{"id":"https://openalex.org/W2746091333","doi":"https://doi.org/10.1021/acs.biochem.7b00658","title":"Pathogenic Mutations Induce Partial Structural Changes in the Native \u03b2-Sheet Structure of Transthyretin and Accelerate Aggregation","display_name":"Pathogenic Mutations Induce Partial Structural Changes in the Native \u03b2-Sheet Structure of Transthyretin and Accelerate Aggregation","publication_year":2017,"publication_date":"2017-08-18","ids":{"openalex":"https://openalex.org/W2746091333","doi":"https://doi.org/10.1021/acs.biochem.7b00658","mag":"2746091333","pmid":"https://pubmed.ncbi.nlm.nih.gov/28820582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745580"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.7b00658","doi":"https://doi.org/10.1021/acs.biochem.7b00658","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00658","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039968882","display_name":"Kwang Hun Lim","orcid":"https://orcid.org/0000-0002-0971-200X","observed_orcids":["https://orcid.org/0000-0002-0971-200X"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kwang Hun Lim","raw_affiliation_strings":["Department\rof Chemistry, East Carolina University, Greenville, North Carolina 27858, United States"],"raw_orcid":"https://orcid.org/0000-0002-0971-200X","affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, East Carolina University, Greenville, North Carolina 27858, United States","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066566148","display_name":"Anvesh K. R. Dasari","orcid":"https://orcid.org/0000-0001-7248-1876","observed_orcids":["https://orcid.org/0000-0001-7248-1876"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anvesh K. R. Dasari","raw_affiliation_strings":["Department\rof Chemistry, East Carolina University, Greenville, North Carolina 27858, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, East Carolina University, Greenville, North Carolina 27858, United States","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005279646","display_name":"Renze Ma","orcid":"https://orcid.org/0000-0003-0437-351X","observed_orcids":["https://orcid.org/0000-0003-0437-351X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renze Ma","raw_affiliation_strings":["Department\rof Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708-0346, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708-0346, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073090269","display_name":"Ivan Hung","orcid":"https://orcid.org/0000-0001-8916-739X","observed_orcids":["https://orcid.org/0000-0001-8916-739X"]},"institutions":[{"id":"https://openalex.org/I4210132808","display_name":"National High Magnetic Field Laboratory","ror":"https://ror.org/03s53g630","country_code":"US","type":"facility","lineage":["https://openalex.org/I103163165","https://openalex.org/I1311060795","https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I33213144","https://openalex.org/I4210120050","https://openalex.org/I4210132808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Hung","raw_affiliation_strings":["Center\rof Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center\rof Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, United States","institution_ids":["https://openalex.org/I4210132808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081032200","display_name":"Zhehong Gan","orcid":"https://orcid.org/0000-0002-9855-5113","observed_orcids":["https://orcid.org/0000-0002-9855-5113"]},"institutions":[{"id":"https://openalex.org/I4210132808","display_name":"National High Magnetic Field Laboratory","ror":"https://ror.org/03s53g630","country_code":"US","type":"facility","lineage":["https://openalex.org/I103163165","https://openalex.org/I1311060795","https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I33213144","https://openalex.org/I4210120050","https://openalex.org/I4210132808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhehong Gan","raw_affiliation_strings":["Center\rof Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center\rof Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, United States","institution_ids":["https://openalex.org/I4210132808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081499831","display_name":"Jeffery W. Kelly","orcid":"https://orcid.org/0000-0001-8943-3395","observed_orcids":["https://orcid.org/0000-0001-8943-3395","https://orcid.org/0000-0003-4921-1135"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery W. Kelly","raw_affiliation_strings":["Department\rof Molecular and Experimental Medicine and Skaggs Institute for Chemical\rBiology, The Scripps Research Institute, La Jolla, California 92037, United States"],"raw_orcid":"https://orcid.org/0000-0001-8943-3395","affiliations":[{"raw_affiliation_string":"Department\rof Molecular and Experimental Medicine and Skaggs Institute for Chemical\rBiology, The