{"id":"https://openalex.org/W2742884987","doi":"https://doi.org/10.1021/acs.jnatprod.7b00331","title":"Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species","display_name":"Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species","publication_year":2017,"publication_date":"2017-08-10","ids":{"openalex":"https://openalex.org/W2742884987","doi":"https://doi.org/10.1021/acs.jnatprod.7b00331","mag":"2742884987","pmid":"https://pubmed.ncbi.nlm.nih.gov/28796494"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.7b00331","doi":"https://doi.org/10.1021/acs.jnatprod.7b00331","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.7b00331","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029740465","display_name":"Manuel A. Aparicio-Cuevas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Manuel A. Aparicio-Cuevas","raw_affiliation_strings":["\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030517128","display_name":"Isabel Rivero\u2010Cruz","orcid":"https://orcid.org/0000-0003-0185-5775","observed_orcids":["https://orcid.org/0000-0003-0185-5775"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Isabel Rivero-Cruz","raw_affiliation_strings":["\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049775484","display_name":"Mariano S\u00e1nchez\u2010Castellanos","orcid":"https://orcid.org/0000-0003-0566-0975","observed_orcids":["https://orcid.org/0000-0003-0566-0975"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Mariano S\u00e1nchez-Castellanos","raw_affiliation_strings":["Departamento de Qu\u00edmica, Centro de Investigaci\u00f3n y de Estudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico","Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States","Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States","\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica, Centro de Investigaci\u00f3n y de Estudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016554938","display_name":"Daniel Men\u00e9ndez","orcid":"https://orcid.org/0000-0002-4868-9682","observed_orcids":["https://orcid.org/0000-0002-4868-9682"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Men\u00e9ndez","raw_affiliation_strings":["Genome Integrity\rand Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Integrity\rand Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045136472","display_name":"Huzefa A. Raja","orcid":"https://orcid.org/0000-0002-0824-9463","observed_orcids":["https://orcid.org/0000-0002-0824-9463"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huzefa A. Raja","raw_affiliation_strings":["Department\rof Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067490486","display_name":"Pedro Joseph\u2010Nathan","orcid":"https://orcid.org/0000-0003-3347-3990","observed_orcids":["https://orcid.org/0000-0003-3347-3990"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pedro Joseph-Nathan","raw_affiliation_strings":["Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n y de\rEstudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n y de\rEstudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054136477","display_name":"Mar\u00eda del Carm\u00e9n Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-7180-3749","observed_orcids":["https://orcid.org/0000-0001-7180-3749"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Mar\u00eda del Carmen Gonz\u00e1lez","raw_affiliation_strings":["Departamento de Qu\u00edmica, Centro de Investigaci\u00f3n y de Estudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico","Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States","Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States","\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica, Centro de Investigaci\u00f3n y de Estudios, Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado 14-740, Ciudad de M\u00e9xico 07000, M\u00e9xico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016310012","display_name":"Mario Figueroa","orcid":"https://orcid.org/0000-0001-7004-0591","observed_orcids":["https://orcid.org/0000-0001-7004-0591"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Mario Figueroa","raw_affiliation_strings":["\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0001-7004-0591","affiliations":[{"raw_affiliation_string":"\u2020 Facultad de Qu\u00edmica, \u00a7 Instituto de Qu\u00edmica, and \u2225 Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016310012"],"corresponding_institution_ids":["https://openalex.org/I8961855"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.673,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.88593643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"80","issue":"8","first_page":"2311","last_page":"2318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.8240000009536743},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.878000020980835},{"id":"https://openalex.org/keywords/vibrational-circular-dichroism","display_name":"vibrational