{"id":"https://openalex.org/W2746246740","doi":"https://doi.org/10.1158/0008-5472.can-17-1294","title":"S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma","display_name":"S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma","publication_year":2017,"publication_date":"2017-08-14","ids":{"openalex":"https://openalex.org/W2746246740","doi":"https://doi.org/10.1158/0008-5472.can-17-1294","mag":"2746246740","pmid":"https://pubmed.ncbi.nlm.nih.gov/28807938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5626628"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-17-1294","doi":"https://doi.org/10.1158/0008-5472.can-17-1294","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-17-1294","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5626628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042704409","display_name":"Kin-Hoe Chow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kin-Hoe Chow","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702736","display_name":"Hee Jung Park","orcid":"https://orcid.org/0000-0001-6278-7812","observed_orcids":["https://orcid.org/0000-0001-6278-7812"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hee Jung Park","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043408006","display_name":"Joshy George","orcid":"https://orcid.org/0000-0001-8510-8229","observed_orcids":["https://orcid.org/0000-0001-8510-8229"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshy George","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052576209","display_name":"Keiko Yamamoto","orcid":"https://orcid.org/0000-0003-2343-2984","observed_orcids":["https://orcid.org/0000-0003-2343-2984"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keiko Yamamoto","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080508466","display_name":"Andrew D. Gallup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Gallup","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069935132","display_name":"Joel H. Graber","orcid":"https://orcid.org/0000-0001-5137-4553","observed_orcids":["https://orcid.org/0000-0001-5137-4553"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel H. Graber","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011440144","display_name":"Yuanxin Chen","orcid":"https://orcid.org/0000-0002-9974-5525","observed_orcids":["https://orcid.org/0000-0002-9974-5525"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanxin Chen","raw_affiliation_strings":["2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida","3Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida","4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"3Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090210760","display_name":"Wen Jiang","orcid":"https://orcid.org/0000-0001-9154-633X","observed_orcids":["https://orcid.org/0000-0001-9154-633X","https://orcid.org/0000-0003-0612-2917","https://orcid.org/0000-0002-6073-3260","https://orcid.org/0000-0001-6858-2666"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Jiang","raw_affiliation_strings":["5Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069602380","display_name":"Dennis A. Steindler","orcid":"https://orcid.org/0000-0002-9891-8455","observed_orcids":["https://orcid.org/0000-0002-9891-8455"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis A. Steindler","raw_affiliation_strings":["6Neuroscience and Aging Laboratory, School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Neuroscience and Aging Laboratory, School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111972623","display_name":"Eric G. Neilson","orcid":"https://orcid.org/0009-0005-9550-3384","observed_orcids":["https://orcid.org/0009-0005-9550-3384"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric G. Neilson","raw_affiliation_strings":["7Feinberg School of Medicine, Northwestern University, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017997501","display_name":"Betty Y.S. Kim","orcid":"https://orcid.org/0000-0001-6890-8355","observed_orcids":["https://orcid.org/0000-0001-6890-8355"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Y.S. Kim","raw_affiliation_strings":["2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida","3Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida","4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"3Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012064648","display_name":"Kyuson Yun","orcid":"https://orcid.org/0000-0003-2253-4153","observed_orcids":["https://orcid.org/0000-0003-2253-4153"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kyuson Yun","raw_affiliation_strings":["1The Jackson Laboratory, Bar Harbor, Maine","8Kenneth R. Peak Brain and Pituitary Tumor Center, Department of Neurosurgery, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"8Kenneth R. Peak Brain and Pituitary Tumor Center, Department of Neurosurgery, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas","institution_ids":["https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5012064648"],"corresponding_institution_ids":["https://openalex.org/I4210115256","https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":6.2865,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.97574195,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"77","issue":"19","first_page":"5360","last_page":"5373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a4","display_name":"S100A4","score":1.0},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mesenchymal-transition","display_name":"mesenchymal transition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.6919999718666077},{"id":"https://openalex.org/keywords/snail2","display_name":"Snail2","score":0.7009999752044678},{"id":"https://openalex.org/keywords/zeb","display_name":"ZEB","score":0.9810000061988831},{"id":"https://openalex.org/keywords/perivascular-niche","display_name":"perivascular