{"id":"https://openalex.org/W2743418290","doi":"https://doi.org/10.1126/scitranslmed.aam7049","title":"Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer","display_name":"Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer","publication_year":2017,"publication_date":"2017-08-02","ids":{"openalex":"https://openalex.org/W2743418290","doi":"https://doi.org/10.1126/scitranslmed.aam7049","mag":"2743418290","pmid":"https://pubmed.ncbi.nlm.nih.gov/28768804"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.aam7049","doi":"https://doi.org/10.1126/scitranslmed.aam7049","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aam7049","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009131786","display_name":"Delphine M\u00e9rino","orcid":"https://orcid.org/0000-0002-8075-6275","observed_orcids":["https://orcid.org/0000-0002-8075-6275"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Delphine Merino","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8075-6275","affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038506293","display_name":"James Richard Whittle","orcid":"https://orcid.org/0000-0002-4740-2037","observed_orcids":["https://orcid.org/0000-0002-4740-2037"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"James R. Whittle","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4740-2037","affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006723728","display_name":"Fran\u00e7ois Vaillant","orcid":"https://orcid.org/0000-0003-3229-3760","observed_orcids":["https://orcid.org/0000-0003-3229-3760"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Vaillant","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3229-3760","affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083256169","display_name":"Antonin Serrano","orcid":"https://orcid.org/0000-0002-8178-6441","observed_orcids":["https://orcid.org/0000-0002-8178-6441"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Antonin Serrano","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107981263","display_name":"Jia-Nan Gong","orcid":"https://orcid.org/0000-0002-6554-1815","observed_orcids":["https://orcid.org/0000-0002-6554-1815"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jia-Nan Gong","raw_affiliation_strings":["Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6554-1815","affiliations":[{"raw_affiliation_string":"Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011239443","display_name":"G\u00f6knur Giner","orcid":"https://orcid.org/0000-0001-6832-9820","observed_orcids":["https://orcid.org/0000-0001-6832-9820"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Goknur Giner","raw_affiliation_strings":["Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044251543","display_name":"Ana Leticia Maragno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ana Leticia Maragno","raw_affiliation_strings":["Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010727651","display_name":"Ma\u00efa Chanrion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ma\u00efa Chanrion","raw_affiliation_strings":["Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054906244","display_name":"Emilie Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Schneider","raw_affiliation_strings":["Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076938587","display_name":"Bhupinder Pal","orcid":"https://orcid.org/0000-0002-3684-4331","observed_orcids":["https://orcid.org/0000-0002-3684-4331"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bhupinder Pal","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435189","display_name":"Xiang Li","orcid":"https://orcid.org/0000-0001-6222-4446","observed_orcids":["https://orcid.org/0000-0001-6222-4446"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xiang Li","raw_affiliation_strings":["Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073982345","display_name":"Grant Dewson","orcid":"https://orcid.org/0000-0003-4251-8898","observed_orcids":["https://orcid.org/0000-0003-4251-8898"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Grant Dewson","raw_affiliation_strings":["Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057007629","display_name":"Julius Gr\u00e4sel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Julius Gr\u00e4sel","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kevin Liu","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494081","display_name":"Najoua Lalaoui","orcid":"https://orcid.org/0000-0002-0165-3324","observed_orcids":["https://orcid.org/0000-0002-0165-3324"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Najoua Lalaoui","raw_affiliation_strings":["Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0165-3324","affiliations":[{"raw_affiliation_string":"Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103151515","display_name":"David Segal","orcid":"https://orcid.org/0000-0003-4003-4515","observed_orcids":["https://orcid.org/0000-0003-4003-4515"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Segal","raw_affiliation_strings":["Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080688847","display_name":"Marco J. Herold","orcid":"https://orcid.org/0000-0001-7539-7581","observed_orcids":["https://orcid.org/0000-0001-7539-7581"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marco J. Herold","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040208750","display_name":"David C.S. Huang","orcid":"https://orcid.org/0000-0002-3101-4873","observed_orcids":["https://orcid.org/0000-0002-3101-4873"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David C. S. Huang","raw_affiliation_strings":["Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3101-4873","affiliations":[{"raw_affiliation_string":"Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054704071","display_name":"Gordon K. Smyth","orcid":"https://orcid.org/0000-0001-9221-2892","observed_orcids":["https://orcid.org/0000-0001-9221-2892"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gordon K. Smyth","raw_affiliation_strings":["Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9221-2892","affiliations":[{"raw_affiliation_string":"Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108684212","display_name":"Olivier