{"id":"https://openalex.org/W2745861997","doi":"https://doi.org/10.1093/neuros/nyx372","title":"3K3A-Activated Protein C and Implanted Neural Stem Cells Stimulate Repair and Functional Recovery After Ischemic Stroke","display_name":"3K3A-Activated Protein C and Implanted Neural Stem Cells Stimulate Repair and Functional Recovery After Ischemic Stroke","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2745861997","doi":"https://doi.org/10.1093/neuros/nyx372","mag":"2745861997","pmid":"https://pubmed.ncbi.nlm.nih.gov/28859455"},"language":"en","primary_location":{"id":"doi:10.1093/neuros/nyx372","doi":"https://doi.org/10.1093/neuros/nyx372","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyx372","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036576070","display_name":"Joslyn K. Strebe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joslyn K. Strebe","raw_affiliation_strings":["Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madison, Wisconsin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068981657","display_name":"Jonathan A. Lubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Lubin","raw_affiliation_strings":["Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madison, Wisconsin","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054371127","display_name":"John S. Kuo","orcid":"https://orcid.org/0000-0001-6809-4806","observed_orcids":["https://orcid.org/0000-0001-6809-4806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Kuo","raw_affiliation_strings":["Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madison, Wisconsin","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.116,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42617587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"81","issue":"3","first_page":"N20","last_page":"N21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neural-stem-cell-transplantation","display_name":"neural stem cell transplantation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fetal-neural-stem-cells","display_name":"fetal neural stem cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.6520000100135803},{"id":"https://openalex.org/keywords/sensorimotor-function","display_name":"sensorimotor function","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.42899999022483826},{"id":"https://openalex.org/keywords/cyclosporine-immunosuppression","display_name":"cyclosporine immunosuppression","score":0.8399999737739563},{"id":"https://openalex.org/keywords/stroke-rehabilitation","display_name":"stroke rehabilitation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/brain-regeneration","display_name":"brain regeneration","score":0.41600000858306885},{"id":"https://openalex.org/keywords/lentiviral-transduction","display_name":"lentiviral transduction","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8663779497146606},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7625576257705688},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6629303097724915},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5506488680839539},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4441399872303009},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4289303421974182},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4216799736022949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35139235854148865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3314670920372009},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32172298431396484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32032135128974915},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32030701637268066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19182276725769043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09239599108695984},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuros/nyx372","doi":"https://doi.org/10.1093/neuros/nyx372","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyx372","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:28859455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28859455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2507506174"],"related_works":["https://openalex.org/W2507506174","https://openalex.org/W1971288914","https://openalex.org/W2912475002","https://openalex.org/W2525410