Scripps Research Institute, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110978629","display_name":"Michael C. Fitzgerald","orcid":"https://orcid.org/0000-0002-6719-4722","observed_orcids":["https://orcid.org/0000-0002-6719-4722"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Fitzgerald","raw_affiliation_strings":["Department\rof Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708-0346, United States"],"raw_orcid":"https://orcid.org/0000-0002-6719-4722","affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708-0346, United States","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039968882"],"corresponding_institution_ids":["https://openalex.org/I186335123"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4517,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81143436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"56","issue":"36","first_page":"4808","last_page":"4818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.8669999837875366},{"id":"https://openalex.org/keywords/amyloid-core","display_name":"amyloid core","score":0.7620000243186951},{"id":"https://openalex.org/keywords/methionine-oxidation","display_name":"methionine oxidation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.40799999237060547},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7585328221321106},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7346348166465759},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.7346091270446777},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5973849296569824},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4866071939468384},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.4539574682712555},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43282926082611084},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4113597869873047},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3863150179386139},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3224601745605469},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.2301713526248932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11911982297897339},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08989390730857849},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0577065646648407},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biochem.7b00658","doi":"https://doi.org/10.1021/acs.biochem.7b00658","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00658","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:28820582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28820582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4655272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745580","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5745580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4655272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745580","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G148985590","display_name":"Mechanistic studies of transthyretin misfolding and amyloid formation through a c","funder_award_id":"R15NS084138","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1800297237","display_name":null,"funder_award_id":"DK 46335","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2348009746","display_name":"Solid-state NMR Structural Characterizations of Polymorphic Transthyretin Amyloids","funder_award_id":"R01NS097490","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5314500761","display_name":null,"funder_award_id":"NS097490","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7444057152","display_name":null,"funder_award_id":"NS084138","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G78043957","display_name":"Probing the biochemical mechanism of amyloid disease","funder_award_id":"R37DK046335","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000862409","display_name":"Probing the biochemical mechanism of amyloid disease","funder_award_id":"R01DK046335","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320333240","display_name":"Skaggs Institute for Chemical Biology, Scripps Research Institute","ror":null},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W219891006","https://openalex.org/W1508259544","https://openalex.org/W1871755391","https://openalex.org/W1964533214","https://openalex.org/W1967144890","https://openalex.org/W1971840315","https://openalex.org/W1973897761","https://openalex.org/W1980125299","https://openalex.org/W1982912456","https://openalex.org/W1983747484","https://openalex.org/W1985297174","https://openalex.org/W1992519329","https://openalex.org/W1994157101","https://openalex.org/W1997405117","https://openalex.org/W1997609831","https://openalex.org/W1999248724","https://openalex.org/W2005279391","https://openalex.org/W2008706884","https://openalex.org/W2009839154","https://openalex.org/W2011246655","https://openalex.org/W2011