Geneste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Geneste","raw_affiliation_strings":["Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080942529","display_name":"Guillaume Less\u00e8ne","orcid":"https://orcid.org/0000-0002-1193-8147","observed_orcids":["https://orcid.org/0000-0002-1193-8147"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Guillaume Lessene","raw_affiliation_strings":["Chemical Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1193-8147","affiliations":[{"raw_affiliation_string":"Chemical Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013309333","display_name":"Jane E. Visvader","orcid":"https://orcid.org/0000-0001-9173-6977","observed_orcids":["https://orcid.org/0000-0001-9173-6977"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jane E. Visvader","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9173-6977","affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079753000","display_name":"Geoffrey John Lindeman","orcid":"https://orcid.org/0000-0001-9386-2416","observed_orcids":["https://orcid.org/0000-0001-9386-2416"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Geoffrey J. Lindeman","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia","Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia","Parkville Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Victoria 3050, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Parkville Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Victoria 3050, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I2800555584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006723728","https://openalex.org/A5009131786","https://openalex.org/A5013309333","https://openalex.org/A5038506293","https://openalex.org/A5079753000"],"corresponding_institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976","https://openalex.org/I2800555584"],"apc_list":null,"apc_paid":null,"fwci":8.0856,"has_fulltext":false,"cited_by_count":195,"citation_normalized_percentile":{"value":0.9856297,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"401","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s63845","display_name":"S63845","score":0.906000018119812},{"id":"https://openalex.org/keywords/mcl-1-inhibitors","display_name":"Mcl-1 inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bh3-mimetics","display_name":"BH3 mimetics","score":0.9729999899864197},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9020000100135803},{"id":"https://openalex.org/keywords/her2-amplified-breast-cancer","display_name":"HER2-amplified breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.7829999923706055},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9419999718666077},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.859000027179718},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.8742783665657043},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.745608389377594},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7253893613815308},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.6747291684150696},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6330274939537048},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6212597489356995},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5558733940124512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.535456657409668},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.43772539496421814},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42601141333580017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2968202233314514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24816977977752686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10825124382972717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077341","descriptor_name":"Lapatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.aam7049","doi":"https://doi.org/10.1126/scitranslmed.aam7049","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aam7049","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:28768804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28768804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:oak.novartis.com:32387","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/32387/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400709","display_name":"The Novartis Repository (Novartis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1283582996","host_organization_name":"Novartis (Switzerland)","host_organization_lineage":["https://openalex.org/I1283582996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1541584755","display_name":null,"funder_award_id":"award310803","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1771250681","display_name":"Elucidating the in vivo role of the pro-survival gene Mcl-1 in mammary gland development and breast cancer","funder_award_id":"1086727","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2268267925","display_name":null,"funder_award_id":"award310806","funder_id":"https://openalex.org/F4320320438","funder_display_name":"National Breast Cancer Foundation"},{"id":"https://openalex.org/G3417917754","display_name":"The Australian Centre for Translational Breast Cancer Research","funder_award_id":"1040978","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G395012438","display_name":null,"funder_award_id":"award310807","funder_id":"https://openalex.org/F4320320593","funder_display_name":"Royal Australasian College of Physicians"},{"id":"https://openalex.org/G4086183777","display_name":null,"funder_award_id":"award310805","funder_id":"https://openalex.org/F4320310187","funder_display_name":"Victorian Cancer Agency"},{"id":"https://openalex.org/G4287041437","display_name":"Apoptosis and Stem Cells in Cancer","funder_award_id":"1016701","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4523450193","display_name":"Deciphering tumour heterogeneity of breast cancer metastases using barcoded patient derived