{"id":"https://openalex.org/W2745332172","doi":null,"title":"Evaluating sex differences and the effect of perinatal testosterone in the VPA mouse model of autism","display_name":"Evaluating sex differences and the effect of perinatal testosterone in the VPA mouse model of autism","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2745332172","mag":"2745332172"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.murraystate.edu:postersatthecapitol-1156","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.murraystate.edu/postersatthecapitol/2017/UL/10","pdf_url":null,"source":{"id":"https://openalex.org/S4377196635","display_name":"Murray State's Digital Commons (Murray State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I127362389","host_organization_name":"Murray State University","host_organization_lineage":["https://openalex.org/I127362389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Posters-at-the-Capitol","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kristen R. Hamilton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristen R. Hamilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"E.L. Bryan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.L. Bryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20930857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.796999990940094},{"id":"https://openalex.org/keywords/prenatal-testosterone","display_name":"prenatal testosterone","score":0.4410000145435333},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9139999747276306},{"id":"https://openalex.org/keywords/masculinization","display_name":"masculinization","score":0.6629999876022339},{"id":"https://openalex.org/keywords/motor-development","display_name":"motor development","score":0.8169999718666077},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6570000052452087},{"id":"https://openalex.org/keywords/sociability","display_name":"sociability","score":0.9549999833106995},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.675000011920929},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.6869999766349792},{"id":"https://openalex.org/keywords/wheel-running","display_name":"wheel running","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cognitive-rigidity","display_name":"cognitive rigidity","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7551604509353638},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.642098069190979},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.46021923422813416},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4576728343963623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34824371337890625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34367164969444275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23641860485076904}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.murraystate.edu:postersatthecapitol-1156","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.murraystate.edu/postersatthecapitol/2017/UL/10","pdf_url":null,"source":{"id":"https://openalex.org/S4377196635","display_name":"Murray State's Digital Commons (Murray State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I127362389","host_organization_name":"Murray State University","host_organization_lineage":["https://openalex.org/I127362389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Posters-at-the-Capitol","raw_type":"text"},{"id":"mag:2745332172","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.murraystate.edu/postersatthecapitol/2017/UL/10/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3183432498","https://openalex.org/W2591604473","https://openalex.org/W4413990808","https://openalex.org/W4409280246","https://openalex.org/W2973024503","https://openalex.org/W4319037051","https://openalex.org/W4205813349","https://openalex.org/W7211913030","https://openalex.org/W2408968750","https://openalex.org/W2017055292"],"abstract_inverted_index":{"Autism":[0],"spectrum":[1],"disorder":[2],"(ASD)":[3],"is":[4],"more":[5,65],"common":[6],"in":[7,40,107,118,121,130,143,163],"males":[8,137],"than":[9],"females,":[10,187],"but":[11],"the":[12,55,144,160,164,169,173],"mechanism":[13],"of":[14,21,50,54,60,127,155,189,234,244],"this":[15,73],"bias":[16],"remains":[17],"unknown.":[18],"Elevated":[19],"levels":[20],"fetal":[22],"testosterone":[23,93],"(fT)":[24],"have":[25,140],"been":[26],"correlated":[27],"with":[28,62,92],"ASD":[29,38,51],"diagnosis.":[30],"Valproic":[31],"acid":[32],"(VPA),":[33,84],"an":[34,242],"antiepileptic":[35],"medication,":[36],"increases":[37],"risk":[39,104],"humans":[41],"when":[42],"used":[43,72],"during":[44],"pregnancy.":[45],"The":[46],"VPA":[47,69,98,116,222,239],"rodent":[48],"model":[49,74],"mimics":[52],"many":[53],"behavioral":[56],"and":[57,85,111,125,153,159,183],"morphological":[58],"features":[59],"ASD,":[61],"male":[63],"rodents":[64],"vulnerable":[66],"to":[67,75,81,86,139,212,238],"some":[68],"effects.":[70],"We":[71,113],"test":[76],"differential":[77],"susceptibility":[78],"by":[79,150,197],"sex":[80,235],"prenatal":[82,97,221],"insult":[83],"determine":[87],"whether":[88],"masculinizing":[89],"females":[90],"perinatally":[91],"propionate":[94],"(TP)":[95],"following":[96,200],"treatment":[99,190,213,223,240],"would":[100],"also":[101],"masculinize":[102],"their":[103],"for":[105],"abnormalities":[106],"ASD-related":[108],"brain":[109],"development":[110,129,132],"behavior.":[112],"demonstrated":[114],"that":[115,207,220],"exposure":[117],"utero":[119],"resulted":[120],"both":[122],"delayed":[123],"maturation":[124],"regression":[126],"skill":[128],"motor":[131,225],"tests.":[133],"In":[134,172],"addition,":[135],"VPA-TP":[136],"appeared":[138],"reduced":[141],"anxiety":[142],"elevated":[145],"plus":[146],"maze,":[147],"as":[148,195],"measured":[149,196],"increased":[151],"frequency":[152],"duration":[154,162],"open":[156],"arm":[157],"entries":[158],"shortest":[161],"closed":[165],"arms,":[166],"while":[167],"displaying":[168],"highest":[170],"velocity.":[171],"wheel":[174],"running":[175],"assay":[176],"all":[177],"mice":[178],"displayed":[179,192],"normal":[180],"routine":[181],"gaining":[182],"cognitive":[184],"rigidity;":[185],"however,":[186,227],"regardless":[188],"group,":[191],"higher":[193],"sociability":[194],"time":[198],"spent":[199],"a":[201],"novel":[202],"mouse.":[203],"Finally,":[204],"we":[205,228],"found":[206],"cerebellum":[208],"volume":[209],"was":[210],"unrelated":[211],"group.":[214],"Our":[215],"study":[216],"supports":[217],"previous":[218],"findings":[219],"impacts":[224],"development;":[226],"did":[229],"not":[230],"find":[231],"major":[232],"effects":[233],"on":[236],"vulnerability":[237],"or":[241],"effect":[243],"perinatal":[245],"testosterone.":[246]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-08-31T00:00:00"}