{"id":"https://openalex.org/W2742890627","doi":"https://doi.org/10.18632/oncotarget.19932","title":"The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis","display_name":"The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis","publication_year":2017,"publication_date":"2017-08-04","ids":{"openalex":"https://openalex.org/W2742890627","doi":"https://doi.org/10.18632/oncotarget.19932","mag":"2742890627","pmid":"https://pubmed.ncbi.nlm.nih.gov/28978186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5620326"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.19932","doi":"https://doi.org/10.18632/oncotarget.19932","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19932","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19932&path%5B%5D=63613","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19932&path%5B%5D=63613","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008804367","display_name":"Peng Gao","orcid":"https://orcid.org/0000-0003-3321-4622","observed_orcids":["https://orcid.org/0000-0003-3321-4622"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Gao","raw_affiliation_strings":["Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009651909","display_name":"Na Niu","orcid":"https://orcid.org/0000-0002-7983-0474","observed_orcids":["https://orcid.org/0000-0002-7983-0474"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Na Niu","raw_affiliation_strings":["Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004973662","display_name":"Tianshu Wei","orcid":"https://orcid.org/0000-0002-7494-8609","observed_orcids":["https://orcid.org/0000-0002-7494-8609"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianshu Wei","raw_affiliation_strings":["Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015393577","display_name":"Hideto Tozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4405287250","display_name":"Isotope Science Center, The University of Tokyo","ror":"https://ror.org/04jggjp59","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287250","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideto Tozawa","raw_affiliation_strings":["The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I4405287250","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108053960","display_name":"Xiaocui Chen","orcid":"https://orcid.org/0009-0008-4329-1449","observed_orcids":["https://orcid.org/0009-0008-4329-1449"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaocui Chen","raw_affiliation_strings":["Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057583869","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-9004-1161","observed_orcids":["https://orcid.org/0000-0001-9004-1161"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiqing Zhang","raw_affiliation_strings":["Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366282","display_name":"Jiandong Zhang","orcid":"https://orcid.org/0000-0002-3042-2381","observed_orcids":["https://orcid.org/0000-0002-3042-2381"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandong Zhang","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045784267","display_name":"Youichiro Wada","orcid":"https://orcid.org/0000-0003-4543-5991","observed_orcids":["https://orcid.org/0000-0003-4543-5991"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4405287250","display_name":"Isotope Science Center, The University of Tokyo","ror":"https://ror.org/04jggjp59","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287250","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youichiro Wada","raw_affiliation_strings":["The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I4405287250","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078618089","display_name":"Carolyn M. Kapron","orcid":"https://orcid.org/0000-0001-8630-8214","observed_orcids":["https://orcid.org/0000-0001-8630-8214"]},"institutions":[{"id":"https://openalex.org/I662221","display_name":"Trent University","ror":"https://ror.org/03ygmq230","country_code":"CA","type":"education","lineage":["https://openalex.org/I662221"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carolyn M. Kapron","raw_affiliation_strings":["Department of Biology, Trent University, Peterborough, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Trent University, Peterborough, Ontario, Canada","institution_ids":["https://openalex.org/I662221"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100763003","display_name":"Ju