{"id":"https://openalex.org/W274427786","doi":null,"title":"Evolutionary Systems Biology in Yeast","display_name":"Evolutionary Systems Biology in Yeast","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W274427786","mag":"274427786"},"language":"en","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:15920","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15920","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000963958","display_name":"Guang\u2010Zhong Wang","orcid":"https://orcid.org/0000-0001-6432-8310","observed_orcids":["https://orcid.org/0000-0001-6432-8310"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guang\u2010Zhong Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6432-8310","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000963958"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.24060000479221344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iae","display_name":"IAE","score":0.9829999804496765},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.8029999732971191},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.7039999961853027},{"id":"https://openalex.org/keywords/antisense-transcripts","display_name":"antisense transcripts","score":0.7649999856948853},{"id":"https://openalex.org/keywords/chromatin-conformation","display_name":"chromatin conformation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.5789999961853027},{"id":"https://openalex.org/keywords/co-expression","display_name":"co-expression","score":0.5180000066757202},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.796999990940094},{"id":"https://openalex.org/keywords/ancestral-gene-order","display_name":"ancestral gene order","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-order-evolution","display_name":"gene order evolution","score":0.34700000286102295},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.40700000524520874},{"id":"https://openalex.org/keywords/network-evolution","display_name":"network evolution","score":0.3540000021457672},{"id":"https://openalex.org/keywords/yeast-genomics","display_name":"yeast genomics","score":0.34599998593330383},{"id":"https://openalex.org/keywords/stochastic-simulation-model","display_name":"stochastic simulation model","score":0.4880000054836273},{"id":"https://openalex.org/keywords/subtelomeric-genes","display_name":"subtelomeric genes","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6865566372871399},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6599652171134949},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6462500691413879},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5433815121650696},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5235036015510559},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4808957576751709},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.4644728899002075},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4471476674079895},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.4268014430999756},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42470207810401917},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.42433908581733704},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4180063009262085},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41717109084129333},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.41218215227127075},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:15920","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15920","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:274427786","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DerivateServlet/Derivate-16988/diss_wang.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W420546067","https://openalex.org/W1502617758","https://openalex.org/W1513428285","https://openalex.org/W1554180547","https://openalex.org/W1580917887","https://openalex.org/W1641544182","https://openalex.org/W1644749979","https://openalex.org/W1691213292","https://openalex.org/W1771060896","https://openalex.org/W1774748215","https://openalex.org/W1795468129","https://openalex.org/W1913751214","https://openalex.org/W1932560099","https://openalex.org/W1935467915","https://openalex.org/W1963604994","https://openalex.org/W1964612763","https://openalex.org/W1965066153","https://openalex.org/W1966794959","https://openalex.org/W1968002146","https://openalex.org/W1968055625","https://openalex.org/W1968916935","https://openalex.org/W1969452055","https://openalex.org/W1969761972","https://openalex.org/W1970970926","https://openalex.org/W1971231926","https://openalex.org/W1972122284","https://openalex.org/W1973260612","https://openalex.org/W1974094308","https