{"id":"https://openalex.org/W2744891122","doi":"https://doi.org/10.1371/journal.pone.0181913","title":"Evolution of Caenorhabditis elegans host defense under selection by the bacterial parasite Serratia marcescens","display_name":"Evolution of Caenorhabditis elegans host defense under selection by the bacterial parasite Serratia marcescens","publication_year":2017,"publication_date":"2017-08-09","ids":{"openalex":"https://openalex.org/W2744891122","doi":"https://doi.org/10.1371/journal.pone.0181913","mag":"2744891122","pmid":"https://pubmed.ncbi.nlm.nih.gov/28792961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5549931"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0181913","doi":"https://doi.org/10.1371/journal.pone.0181913","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0181913","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181913&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181913&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042373306","display_name":"McKenna J. Penley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"McKenna J. Penley","raw_affiliation_strings":["Department of Biology, Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006402888","display_name":"Giang T. Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giang T. Ha","raw_affiliation_strings":["Department of Biology, Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014643355","display_name":"Levi T. Morran","orcid":"https://orcid.org/0000-0002-6422-0374","observed_orcids":["https://orcid.org/0000-0002-6422-0374"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Levi T. Morran","raw_affiliation_strings":["Department of Biology, Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014643355"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.9053,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74524526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"e0181913","last_page":"e0181913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10815","display_name":"Parasite Biology and Host Interactions","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host-parasite-coevolution","display_name":"host-parasite coevolution","score":0.8920000195503235},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.6800000071525574},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.925000011920929},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9879999756813049},{"id":"https://openalex.org/keywords/self-fertilization","display_name":"self-fertilization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/outcrossing","display_name":"outcrossing","score":0.906000018119812},{"id":"https://openalex.org/keywords/mating-systems","display_name":"mating systems","score":0.7720000147819519},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.8479999899864197},{"id":"https://openalex.org/keywords/life-history","display_name":"life history","score":0.4869999885559082},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6880000233650208},{"id":"https://openalex.org/keywords/fecundity","display_name":"fecundity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/breeding-phenology","display_name":"breeding phenology","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rate-of-adaptation","display_name":"rate of adaptation","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9003722667694092},{"id":"https://openalex.org/C107917433","wikidata":"https://www.wikidata.org/wiki/Q779009","display_name":"Outcrossing","level":3,"score":0.8822116851806641},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.740358829498291},{"id":"https://openalex.org/C2780926781","wikidata":"https://www.wikidata.org/wiki/Q24344273","display_name":"Selfing","level":3,"score":0.701644778251648},{"id":"https://openalex.org/C514575182","wikidata":"https://www.wikidata.org/wiki/Q228395","display_name":"Mating","level":2,"score":0.6764996647834778},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6608293056488037},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5976773500442505},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5602524280548096},{"id":"https://openalex.org/C116402615","wikidata":"https://www.wikidata.org/wiki/Q4584563","display_name":"Mating system","level":3,"score":0.5491346716880798},{"id":"https://openalex.org/C2780354846","wikidata":"https://www.wikidata.org/wiki/Q24962946","display_name":"Local adaptation","level":3,"score":0.41147294640541077},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.41131290793418884},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3797285258769989},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.30983906984329224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18875044584274292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09631502628326416},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.05327051877975464},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C2780618852","wikidata":"https://www.wikidata.org/wiki/Q79932","display_name":"Pollen","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012706","descriptor_name":"Serratia marcescens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012706","descriptor_name":"Serratia marcescens","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057945","descriptor_name":"Self-Fertilization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0181913","doi":"https://doi.org/10.1371/journal.pone.0181913","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0181913","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181913&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5549931","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5549931","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:28792961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28792961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e5f55389b2e34f9aa580898023a8b575","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5f55389b2e34f9aa580898023a8b575","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 