{"id":"https://openalex.org/W2742859372","doi":"https://doi.org/10.1038/s41598-017-09211-3","title":"Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function","display_name":"Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function","publication_year":2017,"publication_date":"2017-08-11","ids":{"openalex":"https://openalex.org/W2742859372","doi":"https://doi.org/10.1038/s41598-017-09211-3","mag":"2742859372","pmid":"https://pubmed.ncbi.nlm.nih.gov/28819166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5561267"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-09211-3","doi":"https://doi.org/10.1038/s41598-017-09211-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09211-3","pdf_url":"https://www.nature.com/articles/s41598-017-09211-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-09211-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102880334","display_name":"Jianbing Huang","orcid":"https://orcid.org/0000-0002-0528-1150","observed_orcids":["https://orcid.org/0000-0002-0528-1150"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianbing Huang","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674985","display_name":"Liqing Wang","orcid":"https://orcid.org/0000-0001-7600-6992","observed_orcids":["https://orcid.org/0000-0001-7600-6992"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liqing Wang","raw_affiliation_strings":["Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036092314","display_name":"Satinder Dahiya","orcid":"https://orcid.org/0000-0002-2189-4846","observed_orcids":["https://orcid.org/0000-0002-2189-4846"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satinder Dahiya","raw_affiliation_strings":["Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086503568","display_name":"Ulf Henning Beier","orcid":"https://orcid.org/0000-0002-3672-572X","observed_orcids":["https://orcid.org/0000-0002-3672-572X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulf H. Beier","raw_affiliation_strings":["Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110552453","display_name":"Rongxiang Han","orcid":"https://orcid.org/0009-0008-5597-3199","observed_orcids":["https://orcid.org/0009-0008-5597-3199"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongxiang Han","raw_affiliation_strings":["Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059890911","display_name":"Arabinda Samanta","orcid":"https://orcid.org/0009-0007-6252-5282","observed_orcids":["https://orcid.org/0009-0007-6252-5282"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arabinda Samanta","raw_affiliation_strings":["Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006801232","display_name":"Joel A. Bergman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Bergman","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108222207","display_name":"Eduardo M. Sotomayor","orcid":"https://orcid.org/0009-0009-5081-3855","observed_orcids":["https://orcid.org/0009-0009-5081-3855"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo M. Sotomayor","raw_affiliation_strings":["George Washington University Cancer Center, Washington, DC, 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University Cancer Center, Washington, DC, 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004256523","display_name":"Edward Seto","orcid":"https://orcid.org/0000-0001-7562-7316","observed_orcids":["https://orcid.org/0000-0001-7562-7316"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Seto","raw_affiliation_strings":["George Washington University Cancer Center, Washington, DC, 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University Cancer Center, Washington, DC, 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026395120","display_name":"Alan P. Kozikowski","orcid":"https://orcid.org/0000-0003-4795-5368","observed_orcids":["https://orcid.org/0000-0003-4795-5368","https://orcid.org/0009-0004-2541-2826"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P. Kozikowski","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047555474","display_name":"Wayne W. Hancock","orcid":"https://orcid.org/0000-0002-7211-5291","observed_orcids":["https://orcid.org/0000-0002-7211-5291"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wayne W. Hancock","raw_affiliation_strings":["Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. whancock@mail.med.upenn.edu","Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. whancock@mail.med.upenn.edu","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5047555474"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":4.1925,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.95437097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"8626","last_page":"8626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac11","display_name":"HDAC11","score":0.9020000100135803},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.9049999713897705},{"id":"https://openalex.org/keywords/allograft-survival","display_name":"allograft survival","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cardiac-allograft","display_name":"cardiac allograft","score":0.781000018119812},{"id":"https://openalex.org/keywords/transplant-arteriosclerosis","display_name":"transplant arteriosclerosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mhc-mismatch","display_name":"MHC mismatch","score":0.906000018119812},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6690000295639038},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.6340000033378601},{"id":"https://openalex.org/keywords/transplantation-immunology","display_name":"transplantation immunology","score":0.49399998784065247},{"id":"https://openalex.org/keywords/autoimmune-disease-treatment","display_name":"autoimmune disease