{"id":"https://openalex.org/W2744723725","doi":"https://doi.org/10.1038/nrneph.2017.113","title":"Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS","display_name":"Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS","publication_year":2017,"publication_date":"2017-08-07","ids":{"openalex":"https://openalex.org/W2744723725","doi":"https://doi.org/10.1038/nrneph.2017.113","mag":"2744723725","pmid":"https://pubmed.ncbi.nlm.nih.gov/28781373"},"language":"en","primary_location":{"id":"doi:10.1038/nrneph.2017.113","doi":"https://doi.org/10.1038/nrneph.2017.113","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrneph.2017.113","pdf_url":null,"source":{"id":"https://openalex.org/S18618073","display_name":"Nature Reviews Nephrology","issn_l":"1745-8323","issn":["1745-8323","1745-8331","1759-5061","1759-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085734264","display_name":"Volker Vallon","orcid":"https://orcid.org/0000-0002-9211-2063","observed_orcids":["https://orcid.org/0000-0002-9211-2063"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Volker Vallon","raw_affiliation_strings":["Division of Nephrology &Hypertension, Departments of Medicine and Pharmacology, University of California San Diego &VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA","Volker Vallon and Scott C. Thomson are at the Division of Nephrology & Hypertension, Departments of Medicine and Pharmacology, University of California San Diego & VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology &Hypertension, Departments of Medicine and Pharmacology, University of California San Diego &VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"Volker Vallon and Scott C. Thomson are at the Division of Nephrology & Hypertension, Departments of Medicine and Pharmacology, University of California San Diego & VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA.,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020811053","display_name":"Scott Culver Thomson","orcid":"https://orcid.org/0000-0001-8853-0505","observed_orcids":["https://orcid.org/0000-0001-8853-0505"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Thomson","raw_affiliation_strings":["Division of Nephrology &Hypertension, Departments of Medicine and Pharmacology, University of California San Diego &VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA","Volker Vallon and Scott C. Thomson are at the Division of Nephrology & Hypertension, Departments of Medicine and Pharmacology, University of California San Diego & VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology &Hypertension, Departments of Medicine and Pharmacology, University of California San Diego &VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"Volker Vallon and Scott C. Thomson are at the Division of Nephrology & Hypertension, Departments of Medicine and Pharmacology, University of California San Diego & VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA.,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085734264"],"corresponding_institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210099595"],"apc_list":null,"apc_paid":null,"fwci":2.2969,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89182908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"9","first_page":"517","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/canagliflozin","display_name":"canagliflozin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/canvas-trial","display_name":"CANVAS trial","score":0.7540000081062317},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/renal-outcomes","display_name":"renal outcomes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sodium-glucose-cotransporter","display_name":"sodium-glucose cotransporter","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glucose-reabsorption","display_name":"glucose reabsorption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/sodium-reabsorption","display_name":"sodium reabsorption","score":0.9200000166893005},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2777451236","wikidata":"https://www.wikidata.org/wiki/Q5030940","display_name":"Canagliflozin","level":4,"score":0.9692975282669067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9438601732254028},{"id":"https://openalex.org/C90466245","wikidata":"https://www.wikidata.org/wiki/Q7312490","display_name":"Renal glucose reabsorption","level":4,"score":0.860343337059021},{"id":"https://openalex.org/C57476199","wikidata":"https://www.wikidata.org/wiki/Q7312501","display_name":"Renal sodium reabsorption","level":4,"score":0.6808176636695862},{"id":"https://openalex.org/C2775887513","wikidata":"https://www.wikidata.org/wiki/Q5373824","display_name":"Empagliflozin","level":4,"score":0.551051914691925},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.540871262550354},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.540175199508667},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.49713805317878723},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.49376949667930603},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.45872896909713745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44216081500053406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.438317209482193},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.42094987630844116},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.416268914937973},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3655471205711365}],"mesh":[{"descriptor_ui":"D000068896","descriptor_name":"Canagliflozin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000068896","descriptor_name":"Canagliflozin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrneph.2017.113","doi":"https://doi.org/10.1038/nrneph.2017.113","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrneph.2017.113","pdf_url":null,"source":{"id":"https://openalex.org/S18618073","display_name":"Nature Reviews Nephrology","issn_l":"1745-8323","issn":["1745-8323","1745-8331","1759-5061","1759-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Nephrology","raw_type":"journal-article"},{"id":"pmid:28781373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28781373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Nephrology","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W256316318","https://openalex.org/W2112710337","https://openalex.org/W2128592897","https://openalex.org/W2146264128","https://openalex.org/W2332612176","https://openalex.org/W2412800896","https://openalex.org/W2416348735","https://openalex.org/W2424539745","https://openalex.org/W2553261268","https://openalex.org/W2626446274"],"related_works":["https://openalex.org/W3005136917","https://openalex.org/W2967080110","https://openalex.org/W2808778904","https://openalex.org/W2788428323","https://openalex.org/W2984471300","https://openalex.org/W2941279567","https://openalex.org/W4396769057","https://openalex.org/W2947319348","https://openalex.org/W2965286425","https://openalex.org/W4238777235"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}