8, p e0181913 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5294476","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evolution_of_i_Caenorhabditis_elegans_i_host_defense_under_selection_by_the_bacterial_parasite_i_Serratia_marcescens_i_/5294476","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0181913","doi":"https://doi.org/10.1371/journal.pone.0181913","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0181913","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181913&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2744891122.pdf","grobid_xml":"https://content.openalex.org/works/W2744891122.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1887269475","https://openalex.org/W1944127002","https://openalex.org/W1966293708","https://openalex.org/W1969810322","https://openalex.org/W1978705062","https://openalex.org/W1980232909","https://openalex.org/W1984067346","https://openalex.org/W1992363450","https://openalex.org/W2004778468","https://openalex.org/W2005670649","https://openalex.org/W2013977400","https://openalex.org/W2014496483","https://openalex.org/W2020020396","https://openalex.org/W2026531906","https://openalex.org/W2032240789","https://openalex.org/W2032319419","https://openalex.org/W2039816485","https://openalex.org/W2056580026","https://openalex.org/W2066227234","https://openalex.org/W2068625309","https://openalex.org/W2073784722","https://openalex.org/W2084071695","https://openalex.org/W2095957977","https://openalex.org/W2097065022","https://openalex.org/W2108432836","https://openalex.org/W2109947766","https://openalex.org/W2116312978","https://openalex.org/W2118020384","https://openalex.org/W2124633191","https://openalex.org/W2127588110","https://openalex.org/W2130315111","https://openalex.org/W2130582949","https://openalex.org/W2139260005","https://openalex.org/W2139822044","https://openalex.org/W2144549988","https://openalex.org/W2146182675","https://openalex.org/W2148206764","https://openalex.org/W2155668551","https://openalex.org/W2157158700","https://openalex.org/W2160591054","https://openalex.org/W2167243456","https://openalex.org/W2171760913","https://openalex.org/W2316973238","https://openalex.org/W2331649897","https://openalex.org/W2344656304","https://openalex.org/W4232591682","https://openalex.org/W4235889269"],"related_works":["https://openalex.org/W2731324396","https://openalex.org/W1969810322","https://openalex.org/W6929556952","https://openalex.org/W2808139571","https://openalex.org/W6929390791","https://openalex.org/W6929623418","https://openalex.org/W2344656304","https://openalex.org/W7167848614","https://openalex.org/W2891309530","https://openalex.org/W7214115614"],"abstract_inverted_index":{"Parasites":[0],"can":[1,44],"impose":[2],"strong":[3],"selection":[4],"on":[5,48],"hosts.":[6],"In":[7],"response,":[8],"some":[9],"host":[10,27,37,52,66,94,110,134,156,185,223,229,234,251],"populations":[11,28,67,111,135,146,186,211],"have":[12,29,45],"adapted":[13,136],"via":[14],"the":[15,62,79,90,116,143,148,155,173,193,196,205,219,233,238,244,250],"evolution":[16,114,220],"of":[17,51,92,151,154,175,195,221,240,246],"defenses":[18],"that":[19,35,82,127,142],"prevent":[20],"or":[21,169],"impede":[22],"infection":[23],"by":[24,218],"parasites.":[25,86],"However,":[26,178],"also":[30,77],"evolved":[31,93],"life":[32,98,230],"history":[33],"shifts":[34],"maximize":[36],"fitness":[38],"despite":[39],"infection.":[40],"Outcrossing":[41],"and":[42,56,103,105,131,141,182,208,225],"self-fertilization":[43],"contrasting":[46],"effects":[47],"evolutionary":[49],"trajectories":[50],"populations.":[53,252],"While":[54],"selfing":[55],"outcrossing":[57,107,133,145,184,210],"are":[58],"known":[59],"to":[60,71,85,122,137,161],"affect":[61],"rate":[63,239],"at":[64,214],"which":[65],"adapt":[68],"in":[69,192,203,216,228,249],"response":[70],"parasites,":[72],"these":[73],"mating":[74,101,130,158,181,207,235],"systems":[75],"may":[76],"influence":[78],"specific":[80],"traits":[81],"underlie":[83],"adaptation":[84,202],"Here,":[87],"we":[88,125],"determined":[89],"role":[91],"defense":[95,224],"versus":[96],"altered":[97,237],"history,in":[99],"mixed":[100,129,180,206],"(selfing":[102],"outcrossing)":[104],"obligately":[106,132,144,183,209],"C.":[108],"elegans":[109],"after":[112,198],"experimental":[113,176,199],"with":[115],"bacterial":[117],"parasite,":[118],"S.":[119,138],"marcescens.":[120],"Similar":[121],"previous":[123],"studies,":[124],"found":[126],"both":[128,179,204],"marcescens":[139],"exposure,":[140],"exhibited":[147,187],"greatest":[149],"rates":[150,191],"adaptation.":[152],"Regardless":[153],"population":[157],"system,":[159],"exposure":[160],"parasites":[162],"did":[163],"not":[164,226,243],"significantly":[165,188],"alter":[166],"reproductive":[167],"timing":[168],"total":[170],"fecundity":[171],"over":[172],"course":[174],"evolution.":[177,200],"reduced":[189],"mortality":[190],"presence":[194],"parasite":[197],"Therefore,":[201],"was":[212],"driven,":[213],"least":[215],"part,":[217],"increased":[222],"changes":[227],"history.":[231],"Thus,":[232],"system":[236],"adaptation,":[241],"but":[242],"nature":[245],"adaptive":[247],"change":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-17T00:00:00"}