314617","https://openalex.org/W2011540010","https://openalex.org/W2011606718","https://openalex.org/W2013703514","https://openalex.org/W2013962664","https://openalex.org/W2014668312","https://openalex.org/W2014844151","https://openalex.org/W2014875724","https://openalex.org/W2015654033","https://openalex.org/W2019261756","https://openalex.org/W2021312533","https://openalex.org/W2022945618","https://openalex.org/W2023014768","https://openalex.org/W2025112049","https://openalex.org/W2037566762","https://openalex.org/W2041454099","https://openalex.org/W2049838034","https://openalex.org/W2049951693","https://openalex.org/W2050372354","https://openalex.org/W2059346748","https://openalex.org/W2060624358","https://openalex.org/W2060804178","https://openalex.org/W2067212206","https://openalex.org/W2072613948","https://openalex.org/W2075394788","https://openalex.org/W2081855136","https://openalex.org/W2084720360","https://openalex.org/W2091983900","https://openalex.org/W2092514245","https://openalex.org/W2092655393","https://openalex.org/W2094587801","https://openalex.org/W2105872266","https://openalex.org/W2116033626","https://openalex.org/W2122495582","https://openalex.org/W2126720648","https://openalex.org/W2129812451","https://openalex.org/W2154119752","https://openalex.org/W2171196571","https://openalex.org/W2266690651","https://openalex.org/W2309468815","https://openalex.org/W2314304229","https://openalex.org/W2324678298","https://openalex.org/W2329183655","https://openalex.org/W2335504284","https://openalex.org/W2416362275","https://openalex.org/W2510347503","https://openalex.org/W2952572878","https://openalex.org/W4235939487"],"related_works":["https://openalex.org/W2892967415","https://openalex.org/W2810511330","https://openalex.org/W2019304359","https://openalex.org/W2510347503","https://openalex.org/W1997405117","https://openalex.org/W2040310491","https://openalex.org/W2309468815","https://openalex.org/W2154119752","https://openalex.org/W2074129275","https://openalex.org/W2060804178"],"abstract_inverted_index":{"Amyloid":[0],"formation":[1],"of":[2,11,29,40,64,71,80,83,103,152,187,205,209,213,224],"natively":[3],"folded":[4,193],"proteins":[5],"involves":[6],"global":[7],"and/or":[8],"local":[9],"unfolding":[10],"the":[12,45,84,111,128,149,157,161,183,196,210,214,221,239,245,249,252,259],"native":[13,150,246],"state":[14,151],"to":[15,43,60,134,165],"form":[16],"aggregation-prone":[17],"intermediates.":[18],"Here":[19],"we":[20],"report":[21],"solid-state":[22,90],"nuclear":[23],"magnetic":[24],"resonance":[25],"(NMR)":[26],"structural":[27,46,62],"studies":[28],"amyloid":[30,69,100,118,131,168],"derived":[31],"from":[32,236],"wild-type":[33],"(WT)":[34],"and":[35,73,78,106,110,124,189,231],"more":[36,145,166],"aggressive":[37],"mutant":[38,75,112,130,190,197,261],"forms":[39,76],"transthyretin":[41],"(TTR)":[42],"investigate":[44,61],"changes":[47],"associated":[48],"with":[49,121,175],"effective":[50,167],"TTR":[51,96,113],"aggregation.":[52],"We":[53],"employed":[54],"selective":[55],"13":[56,85,87],"C":[57,88],"labeling":[58],"schemes":[59],"features":[63],"\u03b2-structured":[65],"core":[66,101,119],"regions":[67],"in":[68,148,238,244,258],"states":[70,186,199],"WT":[72,95,188,206],"two":[74],"(V30M":[77],"L55P)":[79],"TTR.":[81,207],"Analyses":[82,208],"C\u2013":[86],"correlation":[89],"NMR":[91,171],"spectra":[92],"revealed":[93,219],"that":[94,156,181,204,220,251],"aggregates":[97],"contain":[98],"an":[99],"consisting":[102],"nativelike":[104,122],"CBEF":[105,123],"DAGH":[107],"\u03b2-sheet":[108],"structures,":[109],"amyloids":[114],"adopt":[115,192],"a":[116,136],"similar":[117],"structure":[120],"AGH":[125],"\u03b2-structures.":[126],"However,":[127],"V30M":[129,240,260],"was":[132],"shown":[133],"have":[135],"different":[137],"DA":[138,162,253],"\u03b2-structure.":[139],"In":[140],"addition,":[141],"strand":[142],"D":[143,230],"is":[144,233],"disordered":[146],"even":[147],"L55P":[153],"TTR,":[154],"indicating":[155],"pathogenic":[158],"mutations":[159],"affect":[160],"\u03b2-structure,":[163],"leading":[164],"formation.":[169],"The":[170],"results":[172],"are":[173,200],"consistent":[174],"our":[176],"mass":[177],"spectrometry-based":[178],"thermodynamic":[179],"analyses":[180],"showed":[182],"amyloidogenic":[184],"precursor":[185,198],"TTRs":[191],"structures":[194],"but":[195],"less":[201],"stable":[202],"than":[203],"oxidation":[211,237],"rate":[212],"methionine":[215],"side":[216,222],"chain":[217,223],"also":[218],"residue":[225],"Met-30":[226],"pointing":[227],"between":[228],"strands":[229],"A":[232],"not":[234],"protected":[235,243],"mutant,":[241],"while":[242],"state,":[247],"supporting":[248],"possibility":[250],"\u03b2-structure":[254],"might":[255],"be":[256],"disrupted":[257],"amyloid.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-31T00:00:00"}