therapy","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7131096124649048},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.7036131024360657},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6503275632858276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.580359697341919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5641388297080994},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5393597483634949},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5217148661613464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3284926414489746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2831059694290161},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.23259124159812927},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16306087374687195},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13564032316207886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06620249152183533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.057539552450180054}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064591","descriptor_name":"Allografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-017-09211-3","doi":"https://doi.org/10.1038/s41598-017-09211-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09211-3","pdf_url":"https://www.nature.com/articles/s41598-017-09211-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4459275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5561267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5561267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5561267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28819166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28819166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5a235acd97ca4a28899dd27f87d82b68","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a235acd97ca4a28899dd27f87d82b68","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-09211-3","doi":"https://doi.org/10.1038/s41598-017-09211-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09211-3","pdf_url":"https://www.nature.com/articles/s41598-017-09211-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G291728713","display_name":"ANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAY","funder_award_id":"R56AI095276","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5609491138","display_name":"Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell function","funder_award_id":"K08AI095353","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G64827991","display_name":"Immune chemistry and therapeutic features of FOXP3","funder_award_id":"P01AI073489","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000296959","display_name":null,"funder_award_id":"AI073489","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2742859372.pdf","grobid_xml":"https://content.openalex.org/works/W2742859372.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1495880776","https://openalex.org/W1539668795","https://openalex.org/W1604495350","https://openalex.org/W1829683318","https://openalex.org/W1974050018","https://openalex.org/W1975692560","https://openalex.org/W1979610433","https://openalex.org/W1985277568","https://openalex.org/W1985845937","https://openalex.org/W1992375755","https://openalex.org/W1992641327","https://openalex.org/W1992817469","https://openalex.org/W2009826707","https://openalex.org/W2013407554","https://openalex.org/W2024013245","https://openalex.org/W2027488189","https://openalex.org/W2030284768","https://openalex.org/W2032988478","https://openalex.org/W2042224490","https://openalex.org/W2042597829","https://openalex.org/W2047559139","https://openalex.org/W2050791058","https://openalex.org/W2067739721","https://openalex.org/W2070089404","https://openalex.org/W2077627479","https://openalex.org/W2082426890","https://openalex.org/W2084326457","https://openalex.org/W2092717823","https://openalex.org/W2099060358","https://openalex.org/W2102489631","https://openalex.org/W2102650038","https://openalex.org/W2103785661","https://openalex.org/W2110709781","https://openalex.org/W2111292063","https://openalex.org/W2112351720","https://openalex.org/W2140594545","https://openalex.org/W2141615498","https://openalex.org/W2144657878","https://openalex.org/W2146955123","https://openalex.org/W2147415114","https://openalex.org/W2158217645","https://openalex.org/W2163132655","https://openalex.org/W2164453551","https://openalex.org/W2165494158","https://openalex.org/W2173141813","https://openalex.org/W2238440719","https://openalex.org/W2265913260","https://openalex.org/W2325412747","https://openalex.org/W2414906602"],"related_works":["https://openalex.org/W2809934491","https://openalex.org/W4242038389","https://openalex.org/W2772674818","https://openalex.org/W2794772915","https://openalex.org/W3000328267","https://openalex.org/W2019080597","https://openalex.org/W2141615498","https://openalex.org/W2055946087","https://openalex.org/W2071518233","https://openalex.org/W2102489631"],"abstract_inverted_index":{"Current":[0],"interest":[1],"in":[2,10,85,144,170],"Foxp3+":[3,73,103],"T-regulatory":[4],"(Treg)":[5],"cells":[6],"as":[7],"therapeutic":[8],"targets":[9],"transplantation":[11,196],"is":[12,57],"largely":[13],"focused":[14],"on":[15,94],"their":[16,77],"harvesting":[17],"pre-transplant,":[18],"expansion":[19],"and":[20,41,76,98,111,116,138,183,189,197],"infusion":[21],"post-transplantation.":[22],"An":[23],"alternate":[24],"strategy":[25],"of":[26,29,47,70,114,125,133,141,154,162,185],"pharmacologic":[27,187],"modulation":[28],"Treg":[30,74],"function":[31],"using":[32],"histone/protein":[33],"deacetylase":[34],"inhibitors":[35],"(HDACi)":[36],"may":[37,190],"allow":[38],"more":[39],"titratable":[40],"longer-term":[42],"dosing.":[43],"However,":[44],"the":[45,160,180],"effects":[46],"broadly":[48],"acting":[49],"HDACi":[50],"vary,":[51],"such":[52],"that":[53],"HDAC":[54],"isoform-selective":[55],"targeting":[56,156],"likely":[58],"required.":[59],"We":[60],"report":[61],"data":[62,175],"from":[63],"mice":[64],"with":[65,80],"constitutive":[66],"or":[67,96],"conditional":[68,123],"deletion":[69,90,124],"HDAC11":[71,83,89,106,126,155],"within":[72,127],"cells,":[75],"use,":[78],"along":[79],"small":[81],"molecule":[82],"inhibitors,":[84,188],"allograft":[86,149,168],"models.":[87],"Global":[88],"had":[91],"no":[92],"effect":[93],"health":[95],"development,":[97],"compared":[99,119],"to":[100,120,130,165],"WT":[101,121],"controls,":[102],"Tregs":[104,128],"lacking":[105],"showed":[107],"increased":[108,112],"suppressive":[109],"function,":[110],"expression":[113],"Foxp3":[115],"TGF-\u03b2.":[117],"Likewise,":[118],"recipients,":[122],"led":[129],"long-term":[131,167],"survival":[132],"fully":[134,171],"MHC-mismatched":[135],"cardiac":[136],"allografts,":[137],"prevented":[139],"development":[140,182],"transplant":[142],"arteriosclerosis":[143],"an":[145,163],"MHC":[146],"class":[147],"II-mismatched":[148],"model.":[150],"The":[151],"translational":[152],"significance":[153],"was":[157],"shown":[158],"by":[159],"ability":[161],"HDAC11i":[164],"promote":[166],"allografts":[169],"MHC-disparate":[172],"strains.":[173],"These":[174],"are":[176],"powerful":[177],"stimuli":[178],"for":[179,195],"further":[181],"testing":[184],"HDAC11-selective":[186],"ultimately":[191],"provide":[192],"new":[193],"therapies":[194],"autoimmune":[198],"diseases.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}
