{"id":"https://openalex.org/W2746264805","doi":"https://doi.org/10.1155/2017/4354723","title":"Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins","display_name":"Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2746264805","doi":"https://doi.org/10.1155/2017/4354723","mag":"2746264805","pmid":"https://pubmed.ncbi.nlm.nih.gov/28894619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5574310"},"language":"en","primary_location":{"id":"doi:10.1155/2017/4354723","doi":"https://doi.org/10.1155/2017/4354723","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2017/4354723","pdf_url":"http://downloads.hindawi.com/journals/jtr/2017/4354723.pdf","source":{"id":"https://openalex.org/S70918154","display_name":"Journal of Thyroid Research","issn_l":"2042-0072","issn":["2042-0072","2090-8067"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thyroid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/jtr/2017/4354723.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058904258","display_name":"Datis Kharrazian","orcid":"https://orcid.org/0000-0001-7985-476X","observed_orcids":["https://orcid.org/0000-0001-7985-476X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Datis Kharrazian","raw_affiliation_strings":["Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA","Harvard Medical School, Boston, MA, USA","TRANSCEND Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0001-7985-476X","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"TRANSCEND Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074539208","display_name":"Martha R. Herbert","orcid":"https://orcid.org/0000-0002-3775-5488","observed_orcids":["https://orcid.org/0000-0002-3775-5488"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Herbert","raw_affiliation_strings":["Harvard Medical School, Boston, MA, USA","TRANSCEND Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"TRANSCEND Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017537703","display_name":"Aristo Vojdani","orcid":"https://orcid.org/0000-0003-2925-9334","observed_orcids":["https://orcid.org/0000-0003-2925-9334"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210124820","display_name":"Immunosciences Lab (United States)","ror":"https://ror.org/030gh7x86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aristo Vojdani","raw_affiliation_strings":["Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA","Immunosciences Laboratory, Inc., Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2925-9334","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Immunosciences Laboratory, Inc., Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210124820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058904258"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I26347476","https://openalex.org/I4210087915"],"apc_list":{"value":950,"currency":"USD","value_usd":950},"apc_paid":{"value":950,"currency":"USD","value_usd":950},"fwci":1.3568,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79497614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2017","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-thyroid-disease","display_name":"autoimmune thyroid disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.7990000247955322},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.7509999871253967},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.996999979019165},{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.972000002861023},{"id":"https://openalex.org/keywords/5-deiodinase","display_name":"5'-deiodinase","score":0.921999990940094},{"id":"https://openalex.org/keywords/thyroid-peroxidase","display_name":"thyroid peroxidase","score":0.8339999914169312},{"id":"https://openalex.org/keywords/thyroxine-binding-globulin","display_name":"thyroxine-binding globulin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone-receptor","display_name":"thyroid-stimulating hormone receptor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/food-additives","display_name":"food additives","score":0.37299999594688416},{"id":"https://openalex.org/keywords/herbs-and-spices","display_name":"herbs and spices","score":0.7559999823570251},{"id":"https://openalex.org/keywords/food-gums","display_name":"food gums","score":0.5630000233650208},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.8158776164054871},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7506966590881348},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.7029293179512024},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.5842211246490479},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5774683952331543},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.562807559967041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5245100259780884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5229207277297974},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4732433259487152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46137937903404236},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.45531994104385376},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4259451925754547},{"id":"https://openalex.org/C2778417266","wikidata":"https://www.wikidata.org/wiki/Q24781273","display_name":"Deiodinase","level":4,"score":0.42551150918006897},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.421662300825119},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.41990137100219727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2996636927127838}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1155/2017/4354723","doi":"https://doi.org/10.1155/2017/4354723","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2017/4354723","pdf_url":"http://downloads.hindawi.com/journals/jtr/2017/4354723.pdf","source":{"id":"https://openalex.org/S70918154","display_name":"Journal