{"id":"https://openalex.org/W2745754128","doi":"https://doi.org/10.1093/ofid/ofx163.031","title":"QTc Prolongation in Patients Receiving Triazoles and Amiodarone","display_name":"QTc Prolongation in Patients Receiving Triazoles and Amiodarone","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2745754128","doi":"https://doi.org/10.1093/ofid/ofx163.031","mag":"2745754128"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofx163.031","doi":"https://doi.org/10.1093/ofid/ofx163.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.031","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofx163.031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Katherine Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132446568","display_name":"Campbell University","ror":"https://ror.org/00dv9q566","country_code":"US","type":"education","lineage":["https://openalex.org/I132446568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Cook","raw_affiliation_strings":["Pharmacy, Campbell University College of Pharmacy and Health Sciences, Buies Creek, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Campbell University College of Pharmacy and Health Sciences, Buies Creek, North Carolina","institution_ids":["https://openalex.org/I132446568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090924698","display_name":"Thitinan Sraubol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132446568","display_name":"Campbell University","ror":"https://ror.org/00dv9q566","country_code":"US","type":"education","lineage":["https://openalex.org/I132446568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thitinan Sraubol","raw_affiliation_strings":["Pharmacy, Campbell University College of Pharmacy and Health Sciences, Buies Creek, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Campbell University College of Pharmacy and Health Sciences, Buies Creek, North Carolina","institution_ids":["https://openalex.org/I132446568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007074190","display_name":"Kristen Bova Campbell","orcid":"https://orcid.org/0000-0001-7729-6434","observed_orcids":["https://orcid.org/0000-0001-7729-6434"]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Bova Campbell","raw_affiliation_strings":["Pharmacy, Duke University Hospital, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Duke University Hospital, Durham, North Carolina","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074036584","display_name":"Ahmad Mourad","orcid":"https://orcid.org/0000-0002-3149-597X","observed_orcids":["https://orcid.org/0000-0002-3149-597X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Mourad","raw_affiliation_strings":["Medicine, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024970293","display_name":"Jonathan A. Stiber","orcid":"https://orcid.org/0000-0002-2301-585X","observed_orcids":["https://orcid.org/0000-0002-2301-585X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Stiber","raw_affiliation_strings":["Medicine, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028777325","display_name":"John R. Perfect","orcid":"https://orcid.org/0000-0002-8742-3676","observed_orcids":["https://orcid.org/0000-0002-8742-3676","https://orcid.org/0000-0003-0019-8638"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R Perfect","raw_affiliation_strings":["Medicine, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028005649","display_name":"Melissa D. Johnson","orcid":"https://orcid.org/0000-0002-6606-9460","observed_orcids":["https://orcid.org/0000-0002-6606-9460"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Johnson","raw_affiliation_strings":["Medicine, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"suppl_1","first_page":"S84","last_page":"S84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/triazole-antifungals","display_name":"triazole antifungals","score":0.875},{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.7730000019073486},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"torsades de pointes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.890999972820282},{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.996999979019165},{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":0.5860000252723694},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.4490000009536743},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cardiac-safety","display_name":"cardiac safety","score":0.3919999897480011},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"electrocardiogram","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9394168853759766},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.839372456073761},{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.7508028745651245},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.7395541667938232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6186123490333557},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5089468955993652},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.4722387492656708},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.42250674962997437},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.4114750325679779},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3459683954715729},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.14518669247627258}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofx163.031","doi":"https://doi.org/10.1093/ofid/ofx163.