705","https://openalex.org/W2882986416","https://openalex.org/W2896978669","https://openalex.org/W3136209694","https://openalex.org/W4310986243","https://openalex.org/W3215729057","https://openalex.org/W2539582898"],"abstract_inverted_index":{"Stroke":[0],"is":[1,51,61,111,734],"a":[2,52,62,78,112,151,254,276,328,366,390,718,741],"leading":[3],"cause":[4],"of":[5,237,334,379,432,469,483,731,747],"death":[6],"and":[7,34,44,57,70,84,95,98,102,123,181,205,266,270,296,300,311,320,343,372,377,422,428,439,441,452,457,472,509,515,525,529,533,570,662,672,729,755,775,793,801],"disability":[8],"in":[9,77,105,142,158,214,226,248,382,604,654,699,709,740,750,772,782],"the":[10,159,249,323,356,460,464,467,470,481,628,634,745,763,796],"United":[11],"States.":[12],"Many":[13],"patients":[14],"have":[15],"long-term":[16,241],"functional":[17,45,103,344,613,690,797],"deficits":[18],"after":[19,184,281,316,346,437,519,641],"surviving":[20],"ischemic":[21,130,160],"strokes.":[22],"Current":[23],"treatments":[24],"for":[25,753],"stroke-related":[26],"brain":[27,74,119],"damage":[28,120,798],"are":[29,398,536],"focused":[30],"on":[31,309],"limiting":[32],"complications":[33],"preventing":[35],"additional":[36],"strokes,":[37],"but":[38,713],"do":[39],"not":[40,736],"directly":[41],"promote":[42],"regeneration":[43],"recovery.":[46],"Activated":[47],"protein":[48,593],"C":[49,373,384,594],"(APC)":[50],"blood":[53],"protease":[54],"with":[55,89,150,169,187,286,389,454,657,677,706],"anticoagulation":[56],"cell-signaling":[58],"activities;":[59],"3K3A-APC":[60,87,173,200,250,293,339,413,442,450,522,551,555,562],"recombinant":[63,172],"APC":[64],"developed":[65],"to":[66,72,116,232,447,466,633,648,660,688,703,761,769,779],"minimize":[67],"hemorrhagic":[68],"risk,":[69],"reported":[71],"stimulate":[73],"regenerative":[75,751],"potential":[76],"recent":[79],"Nature":[80,606],"Medicine":[81],"article.1":[82],"Wang":[83,584,621],"colleagues1":[85],"administered":[86],"combined":[88,324,443,786],"implanted":[90,157],"human":[91,171,600],"NSC":[92,224,242,264,440,691,733],"(neural":[93],"stem":[94,602],"progenitor":[96],"cells),":[97],"stimulated":[99],"circuit":[100,615],"restoration":[101],"recovery":[104],"post-stroke":[106],"mice.":[107,145,605],"This":[108,166],"treatment":[109,289,326,340,767],"regimen":[110],"promising":[113],"new":[114],"approach":[115],"possibly":[117],"treat":[118],"from":[121,230,385,463,578,627,799],"stroke":[122,754,783,800],"other":[124,288,725,756,802],"neurological":[125,757,803],"disorders.":[126,804],"In":[127,244,531,664],"this":[128,773],"study,":[129],"strokes":[131],"were":[132,156,194,211,353,651,667,686],"created":[133],"by":[134,337,418,499,503,567,576,599],"permanent":[135],"distal":[136],"middle":[137],"cerebral":[138],"artery":[139],"occlusion":[140],"(dMCAO)":[141],"8-wk-old":[143],"male":[144],"Human":[146],"fetal":[147],"NSCs":[148,202,206,210,295,387,411,415,453,524,528,549,560,564,675,698,749],"(transduced":[149],"lentiviral":[152,678],"luciferase":[153,218,246,380],"expression":[154,679],"vector)":[155],"mouse":[161],"brains":[162],"7":[163],"d":[164,183,436],"post-dMCAO.":[165],"was":[167,639],"followed":[168,502],"IV":[170],"or":[174,527,554,738],"vehicle":[175,198,291,297,417,448,520,526,553,566,661],"control":[176,227],"at":[177,355],"7,":[178],"9,":[179],"11,":[180],"13":[182],"dMCAO,":[185],"along":[186],"daily":[188],"cyclosporine":[189],"immunosuppression":[190],"(Figure":[191],"A).":[192],"There":[193],"4":[195,235],"experimental":[196],"groups:":[197,290],"alone,":[199,201,292,294,449,521,523],"+":[203,207,412,416,550,561,565],"vehicle,":[204],"3K3A-APC.":[208,530],"Implanted":[209],"examined":[212],"longitudinally":[213],"vivo":[215],"using":[216],"noninvasive":[217],"bioluminescence":[219],"imaging.":[220,362],"Luciferase":[221],"signal":[222,247,381],"(indicating":[223],"presence)":[225],"mice":[228,273,303,405,493,543,655,716],"declined":[229],"100%":[231],"36%":[233],"within":[234],"wk":[236,283,315],"implantation,":[238],"suggesting":[239],"poor":[240],"survival.":[243],"contrast,":[245],"treated":[251,656,715],"group":[252],"showed":[253,305,327,645,717],"time-dependent":[255],"increase":[256,258,708],"(1.9-5.3-fold":[257],"between":[259,669],"2-5":[260],"wk)":[261],"indicating":[262],