circular dichroism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/multidrug-resistance-reversal","display_name":"multidrug resistance reversal","score":0.9049999713897705},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.972000002861023},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C53144768","wikidata":"https://www.wikidata.org/wiki/Q5428855","display_name":"Facultative","level":2,"score":0.8705655336380005},{"id":"https://openalex.org/C2779175654","wikidata":"https://www.wikidata.org/wiki/Q335130","display_name":"Aspergillus","level":2,"score":0.4798390567302704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4431137144565582},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3753450810909271},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3697358965873718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3204635977745056},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2916961908340454}],"mesh":[{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jnatprod.7b00331","doi":"https://doi.org/10.1021/acs.jnatprod.7b00331","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.7b00331","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:28796494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28796494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.8899999856948853}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1056069748","display_name":null,"funder_award_id":"INFRA 252226","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G2597701114","display_name":null,"funder_award_id":"INFRA 252226","funder_id":"https://openalex.org/F4320324348","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Guatemala"},{"id":"https://openalex.org/G6042340683","display_name":null,"funder_award_id":"CB 236564","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G693051210","display_name":null,"funder_award_id":"CB 236564","funder_id":"https://openalex.org/F4320324348","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Guatemala"},{"id":"https://openalex.org/G7839579701","display_name":null,"funder_award_id":"205017","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320324348","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Guatemala","ror":"https://ror.org/03pr08s76"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W339230926","https://openalex.org/W1548825336","https://openalex.org/W1936011783","https://openalex.org/W1966372267","https://openalex.org/W1975124577","https://openalex.org/W2006434892","https://openalex.org/W2013266664","https://openalex.org/W2023930858","https://openalex.org/W2026875867","https://openalex.org/W2028910091","https://openalex.org/W2039318033","https://openalex.org/W2039748921","https://openalex.org/W2043157255","https://openalex.org/W2050569275","https://openalex.org/W2055904567","https://openalex.org/W2062294077","https://openalex.org/W2071107415","https://openalex.org/W2076149108","https://openalex.org/W2084831115","https://openalex.org/W2133800193","https://openalex.org/W2252553152","https://openalex.org/W2399924328","https://openalex.org/W2949909009","https://openalex.org/W2952658628"],"related_works":["https://openalex.org/W2025125214","https://openalex.org/W2504666487","https://openalex.org/W2567481685","https://openalex.org/W1972390356","https://openalex.org/W2039748921","https://openalex.org/W4225129443","https://openalex.org/W3193788901","https://openalex.org/W2142709754","https://openalex.org/W3103566355","https://openalex.org/W2743970030"],"abstract_inverted_index":{"Two":[0],"new":[1,7],"dioxomorpholines,":[2],"1":[3,43],"and":[4,10,32,35,44,52,61],"2,":[5],"three":[6],"derivatives,":[8],"3-5,":[9],"the":[11,78],"known":[12],"compound":[13],"PF1233":[14],"B":[15],"(6)":[16],"were":[17,28,63,83],"isolated":[18],"from":[19],"a":[20,66,90],"marine-facultative":[21],"Aspergillus":[22],"sp.":[23],"MEXU":[24],"27854.":[25],"Their":[26],"structures":[27],"established":[29],"by":[30,48],"1D":[31],"2D":[33],"NMR":[34],"HRESIMS":[36],"data":[37],"analysis.":[38],"The":[39],"absolute":[40],"configuration":[41],"of":[42,50,68,85],"2":[45],"was":[46],"elucidated":[47],"comparison":[49],"experimental":[51],"DFT-calculated":[53],"vibrational":[54],"circular":[55],"dichroism":[56],"spectra.":[57],"Compounds":[58],"3,":[59],"5,":[60],"6":[62],"noncytotoxic":[64],"to":[65],"panel":[67],"human":[69],"cancer":[70],"cell":[71,92],"lines":[72],"with":[73],"different":[74],"functional":[75],"status":[76],"for":[77],"tumor-suppressor":[79],"protein":[80],"p53,":[81],"but":[82],"inhibitors":[84],"P-glycoprotein-reversing":[86],"multidrug":[87],"resistance":[88],"in":[89],"doxorubicin-resistant":[91],"line.":[93]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-08-17T00:00:00"}