Liu","orcid":"https://orcid.org/0000-0001-9932-2613","observed_orcids":["https://orcid.org/0000-0001-9932-2613"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Liu","raw_affiliation_strings":["Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008804367","https://openalex.org/A5009651909"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517","https://openalex.org/I4210153274"],"apc_list":null,"apc_paid":null,"fwci":0.694,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.58568354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"40","first_page":"69139","last_page":"69161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.718999981880188},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7369999885559082},{"id":"https://openalex.org/keywords/tumor-growth-and-metastasis","display_name":"tumor growth and metastasis","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.8086097240447998},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7570962905883789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6480262279510498},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6166249513626099},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5377691984176636},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.495809406042099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4663604497909546},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3970232307910919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3147720992565155},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21460571885108948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16930431127548218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12774652242660522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07454687356948853}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.19932","doi":"https://doi.org/10.18632/oncotarget.19932","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19932","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19932&path%5B%5D=63613","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:28978186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28978186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5620326","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5620326/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.19932","doi":"https://doi.org/10.18632/oncotarget.19932","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19932","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19932&path%5B%5D=63613","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1407206113","display_name":"\u8840\u7ba1\u6027\u8840\u53cb\u75c5\u56e0\u5b50(vWF) \u5728\u5fc3\u808c\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u8f6c\u5f55\u8c03\u63a7\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81370269","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4291754212","display_name":"Notch\u901a\u8def\u5728\u6210\u5e74\u5fc3\u808c\u5fae\u8840\u7ba1\u5185\u76ae\u5411\u95f4\u8d28\u7ec6\u80de\u8f6c\u5316\u7684\u4f5c\u7528\u53ca\u5176\u673a\u7406\u7814\u7a76","funder_award_id":"81570255","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4999326724","display_name":null,"funder_award_id":"ZR2014HQ058","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2742890627.pdf","grobid_xml":"https://content.openalex.org/works/W2742890627.grobid-xml"},"referenced_works_count":208,"referenced_works":["https://openalex.org/W113297639","https://openalex.org/W1497501192","https://openalex.org/W1537984360","https://openalex.org/W1585058857","https://openalex.org/W1601667381","https://openalex.org/W1603454735","https://openalex.org/W1775759920","https://openalex.org/W1821858011","https://openalex.org/W1834266271","https://openalex.org/W1871603236","https://openalex.org/W1873822182","https://openalex.org/W1915538437","https://openalex.org/W1915663515","https://openalex.org/W1964704428","https://openalex.org/W1964905528","https://openalex.org/W1965037168","https://openalex.org/W1965543435","https://openalex.org/W1966213291","https://openalex.org/W1967429436","https://openalex.org/W1971324461","https://openalex.org/W1972627489","https://openalex.org/W1973134698","https://openalex.org/W1973836804","https://openalex.org/W1974968368","https://openalex.org/W1977031737","https://openalex.org/W1977681992","https://openalex.org/W1978139448","https://openalex.org/W1978564046","https://openalex.org/W1978646961","https://openalex.org/W1978709703","https://openalex.org/W1979090251","https://openalex.org/W1979520335","https://openalex.org/W1980121152","https://openalex.org/W1982099466","https://openalex.org/W1982317652","https://openalex.org/W1982782750","https://openalex.org/W1983989619","https://openalex.org/W1985510294","https://openalex.org/W1989430790","https://openalex.org/W1990827391","https://openalex.org/W1992112921","https://openalex.org/W1992912767","https://