"improved":[263],"survival":[265,336],"proliferation":[267],"(Figures":[268,298,318],"B":[269,371,376],"C).":[271],"3K3A-APC-treated":[272],"also":[274,304],"exhibited":[275],"significantly":[277],"higher":[278,720],"cortical-width":[279,433],"index":[280,434],"5":[282,314,395,404,488,492,542],"when":[284],"compared":[285,446,659],"all":[287,701],"D":[299,421,427],"E).":[301],"Treated":[302],"significant":[306],"sensorimotor":[307],"functions":[308],"rotarod":[310,512],"adhesive-removal":[312,516],"tests":[313],"dMCAO":[317,438],"F":[319,508,514,532],"G).":[321],"Clearly,":[322],"3K3A-APC/NSC":[325,618,714,787],"substantial":[329,653],"post-ischemic":[330],"repair":[331,598],"potential.Figure.:":[332],"Promotion":[333],"NSC-transplant":[335],"late":[338],"improves":[341],"structural":[342],"outcomes":[345],"dMCAO.":[347,642],"A,":[348],"Experimental":[349],"design:":[350],"outcome":[351],"parameters":[352],"measured":[354],"indicated":[357],"times.":[358],"VSD,":[359],"voltage-sensitive":[360],"dye":[361],"Dashed":[363,476],"arrows":[364],"represent":[365],"separate":[367],"extended":[368],"longitudinal":[369],"experiment.":[370],"Bioluminescence":[374],"imaging":[375],"quantification":[378],"Vivo":[383,425],"engrafted":[386],"transduced":[388,676],"CMV-GFP-T2A-luciferase":[391],"lentivirus.":[392],"Scale":[393,486],"bar,":[394,487],"mm;":[396],"values":[397,535],"means":[399,537],"\u00b1":[400,538],"s.d.;":[401,539],"n":[402,490,540],"=":[403,491,541],"per":[406,494,544],"group;":[407,495,545],"**P":[408,557],"<":[409,497,547,558],".05,":[410,548,559],"vs":[414,552,563],"Student's":[419],"t-test.":[420],"E":[423,431],"Ex":[424],"images":[426],"scatter":[429],"plot":[430],"35":[435],"treatment,":[444],"as":[445],"alone":[451],"vehicle;":[455],"x":[456],"y":[458],"mark":[459],"maximum":[461],"width":[462],"midline":[465],"edge":[468,482],"infarcted":[471],"noninfarcted":[473],"hemispheres,":[474],"respectively.":[475],"line,":[477],"mirror":[478],"image":[479],"showing":[480],"contralateral":[484],"hemisphere.":[485],"mm.":[489],"P":[496],".05":[498],"1-way":[500,568],"ANOVA":[501,569],"Bonferroni's":[504,571],"post":[505,572],"hoc":[506,573],"test.":[507,574],"G":[510,518],"The":[511,696,785],"test":[513,517],"G,":[534],"*P":[546],"alone;":[556],"Reprinted":[575],"permission":[577],"Macmillan":[579],"Publishers":[580],"Ltd:":[581],"NATURE":[582],"MEDICINE,":[583],"Y,":[585],"Zhao":[586],"Z,":[587],"Rege":[588],"SV":[589],"et":[590,622],"al.":[591],"3K3A-activated":[592],"stimulates":[595,790],"postischemic":[596],"neuronal":[597,614,694],"neural":[601],"cells":[603],"Med.":[607],"2016":[608],"Sep;22(9):1050-5,1":[609],"copyright":[610],"2016.To":[611],"demonstrate":[612],"integration":[616,692],"following":[617],"combination":[619],"therapy,":[620],"al1":[623],"traced":[624],"axonal":[625],"projection":[626],"primary":[629],"motor":[630],"cortex":[631],"(M1)":[632],"somatosensory":[635],"region":[636],"(S1)":[637],"that":[638,646],"damaged":[640],"Anterograde":[643],"labeling":[644],"projections":[647],"stroke-damaged":[649],"S1":[650,700],"more":[652],"3K3A-APC/NSCs":[658],"NSCs.":[663],"addition,":[665],"synapses":[666],"observed":[668],"host":[670],"neurons":[671],"NSC-derived":[673],"neurons.":[674],"vectors":[680],"carrying":[681],"intracellular":[682],"calcium":[683],"indicator":[684],"(GCaMP3)":[685],"used":[687],"assess":[689],"into":[693],"circuitry.":[695],"GCaMP3-expressing":[697],"responded":[702],"forelimb":[704],"stimulation":[705],"an":[707],"transcranial":[710],"GFP":[711],"fluorescence,":[712],"3-fold":[719],"average":[721],"peak":[722],"amplitude":[723],"than":[724],"groups.":[726],"Since":[727],"creation":[728],"validation":[730],"personalized":[732],"still":[735,759],"easy":[737],"practical":[739],"rapid":[742],"time":[743],"scale,":[744],"use":[746],"generic":[748],"therapies":[752],"disorders":[758],"needs":[760],"overcome":[762],"immunogenic":[764],"challenge.":[765],"Cyclosporine":[766],"appears":[768],"be":[770,777],"sufficient":[771],"report,":[774],"could":[776,794],"translated":[778],"clinical":[780],"trials":[781],"patients.":[784],"therapy":[788],"strongly":[789],"neurogenic":[791],"regeneration,":[792],"ameliorate":[795]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-08-31T00:00:00"}
