{"id":"https://openalex.org/W2744338276","doi":"https://doi.org/10.1159/000478747","title":"Orbital Epstein-Barr Virus-Positive Polymorphic B-Cell Lymphoproliferative Disorder in an Apparently Immunocompetent Woman","display_name":"Orbital Epstein-Barr Virus-Positive Polymorphic B-Cell Lymphoproliferative Disorder in an Apparently Immunocompetent Woman","publication_year":2017,"publication_date":"2017-08-10","ids":{"openalex":"https://openalex.org/W2744338276","doi":"https://doi.org/10.1159/000478747","mag":"2744338276","pmid":"https://pubmed.ncbi.nlm.nih.gov/29344502","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5757600"},"language":"en","primary_location":{"id":"doi:10.1159/000478747","doi":"https://doi.org/10.1159/000478747","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000478747","pdf_url":null,"source":{"id":"https://openalex.org/S2765040191","display_name":"Ocular Oncology and Pathology","issn_l":"2296-4657","issn":["2296-4657","2296-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ocular Oncology and Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5757600","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036668154","display_name":"Michael D. Abendroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Abendroth","raw_affiliation_strings":["Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Ophthalmology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073534613","display_name":"Michael G. Bayerl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Bayerl","raw_affiliation_strings":["Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Pathology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Pathology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael J. Wilkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Wilkinson","raw_affiliation_strings":["Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Ophthalmology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004302802","display_name":"David F. Claxton","orcid":"https://orcid.org/0000-0001-9209-2405","observed_orcids":["https://orcid.org/0000-0001-9209-2405"]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Claxton","raw_affiliation_strings":["Department of Division of Hematology and Oncology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Division of Hematology and Oncology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Division of Hematology and Oncology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Division of Hematology and Oncology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":null,"display_name":"Charles S. Specht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles S. Specht","raw_affiliation_strings":["Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Ophthalmology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I82783531"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12342995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":"1","first_page":"61","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13314","display_name":"Lymphadenopathy Diagnosis and Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lacrimal-gland","display_name":"lacrimal gland","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immunocompetent-patient","display_name":"immunocompetent patient","score":0.8090000152587891},{"id":"https://openalex.org/keywords/reed-sternberg-like-cells","display_name":"Reed-Sternberg-like cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pax5","display_name":"PAX5","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cd30","display_name":"CD30","score":0.996999979019165},{"id":"https://openalex.org/keywords/ebv-encoded-rna","display_name":"EBV-encoded RNA","score":0.9169999957084656},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C70905583","wikidata":"https://www.wikidata.org/wiki/Q3648608","display_name":"CD30","level":3,"score":0.6849390268325806},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.6671192646026611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6309512257575989},{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.5893244743347168},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.571734607219696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5678593516349792},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5605037808418274},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5511406064033508},{"id":"https://openalex.org/C2779298748","wikidata":"https://www.wikidata.org/wiki/Q913628","display_name":"Lacrimal gland","level":2,"score":0.5290977954864502},{"id":"https://openalex.org/C2779390272","wikidata":"https://www.wikidata.org/wiki/Q2167074","display_name":"Reed\u2013Sternberg