{"id":"https://openalex.org/W2746088136","doi":null,"title":"Fibulin-4A in zebrafish development","display_name":"Fibulin-4A in zebrafish development","publication_year":2017,"publication_date":"2017-06-29","ids":{"openalex":"https://openalex.org/W2746088136","mag":"2746088136"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:31143","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","pdf_url":"http://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068804535","display_name":"Sandeep Khatri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sandeep Khatri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068804535"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09258898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibulin-4","display_name":"fibulin-4","score":0.8429999947547913},{"id":"https://openalex.org/keywords/zebrafish-embryonic-development","display_name":"zebrafish embryonic development","score":0.8700000047683716},{"id":"https://openalex.org/keywords/elastic-fiber-formation","display_name":"elastic fiber formation","score":0.699999988079071},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cutis-laxa","display_name":"cutis laxa","score":0.8629999756813049},{"id":"https://openalex.org/keywords/notochord","display_name":"notochord","score":0.675000011920929},{"id":"https://openalex.org/keywords/somitogenesis","display_name":"somitogenesis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/vascular-progenitor-cells","display_name":"vascular progenitor cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/heart-field","display_name":"heart field","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cardiovascular-defects","display_name":"cardiovascular defects","score":0.7630000114440918},{"id":"https://openalex.org/keywords/musculoskeletal-defects","display_name":"musculoskeletal defects","score":0.8830000162124634},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.8360000252723694},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.5820000171661377},{"id":"https://openalex.org/keywords/rare-diseases","display_name":"rare diseases","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2776133846","wikidata":"https://www.wikidata.org/wiki/Q243469","display_name":"Notochord","level":4,"score":0.8706498146057129},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8674215078353882},{"id":"https://openalex.org/C2778122751","wikidata":"https://www.wikidata.org/wiki/Q5446488","display_name":"Fibulin","level":3,"score":0.7717664241790771},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7267707586288452},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.72001713514328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6879762411117554},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.4797045588493347},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43516066670417786},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41036325693130493},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3643001616001129},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.35413527488708496},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.33846181631088257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3221791386604309},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21512055397033691},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.14546826481819153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14514091610908508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12435215711593628},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:31143","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","pdf_url":"http://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2746088136","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/31143/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:31143","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","pdf_url":"http://d-scholarship.pitt.edu/31143/1/KhatriSandeep_edtpitt_April_2017.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2746088136.pdf","grobid_xml":"https://content.openalex.org/works/W2746088136.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W917998901","https://openalex.org/W1581754100","https://openalex.org/W1653019055","https://openalex.org/W1664754128","https://openalex.org/W1966371500","https://openalex.org/W1977059167","https://openalex.org/W1985876436","https://openalex.org/W1986853263","https://openalex.org/W1989896013","https://openalex.org/W1998975199","https://openalex.org/W1999068651","https://openalex.org/W2005509305","https://openalex.org/W2013282820","https://openalex.org/W2013322971","https://openalex.org/W2013971533","https://openalex.org/W2015718788","https://openalex.org/W2017217412","https://openalex.org/W2019002861","https://openalex.org/W2020686495","https://openalex.org/W2025808191","https://openalex.org/W2026088495","https://openalex.org/W2029236961","https://openalex.org/W2031924958","https://openalex.org/W2032622848","https://openalex.org/W2035653659","https://openalex.org/W2035876629","https://openalex.org/W2037115738","https://openalex.org/W2038046746","https://openalex.org/W2043157186","https://openalex.org/W2044069347","https://openalex.org/W2045348184","https://openalex.org/W2045371528","https://openalex.org/W2053146170","https://openalex.org/W2053497293","https://openalex.org/W2054248890","https://openalex.org/W2057967719","https://openalex.org/W2059139768","https://openalex.org/W2059599014","https://openalex.org/W2063485448","https://openalex.org/W2074629755","https://openalex.org/W2075873658","https://openalex.org/W2080367933","https://openalex.org/W2082144118","https://openalex.org/W2084119854","https://openalex.org/W2085633386","https://openalex.org/W2094165314","https://openalex.org/W2096251733","https://openalex.org/W2097212244","https://openalex.org/W2097273361","https://openalex.org/W2097762351","https://openalex.org/W2098643301","https://openalex.org/W2105683352","https://openalex.org/W2106053174