{"id":"https://openalex.org/W2745899784","doi":"https://doi.org/10.1161/01.hyp.36.suppl_1.685-c","title":"Effect of Antioxidants on Salt-Induced Hypertension and Renal Dysfunction.","display_name":"Effect of Antioxidants on Salt-Induced Hypertension and Renal Dysfunction.","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2745899784","doi":"https://doi.org/10.1161/01.hyp.36.suppl_1.685-c","mag":"2745899784"},"language":"en","primary_location":{"id":"mag:2745899784","doi":"https://doi.org/10.1161/01.hyp.36.suppl_1.685-c","is_oa":false,"landing_page_url":"http://hyper.ahajournals.org/content/36/Suppl_1/685.4","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hypertension","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049891784","display_name":"Mar\u00eda Rosa Trolliet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda R. Trolliet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059543131","display_name":"Patrick M. Forde","orcid":"https://orcid.org/0000-0001-6925-6344","observed_orcids":["https://orcid.org/0000-0001-6925-6344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick M. Forde","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6925-6344","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Murray A. Rudd","orcid":"https://orcid.org/0000-0001-9533-5070","observed_orcids":["https://orcid.org/0000-0001-9533-5070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murray A. Rudd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9533-5070","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028396638","display_name":"Joseph Loscalzo","orcid":"https://orcid.org/0000-0002-1153-8047","observed_orcids":["https://orcid.org/0000-0002-1153-8047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Loscalzo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1153-8047","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37546468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":null,"first_page":"685","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08820000290870667,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salt-sensitive-hypertension","display_name":"salt-sensitive hypertension","score":0.8629999756813049},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6949999928474426},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.7519999742507935},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6840000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9210000038146973},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.7310000061988831},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dahl-salt-resistant-rats","display_name":"Dahl salt-resistant rats","score":0.9580000042915344},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.6600000262260437},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.5860000252723694},{"id":"https://openalex.org/keywords/inulin-clearance","display_name":"inulin clearance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5040000081062317},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7480628490447998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7154449820518494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7142215967178345},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6641051769256592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6203233599662781},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5778008699417114},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5060924887657166},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4974105656147003},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4835605323314667},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.43230679631233215},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.4170778691768646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32726988196372986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17807996273040771},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06570148468017578}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2745899784","doi":"https://doi.org/10.1161/01.hyp.36.suppl_1.685-c","is_oa":false,"landing_page_url":"http://hyper.ahajournals.org/content/36/Suppl_1/685.4","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hypertension","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112606867","https://openalex.org/W2011927381","https://openalex.org/W202230205","https://openalex.org/W2007727705","https://openalex.org/W2012013333","https://openalex.org/W1511689500","https://openalex.org/W1987401718","https://openalex.org/W2064858030","https://openalex.org/W1991438746","https://openalex.org/W2014193928"],"abstract_inverted_index":{"43":[0],"We":[3],"have":[4,182],"demonstrated":[5],"that":[6,175,300,329],"the":[7,17,26,41,50,103,112,125,162,203,301,317,330,338],"development":[8,42,318],"of":[9,28,43,52,63,87,142,151,164,304,319,340],"salt-dependent":[10,64],"hypertension":[12,321,346],"and":[13,70,140,155,167,187,196,286,322,328,343,347],"renal":[14,46,193,323,348],"dysfunction":[15,324],"in":[16,310,316,325],"Dahl":[18,67],"salt-sensitive":[19],"(DSS)":[20],"rat":[21],"is":[23],"accompanied":[24],"by":[25],"accumulation":[27],"reactive":[29],"oxygen":[30],"species":[31],"(ROS).":[32],"To":[33],"determine":[35],"whether":[36],"oxidative":[37,152],"stress":[38],"contributes":[39],"to":[40,124,181],"progressive":[45],"dysfunction,":[47],"we":[48],"examined":[49],"effect":[51],"dietary":[53],"vitamin":[55,88,334],"E,":[56],"a":[57,61,148,314],"natural":[58],"antioxidant,":[59],"on":[60,75,111,116],"model":[62],"hypertension.":[66],"salt-resistant":[68],"(DSR)":[69],"DSS":[71,114,177,311],"rats":[72,115,127,179,206,312],"were":[73,120,158],"kept":[74],"8%":[76,81],"NaCl":[78,82],"(HS)":[79],"or":[80],"+":[83],"1000":[84],"U./kg":[85],"chow":[86],"E":[89,335],"(HSE)":[90],"for":[91,161],"2":[92,234,274],"weeks.":[94],"During":[95],"this":[96,326],"time":[97],"blood":[98,156],"pressure":[99],"was":[100],"monitored":[101],"using":[102],"tail":[104],"plethismography":[106],"method.":[107],"After":[108],"14":[109],"days":[110],"diets,":[113],"HS":[117],"diet":[118],"hypertensive,":[121],"as":[122],"compared":[123],"DSR":[126,205],"(171.3":[128],"\u00b1":[129,134,212,216,223,227,237,241,251,255,263,267,277,281,289,293],"7.4":[130],"vs.":[131,214,225,239,253,265,279,291],"138.4":[133],"2.4":[135],"mmHg;":[136],"p":[137,219,231,246],"PAH":[138,185,208,247],")":[139],"clearance":[141],"inulin":[143],"(Cl":[144,207],"In":[145,189,220,259],").":[146],"As":[147],"measure":[150],"stress,":[153],"kidney":[154],"samples":[157],"harvested":[159],"determination":[163],"superoxide":[165,194],"production":[166,303,339],"plasma":[168,198],"8-isoprostanes":[170],"(8-IP),":[171],"respectively.":[172],"Results":[173],"show":[174],"hypertensive":[176],"appear":[180],"lower":[183],"Cl":[184,188,258],",":[190],"greater":[192,197],"production,":[195],"8-IP":[199],"concentration":[201],"than":[202],"normotensive":[204],":":[209,221,235,248,260,275],"1.93":[211],"0.15":[213],"4.11":[215],"0.5":[217],"ml/min,":[218],"1.21":[222],"0.19":[224],"2.05":[226],"0.60":[228],"ml/min.,":[229],"-":[232,272],"664":[236],"33":[238],"374":[240],"13":[242],"nmol/mg":[244,283],"protein/min,":[245],"3.31":[250],"0.34":[252],"3.29":[254],"0.45":[256],"ml/min;":[257],"1.89":[262],"0.16":[264],"2.03":[266],"0.08":[268],"ml/min.;":[269],"O":[271],"372":[276],"10":[278],"344":[280],"23":[282],"protein/min;":[285],"8-IP:":[287],"276.1":[288],"33.2":[290],"278.5":[292],"28.3":[294],"pM).":[295],"These":[297],"results":[298],"suggest":[299],"incremental":[302],"ROS":[305,341],"during":[306],"salt":[308],"feeding":[309],"plays":[313],"role":[315],"model,":[327],"lipid-soluble":[332],"antioxidant":[333],"can":[336],"attenuate":[337],"prevent":[344],"salt-induced":[345],"dysfunction.":[350]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-31T00:00:00"}
