex.org/W2046983302","https://openalex.org/W2055062383","https://openalex.org/W2055844573","https://openalex.org/W2064345727","https://openalex.org/W2067592470","https://openalex.org/W2072268794","https://openalex.org/W2077174583","https://openalex.org/W2086939643","https://openalex.org/W2093164779","https://openalex.org/W2097514725","https://openalex.org/W2107208293","https://openalex.org/W2112006376","https://openalex.org/W2113028183","https://openalex.org/W2123171945","https://openalex.org/W2128778774","https://openalex.org/W2129381867","https://openalex.org/W2136292511","https://openalex.org/W2142421083","https://openalex.org/W2145153331","https://openalex.org/W2147438935","https://openalex.org/W2151257334","https://openalex.org/W2159729767","https://openalex.org/W2163830908","https://openalex.org/W2167840876","https://openalex.org/W2276124084","https://openalex.org/W2336517627"],"related_works":["https://openalex.org/W2735547487","https://openalex.org/W1984042020","https://openalex.org/W2075626657","https://openalex.org/W2154304147","https://openalex.org/W2151257334","https://openalex.org/W1976711506","https://openalex.org/W1968892699","https://openalex.org/W1969939915","https://openalex.org/W1979758273","https://openalex.org/W2150138231"],"abstract_inverted_index":{"Bisphosphonates":[0],"(BPs)":[1],"are":[2,38],"the":[3,69,85,92,138,152,200,212,229,251,257],"most":[4],"widely":[5],"used":[6],"anti-resorptive":[7],"agents":[8],"for":[9],"osteoporotic":[10],"and":[11,50,112,115,161,167,174,181],"cancer":[12],"patients.":[13],"With":[14],"frequent":[15],"use":[16],"of":[17,26,94,131,142,171,192,202,214,237,260],"BPs":[18,33,47,90,241],"in":[19,53,62,68,151,195,218,220,243],"multiple":[20],"clinical":[21],"settings,":[22],"a":[23,29,144],"growing":[24],"body":[25],"evidence":[27],"supports":[28],"notion":[30],"that":[31,37,46,124,146,199,235],"some":[32],"cause":[34],"side":[35],"effects":[36],"specific":[39],"to":[40,117],"soft":[41,261],"tissues.":[42],"Previously,":[43],"we":[44,82],"reported":[45],"inhibit":[48,91],"proliferation":[49,93,239],"induce":[51],"senescence":[52],"normal":[54,101],"human":[55,102],"oral":[56,103,222],"keratinocytes":[57],"(NHOKs).":[58],"Cell":[59],"cycle":[60,73,129],"analysis":[61,122],"BP-treated":[63],"NHOKs":[64,97],"revealed":[65],"an":[66],"increase":[67],"S":[70],"phase":[71],"cell":[72,128,153],"arrest":[74],"(Kim":[75],"et":[76],"al,":[77],"2011).":[78],"In":[79],"this":[80],"study,":[81,227],"further":[83],"examined":[84],"underlying":[86,258],"mechanisms":[87,259],"by":[88,158,165,179,240,246,264],"which":[89,254],"NHOKs.":[95],"Primary":[96],"were":[98,107,134,176],"established":[99],"from":[100],"epithelium.":[104],"These":[105],"cells":[106],"treated":[108],"with":[109,127,149],"pamidronate":[110],"(PAM)":[111],"zoledronate":[113],"(ZOL)":[114],"subjected":[116],"microarray":[118,230],"gene":[119,231],"profiling.":[120],"Microarray":[121],"showed":[123,190,211],"genes":[125],"associated":[126,148],"control":[130],"chromosomal":[132],"replication":[133],"significantly":[135],"dysregulated.":[136],"Among":[137],"validated":[139],"genes,":[140],"expression":[141,205,217,232,249],"CCNA2,":[143],"cyclin":[145,203,215],"is":[147,206],"S-phase":[150],"cycle,":[154],"was":[155],"drastically":[156],"inhibited":[157],"both":[159],"PAM":[160,180],"ZOL":[162],"as":[163],"determined":[164],"qRT-PCR":[166],"Western":[168],"blotting.":[169],"Expression":[170],"CCND1,":[172],"Cdk6,":[173],"Cdk2":[175],"not":[177],"affected":[178],"ZOL.":[182],"The":[183],"luciferase":[184,193],"reporter":[185],"assay":[186],"using":[187],"CCNA2":[188,248],"promoter":[189],"suppression":[191],"activity":[194],"ZOL-treated":[196,221],"NHOK,":[197],"indicating":[198],"loss":[201],"A2":[204,216],"transcriptionally":[207],"regulated.":[208],"Immunohistochemistry":[209],"also":[210],"inhibition":[213,236],"NHOK":[219,238],"mucosa":[223],"tissue":[224,262],"constructs.":[225],"Our":[226],"through":[228],"profiling,":[233],"demonstrates":[234],"is,":[242],"part,":[244],"mediated":[245],"suppressing":[247],"at":[250],"transcriptional":[252],"level,":[253],"may":[255],"explain":[256],"toxicity":[263],"BPs.":[265]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