://openalex.org/W1975931018","https://openalex.org/W1978182054","https://openalex.org/W1978329448","https://openalex.org/W1979076392","https://openalex.org/W1983493033","https://openalex.org/W1984563220","https://openalex.org/W1986263614","https://openalex.org/W1986544564","https://openalex.org/W1987639269","https://openalex.org/W1992140809","https://openalex.org/W1992909271","https://openalex.org/W1993009001","https://openalex.org/W1994145712","https://openalex.org/W1994595131","https://openalex.org/W1996791690","https://openalex.org/W1998259086","https://openalex.org/W1998988447","https://openalex.org/W1999777663","https://openalex.org/W1999808854","https://openalex.org/W2000004737","https://openalex.org/W2003931365","https://openalex.org/W2004801113","https://openalex.org/W2006124679","https://openalex.org/W2006821612","https://openalex.org/W2007844697","https://openalex.org/W2008616402","https://openalex.org/W2008867005","https://openalex.org/W2009154103","https://openalex.org/W2011394676","https://openalex.org/W2013947447","https://openalex.org/W2016786878","https://openalex.org/W2017549616","https://openalex.org/W2019591778","https://openalex.org/W2020800417","https://openalex.org/W2022589976","https://openalex.org/W2024156663","https://openalex.org/W2028979517","https://openalex.org/W2029158589","https://openalex.org/W2029741513","https://openalex.org/W2031496082","https://openalex.org/W2032510252","https://openalex.org/W2032601764","https://openalex.org/W2037601806","https://openalex.org/W2037686178","https://openalex.org/W2037768790","https://openalex.org/W2038012561","https://openalex.org/W2039569152","https://openalex.org/W2039790548","https://openalex.org/W2042715208","https://openalex.org/W2042797800","https://openalex.org/W2043093337","https://openalex.org/W2043487490","https://openalex.org/W2044505072","https://openalex.org/W2045155691","https://openalex.org/W2046855815","https://openalex.org/W2049783361","https://openalex.org/W2050256724","https://openalex.org/W2050826226","https://openalex.org/W2054755820","https://openalex.org/W2056182546","https://openalex.org/W2056904820","https://openalex.org/W2059017497","https://openalex.org/W2060337051","https://openalex.org/W2060705109","https://openalex.org/W2060915805","https://openalex.org/W2061507735","https://openalex.org/W2063593640","https://openalex.org/W2063619692","https://openalex.org/W2064322162","https://openalex.org/W2065304353","https://openalex.org/W2065329469","https://openalex.org/W2067163733","https://openalex.org/W2067432938","https://openalex.org/W2069614478","https://openalex.org/W2070993269","https://openalex.org/W2074443723","https://openalex.org/W2077046573","https://openalex.org/W2077127806","https://openalex.org/W2081933515","https://openalex.org/W2083011190","https://openalex.org/W2083646206","https://openalex.org/W2084186147","https://openalex.org/W2090833124","https://openalex.org/W2091198609","https://openalex.org/W2091452413","https://openalex.org/W2091507729","https://openalex.org/W2091687284","https://openalex.org/W2094238140","https://openalex.org/W2095321122","https://openalex.org/W2096248890","https://openalex.org/W2096435101","https://openalex.org/W2097128462","https://openalex.org/W2097242011","https://openalex.org/W2097520363","https://openalex.org/W2098622547","https://openalex.org/W2107067224","https://openalex.org/W2109248504","https://openalex.org/W2112364806","https://openalex.org/W2112609377","https://openalex.org/W2112704704","https://openalex.org/W2112780227","https://openalex.org/W2113237238","https://openalex.org/W2113613985","https://openalex.org/W2113654464","https://openalex.org/W2113679644","https://openalex.org/W2113708808","https://openalex.org/W2114870653","https://openalex.org/W2115148114","https://openalex.org/W2116088151","https://openalex.org/W2119114096","https://openalex.org/W2123045306","https://openalex.org/W2124847289","https://openalex.org/W2125068693","https://openalex.org/W2125204768","https://openalex.org/W2125346198","https://openalex.org/W2127013070","https://openalex.org/W2127230663","https://openalex.org/W2128119325","https://openalex.org/W2130871092","https://openalex.org/W2131265311","https://openalex.org/W2131930552","https://openalex.org/W2131933020","https://openalex.org/W2132022258","https://openalex.org/W2132452290","https://openalex.org/W2132898753","https://openalex.org/W2133102806","https://openalex.org/W2133452708","https://openalex.org/W2133831748","https://openalex.org/W2135123683","https://openalex.org/W2138470019","https://openalex.org/W2141688036","https://openalex.org/W2143157299","https://openalex.org/W2146060062","https://openalex.org/W2147041906","https://openalex.org/W2147734340","https://openalex.org/W2148902358","https://openalex.org/W2149641002","https://openalex.org/W2149700511","https://openalex.org/W2151385152","https://openalex.org/W2151618686","https://openalex.org/W2152075687","https://openalex.org/W2152556351","https://openalex.org/W2152859623","https://openalex.org/W2152876917","https://openalex.org/W2153283265","https://openalex.org/W2154600255","https://openalex.org/W2155919888","https://openalex.org/W2156022009","https://openalex.org/W2159460045","https://openalex.org/W2159903739","https://openalex.org/W2161316685","https://openalex.org/W2161493476","https://openalex.org/W2161988890","https://openalex.org/W2161989035","https://openalex.org/W2162891889","https://openalex.org/W2164841210","https://openalex.org/W2165418074","https://openalex.org/W2165773079","https://openalex.org/W2166760188","https://openalex.org/W2166937684","https://openalex.org/W2167869241","https://openalex.org/W2168221215","https://openalex.org/W2168258419","https://openalex.org/W2168909179","https://openalex.org/W2169079604","https://openalex.org/W2169208148","https://openalex.org/W2169336096","https://openalex.org/W2170033314","https://openalex.org/W2170392103","https://openalex.org/W2170725201","https://openalex.org/W2170778160","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2171769276","https://openalex.org/W2917431650","https://openalex.org/W7073557482","https://openalex.org/W7097227089","https://openalex.org/W7098783025"],"related_works":["https://openalex.org/W2320067231","https://openalex.org/W2055213458","https://openalex.org/W2038539945","https://openalex.org/W1976189901","https://openalex.org/W2123717630","https://openalex.org/W4294883078","https://openalex.org/W4306367219","https://openalex.org/W7095399139","https://openalex.org/W1857142138","https://openalex.org/W2171389822"],"abstract_inverted_index":{"Since":[0],"the":[1,4,12,20,23,28,50,85,186,221,371,378,431,464,477,483,487,514,527,582,594,618,622,629,634,652,669,685,708,725,730,744,747],"release":[2,709],"of":[3,22,41,181,189,200,308,316,395,434,446,467,479,486,506,526,584,597,605,621,654,668,684,699,710,724,732,740,743],"yeast":[5,24,51,102,401],"whole":[6],"genome":[7,52,381],"sequence":[8],"in":[9,14,31,109,132,161,280,296,398,422,430,521,543,549,587,673,702,713,729],"1996":[10],"and":[11,37,55,74,84,293,306,470,563,579,608,646,687,693],"advances":[13],"high-throughput":[15],"technologies,":[16],"scientists":[17],"have":[18,44,241,251,333,495,502],"studied":[19,96,322,459],"evolution":[21,489,542,586],"Saccharomyces":[25,435],"cerevisiae":[26,436],"at":[27],"genomics":[29,36,73],"level":[30,478,578],"two":[32,493,697],"major":[33,80],"ways:":[34],"comparative":[35],"systems":[38],"biology.":[39],"Both":[40],"these":[42,68],"approaches":[43],"provided":[45],"important":[46],"insights":[47],"into":[48],"how":[49,56,158,460],"is":[53,125,127,134,140,159,208,341,355,361,373,385,449,482,601,636,661,677,715],"organized":[54,177],"networks":[57,75,546],"evolve":[58,519],"to":[59,152,211,350,364,377,388,613,617,638,719,750],"achieve":[60],"phenotypic":[61,595,641,666,688,700,711],"features.":[62],"In":[63,624],"this":[64,89,359,390,511],"thesis,":[65],"I":[66,82,95,321,458,591],"study":[67],"issues":[69],"by":[70,88,336,453],"analyzing":[71],"both":[72,576],"data.":[76],"The":[79,224],"questions":[81],"asked":[83],"findings":[86],"raised":[87],"thesis":[90],"are":[91,99,107,263,288,294,313,420,696],"as":[92,174,557,559],"follows:":[93],"First,":[94],"why":[97],"there":[98,340,676],"so":[100],"many":[101,412],"non-coding":[103,202],"transcripts":[104,262],"(>60%)":[105],"that":[106,168,197,228,267,303,344,419,444,476,510,516,575,651,707,737],"transcribed":[108],"bi-directional":[110],"orientation":[111,170,282,305],"with":[112,144,232,237,265,665],"a":[113,190,205,213,238,268,365,393,407,468,503,602,678,720],"coding":[114,230],"gene.":[115,198],"For":[116,136],"some":[117],"genes,":[118,121,138],"notably":[119],"essential":[120,277,297],"expression":[122,124,133,163,180,253,481,497,534,555,577],"when":[123,628],"needed":[126],"vital,":[128],"hence":[129],"low":[130,275],"noise":[131,139,160,195,243,317],"favorable.":[135,375],"other":[137,245,423],"necessary":[141],"for":[142,148,175,196,274,411,533,554,560,752],"coping":[143],"environmental":[145],"stochasticity":[146],"or":[147,369],"providing":[149],"dice-like":[150],"mechanisms":[151],"control":[153],"cell":[154],"fate.":[155],"But":[157,548],"gene":[162,169,178,183,248,298,304,347,396,414,518,561,564,727],"modulated?":[164],"We":[166,301,442,508,649],"hypothesize":[167],"may":[171],"