{"id":"https://openalex.org/W2744674244","doi":"https://doi.org/10.1007/s00216-017-0514-4","title":"An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate","display_name":"An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate","publication_year":2017,"publication_date":"2017-08-10","ids":{"openalex":"https://openalex.org/W2744674244","doi":"https://doi.org/10.1007/s00216-017-0514-4","mag":"2744674244","pmid":"https://pubmed.ncbi.nlm.nih.gov/28799108","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5737010"},"language":"en","primary_location":{"id":"doi:10.1007/s00216-017-0514-4","doi":"https://doi.org/10.1007/s00216-017-0514-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00216-017-0514-4","pdf_url":null,"source":{"id":"https://openalex.org/S18188872","display_name":"Analytical and Bioanalytical Chemistry","issn_l":"1618-2642","issn":["1618-2642","1618-2650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and Bioanalytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5737010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100379183","display_name":"Li Chen","orcid":"https://orcid.org/0000-0001-8685-3466","observed_orcids":["https://orcid.org/0000-0001-8685-3466","https://orcid.org/0000-0001-9757-5035"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081915409","display_name":"Gregory S. Ducker","orcid":"https://orcid.org/0000-0002-8651-6846","observed_orcids":["https://orcid.org/0000-0002-8651-6846"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S. Ducker","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003316821","display_name":"Wenyun Lu","orcid":"https://orcid.org/0000-0003-1787-2617","observed_orcids":["https://orcid.org/0000-0003-1787-2617"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyun Lu","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049350732","display_name":"Xin Teng","orcid":"https://orcid.org/0000-0002-8354-0090","observed_orcids":["https://orcid.org/0000-0002-8354-0090"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Teng","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053467552","display_name":"Joshua D. Rabinowitz","orcid":"https://orcid.org/0000-0002-1247-4727","observed_orcids":["https://orcid.org/0000-0002-1247-4727"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua D. Rabinowitz","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA. Joshr@princeton.edu","Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA. Joshr@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053467552"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":4.4898,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94900044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"409","issue":"25","first_page":"5955","last_page":"5964"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrofolate","display_name":"tetrahydrofolate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/5-methyltetrahydrofolate","display_name":"5-methyltetrahydrofolate","score":0.8730000257492065},{"id":"https://openalex.org/keywords/5-formyltetrahydrofolate","display_name":"5-formyltetrahydrofolate","score":0.890999972820282},{"id":"https://openalex.org/keywords/10-formyltetrahydrofolate","display_name":"10-formyltetrahydrofolate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/derivatization","display_name":"derivatization","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.909366250038147},{"id":"https://openalex.org/C2777454769","wikidata":"https://www.wikidata.org/wiki/Q11172462","display_name":"Methylene","level":2,"score":0.7760725021362305},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.7042952179908752},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.5951102375984192},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.5599840879440308},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5524085760116577},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.5483759045600891},{"id":"https://openalex.org/C82894169","wikidata":"https://www.wikidata.org/wiki/Q898552","display_name":"Carbanion","level":2,"score":0.486553817987442},{"id":"https://openalex.org/C2779321498","wikidata":"https://www.wikidata.org/wiki/Q418193","display_name":"Sodium cyanoborohydride","level":2,"score":0.4773699939250946},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.4499432444572449},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4373064637184143},{"id":"https://openalex.org/C171679685","wikidata":"https://www.wikidata.org/wiki/Q3707695","display_name":"Isotope dilution","level":3,"score":0.4279821515083313},{"id":"https://openalex.org/C69928629","wikidata":"https://www.wikidata.org/wiki/Q1386472","display_name":"Kinetic isotope effect","level":3,"score":0.4139508903026581},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41259047389030457},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.304343044757843},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.24612277746200562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0770258903503418},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00216-017-0514-4","doi":"https://doi.org/10.1007/s00216-017-0514-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00216-017-0514-4","pdf_url":null,"source":{"id":"https://openalex.org/S18188872","display_name":"Analytical and Bioanalytical Chemistry","issn_l":"1618-2642","issn":["1618-2642","1618-2650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and Bioanalytical Chemistry","raw_type":"journal-article"},{"id":"pmid:28799108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28799108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and bioanalytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5109563","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5737010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5737010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5737010","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Bioanal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5109563","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5737010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1963032496","display_name":null,"funder_award_id":"PF-15-190-01-TBE","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G8057426461","display_name":null,"funder_award_id":"SU2C-AACR-DT0509","funder_id":"https://openalex.org/F4320332898","funder_display_name":"Stand Up To Cancer"},{"id":"https://openalex.org/G9000887998","display_name":"Revealing cancer metabolism via mass spectrometry and isotope tracers","funder_award_id":"R50CA211437","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911752","display_name":"Tumor cell metabolism in action","funder_award_id":"R01CA163591","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000916849","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016359","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332898","display_name":"Stand Up To Cancer","ror":"https://ror.org/01dmpb598"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W3409383","https://openalex.org/W337405371","https://openalex.org/W1491639452","https://openalex.org/W1491882973","https://openalex.org/W1514049495","https://openalex.org/W1527208134","https://openalex.org/W1867620329","https://openalex.org/W1969778914","https://openalex.org/W1979638914","https://openalex.org/W1980524534","https://openalex.org/W1982096731","https://openalex.org/W1985734471","https://openalex.org/W1988144858","https://openalex.org/W1989356642","https://openalex.org/W1992779972","https://openalex.org/W1994124478","https://openalex.org/W1995525156","https://openalex.org/W2000144783","https://openalex.org/W2002583208","https://openalex.org/W2011669229","https://openalex.org/W2017035524","https://openalex.org/W2025220988","https://openalex.org/W2027139471","https://openalex.org/W2030980715","https://openalex.org/W2034679684","https://openalex.org/W2041291474","https://openalex.org/W2043451976","https://openalex.org/W2046963845","https://openalex.org/W2048349001","https://openalex.org/W2049674359","https://openalex.org/W2051522090","https://openalex.org/W2056974877","https://openalex.org/W2067428649","https://openalex.org/W2094177396","https://openalex.org/W2095295126","https://openalex.org/W2135521008","https://openalex.org/W2136532823","https://openalex.org/W2149917889","https://openalex.org/W2151186467","https://openalex.org/W2157838142","https://openalex.org/W2183983923","https://openalex.org/W2405069786","https://openalex.org/W2503513225","https://openalex.org/W2520894026","https://openalex.org/W2610435987"],"related_works":["https://openalex.org/W2804972413","https://openalex.org/W3044499100","https://openalex.org/W4409321873","https://openalex.org/W2027414766","https://openalex.org/W2150910607","https://openalex.org/W2807478135","https://openalex.org/W2049674359","https://openalex.org/W2945356381","https://openalex.org/W2012321407","https://openalex.org/W4410775212"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}