xenografts","funder_award_id":"1101378","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5409493048","display_name":null,"funder_award_id":"award310802","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G542769893","display_name":null,"funder_award_id":"award310804","funder_id":"https://openalex.org/F4320320390","funder_display_name":"Australian Cancer Research Foundation"},{"id":"https://openalex.org/G5668503272","display_name":null,"funder_award_id":"award310801","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G696298272","display_name":null,"funder_award_id":"award310809","funder_id":"https://openalex.org/F4320320438","funder_display_name":"National Breast Cancer Foundation"},{"id":"https://openalex.org/G7683690874","display_name":null,"funder_award_id":"award310800","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8550566643","display_name":null,"funder_award_id":"NT-13-06","funder_id":"https://openalex.org/F4320320438","funder_display_name":"National Breast Cancer Foundation"},{"id":"https://openalex.org/G8996902947","display_name":null,"funder_award_id":"TRP13041","funder_id":"https://openalex.org/F4320310187","funder_display_name":"Victorian Cancer Agency"}],"funders":[{"id":"https://openalex.org/F4320310187","display_name":"Victorian Cancer Agency","ror":"https://ror.org/0316wrd42"},{"id":"https://openalex.org/F4320320390","display_name":"Australian Cancer Research Foundation","ror":"https://ror.org/0459phn12"},{"id":"https://openalex.org/F4320320438","display_name":"National Breast Cancer Foundation","ror":"https://ror.org/0120ky124"},{"id":"https://openalex.org/F4320320593","display_name":"Royal Australasian College of Physicians","ror":"https://ror.org/047hk9367"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1489498714","https://openalex.org/W1551855406","https://openalex.org/W1917773519","https://openalex.org/W1978244665","https://openalex.org/W1979248048","https://openalex.org/W1990983360","https://openalex.org/W1991213319","https://openalex.org/W1998521798","https://openalex.org/W2005895632","https://openalex.org/W2017333581","https://openalex.org/W2024613683","https://openalex.org/W2027395744","https://openalex.org/W2027482010","https://openalex.org/W2031211461","https://openalex.org/W2039640090","https://openalex.org/W2048774662","https://openalex.org/W2050169742","https://openalex.org/W2059416155","https://openalex.org/W2059958613","https://openalex.org/W2063964334","https://openalex.org/W2069002336","https://openalex.org/W2069626574","https://openalex.org/W2071599920","https://openalex.org/W2085419794","https://openalex.org/W2088802752","https://openalex.org/W2091562724","https://openalex.org/W2098842169","https://openalex.org/W2098910097","https://openalex.org/W2100665941","https://openalex.org/W2100762532","https://openalex.org/W2105218405","https://openalex.org/W2107018762","https://openalex.org/W2110065044","https://openalex.org/W2110525250","https://openalex.org/W2110905563","https://openalex.org/W2114104545","https://openalex.org/W2123122199","https://openalex.org/W2127376103","https://openalex.org/W2127617517","https://openalex.org/W2132740145","https://openalex.org/W2136910701","https://openalex.org/W2137526110","https://openalex.org/W2138207763","https://openalex.org/W2142415307","https://openalex.org/W2146512944","https://openalex.org/W2146674923","https://openalex.org/W2152621384","https://openalex.org/W2153056550","https://openalex.org/W2153215028","https://openalex.org/W2161382947","https://openalex.org/W2166311434","https://openalex.org/W2168362647","https://openalex.org/W2172242534","https://openalex.org/W2192121806","https://openalex.org/W2252711380","https://openalex.org/W2275993376","https://openalex.org/W2288929640","https://openalex.org/W2293393098","https://openalex.org/W2311842365","https://openalex.org/W2534349779","https://openalex.org/W2548153839","https://openalex.org/W2550870820","https://openalex.org/W2560357342","https://openalex.org/W2561435396","https://openalex.org/W2563571637","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W4386618085","https://openalex.org/W2587205230","https://openalex.org/W4410316984","https://openalex.org/W2098910097","https://openalex.org/W4220834105","https://openalex.org/W2564417534","https://openalex.org/W4377029693","https://openalex.org/W2911830656","https://openalex.org/W2791507512","https://openalex.org/W3143925138"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,9,29,70,109,113,138],"BH3":[3],"mimetics,":[4],"which":[5],"antagonize":[6],"prosurvival":[7,22,114],"proteins":[8,115],"the":[10,21,55,135],"BCL-2":[11],"family,":[12],"represents":[13],"a":[14,131],"potential":[15,117],"breakthrough":[16],"in":[17,37,59,78,87,124,141],"cancer":[18,61,81],"therapy.":[19],"Targeting":[20],"member":[23],"MCL-1":[24,42,56,139],"has":[25],"been":[26],"an":[27],"area":[28],"intense":[30],"interest":[31],"because":[32],"it":[33],"is":[34,43],"frequently":[35],"deregulated":[36],"cancer.":[38,90,126,143],"In":[39],"breast":[40,60,80,89,125,142],"cancer,":[41],"often":[44],"amplified,":[45],"and":[46,64,82,111],"high":[47,68],"expression":[48,69],"predicts":[49],"poor":[50],"patient":[51],"outcome.":[52],"We":[53],"tested":[54],"inhibitor":[57],"S63845":[58,72,123],"cell":[62],"lines":[63],"patient-derived":[65],"xenografts":[66],"with":[67,76,83,95],"MCL-1.":[71],"displayed":[73],"synergistic":[74],"activity":[75],"docetaxel":[77],"triple-negative":[79],"trastuzumab":[84],"or":[85],"lapatinib":[86],"HER2-amplified":[88],"Using":[91],"S63845-resistant":[92],"cells":[93],"combined":[94],"CRISPR":[96],"(clustered":[97],"regularly":[98],"interspaced":[99],"short":[100],"palindromic":[101],"repeats)-Cas9":[102],"(CRISPR-associated":[103],"9)":[104],"technology,":[105],"we":[106],"identified":[107],"deletion":[108],"BAK":[110],"up-regulation":[112],"as":[116],"mechanisms":[118],"that":[119],"confer":[120],"resistance":[121],"to":[122],"Collectively,":[127],"our":[128],"findings":[129],"provide":[130],"strong":[132],"rationale":[133],"for":[134],"clinical":[136],"evaluation":[137],"inhibitors":[140]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-08-17T00:00:00"}