cell","level":4,"score":0.5100250840187073},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.49817585945129395},{"id":"https://openalex.org/C2776804306","wikidata":"https://www.wikidata.org/wiki/Q3959958","display_name":"CD15","level":4,"score":0.4737741947174072},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.4497954845428467},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4123145341873169},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.386112242937088},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3635789155960083},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27413254976272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18913733959197998},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.08298465609550476},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1159/000478747","doi":"https://doi.org/10.1159/000478747","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000478747","pdf_url":null,"source":{"id":"https://openalex.org/S2765040191","display_name":"Ocular Oncology and Pathology","issn_l":"2296-4657","issn":["2296-4657","2296-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ocular Oncology and Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5234565","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5757600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5757600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5757600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ocul Oncol Pathol","raw_type":"Text"},{"id":"pmid:29344502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29344502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ocular oncology and pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5234565","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5757600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1965863550","https://openalex.org/W1977977797","https://openalex.org/W1994636455","https://openalex.org/W2007749715","https://openalex.org/W2013715522","https://openalex.org/W2023003954","https://openalex.org/W2036580459","https://openalex.org/W2074266082","https://openalex.org/W2085851071","https://openalex.org/W2108794832","https://openalex.org/W2120228756","https://openalex.org/W2143311614","https://openalex.org/W2162790232","https://openalex.org/W2237741403"],"related_works":["https://openalex.org/W2098416652","https://openalex.org/W4416130198","https://openalex.org/W2154747383","https://openalex.org/W2093113492","https://openalex.org/W2038383269","https://openalex.org/W4283164359","https://openalex.org/W2111179023","https://openalex.org/W2243714181","https://openalex.org/W2036580459","https://openalex.org/W2234219211"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,19,27,40,92],"rare":[3],"case":[4],"of":[5,18,30,55,74,94,107,139,184],"Epstein-Barr":[6],"virus":[7],"(EBV)-positive":[8],"polymorphic":[9,95,111],"B-cell":[10,96,112],"lymphoproliferative":[11],"disorder":[12],"(LPD)":[13],"involving":[14,42],"the":[15,43,56,70,105,119,137,175],"lacrimal":[16,45],"gland":[17,46],"28-year-old,":[20],"apparently":[21],"immunocompetent":[22],"woman.":[23],"She":[24],"presented":[25],"with":[26,60,116,172,181],"chief":[28],"complaint":[29],"orbital":[31,168],"swelling":[32],"and":[33,35,47,50,65,85,87,124,174],"tenderness":[34],"was":[36],"found":[37],"to":[38,159],"have":[39],"lesion":[41,57],"right":[44],"distal":[48],"superior":[49],"lateral":[51],"rectus":[52],"muscles.":[53],"Histology":[54],"revealed":[58],"histiocytes":[59],"pleomorphic":[61],"nuclei,":[62],"reactive":[63],"lymphocytes,":[64],"scattered":[66],"cells":[67,73,80],"that":[68],"resembled":[69],"Reed-Sternberg":[71],"(R-S)":[72],"classical":[75],"Hodgkin":[76],"lymphoma.":[77],"The":[78,167],"R-S-like":[79],"were":[81],"positive":[82],"for":[83,89,101,187],"PAX5":[84],"CD30":[86],"negative":[88],"CD15,":[90],"supporting":[91],"diagnosis":[93],"LPD.":[97],"In":[98],"situ":[99],"hybridization":[100],"EBV-encoded":[102],"RNA":[103],"demonstrated":[104],"presence":[106],"EBV.":[108],"Most":[109],"EBV-positive":[110],"LPDs":[113],"are":[114],"associated":[115],"immunodeficiency.":[117],"However,":[118],"patient":[120,176],"described":[121],"is":[122],"HIV-negative":[123],"has":[125,142,177],"no":[126,182],"identifiable":[127],"defects":[128],"in":[129,150],"immunoglobulin":[130],"levels":[131],"or":[132,153],"cell-mediated":[133],"immunity.":[134],"This":[135],"raises":[136],"question":[138],"whether":[140,154],"she":[141],"an":[143,164],"underlying":[144],"immunodeficiency":[145],"resulting":[146],"from":[147],"subtle":[148],"changes":[149],"T-cell":[151],"physiology,":[152],"chronic":[155],"EBV":[156],"infection":[157],"contributed":[158],"her":[160],"immune":[161],"dysfunction":[162],"through":[163],"unclear":[165],"mechanism.":[166],"mass":[169],"partially":[170],"regressed":[171],"chemotherapy,":[173],"done":[178],"well":[179],"clinically":[180],"recurrence":[183],"this":[185],"EBV-LPD":[186],"over":[188],"2":[189],"years.":[190]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-08-17T00:00:00"}