","https://openalex.org/W2108085784","https://openalex.org/W2110693748","https://openalex.org/W2110954036","https://openalex.org/W2110994430","https://openalex.org/W2112475367","https://openalex.org/W2114154263","https://openalex.org/W2114232003","https://openalex.org/W2115182078","https://openalex.org/W2117200840","https://openalex.org/W2118995117","https://openalex.org/W2119792393","https://openalex.org/W2122588714","https://openalex.org/W2122935525","https://openalex.org/W2123515098","https://openalex.org/W2124836729","https://openalex.org/W2125349610","https://openalex.org/W2126393744","https://openalex.org/W2127663160","https://openalex.org/W2129608867","https://openalex.org/W2130886644","https://openalex.org/W2131054005","https://openalex.org/W2133200369","https://openalex.org/W2134268326","https://openalex.org/W2136963255","https://openalex.org/W2137724492","https://openalex.org/W2138946261","https://openalex.org/W2139930644","https://openalex.org/W2141279088","https://openalex.org/W2143149809","https://openalex.org/W2143286808","https://openalex.org/W2146071785","https://openalex.org/W2148669468","https://openalex.org/W2149069408","https://openalex.org/W2150043501","https://openalex.org/W2150504557","https://openalex.org/W2153194591","https://openalex.org/W2154568166","https://openalex.org/W2155290141","https://openalex.org/W2156262209","https://openalex.org/W2157810393","https://openalex.org/W2160475742","https://openalex.org/W2160514176","https://openalex.org/W2163330499","https://openalex.org/W2167504764","https://openalex.org/W2168870153","https://openalex.org/W2172114097","https://openalex.org/W2316067769","https://openalex.org/W2405919465","https://openalex.org/W4323284458"],"related_works":["https://openalex.org/W2471339369","https://openalex.org/W7212051935","https://openalex.org/W1948489980","https://openalex.org/W7035947935","https://openalex.org/W4389022458","https://openalex.org/W2054292017","https://openalex.org/W2610409093","https://openalex.org/W1986101467","https://openalex.org/W2077701521","https://openalex.org/W3176256244"],"abstract_inverted_index":{"Fibulin-4":[0],"is":[1,311],"an":[2,112,201,327],"extracellular":[3],"matrix":[4],"protein":[5,76,94],"required":[6],"for":[7,50,117,122,237,321,330],"the":[8,11,17,34,43,56,60,67,80,96,123,131,158,165,192,204,210,225,260,271,283,295,312],"formation":[9,86],"of":[10,37,42,90,130,155,181,188,203,209,227,247,273,308,314,323],"elastic":[12],"fibers.":[13],"Human":[14],"mutations":[15],"in":[16,55,66,95,104,164,213,266],"fibulin-4":[18,45],"gene":[19],"cause":[20],"autosomal":[21],"recessive":[22],"cutis":[23,325],"laxa":[24],"with":[25,191,254],"widespread":[26],"systemic":[27],"involvement":[28],"and":[29,65,70,93,111,145,169,176,196,207,243,262,279,297,300],"congenital":[30],"presentation.":[31],"To":[32,101],"study":[33],"developmental":[35],"functions":[36],"fibulin-4,":[38],"I":[39,275,286],"studied":[40],"one":[41],"two":[44],"genes,":[46],"fbln4a.":[47],"The":[48,304],"mRNA":[49,190],"fbln4a":[51,91,103,124,141,189,228,241],"RNA":[52,92],"was":[53,77],"expressed":[54],"adaxial":[57],"cells":[58],"around":[59],"notochord":[61,81,296],"during":[62,99],"somite":[63,85],"formation,":[64],"myosepta,":[68],"head,":[69,166],"heart":[71,170,205],"at":[72,148,157],"later":[73],"stages.":[74],"Fbln4a":[75,132,289],"localized":[78],"to":[79,224,337],"sheath":[82],"starting":[83],"from":[84,294],"suggesting":[87],"differential":[88],"expression":[89],"midline":[97],"structures":[98],"development.":[100],"inactivate":[102],"vivo,":[105],"we":[106],"used":[107],"a":[108,127,234,255,318],"retroviral":[109],"mutant":[110,242],"antisense":[113],"morpholino":[114],"oligonucleotide":[115],"(MO)":[116],"transient":[118],"knockdown.":[119],"Embryos":[120],"homozygous":[121],"mutation":[125],"showed":[126,200],"complete":[128],"loss":[129],"protein,":[133],"but":[134],"presented":[135],"no":[136,332],"obvious":[137],"gross":[138],"abnormalities.":[139],"However,":[140],"knockdown":[142,214,244,267],"yielded":[143],"cardiovascular":[144,261],"musculoskeletal":[146],"defects":[147],"2":[149],"days":[150],"post":[151],"fertilization":[152],"including":[153],"pooling":[154],"blood":[156],"caudal":[159],"vein":[160],"plexus,":[161],"vascular":[162,197,211,301],"hemorrhage":[163],"reduced":[167,177],"circulation":[168],"rate,":[171],"bent":[172],"notochord,":[173],"rounded":[174],"somites":[175],"embryo":[178],"length.":[179],"All":[180],"these":[182],"features":[183],"were":[184,218,222],"rescued":[185,258],"by":[186],"co-injection":[187],"MO.":[193],"Early":[194],"cardiac":[195,299],"progenitor":[198,302],"markers":[199],"expansion":[202],"field":[206],"reduction":[208],"fields":[212],"embryos.":[215,268],"Homozygous":[216],"mutants":[217],"resistant,":[219],"whereas":[220],"heterozygotes":[221],"sensitized":[223],"effect":[226],"MO,":[229],"protective":[230],"compensatory":[231],"mechanisms":[232],"as":[233,282,317],"possible":[235],"reason":[236],"phenotypic":[238],"discrepancy":[239],"between":[240],"animals.":[245],"Inhibition":[246],"transforming":[248],"growth":[249],"factor":[250],"beta":[251],"(Tgfb)":[252],"signaling":[253],"small":[256],"molecule":[257],"both":[259],"connective":[263],"tissue":[264],"anomalies":[265],"By":[269],"varying":[270],"period":[272],"treatment,":[274],"identified":[276],"late":[277],"gastrulation":[278],"early":[280],"segmentation":[281],"critical":[284],"periods.":[285],"conclude":[287],"that":[288],"inhibits":[290],"Tgfb":[291,315],"signals":[292],"emanating":[293],"regulates":[298],"pools.":[303],"public":[305],"health":[306],"significance":[307],"this":[309],"work":[310],"identification":[313],"inhibition":[316],"candidate":[319],"approach":[320],"treating":[322],"fibulin-4-related":[324],"laxa,":[326],"orphan":[328],"disease":[329],"which":[331],"treatment":[333],"has":[334],"been":[335],"available":[336],"date.":[338]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-08-31T00:00:00"}
