{"id":"https://openalex.org/W27433231","doi":null,"title":"Human growth hormone release is decreased during sleep in temporal isolation (free-running).","display_name":"Human growth hormone release is decreased during sleep in temporal isolation (free-running).","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W27433231","mag":"27433231","pmid":"https://pubmed.ncbi.nlm.nih.gov/3720426"},"language":"en","primary_location":{"id":"pmid:3720426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3720426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiologia","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078195357","display_name":"Margaret L. Moline","orcid":"https://orcid.org/0000-0003-0807-2167","observed_orcids":["https://orcid.org/0000-0003-0807-2167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Moline","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110860490","display_name":"T. H. Monk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T H Monk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064201204","display_name":"Dean Wagner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Wagner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270944","display_name":"Charles P. Pollak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C P Pollak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039786686","display_name":"Jacob Kream","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kream","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025532515","display_name":"Jeffrey E. Fookson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Fookson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111510937","display_name":"Elliot D. Weitzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Weitzman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087686970","display_name":"Charles Andrew Czeisler","orcid":"https://orcid.org/0000-0002-7408-1849","observed_orcids":["https://orcid.org/0000-0002-7408-1849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Czeisler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5963,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.63116909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"1","first_page":"13","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.382099986076355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0754999965429306,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.8500000238418579},{"id":"https://openalex.org/keywords/free-running","display_name":"free running","score":0.800000011920929},{"id":"https://openalex.org/keywords/temporal-isolation","display_name":"temporal isolation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/circadian-entrainment","display_name":"circadian entrainment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/slow-wave-sleep","display_name":"slow-wave sleep","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rem-latency","display_name":"REM latency","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sleep-onset","display_name":"sleep onset","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.7759344577789307},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.6762558817863464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6597265601158142},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6577820777893066},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.6084445714950562},{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.5809609293937683},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.5167555212974548},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5108342170715332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4273824989795685},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4240882098674774},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.41245758533477783},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.41005590558052063},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3783971965312958},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.37702715396881104},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.35820794105529785},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.18028360605239868},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.12569811940193176},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.11861789226531982},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11653316020965576},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3720426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3720426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiologia","raw_type":"Comparative Study"},{"id":"mag:27433231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3720426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1729310130","https://openalex.org/W1972018390","https://openalex.org/W1982329647","https://openalex.org/W2013251441","https://openalex.org/W2022022551","https://openalex.org/W2030366185","https://openalex.org/W2030846517","https://openalex.org/W2077182350","https://openalex.org/W2087274414","https://openalex.org/W2089433480","https://openalex.org/W2134023104","https://openalex.org/W2140357023","https://openalex.org/W2145789207","https://openalex.org/W2170080889","https://openalex.org/W2724553955","https://openalex.org/W4391868456"],"related_works":["https://openalex.org/W1974584318","https://openalex.org/W2083487816","https://openalex.org/W1978904908","https://openalex.org/W2106631353","https://openalex.org/W2072714418","https://openalex.org/W2042327065","https://openalex.org/W2069537526","https://openalex.org/W1979710595","https://openalex.org/W2332028224","https://openalex.org/W108379970"],"abstract_inverted_index":{"Growth":[0],"hormone":[1],"(hGH)":[2],"secretion":[3,79,93],"was":[4],"measured":[5],"during":[6,42,66,97],"sleep":[7,21,27,32,51,61,71,105,116],"in":[8],"10":[9],"healthy":[10],"male":[11],"subjects":[12],"isolated":[13],"from":[14,70],"all":[15],"time":[16],"cues.":[17],"HGH":[18],"concentrations":[19],"following":[20],"onset":[22,72,106],"were":[23,39],"compared":[24],"between":[25,83],"scheduled":[26],"episodes":[28,33],"(entrainment)":[29],"and":[30,54,75,85],"self-selected":[31],"(free-running).":[34],"Peak":[35],"sleep-related":[36,91,125],"hGH":[37,78,92,108,126],"values":[38],"decreased":[40,64],"significantly":[41,65],"free-running.":[43,67,86],"The":[44,68],"duration":[45],"of":[46,112,115,124],"the":[47,55,58,110,122],"first":[48,59],"slow":[49],"wave":[50],"(SWS)":[52],"episode":[53,62],"latency":[56],"to":[57,73,76],"REM":[60,119],"also":[63],"latencies":[69],"SWS":[74],"peak":[77],"did":[80],"not":[81],"differ":[82],"entrainment":[84],"These":[87],"results":[88],"suggest":[89],"that":[90],"begins":[94],"'on":[95],"time'":[96],"free-running,":[98],"but":[99],"is":[100],"terminated":[101],"earlier.":[102],"Thus,":[103],"while":[104],"facilitates":[107],"release,":[109],"timing":[111],"other":[113],"stages":[114],"such":[117],"as":[118],"may":[120],"alter":[121],"magnitude":[123],"secretion.":[127]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}