niche","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5529999732971191},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6819999814033508},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7806525230407715},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.7591665983200073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6882918477058411},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5752326846122742},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.573554515838623},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5522574186325073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127276182174683},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5031115412712097},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4948276877403259},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43422746658325195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20443028211593628},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.16539371013641357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14762353897094727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06504052877426147}],"mesh":[{"descriptor_ui":"D000071999","descriptor_name":"S100 Calcium-Binding Protein A4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071999","descriptor_name":"S100 Calcium-Binding Protein A4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-17-1294","doi":"https://doi.org/10.1158/0008-5472.can-17-1294","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-17-1294","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:28807938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28807938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5107873","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5626628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5626628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5626628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2017-1207","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2017/205","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2017","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5107873","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5626628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2830253492","display_name":"Comparative Biology of Tissue Repair, Regeneration and Aging","funder_award_id":"P20GM104318","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000870965","display_name":"Summer Research Experience in Neurobiology at the Jackson Laboratory","funder_award_id":"R25NS078795","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1775309324","https://openalex.org/W1835450443","https://openalex.org/W1842991947","https://openalex.org/W1906566368","https://openalex.org/W1972409029","https://openalex.org/W1975957651","https://openalex.org/W1988391379","https://openalex.org/W1995596330","https://openalex.org/W2000307839","https://openalex.org/W2001801229","https://openalex.org/W2010243889","https://openalex.org/W2011638977","https://openalex.org/W2014691022","https://openalex.org/W2018592996","https://openalex.org/W2020969391","https://openalex.org/W2024672608","https://openalex.org/W2029581617","https://openalex.org/W2033372592","https://openalex.org/W2039075677","https://openalex.org/W2039860425","https://openalex.org/W2043664496","https://openalex.org/W2048281866","https://openalex.org/W2060551076","https://openalex.org/W2078510083","https://openalex.org/W2083274861","https://openalex.org/W2091688245","https://openalex.org/W2093731683","https://openalex.org/W2102686515","https://openalex.org/W2107880288","https://openalex.org/W2110265246","https://openalex.org/W2111652340","https://openalex.org/W2111731443","https://openalex.org/W2113942802","https://openalex.org/W2115347412","https://openalex.org/W2119000874","https://openalex.org/W2123434257","https://openalex.org/W2135646984","https://openalex.org/W2149809213","https://openalex.org/W2152387543","https://openalex.org/W2160138651","https://openalex.org/W2161092951","https://openalex.org/W2161289668","https://openalex.org/W2165238621","https://openalex.org/W2205491921","https://openalex.org/W2329080279","https://openalex.org/W2397173338","https://openalex.org/W2397216211","https://openalex.org/W2587809552","https://openalex.org/W2607298867","https://openalex.org/W6676870797","https://openalex.org/W6712302557"],"related_works":["https://openalex.org/W2501022524","https://openalex.org/W2742045844","https://openalex.org/W2899557723","https://openalex.org/W2588583399","https://openalex.org/W2789687717","https://openalex.org/W2084296747","https://openalex.org/W2158151700","https://openalex.org/W4404230837","https://openalex.org/W2783074407","https://openalex.org/W3212173929"],"abstract_inverted_index":{"Abstract":[0],"Glioma":[1],"stem":[2],"cells":[3,37,44,66],"(GSC)":[4],"and":[5,15,48,75,91,121,147],"epithelial\u2013mesenchymal":[6],"transition":[7,127],"(EMT)":[8],"are":[9,22,40,60],"strongly":[10],"associated":[11],"with":[12,42,51,97,124],"therapy":[13],"resistance":[14],"tumor":[16,71],"recurrence,":[17],"but":[18],"the":[19,52,116],"underlying":[20],"mechanisms":[21],"incompletely":[23],"understood.":[24],"Here,":[25],"we":[26,107],"show":[27],"that":[28,45,109,144],"S100A4":[29,81,101,110,135,152],"is":[30,111],"a":[31,83,103,137,141,154],"novel":[32],"biomarker":[33],"of":[34,64,86,100,105,115],"GSCs.":[35],"S100A4+":[36],"in":[38,55,73,76,89,129,140,149],"gliomas":[39],"enriched":[41],"cancer":[43],"have":[46],"tumor-initiating":[47],"sphere-forming":[49],"abilities,":[50],"majority":[53],"located":[54],"perivascular":[56],"niches":[57],"where":[58],"GSCs":[59],"found.":[61],"Selective":[62],"ablation":[63],"S100A4-expressing":[65],"was":[67],"sufficient":[68],"to":[69],"block":[70],"growth":[72],"vitro":[74],"vivo.":[77],"We":[78],"also":[79],"identified":[80],"as":[82,102,136,153],"critical":[84],"regulator":[85,114],"GSC":[87],"self-renewal":[88],"mouse":[90],"patient-derived":[92],"glioma":[93],"tumorspheres.":[94],"In":[95],"contrast":[96],"previous":[98],"reports":[99],"reporter":[104],"EMT,":[106],"discovered":[108],"an":[112],"upstream":[113],"master":[117],"EMT":[118,148],"regulators":[119,128],"SNAIL2":[120],"ZEB":[122],"along":[123],"other":[125],"mesenchymal":[126],"glioblastoma.":[130],"Overall,":[131],"our":[132],"results":[133],"establish":[134],"central":[138],"node":[139],"molecular":[142],"network":[143],"controls":[145],"stemness":[146],"glioblastoma,":[150],"suggesting":[151],"candidate":[155],"therapeutic":[156],"target.":[157],"Cancer":[158],"Res;":[159],"77(19);":[160],"5360\u201373.":[161],"\u00a92017":[162],"AACR.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-31T00:00:00"}