openalex.org/W1994279450","https://openalex.org/W1994601869","https://openalex.org/W1994611438","https://openalex.org/W1995168398","https://openalex.org/W1995383519","https://openalex.org/W1995444593","https://openalex.org/W1995827857","https://openalex.org/W1996873142","https://openalex.org/W1999574305","https://openalex.org/W2000214286","https://openalex.org/W2000383031","https://openalex.org/W2000811703","https://openalex.org/W2001281185","https://openalex.org/W2001446997","https://openalex.org/W2001570908","https://openalex.org/W2001775267","https://openalex.org/W2002117801","https://openalex.org/W2003112634","https://openalex.org/W2005168380","https://openalex.org/W2006249329","https://openalex.org/W2006514214","https://openalex.org/W2007897471","https://openalex.org/W2013534489","https://openalex.org/W2014278521","https://openalex.org/W2016134079","https://openalex.org/W2020892166","https://openalex.org/W2021803409","https://openalex.org/W2022540958","https://openalex.org/W2023417206","https://openalex.org/W2024405339","https://openalex.org/W2025036947","https://openalex.org/W2026865847","https://openalex.org/W2029169197","https://openalex.org/W2029245949","https://openalex.org/W2030537668","https://openalex.org/W2032260589","https://openalex.org/W2032425910","https://openalex.org/W2032511198","https://openalex.org/W2035134361","https://openalex.org/W2035261278","https://openalex.org/W2035380667","https://openalex.org/W2037604062","https://openalex.org/W2040010231","https://openalex.org/W2043313378","https://openalex.org/W2044227662","https://openalex.org/W2044951483","https://openalex.org/W2046795682","https://openalex.org/W2050064198","https://openalex.org/W2051638902","https://openalex.org/W2052715855","https://openalex.org/W2053814095","https://openalex.org/W2059127283","https://openalex.org/W2059646584","https://openalex.org/W2062131975","https://openalex.org/W2064283969","https://openalex.org/W2065195919","https://openalex.org/W2069027997","https://openalex.org/W2069305322","https://openalex.org/W2071640699","https://openalex.org/W2072669480","https://openalex.org/W2073924006","https://openalex.org/W2074211754","https://openalex.org/W2074503162","https://openalex.org/W2075215717","https://openalex.org/W2075394689","https://openalex.org/W2076473876","https://openalex.org/W2077523906","https://openalex.org/W2077719385","https://openalex.org/W2083802827","https://openalex.org/W2084284769","https://openalex.org/W2084418060","https://openalex.org/W2086101597","https://openalex.org/W2088095644","https://openalex.org/W2092854448","https://openalex.org/W2093155739","https://openalex.org/W2095818256","https://openalex.org/W2098637032","https://openalex.org/W2098921739","https://openalex.org/W2099791897","https://openalex.org/W2099913692","https://openalex.org/W2100382285","https://openalex.org/W2102912734","https://openalex.org/W2103331330","https://openalex.org/W2103366137","https://openalex.org/W2107786623","https://openalex.org/W2109849382","https://openalex.org/W2110672879","https://openalex.org/W2111608713","https://openalex.org/W2111630252","https://openalex.org/W2113095561","https://openalex.org/W2113162775","https://openalex.org/W2113231588","https://openalex.org/W2113744343","https://openalex.org/W2114081642","https://openalex.org/W2114445658","https://openalex.org/W2116704835","https://openalex.org/W2116966799","https://openalex.org/W2117923390","https://openalex.org/W2118389201","https://openalex.org/W2118417553","https://openalex.org/W2120858735","https://openalex.org/W2121099709","https://openalex.org/W2121314018","https://openalex.org/W2123105952","https://openalex.org/W2123373938","https://openalex.org/W2124618015","https://openalex.org/W2125242137","https://openalex.org/W2125538105","https://openalex.org/W2126018509","https://openalex.org/W2127663041","https://openalex.org/W2127754394","https://openalex.org/W2129532336","https://openalex.org/W2130639482","https://openalex.org/W2131778644","https://openalex.org/W2132992001","https://openalex.org/W2133333487","https://openalex.org/W2134595672","https://openalex.org/W2134847995","https://openalex.org/W2136814213","https://openalex.org/W2137870051","https://openalex.org/W2139520473","https://openalex.org/W2141077451","https://openalex.org/W2146440581","https://openalex.org/W2146784178","https://openalex.org/W2150102205","https://openalex.org/W2151055438","https://openalex.org/W2152338416","https://openalex.org/W2159353151","https://openalex.org/W2164232024","https://openalex.org/W2168478794","https://openalex.org/W2170189698","https://openalex.org/W2171237466","https://openalex.org/W2192333446","https://