of Thyroid Research","issn_l":"2042-0072","issn":["2042-0072","2090-8067"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thyroid Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4486423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5574310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28894619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28894619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thyroid research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5574310","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5574310/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Thyroid Res","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/34492006","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492006","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:af421c6d476e44c2b0699129fb72cc1f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/af421c6d476e44c2b0699129fb72cc1f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Thyroid Research, Vol 2017 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2017/4354723","doi":"https://doi.org/10.1155/2017/4354723","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2017/4354723","pdf_url":"http://downloads.hindawi.com/journals/jtr/2017/4354723.pdf","source":{"id":"https://openalex.org/S70918154","display_name":"Journal of Thyroid Research","issn_l":"2042-0072","issn":["2042-0072","2090-8067"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thyroid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2746264805.pdf","grobid_xml":"https://content.openalex.org/works/W2746264805.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W7277243","https://openalex.org/W34411496","https://openalex.org/W56091179","https://openalex.org/W70067030","https://openalex.org/W138608605","https://openalex.org/W180729608","https://openalex.org/W228409484","https://openalex.org/W243691000","https://openalex.org/W1966824338","https://openalex.org/W1970413119","https://openalex.org/W1975137944","https://openalex.org/W1982864270","https://openalex.org/W1986068446","https://openalex.org/W2004789352","https://openalex.org/W2019185580","https://openalex.org/W2021388819","https://openalex.org/W2032037634","https://openalex.org/W2032179286","https://openalex.org/W2064702948","https://openalex.org/W2069339982","https://openalex.org/W2070757349","https://openalex.org/W2085555367","https://openalex.org/W2090035003","https://openalex.org/W2092061269","https://openalex.org/W2106360167","https://openalex.org/W2108811019","https://openalex.org/W2110690572","https://openalex.org/W2118046075","https://openalex.org/W2122367407","https://openalex.org/W2146236621","https://openalex.org/W2147103913","https://openalex.org/W2199524936","https://openalex.org/W2257843062","https://openalex.org/W2421781351","https://openalex.org/W4242664181"],"related_works":["https://openalex.org/W3139507121","https://openalex.org/W4404997082","https://openalex.org/W1964694821","https://openalex.org/W367202074","https://openalex.org/W2056202026","https://openalex.org/W2061015790","https://openalex.org/W2152685219","https://openalex.org/W2415327204","https://openalex.org/W2767104343","https://openalex.org/W2061345584"],"abstract_inverted_index":{"Many":[0],"hypothyroid":[1],"and":[2,49,61,75,103,114,123,126,135,149,168,179],"autoimmune":[3,199],"thyroid":[4,29,47,50,66,70,72,97,147,176,200],"patients":[5],"experience":[6],"reactions":[7,143],"with":[8,46,144,159,164],"specific":[9,86,153],"foods.":[10],"Additionally,":[11],"food":[12,131,162],"interactions":[13],"may":[14,192],"play":[15,193],"a":[16,19,27,194],"role":[17,40,197],"in":[18,112,187,198],"subset":[20],"of":[21,41,83,172],"individuals":[22],"who":[23],"have":[24],"difficulty":[25],"finding":[26],"suitable":[28],"hormone":[30,93],"dosage.":[31],"Our":[32],"study":[33],"was":[34,157],"designed":[35],"to":[36],"investigate":[37],"the":[38,65,183],"potential":[39,195],"dietary":[42,59,108,140,180,190],"protein":[43,118,141],"immune":[44,56,81,142,155],"reactivity":[45,57,82,156],"hormones":[48],"axis":[51,67],"target":[52,62,85,177],"sites.":[53],"We":[54,78],"identified":[55,158],"between":[58,175],"proteins":[60,109,163,181,191],"sites":[63,178],"on":[64],"that":[68],"includes":[69],"hormones,":[71],"receptors,":[73],"enzymes,":[74],"transport":[76],"proteins.":[77],"also":[79],"measured":[80],"either":[84],"monoclonal":[87],"or":[88],"polyclonal":[89],"antibodies":[90],"for":[91],"thyroid-stimulating":[92],"(TSH)":[94],"receptor,":[95,146],"5'deiodinase,":[96],"peroxidase,":[98,148],"thyroglobulin,":[99,167],"thyroxine-binding":[100,150],"globulin,":[101],"thyroxine,":[102,166],"triiodothyronine":[104],"against":[105],"204":[106],"purified":[107,161],"commonly":[110],"consumed":[111],"cooked":[113],"raw":[115],"forms.":[116],"Dietary":[117],"determinants":[119],"included":[120],"unmodified":[121],"(raw)":[122],"modified":[124],"(cooked":[125],"roasted)":[127],"foods,":[128],"herbs,":[129],"spices,":[130],"gums,":[132],"brewed":[133],"beverages,":[134],"additives.":[136],"There":[137],"were":[138],"no":[139],"TSH":[145],"globulin.":[151],"However,":[152],"antigen-antibody":[154],"several":[160],"triiodothyronine,":[165],"5'deiodinase.":[169],"Laboratory":[170],"analysis":[171],"immunological":[173],"cross-reactivity":[174],"is":[182],"initial":[184],"step":[185],"necessary":[186],"determining":[188],"whether":[189],"immunoreactive":[196],"disease.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-08-31T00:00:00"}
