{"id":"https://openalex.org/W2744766710","doi":null,"title":"New nature-inspired urocanic acid mimic preventing DNA damages and immunosuppressive signalling induced by ultraviolet-B radiations.","display_name":"New nature-inspired urocanic acid mimic preventing DNA damages and immunosuppressive signalling induced by ultraviolet-B radiations.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2744766710","mag":"2744766710","pmid":"https://pubmed.ncbi.nlm.nih.gov/29465390"},"language":"en","primary_location":{"id":"pmid:29465390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29465390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Mollet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"M Mollet","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Lafitte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"P Lafitte","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B Morand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"B Morand","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000297612","display_name":"Thierry Hoarau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"T Hoarau","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050896440","display_name":"P Piot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"P Piot","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A L Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"A L Thomas","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045301982","display_name":"Mathilde Fr\u00e9chet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"M Fr\u00e9chet","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052812276","display_name":"J. Nicolay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160224","display_name":"Exsymol (Monaco)","ror":"https://ror.org/052yc4b30","country_code":"MC","type":"company","lineage":["https://openalex.org/I4210160224"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"J-F Nicola\u00ff","raw_affiliation_strings":["Exsymol S.A.M., Monaco, Principality of Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exsymol S.A.M., Monaco, Principality of Monaco","institution_ids":["https://openalex.org/I4210160224"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160224"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16336678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"1","first_page":"99","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8640000224113464},{"id":"https://openalex.org/keywords/photoprotection","display_name":"photoprotection","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2776381347","wikidata":"https://www.wikidata.org/wiki/Q30536","display_name":"Urocanic acid","level":4,"score":0.895724892616272},{"id":"https://openalex.org/C2777381055","wikidata":"https://www.wikidata.org/wiki/Q308922","display_name":"Damages","level":2,"score":0.5570220947265625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5340140461921692},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5012555122375488},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4988102912902832},{"id":"https://openalex.org/C2776798109","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet","level":2,"score":0.4912239909172058},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4668821692466736},{"id":"https://openalex.org/C2992327504","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet irradiation","level":3,"score":0.4552847146987915},{"id":"https://openalex.org/C3018555722","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet b","level":2,"score":0.4394102096557617},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.434017539024353},{"id":"https://openalex.org/C3017420807","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet a","level":2,"score":0.42755192518234253},{"id":"https://openalex.org/C2987116853","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet light","level":2,"score":0.42363640666007996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41137802600860596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35068780183792114},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3452169597148895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27160966396331787},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23877963423728943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22281426191329956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15025538206100464},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.14892718195915222},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11398616433143616},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.10875862836837769},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.10547089576721191},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09686917066574097},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.058912843465805054},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014560","descriptor_name":"Urocanic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014560","descriptor_name":"Urocanic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29465390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29465390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic science","raw_type":"Journal Article"},{"id":"mag:2744766710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29465390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7018971359","https://openalex.org/W7016130630","https://openalex.org/W2597908859","https://openalex.org/W1999540198","https://openalex.org/W2262155709","https://openalex.org/W2419998989","https://openalex.org/W2250010915","https://openalex.org/W7113396219","https://openalex.org/W2525698383","https://openalex.org/W2433005599"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}