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.031","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5631856","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5631856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofx163.031","doi":"https://doi.org/10.1093/ofid/ofx163.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.031","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2896094597","https://openalex.org/W2152047191","https://openalex.org/W4401417429","https://openalex.org/W7134255350","https://openalex.org/W2431601587","https://openalex.org/W2208576654","https://openalex.org/W2014740122","https://openalex.org/W2030057176","https://openalex.org/W4417427875","https://openalex.org/W7223553975"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Prolonged":[2],"QT":[3,29,41,129],"interval":[4,130,298],"may":[5],"lead":[6],"to":[7,21,83,122,136,142,170,289,315,326,333],"ventricular":[8,162],"arrhythmias,":[9],"torsade":[10],"de":[11],"pointes":[12],"and":[13,26,42,79,106,153,211,242,249,309],"sudden":[14],"death.":[15],"Triazole":[16],"antifungals":[17],"are":[18,331],"often":[19],"administered":[20],"inpatients":[22,68],"with":[23,27,267],"cardiac":[24,166,283],"disease":[25],"other":[28,165,343],"prolonging":[30,345],"drugs.":[31],"Amiodarone":[32],"is":[33,55,313],"a":[34,61,200,247],"commonly":[35],"used":[36,121,141],"antiarrhythmic":[37],"that":[38],"can":[39],"prolong":[40],"be":[43,327],"proarrhythmic":[44],"but":[45,259,324],"safety":[46,336],"of":[47,66,100,114,145,161,202,207,216,244,295,305,337,342],"co-administering":[48],"these":[49],"agents":[50],"in":[51,127,228,287,302,317,339],"the":[52,124,296,340],"clinical":[53,172],"setting":[54,341],"not":[56,260],"known.":[57],"Methods":[58],"We":[59],"conducted":[60],"retrospective,":[62],"observational":[63],"cohort":[64,304],"study":[65],"adult":[67],"at":[69],"Duke":[70],"University":[71],"Medical":[72],"Center":[73],"who":[74],"received":[75,187],"concomitant":[76,102,115,217,290],"systemic":[77],"azoles":[78,308,338],"amiodarone":[80],"from":[81,134,233],"2007":[82],"2013.":[84],"Included":[85],"subjects":[86,177,245],"had":[87,180,246],"\u22651":[88,107],"electrocardiogram":[89],"(EKG)":[90],"performed":[91],"while":[92],"receiving":[93,307],"either":[94],"agent":[95],"alone":[96],"within":[97],"1":[98],"month":[99],"starting":[101],"therapy":[103,218],"(baseline,":[104],"BL)":[105],"follow-up":[108],"(FU)":[109],"EKG":[110,181],"after":[111],"\u22652":[112],"days":[113,221],"therapy.":[116,292],"A":[117],"paired":[118],"t-test":[119],"was":[120,140,219,230,265,280,299],"assess":[123,171,316],"maximum":[125],"change":[126,227],"corrected":[128],"(QTc,":[131],"Bazett\u2019s":[132],"correction)":[133],"BL":[135,154,234,248,255],"FU.":[137],"Logistic":[138],"regression":[139],"evaluate":[143,335],"predictors":[144],"FU":[146,250,268],"QTc":[147,155,229,251,256,269,297,344],"\u2265500":[148,156,252,257,270],"ms":[149,232,258,271],"(age,":[150],"race,":[151,262],"gender,":[152],"ms).":[157],"Patient":[158],"discharge":[159],"diagnoses":[160],"arrhythmias":[163],"or":[164,195,263],"events":[167,284],"were":[168,188,199,285],"reviewed":[169],"outcome.":[173],"Results":[174],"Of":[175],"816":[176],"identified,":[178],"252":[179],"results":[182],"eligible":[183],"for":[184],"analysis.":[185],"Azoles":[186],"fluconazole":[189],"(86.5%),":[190],"voriconazole":[191],"(11.5%),":[192],"posaconazole":[193],"(1.6%)":[194],"itraconazole":[196],"(0.4%).":[197],"Subjects":[198],"median":[201],"65":[203],"(IQR":[204,222],"25\u201388)":[205],"years":[206],"age,":[208,261],"64.3%":[209],"male":[210],"78.6%":[212],"Caucasian.":[213],"Median":[214],"duration":[215],"7":[220],"4\u201311":[223],"days).":[224],"Mean":[225],"maximal":[226],"+32":[231],"(95%":[235],"CI":[236,275],"26.2\u201338.6,":[237],"P":[238],"<":[239],"0.0001).":[240],"25.4":[241],"48.8%":[243],"ms,":[253],"respectively.":[254],"gender":[264],"associated":[266],"(OR":[272],"6.32":[273],"95%":[274],"3.21\u201312.43).":[276],"Thirty-day":[277],"all-cause":[278],"mortality":[279],"26.2%.":[281],"No":[282,350],"apparent":[286],"relation":[288],"azole-amiodarone":[291],"Conclusion":[293],"Prolongation":[294],"frequently":[300],"observed":[301],"this":[303,318],"patients":[306],"amiodarone.":[310],"Clinical":[311],"impact":[312],"challenging":[314],"critically":[319],"ill,":[320],"complex":[321],"patient":[322],"population":[323],"appears":[325],"limited.":[328],"Additional":[329],"analyses":[330],"needed":[332],"further":[334],"agents.":[346],"Disclosures":[347],"All":[348],"authors:":[349],"reported":[351],"disclosures.":[352]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-08-31T00:00:00"}