{"id":"https://openalex.org/W2744096091","doi":"https://doi.org/10.1016/j.celrep.2017.07.034","title":"A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels","display_name":"A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2744096091","doi":"https://doi.org/10.1016/j.celrep.2017.07.034","mag":"2744096091","pmid":"https://pubmed.ncbi.nlm.nih.gov/28793254","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5586213"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2017.07.034","doi":"https://doi.org/10.1016/j.celrep.2017.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2017.07.034","pdf_url":"http://www.cell.com/article/S2211124717310008/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124717310008/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057140211","display_name":"Cerrone S. Cabanos","orcid":"https://orcid.org/0000-0001-5915-3683","observed_orcids":["https://orcid.org/0000-0001-5915-3683"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cerrone Cabanos","raw_affiliation_strings":["Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415832","display_name":"Miao Wang","orcid":"https://orcid.org/0000-0002-1607-0666","observed_orcids":["https://orcid.org/0000-0002-1607-0666","https://orcid.org/0009-0009-2981-2882"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miao Wang","raw_affiliation_strings":["Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648133","display_name":"Xianlin Han","orcid":"https://orcid.org/0000-0002-8615-2413","observed_orcids":["https://orcid.org/0000-0002-8615-2413"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianlin Han","raw_affiliation_strings":["Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019457716","display_name":"Scott B. Hansen","orcid":"https://orcid.org/0000-0003-0086-9753","observed_orcids":["https://orcid.org/0000-0003-0086-9753"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott B. Hansen","raw_affiliation_strings":["Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: shansen@scripps.edu","Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: shansen@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019457716"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":3.5727,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.94180423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"6","first_page":"1287","last_page":"1294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trek-1","display_name":"TREK-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/phosphatidylglycerol","display_name":"phosphatidylglycerol","score":0.9649999737739563},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.7720000147819519},{"id":"https://openalex.org/keywords/lipid-binding-sites","display_name":"lipid binding sites","score":0.503000020980835},{"id":"https://openalex.org/keywords/lipid-signaling","display_name":"lipid signaling","score":0.47999998927116394},{"id":"https://openalex.org/keywords/membrane-excitability","display_name":"membrane excitability","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.6889421343803406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5774872303009033},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.5703308582305908},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5652331113815308},{"id":"https://openalex.org/C85196483","wikidata":"https://www.wikidata.org/wiki/Q6545857","display_name":"Ligand binding assay","level":3,"score":0.5650554895401001},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5420859456062317},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5407137870788574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5108284950256348},{"id":"https://openalex.org/C82617044","wikidata":"https://www.wikidata.org/wiki/Q418536","display_name":"Ligand-gated ion channel","level":4,"score":0.4503903090953827},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4209707975387573},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41828495264053345},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.41606593132019043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2942195534706116},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.29055529832839966},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2595134377479553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2083328664302826},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10770663619041443},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024683","descriptor_name":"Potassium Channels, Tandem Pore Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024683","descriptor_name":"Potassium Channels, Tandem Pore Domain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024683","descriptor_name":"Potassium Channels, Tandem Pore Domain","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.celrep.2017.07.034","doi":"https://doi.org/10.1016/j.celrep.2017.