{"id":"https://openalex.org/W2742526629","doi":"https://doi.org/10.2527/asasann.2017.177","title":"177 Genetic structure of Angus and Salers in relation to SNP associated with pulmonary arterial pressure","display_name":"177 Genetic structure of Angus and Salers in relation to SNP associated with pulmonary arterial pressure","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2742526629","doi":"https://doi.org/10.2527/asasann.2017.177","mag":"2742526629"},"language":"en","primary_location":{"id":"doi:10.2527/asasann.2017.177","doi":"https://doi.org/10.2527/asasann.2017.177","is_oa":false,"landing_page_url":"https://doi.org/10.2527/asasann.2017.177","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046061666","display_name":"Bethany Krehbiel","orcid":"https://orcid.org/0009-0007-7564-5582","observed_orcids":["https://orcid.org/0009-0007-7564-5582"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. C. Krehbiel","raw_affiliation_strings":["Department of Animal Sciences, Colorado State University, Fort Collins","National Animal Germplasm Program, National Laboratory for Genetic Resources Preservation, ARS, USDA, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Colorado State University, Fort Collins","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"National Animal Germplasm Program, National Laboratory for Genetic Resources Preservation, ARS, USDA, Fort Collins, CO","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114014095","display_name":"M. G. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. G. Thomas","raw_affiliation_strings":["Department of Animal Sciences, Colorado State University, Fort Collins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Colorado State University, Fort Collins","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012224869","display_name":"Scott E Speidel","orcid":"https://orcid.org/0000-0003-0247-5096","observed_orcids":["https://orcid.org/0000-0003-0247-5096"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Speidel","raw_affiliation_strings":["Department of Animal Sciences, Colorado State University, Fort Collins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Colorado State University, Fort Collins","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022092453","display_name":"R. M. Enns","orcid":"https://orcid.org/0000-0001-6830-8886","observed_orcids":["https://orcid.org/0000-0001-6830-8886"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Enns","raw_affiliation_strings":["Department of Animal Sciences, Colorado State University, Fort Collins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Colorado State University, Fort Collins","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072178212","display_name":"Harvey D. Blackburn","orcid":"https://orcid.org/0000-0003-0575-1594","observed_orcids":["https://orcid.org/0000-0003-0575-1594"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. D. Blackburn","raw_affiliation_strings":["National Animal Germplasm Program, National Laboratory for Genetic Resources Preservation, ARS, USDA, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Animal Germplasm Program, National Laboratory for Genetic Resources Preservation, ARS, USDA, Fort Collins, CO","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4368,"currency":"USD","value_usd":4368},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0984617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"95","issue":"suppl_4","first_page":"87","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angus-cattle","display_name":"Angus cattle","score":0.8539999723434448},{"id":"https://openalex.org/keywords/salers-cattle","display_name":"Salers cattle","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-artery-pressure","display_name":"pulmonary artery pressure","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.8029999732971191},{"id":"https://openalex.org/keywords/high-altitude-illness","display_name":"high-altitude illness","score":0.9810000061988831},{"id":"https://openalex.org/keywords/genetic-structure","display_name":"genetic structure","score":0.6460000276565552},{"id":"https://openalex.org/keywords/population-structure","display_name":"population structure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8240000009536743},{"id":"https://openalex.org/keywords/allele-frequency-divergence","display_name":"allele frequency divergence","score":0.7279999852180481},{"id":"https://openalex.org/keywords/signatures-of-selection","display_name":"selection signatures","score":0.7440000176429749},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/breed-selection","display_name":"breed selection","score":0.3930000066757202},{"id":"https://openalex.org/keywords/high-altitude-adaptation","display_name":"high-altitude adaptation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/right-heart-failure","display_name":"right heart failure","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cattle-genomics","display_name":"cattle genomics","score":0.31700000166893005},{"id":"https://openalex.org/keywords/genome-wide-association-study-loci","display_name":"genome-wide association study loci","score":0.6159999966621399},{"id":"https://openalex.org/keywords/admixture-analysis","display_name":"admixture