openalex.org/W2193861601","https://openalex.org/W2195075045","https://openalex.org/W2204739685","https://openalex.org/W2218610501","https://openalex.org/W2259227633","https://openalex.org/W2270525285","https://openalex.org/W2281804634","https://openalex.org/W2287534912","https://openalex.org/W2323443286","https://openalex.org/W2331264401","https://openalex.org/W2335330085","https://openalex.org/W2338837994","https://openalex.org/W2340750842","https://openalex.org/W2344923222","https://openalex.org/W2359518746","https://openalex.org/W2408203561","https://openalex.org/W2409351058","https://openalex.org/W2482126388","https://openalex.org/W2487740014","https://openalex.org/W2513262406","https://openalex.org/W2518248979","https://openalex.org/W2518331578","https://openalex.org/W2527798256","https://openalex.org/W2528370921","https://openalex.org/W2529726896","https://openalex.org/W2537744163","https://openalex.org/W2553967508","https://openalex.org/W2584658871","https://openalex.org/W2601388231","https://openalex.org/W2602217931","https://openalex.org/W2610204288","https://openalex.org/W2793323124","https://openalex.org/W4294718043"],"related_works":["https://openalex.org/W2100382285","https://openalex.org/W2006514214","https://openalex.org/W2385398394","https://openalex.org/W2491854147","https://openalex.org/W3029247629","https://openalex.org/W1973009607","https://openalex.org/W2042319069","https://openalex.org/W1985692347","https://openalex.org/W2033899321","https://openalex.org/W2007897471"],"abstract_inverted_index":{"//":[0],"Peng":[1],"Gao":[2],"1,":[3],"*":[4,9,126],",":[5,10,14,18,22,26,30,34],"Na":[6],"Niu":[7],"2,":[8],"Tianshu":[11],"Wei":[12],"1":[13,21,42,43],"Hideto":[15],"Tozawa":[16],"3":[17,33,70,184],"Xiaocui":[19],"Chen":[20],"Caiqing":[23],"Zhang":[24,28],"4":[25,89],"Jiandong":[27],"5":[29,103],"Youichiro":[31],"Wada":[32],"Carolyn":[35],"M.":[36],"Kapron":[37],"6":[38,117],"and":[39,77,175,179,200,251],"Ju":[40,136],"Liu":[41],"Medical":[44],"Research":[45,72],"Center,":[46,81],"Shandong":[47,51,60,65,94,98,108,112],"Provincial":[48,61,95,109],"Qianfoshan":[49,96,110],"Hospital,":[50,97,111],"University,":[52,66,99,113,122],"Jinan,":[53,67,100,114],"Shandong,":[54,68,101,115],"China":[55,69,102,116],"2":[56],"Department":[57,90,104,118],"of":[58,84,91,105,119,165,181,194,207,219,235,273],"Pediatrics,":[59],"Hospital":[62],"Affiliated":[63],"to":[64,131,245],"The":[71,82,253],"Center":[73],"for":[74,172,255,270],"Advanced":[75],"Science":[76,80],"Technology,":[78],"Isotope":[79],"University":[83],"Tokyo,":[85,87],"Meguro-ku,":[86],"Japan":[88],"Respiratory":[92],"Medicine,":[93],"Radiation":[106],"Oncology,":[107],"Biology,":[120],"Trent":[121],"Peterborough,":[123],"Ontario,":[124],"Canada":[125],"These":[127],"authors":[128],"contributed":[129],"equally":[130],"this":[132,213,265],"work":[133],"Correspondence":[134],"to:":[135],"Liu,":[137],"email:":[138],"ju.liu@sdu.edu.cn":[139],"Keywords:":[140],"STAT3,":[141],"tumor":[142,173,210,277],"angiogenesis,":[143],"transcriptional":[144],"regulation,":[145],"endothelial":[146,241],"cells":[147,242],"Received:":[148],"June":[149],"28,":[150],"2017":[151,155,159],"Accepted:":[152],"July":[153],"26,":[154],"Published:":[156],"August":[157],"04,":[158],"ABSTRACT":[160],"Angiogenesis":[161],"is":[162,170,186],"the":[163,217,232,271],"development":[164],"new":[166],"blood":[167],"vessels,":[168],"which":[169],"required":[171],"growth":[174],"metastasis.":[176],"Signal":[177],"transducer":[178],"activator":[180],"transcription":[182,188],"factor":[183,189],"(STAT3)":[185],"a":[187,192,258],"that":[190,205],"regulates":[191],"variety":[193],"cellular":[195],"events":[196],"including":[197],"proliferation,":[198],"differentiation":[199],"apoptosis.":[201],"Previous":[202],"studies":[203],"revealed":[204],"activation":[206],"STAT3":[208,220,256,274],"promotes":[209],"angiogenesis.":[211,228,278],"In":[212],"review,":[214],"we":[215,230],"described":[216],"activities":[218],"signaling":[221,275],"in":[222,227,239,243,276],"different":[223],"cell":[224],"types":[225],"involved":[226],"Particularly,":[229],"elucidated":[231],"molecular":[233],"mechanisms":[234],"STAT3-mediated":[236],"gene":[237],"regulation":[238],"angiogenic":[240],"response":[244],"external":[246],"stimulations":[247],"such":[248],"as":[249,257],"hypoxia":[250],"inflammation.":[252],"potential":[254],"therapeutic":[259],"target":[260],"was":[261],"also":[262],"discussed.":[263],"Overall,":[264],"review":[266],"provides":[267],"mechanistic":[268],"insights":[269],"roles":[272]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-08-17T00:00:00"}