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2017.07.034","pdf_url":"http://www.cell.com/article/S2211124717310008/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:28793254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28793254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5027219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5586213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5586213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5586213","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3b2d05653228457784817828d5ee5d80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3b2d05653228457784817828d5ee5d80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 20, Iss 6, Pp 1287-1294 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2017.07.034","doi":"https://doi.org/10.1016/j.celrep.2017.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2017.07.034","pdf_url":"http://www.cell.com/article/S2211124717310008/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1570335372","display_name":null,"funder_award_id":"DP2 NS087943","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G716402209","display_name":"Molecular Mechanism of Mechanosensation","funder_award_id":"1dp2ns087943-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2744096091.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W108909600","https://openalex.org/W1233113931","https://openalex.org/W1518259698","https://openalex.org/W1613705179","https://openalex.org/W1967930702","https://openalex.org/W1968545456","https://openalex.org/W1979196237","https://openalex.org/W1980779109","https://openalex.org/W1980802466","https://openalex.org/W1987375069","https://openalex.org/W1993192425","https://openalex.org/W1995784704","https://openalex.org/W2007061409","https://openalex.org/W2013853780","https://openalex.org/W2016555254","https://openalex.org/W2020290863","https://openalex.org/W2021882008","https://openalex.org/W2024012749","https://openalex.org/W2032443344","https://openalex.org/W2041345208","https://openalex.org/W2044995040","https://openalex.org/W2059544508","https://openalex.org/W2062279581","https://openalex.org/W2066804978","https://openalex.org/W2076413516","https://openalex.org/W2077365895","https://openalex.org/W2079325827","https://openalex.org/W2084231847","https://openalex.org/W2089781399","https://openalex.org/W2111724662","https://openalex.org/W2113755495","https://openalex.org/W2131597783","https://openalex.org/W2136265229","https://openalex.org/W2151768831","https://openalex.org/W2157194890","https://openalex.org/W2157250445","https://openalex.org/W2336677179","https://openalex.org/W2337576024","https://openalex.org/W2404622021","https://openalex.org/W2564652835"],"related_works":["https://openalex.org/W2020290863","https://openalex.org/W2084231847","https://openalex.org/W3090336390","https://openalex.org/W98403486","https://openalex.org/W3021695443","https://openalex.org/W4322008907","https://openalex.org/W2013853780","https://openalex.org/W4280612641","https://openalex.org/W7099866482","https://openalex.org/W2100097046"],"abstract_inverted_index":{"Lipid":[0],"regulation":[1,133],"of":[2,32,36,43,54,63,148],"ion":[3,27,68],"channels":[4,28],"by":[5],"low-abundance":[6],"signaling":[7],"lipids":[8,90],"phosphatidylinositol":[9],"4,5-bisphosphate":[10],"(PIP":[11],"2":[12,76,111,136],")":[13],"and":[14,29,59,92,99,103,141],"phosphatidic":[15],"acid":[16],"(PA)":[17],"has":[18,50],"emerged":[19],"as":[20],"a":[21,44,48,73,128,152],"central":[22],"cellular":[23],"mechanism":[24],"for":[25,40,67,79,130,151],"controlling":[26],"the":[30,52,55,61,105,146,149,155],"excitability":[31],"nerves.":[33],"A":[34],"lack":[35],"robust":[37],"assays":[38],"suitable":[39],"facile":[41],"detection":[42],"lipid":[45,56,65,132,150],"bound":[46],"to":[47],"channel":[49],"hampered":[51],"probing":[53],"binding":[57],"sites":[58],"measuring":[60],"pharmacology":[62],"putative":[64],"agonists":[66],"channels.":[69],"Here,":[70],"we":[71],"show":[72],"fluorescent":[74],"PIP":[75,110,135],"competition":[77],"assay":[78,108],"detergent-purified":[80],"potassium":[81],"channels,":[82],"including":[83],"TWIK-1-related":[84],"K":[85],"+":[86],"-channel":[87],"(TREK-1).":[88],"Anionic":[89],"PA":[91,140],"phosphatidylglycerol":[93],"(PG)":[94],"bind":[95],"dose":[96],"dependently":[97],"(9.1":[98],"96":[100],"\u03bcM,":[101],"respectively)":[102],"agonize":[104],"channel.":[106,156],"Our":[107],"shows":[109],"binds":[112],"with":[113,139],"high":[114],"affinity":[115,147],"(0.87":[116],"\u03bcM)":[117],"but":[118],"surprisingly":[119],"can":[120,137],"directly":[121],"antagonize":[122],"TREK-1":[123,131],"in":[124],"liposomes.":[125],"We":[126],"propose":[127],"model":[129],"where":[134],"compete":[138],"PG":[142],"agonism":[143],"based":[144],"on":[145],"site":[153],"within":[154]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-17T00:00:00"}