be":[172,212,271,351],"crucial,":[173],"divergently":[176],"pairs,":[179],"one":[182,741],"could":[184],"affect":[185],"chromatin":[187],"conformation":[188],"neighbouring":[191,325,421,447,517,536,566],"gene,":[192],"thereby":[193],"reducing":[194],"Transcription":[199],"antisense":[201],"RNA":[203],"from":[204],"shared":[206],"promoter":[207],"similarly":[209,520],"argued":[210],"noise-reduction":[214],"mechanism.":[215],"Our":[216],"stochastic":[217],"simulation":[218],"models":[219],"confirm":[220],"expectation.":[222],"model":[225],"correctly":[226],"predicts:":[227],"protein":[229,469,480,488,585],"genes":[231,266,278,326,418,448,494,537,569],"bi-promoter":[233,286],"architecture,":[234],"including":[235],"those":[236],"ncRNA":[239,260],"partner,":[240],"lower":[242],"than":[244,284,440],"genes;":[246],"divergent":[247,261,281],"pairs":[249,287,348],"uniquely":[250],"correlated":[252,541,664],"noise;":[254,259,276],"distance":[255],"between":[256,681],"promoters":[257],"predicts":[258],"associated":[264],"priori":[269],"would":[270],"under":[272],"selection":[273],"reside":[279],"more":[283,640],"expected;":[285],"rare":[289],"subtelomerically,":[290],"cluster":[291],"together":[292],"enriched":[295],"clusters.":[299],"conclude":[302,443],"transcription":[307],"ncRNAs,":[309],"even":[310,330,417,552],"if":[311,358,370,492],"unstable,":[312],"candidate":[314],"modulators":[315],"levels.\r":[318],"Second,":[320],"whether":[323],"ancestrally":[324],"still":[327,570],"remain":[328],"co-expressed":[329],"after":[331],"they":[332,499],"been":[334],"separated":[335,413],"chromosomal":[337],"rearrangements.":[338],"Although":[339],"clear":[342,357],"evidence":[343],"closely":[345],"spaced":[346],"tend":[349],"highly":[352],"co-expressed,":[353],"it":[354,384,473],"not":[356,717],"co-expression":[360,372,409,439,445,550,580],"solely":[362],"due":[363,718],"mechanistic":[366],"neighbourhood":[367],"effect,":[368],"selectively":[374],"Thanks":[376],"multiple":[379],"fungi":[380,424],"sequencing":[382],"projects,":[383],"now":[386],"possible":[387],"answer":[389],"question.":[391],"Using":[392],"reconstruction":[394],"order":[397],"an":[399],"ancestral":[400],"based":[402],"on":[403,593],"parsimony,":[404],"we":[405,609],"found":[406,509],"significant":[408],"signal":[410],"pairs.":[415],"Moreover,":[416],"but":[425,736],"were":[426],"never":[427],"genomic":[428],"neighbours":[429,462],"evolutionary":[432,465],"history":[433],"show":[437,540],"higher":[438],"expected.":[441],"indeed":[450,662],"often":[451],"favoured":[452],"natural":[454],"selection.\r":[455],"Third,":[457],"network":[461,529,745],"influence":[463,581],"rate":[466,505,583],"why.":[471],"Recently":[472],"was":[474],"shown":[475],"main":[484],"predictor":[485],"rate.":[490],"Thus,":[491,690],"similar":[496,504],"levels,":[498],"should":[500],"also":[501],"evolution.":[507],"can":[512],"explain":[513],"fact":[515],"most":[522],"biological":[523,606],"networks,":[524,607,627],"regardless":[525],"different":[528,611,615],"topologies.":[530],"Namely,":[531],"controlling":[532,553],"level,":[535],"no":[538],"longer":[539],"almost":[544],"all":[545],"studied.":[547],"network,":[551],"abundance":[556],"well":[558],"essentiality":[562],"length,":[565],"(i.e.,":[567],"co-expressed)":[568],"co-evolve.":[571],"This":[572,704],"finding":[573],"suggests":[574,706],"networks.\r":[588],"Finally,":[590],"focused":[592],"effect":[596],"genetic":[598,625,630,657,694],"hubs.":[599],"Robustness":[600],"basic":[603],"feature":[604],"expect":[610],"proteins":[612],"make":[614],"contributions":[616],"overall":[619],"robustness":[620],"network.":[623],"interaction":[626],"hubs":[631],"function":[632,723,739],"abnormally,":[633],"offspring":[635],"expected":[637],"exhibit":[639],"variation":[642,667,701,712],"(both":[643],"genetically":[644],"caused":[645],"non-genetically":[647],"caused).":[648],"observed":[650],"number":[653],"strong":[655],"negative":[656],"interactions":[658,695],"(synthetic":[659],"lethality)":[660],"positively":[663],"respective":[670],"single-gene":[671],"knockouts":[672,686],"yeast.":[674],"Furthermore,":[675],"high":[679],"correlation":[680],"haploid":[682,691],"fitness":[683,692],"variation.":[689],"predictors":[698],"mutants.":[703],"further":[705],"mutants":[714],"mostly":[716],"specific":[721],"buffering":[722],"mutated":[726],"(as":[728],"case":[731],"chaperones,":[733],"e.g.,":[734],"Hsp90),":[735],"compromised":[738],"part":[742],"reduces":[746],"cell\u2019s":[748],"ability":[749],"compensate":[751],"sub-optimal":[753],"pathways":[754],"elsewhere.":[755]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