analysis","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2776482104","wikidata":"https://www.wikidata.org/wiki/Q38829","display_name":"Breed","level":2,"score":0.6986557841300964},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6145921349525452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5557540655136108},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48753663897514343},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4562070071697235},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.441378116607666},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4381183385848999},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.38859331607818604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37915319204330444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3754541873931885},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3527568280696869},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3318687081336975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2525494694709778},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1062982976436615},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06842845678329468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2527/asasann.2017.177","doi":"https://doi.org/10.2527/asasann.2017.177","is_oa":false,"landing_page_url":"https://doi.org/10.2527/asasann.2017.177","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6309000253677368}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2742771559","https://openalex.org/W2811232117","https://openalex.org/W2883693207","https://openalex.org/W2743250489","https://openalex.org/W4319736465","https://openalex.org/W3016532140","https://openalex.org/W2508605094","https://openalex.org/W2744220874","https://openalex.org/W2626522340","https://openalex.org/W2553012386"],"abstract_inverted_index":{"Cattle":[0],"living":[1],"in":[2,180,309],"the":[3,54,65,146,150,157,191,206,230,247,253,277,286,306],"Rocky":[4],"Mountains":[5],"(elevations":[6],"of":[7,14,45,56,194,242,252,304],">1,500":[8],"m)":[9],"are":[10,48],"often":[11],"at":[12,22,59,86,111],"risk":[13,52],"contracting":[15],"high":[16,23,60,98,267,278,294,359],"altitude":[17,360],"disease.":[18,361],"Low":[19],"atmospheric":[20],"pressure":[21,35],"altitudes":[24],"causes":[25],"pulmonary":[26,41,57],"hypertension":[27,58],"and":[28,69,97,106,209,266,295,329,348],"potentially":[29],"right":[30],"heart":[31],"failure.":[32],"Pulmonary":[33],"arterial":[34],"(PAP)":[36],"is":[37,67],"an":[38],"indicator":[39],"for":[40,53,336],"hypertension.":[42],"PAP":[43,99,133,179,268,279,288,297,327],"measurements":[44],"<41":[46],"mmHg":[47,139],"categorized":[49],"as":[50],"low":[51,91,265,287,296,326],"development":[55],"altitudes.":[61],"Genetic":[62],"resilience":[63,357],"to":[64,142,167,189,201,215,225,355,358,367],"disease":[66],"possible":[68],"can":[70,352],"be":[71,353],"achieved":[72],"through":[73,183,372],"breed":[74,77,122,210,373],"or":[75,333,379],"within":[76,376],"selection.":[78,226,316],"Here,":[79],"we":[80],"explored":[81],"differences":[82,204],"between":[83,149,263,325,346],"Angus":[84,132,181,269,280,289,298,328,347],"raised":[85],"2,150":[87],"m":[88,124],"divided":[89],"into":[90],"(<41":[92],"mmHg;":[93,101],"n":[94,102],"=":[95,103,109,175],"24)":[96,110],"(>41":[100],"41)":[104],"groups":[105,248,270],"Salers":[107,117,349],"(n":[108,174],"loci":[112],"associated":[113,177],"with":[114,178],"PAP.":[115],"The":[116,130],"sampled,":[118],"a":[119,221,370,377],"French":[120],"mountainous":[121],"(<4,800":[123],"elevation),":[125],"were":[126,163,187,199,323],"all":[127],"full":[128],"blood.":[129],"mean":[131],"score":[134],"was":[135],"49":[136],"\u00b1":[137],"2.1":[138],"(range":[140],"35":[141],"115).":[143],"To":[144],"determine":[145],"population":[147],"structure":[148],"two":[151,236],"breeds,":[152],"121,756":[153],"SNP":[154,159,173,243,255,261,314],"pruned":[155],"from":[156,220,285],"777,972":[158],"on":[160],"BovineHD":[161],"BeadChip":[162],"evaluated":[164],"using":[165],"Admixture":[166,227],"infer":[168],"ancestral":[169],"populations.":[170,338],"Previously":[171],"identified":[172,312],"40)":[176],"cattle":[182,363],"genome-wide":[184],"association":[185],"studies":[186],"used":[188,213,354],"assess":[190],"genetic":[192,343],"diversity":[193,344],"both":[195,264,293,337],"breeds.":[196],"Chi-square":[197,240],"tests":[198,241],"performed":[200],"identify":[202,216],"statistical":[203],"among":[205,246],"allele":[207,217,300,321],"frequencies":[208,245,282,301,307,322],"groups.":[211],"We":[212],"TreeSelect":[214,311],"frequency":[218],"divergence":[219],"central":[222],"node":[223],"due":[224],"revealed":[228,249],"by":[229],"lowest":[231],"cross":[232],"validation":[233],"error":[234],"that":[235,250,342],"distinct":[237],"populations":[238],"existed.":[239],"genotypic":[244,281,290],"23":[251],"40":[254],"differed":[256,262],"(P":[257],"<":[258],"0.025).":[259],"Sixteen":[260],"versus":[271],"Salers.":[272,310],"Also":[273],"these":[274],"results":[275,340],"show":[276],"differentiated":[283],"themselves":[284],"frequencies.":[291],"However,":[292],"group":[299],"showed":[302],"evidence":[303],"approaching":[305],"observed":[308],"four":[313],"under":[315],"Of":[317],"those":[318],"SNP,":[319],"three":[320],"similar":[324],"Salers,":[330],"suggesting":[331],"natural":[332],"artificial":[334],"selection":[335,375],"These":[339],"indicate":[341],"exists":[345],"cattle,":[350],"which":[351],"increase":[356],"Therefore,":[362],"breeders":[364],"may":[365],"choose":[366],"address":[368],"such":[369],"problem":[371],"choice,":[374],"breed,":[378],"both.":[380]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-08-17T00:00:00"}